The study about interactions between Cx43 and AKAP95 in lung cancer cells A549

细胞间隙连接蛋白(Connexin，Cx)是跨细胞膜的蛋白质，是构成细胞间隙连接(gapjunction)的重要蛋白。Cx蛋白表达下降引起细胞间隙连接通讯功能下降或消失，使相邻细胞之间不能沟通信息，细胞之间失去了整体的组织协调功能，丧失了对细胞的正常生长和增殖调控能力，导致正常细胞恶变、肿瘤发生。因此认为细胞间隙连接通讯对于调控细胞生长和增殖以及控制细胞的恶性转化有重要作用。近年来也有研究表明Cx蛋白除在细胞膜上形成细胞间隙连接的功能外，尚可直接在细胞内参与细胞周期调节而发挥其对细胞生长和增殖的调控作用。 为了深入研究Cx43蛋白非依赖细胞间隙连接通讯功能对细胞生长调节的作用及其可能作用靶点...Connexin (Cx) is important transmembrane protein that constitutes cytomembrane channel structure-gap junction.The expression of Cx reduced causes intercellular gap connection communication (GJIC) decline or disappearance, that makes adjacent cells communicating information disappearance and losing overall coordination function between cells. Cells lost normal regulation ability of cell growth and ...学位：理学硕士院系专业：海洋与环境学院环境科学与工程系_环境科学学号：2262008115154

2014年8月-2017年7月厦门大学附属中山医院中药配方颗粒和传统中药饮片应用分析

目的:了解中药配方颗粒、传统中药饮片的临床应用情况和医师、患者对中药配方颗粒的态度,探讨中药配方颗粒给传统中药饮片带来的冲击及其应用前景。方法:调取厦门大学附属中山医院2014年8月—2017年7月中药配方颗粒和传统中药饮片使用数据,对两者的使用量、使用金额、处方量及处方金额等进行统计分析;通过问卷调查,了解医师和患者对中药配方颗粒的看法。结果:2014年8月—2015年7月,中药配方颗粒的使用金额稳步上升,传统中药饮片的使用金额快速下降;2015年8月后,传统中药饮片的使用金额相对稳定;2016年8月后,中药配方颗粒的使用金额持续下降,2017年5—7月降至23.12万元,仅为传统中药饮片的28.37%。中药配方颗粒的平均价格指数为(146.38±4.71)元/kg,平均处方金额为(206.15±35.95)元;传统中药饮片的平均价格指数为(117.71±11.81)元/kg,平均处方金额为(151.91±24.47)元。医师和患者对中药配方颗粒看法的问卷调查结果显示,\"完全接受\"和\"不能接受\"者占比较小,\"可以考虑\"者占比最大。结论:作为传统中药饮片的补充,中药配方颗粒的应用有临床基础和社会基础。临床疗效和价格因素是其临床应用的困扰焦点,等效性临床研究和药物经济学评价是解决问题的办法

A Sentence Segmentation Method for Ancient Chinese Texts Based on Recurrent Neural Network

提出一种基于循环神经网络的古文自动断句方法。该方法采用基于GRU (gated recurrent; unit)的双向循环神经网络进行古文断句。在解码过程中, 该算法不仅利用神经网络输出的概率分布, 还进一步引入状态转移概率和长度惩罚,; 以便提高断句准确率。在大规模古籍语料上的实验结果表明, 所提方法能够取得比传统方法更高的断句F1值。This paper proposes an automatic sentence segmentation method for; ancient Chinese texts based on recurrent neural network (RNN). A; bi-directional RNN structure with gated recurrent units (GRU) is; implemented, and state transition probability and length penalty are; employed in decoding to improve the accuracy. Experimental results show; that proposed model achieves higher F1 score than traditional methods.教育部专项简繁汉字智能转换系统; 国家科技支撑计划项目; 教育部博士点基金; 国家自然科学基金; CCF中文信息技术开放课

Distribution Changes of Calcium and Programmed Cell Death in the Pistil of Litchi (Litchi chinensis Sonn.) Flower during Its Development

应用焦锑酸钾沉淀法研究了荔枝雌花和雄花雌蕊发育过程中钙的分布变化。在大孢子母细胞阶段,雌花近珠孔内珠被细胞和花柱细胞的钙沉淀颗粒主要分布在细胞壁和细胞间隙,少部分在液泡;雌花花柱维管细胞中含有很多的钙沉淀颗粒;在雄花的近珠孔内珠被细胞钙沉淀颗粒大多在液泡中;雄花花柱细胞和维管细胞中钙沉淀颗粒很少。大孢子母细胞减数分裂后,雌花雌蕊继续发育,雄花雌蕊败育。雌花维管中的钙沉淀颗粒数量减少,可能被转运到将要发生花粉萌发和受精的部位。雌花近珠孔内珠被细胞壁的钙沉淀颗粒分布增加,花柱细胞从上(近柱头)到下(近子房)钙沉淀颗粒量递增。雄花近珠孔内珠被细胞发生程序性死亡:液泡中的钙进入细胞核启动细胞程序性死亡,核周隙与质膜腔形成连续的通道,钙在核与细胞质之间的流动不受限制;在特定的时间段,钙沉淀颗粒出现在线粒体、过氧化物体和线型内质网的外膜上。钙在细胞中重新分布可能触发和调节细胞程序性死亡的进程。缺乏钙沉淀颗粒的雄花花柱细胞迅速解体。Potassium pyroantimonate precipitationmethod was used for investigating calcium distributionand cell ultrastructure change during development of pis-tils of litchi male and female flower. The results showedthat at the megasporocyte stage of female flowers, cal-cium precipitates was located mainly at cell wall and in-tercellular space of inner integument near the micropyleand style cells, and to a lesser extent in vacuoles. Vascu-lar tissues also contained much calcium precipitates. Ininner integument cells near the micropyle of male flowers,the vacuole contained most of the calcium precipitates.Calcium precipitates in style cell and vascular tissues ofmale flowers was sparse and seldom seen. After meiosisof megasporocyte, pistils of female flowers continued togrow and those of male flowers aborted. In femaleflowers, calcium precipitates concentration became lowerand calcium precipitates was probably transported to theplaces for future pollen bourgeoning and fertilization.Cell wall calcium precipitates concentration increasedin the inner integument cells near the micropyle. Cal-cium precipitates concentration increased from topperstyle cells to lower ones. In male flowers, inner integu-ment cells near the micropyle underwent the programmedcell death (PCD): flow of calcium from vacuoles intonucleus might had triggered the PCD process. A con-tinuous channel was formed between perinuclear spaceand cytoplasm membrane lumen, and calcium flowedfreely between nuclear membrane and plasma membrane.At certain time and locations, calcium precipitates wasnewly appeared at some organelles like endoplasimicreticulum, mitochondria and peroxisomes. This calciumredistribution in cells might trigger and regulate the pro-cess of PCD. In male flowers, style cells containing nocalcium precipitation soon began to degenerate.福建省自然科学基金项目(No.B0310013)资助。~

Connexin43磷酸化调节与细胞间隙连接通讯功能

细胞间隙连接通讯(gap junction intercellular communication,GJIC)对于细胞增殖、分化、内环境稳定及机体新陈代谢、生长发育等生理过程起重要作用。细胞间隙连接是由细胞间隙连接蛋白(connexin,Cx)六聚体形成的跨膜通道结构,细胞间隙连接蛋白是构成细胞间隙连接的蛋白大家族,在人类

我国与东盟国家的产业分工与协作

本文通过对中国与东盟各国产业结构变动的实证分析,发现我国与东盟各国在产业分工中的竞争与互补关系,指出了在东盟区域的产业分工协作中,我国的选择。Through empirical analysis of the industrial structural changes in China and ASEAN countries,the author aims to reveal the competitive and complementary relations between China and ASEAN in industrial division of labor and suggest options for China in coordinating its industrial relations with ASEAN

艰难梭菌粘附的研究进展

艰难梭菌粘附的研究进展厦门大学生物系厦门361005王隽，苏文金“艰难梭菌（ClOSTrIdIuMdIffICIlE）是重要的肠道致病厌氧菌。它是抗生素疗法所引起的伪膜性结肠炎的致病菌，并且是引起抗生素相关的腹泻的最主要病原菌之一，同时还与一些非抗生..

东盟共同体的发展与“一带一路”倡议——专访厦门大学东南亚研究中心主任王勤教授

王勤教授一直致力于东南亚经济、亚太经济和区域经济统一体化研究,取得累累硕果。2017年9月12日至15日,第14届中国—东盟博览会和中国——东盟商务与投资峰会再次相约南宁。硕果金秋,我刊编辑苏显华特别邀请王勤教授,以中国—东盟区域经济一体化的发展研究为主题进行专访

The Karyotypes of Nibea diacanthus

以头肾细胞为材料,采用PHA体内注射,空气干燥法制片,分析了双棘黄姑(Nibeadiacanthus)的染色体组型.结果表明:其染色体组型为:2n=48=24t,NF=48.在已进行过染色体组型分析的石首鱼类中,除大黄鱼外,染色体组型均为2n=48t.The karyotypes of Nibea diacanthus were examined in the paper.The samples were separately injected by PHA and colchicines.The chromosomes were received from the renal tissue by using air drying method and Giemsa staining.The result showed that the chromosome number of Nibea diacanthus was 48;and its karyotype formula was 2n=48=48 t,NF=48;it was the same as the other croakers determined,except Pseudoceana crocea in Sciaenidae.福建省自然科学基金(B0110004)资助细胞数目938770

CCND1基因多态性与肝细胞癌遗传易感性的病例对照研究

目的探讨细胞周期蛋白D1基因(CCND1)rs9344位点多态性与肝细胞癌易感性的关联;方法采用病例对照研究,对经肝内穿刺活检确认的266例原发性肝细胞癌新发病例及经年龄、性别匹配的306例健康对照,应用MALDI-TOF法检测CCND1 rs9344基因多态性,以χ2检验比较CCND1基因型及相关危险因素在病例对照间分布的差异,采用非条件Logistic回归分析基因型与肝癌发病风险的关系。结果 CCND1 rs9344位点存在GG、GA、AA三种基因型,G/A等位基因及各基因型在肝癌组与对照组中分布未见明显差异,但在分层分析中发现,有肝脏疾病史人群中病例组AA基因型携带比例高于对照组,差异有统计学意义,与GG基因型相比,AA基因型伴有肝病史个体罹患肝细胞癌的风险比值比为5.29(OR=5.29,95%CI:1.42-24.49);结论 CCND1 rs9344位点多态性与肝细胞癌易感性无明显相关,AA基因型携带者且有肝脏疾病史对比其他基因型携带者患肝细胞癌的风险较高。厦门市科技局社会发展项目3502Z20124023