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Central mechanism study of transcutaneous auricular vagus nerve stimulation based on ReHo in the treatment of primary insomnia
Authors
何家恺
张磊
+6 more
张金铃
方继良
毕研芝
王瑜
荣培晶
赵斌
Publication date
1 January 2020
Publisher
Abstract
目的:探讨经皮耳迷走神经刺激(taVNS)治疗原发性失眠(PI)的中枢效应机制。方法:纳入PI患者15例,采用治疗前后自身对照的原则,予以taVNS治疗4周,利用静息态功能磁共振技术,采集治疗前后患者的脑核磁数据,通过局部一致性(ReHo)的分析方法,观察taVNS对患者脑区局部一致性的调节作用。结果:PI患者经过taVNS治疗4周后,大脑多个脑区发生局部一致性的改变,其中左侧内侧额上回(t=5.36,P<0.01 )、右侧前扣带回(t=5.36, P<0.01) ReHo值升高,而右侧颞下回(t=-5.19, P<0.01)、双侧颞中回(t=-5.09,P<0.01)、右侧丘脑(t=-4.88,P<0.01 ReHo值降低。结论:taVNS对前额叶、前扣带回、颞叶、丘脑等相关区域功能的调节可能是其治疗PI的中枢效应机制。</p
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Last time updated on 16/09/2020