Effect of Psychological Intervention on Negative Emotion and Pain in Patients with Chronic Temporomandibular Joint Disorder

颞下颌关节紊乱病(Temporomandibular Disorder, TMD)是一组常见于青壮年 期的高发病率慢性综合征, 主要症状为颌面疼痛、关节弹响、下颌运动功能受限, 且具性别差异性, 但发病机制尚不明确。该病常伴有抑郁、焦虑、压力等负性情绪。 本论文探讨了自我参照效应下负性情绪及情景记忆在慢性期疼痛为主 TMD 成年女患者病程特点及影响; 基于研究一中揭示的患者特点, 分别采用认知行为 疗法(Cognitive Behavioral Therapy, CBT)和支持性疗法并结合生理治疗, 干预慢 性期疼痛为主伴抑郁、焦虑情绪 TMD 成年女患者负性情绪, 从身心两维度纵向 比较两种心理干预方法对改善疼痛的效果。 研究一、随机选择 23 名于 2019-2021 年初诊、病程大于三个月且疼痛为主 要症状, 年龄在 19 到 60 岁之间的 TMD 女性患者纳入 CBT 组; 另外选择 24 名 症状相同女患者纳入支持性组。要求 23 名 CBT 组患者用思维记录表记录三周自 己体验到的情绪性情景记忆片段, 然后采用质性分析方法深入分析获得的情绪 性记忆的描述语词, 探讨在自我参照效应下情绪性记忆的特点。研究结果表明: 自我参照效应下慢性期疼痛为主 TMD 成年女患者负性情绪以抑郁情绪为主, 负 性情绪处于高唤醒状态且不稳定, 负性情绪下情景记忆的联系性和组织性来源 记忆概括化、自我参照程度效应减弱。 研究二、对 23 名患者的 CBT 组和 24 名支持性疗法组的患者分别实施 50 分 钟/次/周, 共 8 次的心理干预。同时, 根据生理症状接受镇痛消炎药物治疗、关节 腔透明质酸钠注射治疗、咬合板治疗和理疗。干预性治疗前采用 DC/TMD 中文 版、DASS-21 中文版、PCL-5 中文版量表、心境检查表测查患者数据, 采用思维 记录表记录负性偏差信念, 辅助以皮质醇(Cortisol)指标测试, 以及第三个月随访 时间点进行自我报告的半结构性访谈, 探讨上述疗法从生理-心理层面对患者疼 痛的改善效果。研究结果表明: CBT 患者具有“以偏概全”、“世界是危险的”偏差 信念影响抑郁情绪。与支持性疗法相比, CBT 从生理-心理层面对慢性期疼痛为主 TMD 成年女患者疼痛症状改善效果更显著, 增强患者心理韧性, 获得创伤后心 理成长。 慢性疼痛为主 TMD 成年女患者病程期伴以抑郁为主高唤醒水平的负性情绪, 抑郁情绪成分自责、自罪、内疚、无能为力不足, 以愤怒生气为主; 联系性及组 织性来源记忆自我参照程度效应减弱, 概括化认知负性偏差; 患者具“以偏概 全”、“世界是危险的”偏差信念, 与支持性疗法相比, 采用 CBT 思维调整技术“寻 找符合逻辑的证据”积极思维反刍, 能从生理-心理层面显著改善疼痛缓解抑郁, 提高患者心理韧性获得创伤后成长

Determination of the number of ψ(3686) events taken at BESIII

The number of ψ(3686) events collected by the BESIII detector during the 2021 run period is determined to be (2259.3±11.1)×106 by counting inclusive ψ(3686) hadronic events. The uncertainty is systematic and the statistical uncertainty is negligible. Meanwhile, the numbers of ψ(3686) events collected during the 2009 and 2012 run periods are updated to be (107.7±0.6)×106 and (345.4±2.6)×106, respectively. Both numbers are consistent with the previous measurements within one standard deviation. The total number of ψ(3686) events in the three data samples is (2712.4±14.3)×10^

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies