The Role of SRC-3 in Hepatocyte Proliferation and Xenobiotic Metabolism in the Liver

类固醇激素受体辅激活子（steroidreceptorcoactivator，SRC）作为一类转录协同因子，能够与多种转录因子相互作用并增强其转录活性。SRC-3是SRC家族（SRC-1/NCoA1、SRC-2/GRIP/TIF2、SRC-3/AIB1/ACTR/pCTP/RAC3/TRAM-1）的一员。SRC-3基因敲除会导致小鼠发育延迟、雌鼠乳腺泡萎缩，并导致对雌激素和孕酮的部分耐受性。SRC-3在肿瘤细胞发生发展的过程中也起到了重要的作用，其既有癌基因的作用，又有肿瘤抑制因子的功效，具体取决于所在细胞与依靠的信号通路。此外，SRC-3对于能量和脂类代谢具有促进作用，并且SRC-3对炎症反...Steroid receptor coactivator-3 (SRC-3) is a member of the SRC family (SRC-1/NcoA-1; SRC-2/GRIP1/TIF2; SRC-3/ pCIP/ACTR/AIB-1/RAC-3/TRAM-1), which functions as a transcriptional coactivator for nuclear receptors and other transcription factors. SRC-3 deficient mice show growth retardation, reduction in mammary gland alveolar development, and partial resistance to estrogen and progesterone. SRC-3 c...学位：理学硕士院系专业：生命科学学院生物学系_细胞生物学学号：2172006115219

基于自适应权重AD-Census变换的双目立体匹配

针对AD-Census变换采用固定权重将AD变换代价与Census变换代价合成的双目立体匹配代价无法体现像素点区域特征的问题,提出一种基于自适应权重AD-Census变换的双目立体匹配算法。算法首先通过增加相邻像素点的灰度差阈值条件改善十字支撑自适应窗口;然后以每个像素点的十字支撑自适应窗口的最短臂长为自变量,利用指数形式的函数,进行AD变换代价与Census变换代价合成权重的自适应设置。由于像素点十字支撑自适应窗口的最短臂长能够反映像素点的区域特性,因此自适应设置的权重大小与像素点的区域特性直接相关,计算图像边缘区域像素点的匹配代价时,AD变换的权重大;计算平滑区域像素点的匹配代价时,Census变换的权重大。Middlebury第3代双目立体匹配评估平台的结果显示,基于自适应权重AD-Census变换的双目立体匹配性能与基于AD-Census变换的双目立体匹配性能相比,所有图像集的全部像素点的视差平均误差减小了25%,非遮挡像素点的视差平均误差减小了20%,性能得到了提升;平台上包括Adir在内的多个图像集的匹配结果表明基于自适应权重AD-Census变换的双目立体匹配更适合含纹理丰富、存在重复区域的图像。国家自然科学基金资助项目(61274133

Collision Detection for Virtual Surgery Planning System of Nasopharyngeal Carcinoma

针对鼻咽部及其周围组织的特点,着重论述了一种基于包围盒层次的碰撞检测算法。该方法是解决碰撞检测问题固有时间复杂性的一种有效方法,是用体积略大而几何特征简单的包围盒来近似描述复杂的几何对象,并通过构造树状层次结构来逼近对象的几何模型。在对包围盒树进行遍历过程中,通过包围盒间的快速相交检测来及早排除明显不可能相交的基本几何元素对,从而提高了碰撞检测速度。Focusing on the features of nasopharynx and peripheral tissues, this paper mainly states an algorithm of collision detection based on bounding box hierarchies. It is an effective method to solve the intrinsic time complexity of collision detection problem, which refers to take advantage of bounding box with larger volume and simple geometric features to approximately describe the complicated geometric object and approach the geometric model of object through constructing the tree hierarchy structure. During the ergodic process of hierarchy bounding volumes, the rapid intersec- tion detection among bounding boxes could exclude the elementary geometric element pairs at early time that are obvi- ously impossible to intersect, so as to elevate the speed of collision detection.卫生部联合基金项目(WKJ2005-2-001);; 福建省科技重点项目(2004Y008)~

Research of Visualization Based on VTK

摘要:工具包 （Visualization Toolkit） 是一个面向对象的可视化类库， 它为从事可视化工具开发的广大科研工作者提供强大的技术支持。为此，必须了解和掌握VTK 的框架结构、构成VTK 对象模型和组成成分，以及VTK 在医学可视化应用中的实现。 Abstract Visualization Toolkit is an object-oriented visualization class library. It provides technological support for those who work at visualization. In the paper the structure and the elements of object models of VTK are introduced. Finally a visualization example applied in iatrology for given.国家自然基金:项目批准号：3077056

Segmentation Algorithm of CT Image Liver Based on MRF

介绍了马尔可夫随机场(MArkOV rAndOM fIEld,Mrf)的基本理论,以及基于Mrf的图像分割模型及其求解过程。利用Mrf分割方法对肝脏CT图片进行了分割,实验结果表明:该方法能够有效对肝脏实质进行分割,在一些模糊区域有更好的分割效果,可用于CT图像序列中的肝实质自动分割。In this article the Markov Random Field (MRF),as well as image segmentation based on MRF model and its solution process was described.A method to segment liver in CT image sequence based on MRF was put forward.The experimental result shows that this method can effectively segment liver from CT image.In particular,in some vague regions have a better segmentation and it can be applied to the automatic segmentation of CT image sequence.国家自然科学基金(编号:30770561); 生部科学研究基金—福建省卫生教育联合攻关计划资助项目(编号:WKJ2005-2-001;WKJ2008-2-41); 福建省自然科学基金项目(编号:2009J05156)~

不同饵料、密度和池底对锯缘青蟹大眼幼体蜕皮变态的影响

实验观察了不同饵料、池底、密度对锯缘青蟹大眼幼体蜕皮变态率和残杀率的影响.实验结果表明:投喂裸腹蚤时,大眼幼体蜕皮变态率最高,3种池底大眼幼体蜕皮变态率平均为 78.1%,残杀率最低平均为 11.4%;海泥池底大眼幼体蜕皮变态率最高,投喂3种饵料的大眼幼体蜕皮变态率平均为84.8%,残杀率最低平均为7.6%;裸腹蚤是青蟹大眼幼体培育适宜的饵料,而海泥则是大眼幼体变态适宜的池底.不同培育密度对青蟹大眼幼体蜕皮变态率和残杀率的实验结果表明:当大眼幼体的培育密度为3 尾/dm3 时,其蜕皮变态率最高,而残杀率与大眼幼体培育密度的关系不明确. 【英文摘要】 Effects of different dietary,densities and substrata on metamorphosis rate and cannibalistic rate from protozoea 1 (PZ1) to postlarvae 1(PL1) stages of Scylla serrata megalopae were studied in two separate experiments.In the first experiment,three dietary:Monia mongolica,minced meat of Ruditapes philippinaram which filted through mesh and haima 0 shrimp stuff and three substrata:sea mud,sand and cement were investigated.It showed that the metamorphosis rate of megalopae was higher when it was fed Monia mong...国家海洋 863 项目“锯缘青蟹大规模人工育苗技术”(2002AA603013)资

3D Visualization of Liver CT Series Image Using Ray-casting Algorithm

肝脏CT图像的三维可视化具有重要的科研价值和实用意义。直接体绘制技术已经成为三维体数据集可视化的一种重要方法。光线投射算法是一种实现原理相对简单且绘制结果精确可靠的体绘制算法,但传统算法绘制速度较慢。综合研究了现有的主要优化技术:感兴趣区域划分、空间跳跃技术及体素分类的快速三线性插值的思想,加速了光线投射算法,实现了对肝CT图像三维重建。The visualization of liver CT series image volume data is important to scientific research and practical use.Direct volume rendering is an important method of 3D volume data visualization.As a volume rendering algorithm, Ray-casting Algorithm is easy to realize and its principle is rather simple.However,the rendering speed of traditional Ray-casting Algorithm is very slow.In this paper,we used three existed accelerating techniques:ROI division,space leaping,and the thesis of fast Tri-Linear interpolation based on voxel classified to accelerate Ray-casting Algorithm,and accomplished the 3d reconstruction of liver CT series image.国家自然科学基金(编号:30770561); 卫生部科学研究基金—福建省卫生教育联合攻关计划资助项目(编号:WKJ2005-2-001;WKJ2008-2-41); 福建省青年科技人才项目(编号:2009J05156)~

An Dose Optimization Algorithm in Brachytherapy

高剂量率后装近距离治疗现在已成为放射治疗的常用方法之一,近距放射治疗计划系统的应用也越来越广泛,主要目的就是通过优化源的驻留位置和时间来改善剂量分布,提高治疗质量。提出了一种连续驻留位置和驻留时间的近距离放疗剂量优化算法。在插值路径为直线、照射源为点源的情况下,首先将驻留时间T看成是位置X的一个连续函数,计算每个参考剂量点的剂量,再用计算剂量和目标剂量值之差的加权平方和为目标函数,然后用复合型调优法求解最优的曲线参数。曲线可以根据具体情况进行分段,得到曲线后再用积分的数值逼近方法将其离散化,得到最终的驻留位置和驻留时间。实验结果表明,本算法不仅避免了负的驻留时间问题,还可使相邻驻留位置的驻留时间更加平滑;在最后的离散化过程中,可以得到不同的驻留位置和驻留时间结果,使计划具有更好的灵活性。Brachytherapy is an anti-tumor treatment by means of radioactive sources that are placed at short distances from the target tumor tissues and becoming more and more widely used.In this paper,we proposed an algorithm to optimize the dwell time of radioactive source for computer-based high-dose-rate afterloading implants planning system of brachytherapy.The dwell time was considered as a continuous function of the dwell position,calculated the dose values of referenced dose points.The minimal difference between these dose values and demanded dose values was used as the objective to get the optimized function parameters.The function curve could be separated to several sects.The optimized curve was dispersed using compound trapezoid formula to get the dwell positions and dwell times.This method could avoid the emergence of negative dwell time,and reduce the dwell time gradient as well.When dispersing the curves,different dwell times and dwell positions could be obtained,which made the brachytherapy treatment plan more flexible.国家自然科学基金资助项目(60371012、60701022

Computer Simulation of Nasopharyngeal Carcinoma Brachytherapy

近距离放疗是鼻咽癌治疗的主要手段之一。其计算机仿真可帮助医生制定详细的放疗方案,对鼻咽癌精确放疗具有显著意义。一个完整的鼻咽癌近距离放疗仿真的方案被提出。首先,对CT图像进行分割,重建三维组织模型。然后,设计了基于Ta-chih Lee细化算法的鼻咽腔放疗源虚拟输送路径。最后,对125I柱状放射源放射剂量分布进行了蒙特卡罗仿真。初步实现了鼻咽癌近距离放疗的计算机仿真。Brachytherapy is one of the major means of nasopharyngeal carcinoma treatments. Computer simulation of the process is of great value to radiotherapy planning. A complete solution for computer simulation of nasopharyngeal carcinoma brachytherapy was proposed. Firstly,the CT images of the nasopharyngeal tissues were segmented and the 3D models of nasopharyngeal tissues were reconstructed. Then the 3D delivery path of radioactive source based on Ta-chih Lee’s thinning algorithm was designed. Finally,the simulation of cylindrical 125I dose distribution was realized by Monte Carlo method. A primary computer simulation of nasopharyngeal carcinoma Brachytherapy was realized.国家自然科学基金项目(60601025);; 福建省科技重点项目(2005Y0018