Study on Resistance to Progressive Collapse of Half-through Arch Bridge Based on Suspender Breaking

连续性倒塌是指结构局部构件的破坏导致相邻构件失效，从而引发更多构件破坏，最后导致结构的整体破坏或出现和初始破坏不成比例的大面积倒塌连琐反应。国内外对于房屋建筑结构的抗连续性倒塌已经有相应地规范和设计流程，但桥梁结构的连续倒塌研究较少。虽然房屋建筑关于抗连续性倒塌的成果为桥梁结构的抗连续倒塌分析提供了很好的借鉴，但不同结构的设计标准、结构物的可靠指标、荷载取值等方面的要求并不相同。本文结合中承式拱桥的结构特点，对其由于吊杆破断所引起的抗连续性倒塌机理进行分析，为桥梁抗连续性倒塌性能评估和相关设计规范提供参考。主要工作包括以下三个方面： 首先，通过对由于吊杆破断产生的中承式拱桥垮塌事故进行总结与...The progressive collapse refer to the failure of the local members of the structure leads to the failure of adjacent components. Finally, it can lead the large scale collapse of the disproportionate with the initial small-scale destruction. In domestic and abroad, the resistance to progressive collapse of the building structure has been a corresponding codes and design process. However, there...学位：工程硕士院系专业：建筑与土木工程学院_工程硕士(建筑与土木工程)学号：2532014115178

On the Burden of Proof in Labor Disputes

劳动争议，是指用人单位与劳动者之间，基于劳动合同、劳动法律法规或用人单位的劳动制度形成的劳动合同关系或事实劳动关系而发生的权利义务纠纷，其解决机制主要包括劳动争议仲裁和诉讼。但无论是仲裁还是诉讼，证明责任都是核心问题，直接关系到劳动争议的处理结果。 劳动关系除了具有民事法律关系的平等性之外，还具有特有的类似于行政法的隶属性和管理性。基于劳动关系的特点，我国的劳动实体法的规定均体现对劳动者的倾斜保护。我国现行的劳动争议解决机制设计上已注意到劳动争议本身的特殊性，在争议的解决方式上，我国目前实行的“有限的一裁终决”和“一调一裁两审”制度，明显有别于一般的民事诉讼制度。但劳动争议的证明责任问题却缺...Labor disputes are civil disputes between the employer and laborers, which are based on the labor contract or virtual labor relationships formed by the labor contracts, labor laws and regulations or a labor system. The burden of proof is a core problem, whether in the labor disputes arbitration and lawsuit, which relates directly to the result of the labor disputes. The current labor disputes re...学位：法律硕士院系专业：法学院法律系_法律硕士(JM)学号：X200712000

丙氨酰谷氨酰胺联合肠外营养治疗严重多发伤的临床效果观察

目的观察严重多发伤患者治疗中应用丙氨酰谷氨酰胺联合肠外营养的效果。方法选择医院收治的严重多发伤患者78例纳入此次研究,随机分为观察组和对照组,每组39例。对照组接受临床常规治疗以及肠外营养治疗,观察组在此基础上联合丙氨酰谷氨酰胺治疗。比较2组治疗前后血清水平变化情况、机械通气时间及住ICU时间。结果治疗后,2组血清白蛋白、血清前白蛋白水平较治疗前均升高,且观察组上述指标升高幅度大于对照组(P均<0. 01);观察组机械通气时间、住ICU时间短于对照组,差异有统计学意义(P <0. 01)。结论针对严重多发伤患者实施肠外营养与丙氨酰谷氨酰胺联合治疗,其临床效果显著,可全面改善患者血清水平,缩短患者临床治疗时间

Reviews on Preparation and Determination of a-glucosidase Inhibitor

文中综述了国内外用天然植物和微生物制备具有降血糖作用的α-葡萄糖苷酶抑制剂的工艺过程,并对α-葡萄糖苷酶抑制剂的检测方法进行了总结。The preparation process of α- glucosidase inhibitor from natural plant and microorganism with hypoglycemic activity was detailedly discussed in this paper. And the main determination methods of this inhibitor were detailedly summarized.江西省教育厅科技项目(赣教技字[2007]285号);; 江西科技师范学院人才创新基金项

Screening of α-glucosidase Inhibitors in Active Constituents from Portulaca oleracea L.

[目的]观察马齿苋活性成分对兔小肠黏膜α-葡萄糖苷酶活性的影响,筛选α-葡萄糖苷酶抑制剂。[方法]提取分离马齿苋活性成分,在体外建立微量酶反应体系,PnPg作为底物,以阿卡波糖为参照,检测马齿苋活性成分对α-葡萄糖苷酶活性的影响。[结果]马齿苋总提取液、粗多糖和总生物碱对α-葡萄糖苷酶具有明显抑制作用,抑制效果接近于阿卡波糖,不饱和脂肪酸和总黄酮无抑制作用。[结论]马齿苋防治糖尿病的主要成分是生物碱和多糖,可能具有阿卡波糖样的降糖机制。[Objective] The research aimed to observe the effects of active constituents from Portulaca oleracea L.on α-glucosidase activity in intestine mucous to screen α-glucosidase inhibitors.[Method] The active constituents were extracted from Portulaca oleracea L..The trace enzyme reaction system was constructed in vitro.Taking the pNPG as substrate,and acarbose as control,the effects of the active constituents from Portulaca oleracea L.on α-glucosidase activity.[Result] Total extraction,alkaloids and polysaccharides from Portulaca oleracea L.could obviously inhibit α-glucosidase activity,but polyunsaturated fatty acid and flavonoids had no inhibition.[Conclusion] The main active constituents are alkaloids and polysaccharides from Portulaca oleracea L.for preventing diabetes,and the hypoglycemic mechanism is similar to acarbose.江西省教育厅科技项目(赣教技字〔2007〕285号);江西科技师范学院人才创新基金项目(2005

Anti-resonance features of destructive quantum interference in single-molecule thiophene junctions achieved by electrochemical gating

基于单个有机分子来构筑电子器件为电子器件微型化提供潜在技术方案。本研究发展了可集成电化学门控的单分子电子器件测试芯片技术和科学仪器方法，在实验和理论两个层面对具有相消量子干涉效应的噻吩衍生物分子器件的电输运过程进行了电化学调控研究，从而首次在室温下实现了对单分子电子器件中量子干涉效应的反共振现象的直接观测和调控，为制备基于量子干涉效应的新型分子材料和器件提供了全新的设计思路和策略。该研究充分展示了电化学调控技术在信息材料和器件领域的重要应用潜力，也体现了我校固体表面物理化学国家重点实验室在电化学研究和科学仪器研发领域的技术积累，以及面向科学前沿开展交叉学科探索的研究特色。 该研究工作是在洪文晶教授、上海电力大学陈文博教授、英国兰卡斯特大学Colin Lambert教授指导下完成的。化学化工学院博士生白杰和李晓慧为论文的共同第一作者，刘俊扬副研究员、师佳副教授、研究生唐永翔、刘帅、黄晓娟、谭志冰和萨本栋微纳研究院的杨杨副教授等也参与了研究工作。田中群教授和毛秉伟教授为该工作提供了重要指导。【Abstract】Controlling the electrical conductance and in particular the occurrence of quantum interference in single-molecule junctions through gating effects, has potential for the realization of high-performance functional molecular devices. In this work, we used an electrochemically-gated, mechanically-controllable break junction technique to tune the electronic behaviour of thiophene-based molecular junctions that show destructive quantum interference (DQI) features. By varying the voltage applied to the electrochemical gate at room temperature, we reached a conductance minimum that provides direct evidence of charge transport controlled by an anti-resonance arising from DQI. Our molecular system enables conductance tuning close to two orders of magnitude within the non-faradaic potential region, which is significantly higher than that achieved with molecules not showing DQI. Our experimental results, interpreted using quantum transport theory, demonstrate that electrochemical gating is a promising strategy for obtaining improved in-situ control over the electrical performance of interference-based molecular devices.This research was supported by the National Key R&D Program of China (2017YFA0204902), National Natural Science Foundation of China (21722305, 21673195, 21503179, 21703188), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, Natural Science Foundation of Shanghai (17ZR1447100), Science and Technology Commission of Shanghai Municipality (14DZ2261000), China Postdoctoral Science Foundation (2017M622060) for funding work in Xiamen. It was also supported by EU Horizon 2020 project QuIET under grant agreement no. 767187EC FP7 ITN ‘MOLESCO’ project no. 606728 and UK EPSRC grants EP/N017188/1 and EP/M014452/1 and Leverhulme Trust (Leverhulme Early Career Fellowships no. ECF-2017-186 and ECF-2018-375) for funding instrumentation used in Lancaster. It was also supported by Hungarian and Czech Academies of Sciences (P2015-107) and Hungarian Research Foundation (OTKA 112034) for funding instrumentation used in Hungary. The authors thank Z.-Q. Tian and B.-W. Mao, Xiamen University, for useful discussions. 该工作获得科技部国家重点研发计划课题（2017YFA0204902），国家自然科学基金委优秀青年科学基金等项目（21722305、21673195、21703188、21503179）以及中国博士后科学基金（2017M622060）等项目的资助，也得到了固体表面物理化学国家重点实验室、能源材料化学协同创新中心的支持

Efficient Production of Succinic Acid from Macroalgae Biomass by Recombinant Escherichia coli

丁二酸作为一种重要的C4平台化合物，能够通过化学或生物转化合成许多高附加值的大宗化学品。微生物发酵法生产丁二酸具有反应条件温和，环境友好等特点，受到国内外研究人员的广泛关注。目前，丁二酸生物合成工业化的关键问题主要包括原料成本过高，菌株生产能力较低等。针对这些难题，本研究从构建高产丁二酸菌株出发，探讨大型藻类（巨藻）生物质作为新型碳源发酵生产丁二酸的可行性。 首先，敲除了野生型Escherichia coli W3110厌氧代谢中副产物途径的关键酶：乳酸脱氢酶（ldhA）和丙酮酸甲酸裂解酶（pflB），构建了菌株E. coli BS002。由于胞内氧化还原不平衡及丙酮酸积累等原因，该菌株在严格厌氧条件下无法利用葡萄糖。由于磷酸烯醇式丙酮酸羧化激酶（PCK）在催化磷酸烯醇式丙酮酸（PEP）至草酰乙酸（OAA）的反应过程中伴随ATP的生成，考虑到能量代谢的诸多优势，向E. coli BS002引入Actinobacillus succinogene 130Z PCK，构建了工程菌E. coli BS101 (△ldhA△pflB::Kan/ pTrcHisA-130Zpck)。摇瓶发酵结果表明E. coli BS101消耗8.14 g/L葡萄糖，积累4.77 g/L丁二酸和2.65 g/L丙酮酸，丁二酸得率达到0.88 mol/mol，较野生型E. coli提高约3倍，同时几乎不产生乳酸、甲酸和乙酸。 其次，研究酶的表达水平、HCO3-的供应方式以及浓度对于菌株生长和丁二酸合成的影响，优化PCK催化效率和胞内ATP的供给能力。摇瓶发酵结果表明，当IPTG浓度为0 mmol/L 和NaHCO3浓度为15 g/L时，PCK的催化能力最高，菌株的丁二酸产量和摩尔得率分别达到5.68 g/L和1.15 mol/mol，较之前提高约20%和28%。此外，通过进一步考察胞内ATP的供应强度，证实在最优条件下菌体胞内ATP的水平较未优化时提高近2倍。 此外，考察L. japonica为代表的巨藻生物质作为发酵碳源生产丁二酸。经过简单的预处理和酶解后，L. japonica水解液中主要包含10.31 g/L葡萄糖和10.12 g/L甘露醇。选择以E. coli BS002作为生产菌株，当甘露醇作为单一碳源时，丁二酸摩尔得率高达1.39 mol/mol，较葡萄糖作为碳源时提高近38 %。而且，水解液不需要进行脱毒处理，能够直接被用于菌体生长和丁二酸合成，但是菌株对于葡萄糖和甘露醇的利用过程中存在“diauxic”现象。最终，工程菌利用L. japonica水解液发酵产生17.44 g/L丁二酸、2.73 g/L丙酮酸和1.55 g/L乙酸，丁二酸总摩尔得率达到1.24 mol/mol总糖

生产管理的利器-MES

本文简要介绍了生产管理信息系统的发展历程,生产执行系统-MES提出的背景,定义,在企业信息化建设中的位置,主要功能,MES系统实施需要注意的问题,MES为企业带来的好处和效益

Time and Liberation in Three-Treatise Master Jizang's Madhyamika Thought

In this thesis, I hope to make a small contribution to the study of of Chinese Buddhism. The preliminary discussion in the first and second chapters takes the form of a historiographical overview of some concepts that developed within the Three-Treatise tradition of Chinese Buddhism between the 5th and 6th centuries. This serves to illuminate the intellectual practices of this unique tradition of thought, which has been largely underrepresented in Western-language studies of Buddhism. In the subsequent chapter, I will clarify the exposition of these ideas within Master Jízàng’s commentary on the Mūlamadhyamaka-kārikās《中論》, the Zhōngguānlùn-shū《中觀論疏》 (completed in 608 C.E.). The examination of this work and its immediate contexts promises to shed light upon the development of Mādhyamika thought in East Asia, especially with regards to the basic exegetical strategies of the Three Treatise tradition. The third and fourth chapters elucidates Jízàng’s interpretation and commentary upon two seminal chapters within Nāgārjuna’s Zhōnglùn, the “Contemplation of the Three Characteristics”〈觀三相品〉 and the “Contemplation of Time”〈觀時品〉. The content of these two chapters reflect the doctrinal and philosophical diversity of the intellectual terrain in early 7th-century China. Jízàng’s analysis in these chapters unfolds into a systematic refutation of the “false doctrines” of the Indian Ābhidharmika sects, which, in turn, illuminate the divergent intellectual currents of Jízàng’s milieu, as well as revealing the encyclopedic breadth of Jízàng’s Zhōngguānlùn-shū as well as other monumental commentarial works of the period. The examination of Jízàng’s refutation of the Sarvāstivādins in the fourth chapter – an as of yet unexplored facet of his considerable corpus – serves to enlarge our current comprehension of both Chinese intellectual culture during this critical juncture in Chinese history, and to enrich our understanding of the variegated exegetical and philosophical approaches of the great thinkers of 6th- and 7th-century China