吡非尼酮药物缓释载体PTMAc-PEG-PTMAc水凝胶制备与体外实验

【目的】以PTMAc-PEG-PTMAc三嵌段（PPP）水凝胶为吡非尼酮（PFD）药物缓释载体，评价其药物缓释性能。观察PFD载药水凝胶对人眼Tenon′s囊成纤维细胞（HTF）增殖抑制作用。【方法】制备PPP水凝胶；研究其溶胀率及其影响因素；光学显微镜观察水凝胶（载药与空载）中人眼Tenon′s囊成纤维细胞（HTF）的形态学改变；直接接触法进行PPP载药水凝胶进行体外释药实验。通过测定浓度、计算累积药物释放量，绘制出两种水凝胶体外药物释放曲线。CCK-8法检测不同浓度不同时间点水凝胶材料对细胞活力的影响及载药水凝胶体外抑制HTF增殖。【结果】PPP水凝胶成胶稳定。扫描电镜显示水凝胶呈现三维立体网孔状结构。水凝胶具有溶胀特性。溶胀率随水凝胶材料浓度增加而减少。在体外释药试验显示在前4d有明显的药物突释，此后缓慢释药直至第14天达到平衡。增加载药浓度，减少凝胶体积将明显增加药物累积缓释量；显微镜观察PPP水凝胶有抑制HTF细胞黏附作用；PPP水凝胶与HTF相互作用24、48、72、96h观察细胞活力分别为85.7%、93.0%、82.0%、81.6%，水凝胶不同方位HTF细胞形态不尽相同；水凝胶对细胞有抑制细胞黏附作用。两组不同载药浓度（1mg/mL和2mg/mL）载药水凝胶在24、48、72、96h这4个时间点细胞增殖抑制率分别为25.8%、21.8%、55.4%、25.6%；44.6%、35.9%、55.5%、31.4%。而1mg/mLPFD溶液在24、48、72、96h这4个时间点细胞增殖抑制率分别为28.9%、29.7%，7.8%、7.7%。【结论】PPP水凝胶具备良好药物缓释性能，载吡非尼酮水凝胶能明显抑制HTF增殖且较含等量药物溶液长效

TWO-YEAＲ IMPLEMENTATION ASSESSMENT ( 2016—2018) OF CHINA’S TECHNICALGUIDELINE ON ENVIＲONMENTAL ＲISK ASSESSMENT FOＲ CAＲBON DIOXIDE CAPTUＲE，UTILIZATION AND STOＲAGE ( ON TＲIAL)

《二氧化碳捕集、利用与封存环境风险评估技术指南(试行)》(简称《指南》)发布2年(2016—2018年)以来,在国际国内CO_2捕集、利用与封存(CCUS)领域产生了重要影响。通过企业调研、专家研判、培训宣教、访谈测试等方法评估了其产生的效果和影响。结果表明:《指南》实施2年来,在国际标准、科学文献和国际研讨等领域产生了重要影响,激发了中国CCUS环境风险研究热情,推动和规范了中国CCUS示范项目建设,提高了企业和环境管理者对CCUS环境影响和环境风险的认知,提高了中国对于CCUS技术和环境保护的重视。并提出了进一步完善《指南》、加强其内容与应用成果宣传和提高其国际影响力的建议

TWO-YEAR IMPLEMENTATION ASSESSMENT(2016—2018) OF CHINA’S TECHNICAL GUIDELINE ON ENVIRONMENTAL RISK ASSESSMENT FOR CARBON DIOXIDE CAPTURE,UTILIZATION AND STORAGE( ON TRIAL)

《二氧化碳捕集、利用与封存环境风险评估技术指南(试行)》(简称《指南》)发布2年(2016—2018年)以来,在国际国内CO2捕集、利用与封存(CCUS)领域产生了重要影响。通过企业调研、专家研判、培训宣教、访谈测试等方法评估了其产生的效果和影响。结果表明:《指南》实施2年来,在国际标准、科学文献和国际研讨等领域产生了重要影响,激发了中国CCUS环境风险研究热情,推动和规范了中国CCUS示范项目建设,提高了企业和环境管理者对CCUS环境影响和环境风险的认知,提高了中国对于CCUS技术和环境保护的重视。并提出了进一步完善《指南》、加强其内容与应用成果宣传和提高其国际影响力的建议

Prediction of Energy Resolution in the JUNO Experiment

International audienceThis paper presents the energy resolution study in the JUNO experiment, incorporating the latest knowledge acquired during the detector construction phase. The determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 MeV. To achieve this ambitious goal, significant efforts have been undertaken in the design and production of the key components of the JUNO detector. Various factors affecting the detection of inverse beta decay signals have an impact on the energy resolution, extending beyond the statistical fluctuations of the detected number of photons, such as the properties of liquid scintillator, performance of photomultiplier tubes, and the energy reconstruction algorithm. To account for these effects, a full JUNO simulation and reconstruction approach is employed. This enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy resolution. The study reveals an energy resolution of 2.95% at 1 MeV. Furthermore, the study assesses the contribution of major effects to the overall energy resolution budget. This analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data taking. Moreover, it provides a guideline in comprehending the energy resolution characteristics of liquid scintillator-based detectors

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies