厦门环岛路空间谈

街道是城市空间的重要组成部分,它除承担交通运输任务外,也为城市居民提供了公共生活的活动场所。道路的空间状态不仅仅局限于二维面,而是综合了道路本身及其周边环境等因素。厦门作为我国东南沿海的经济特区,整个城市的发展目标是在2000年初步建成具有国际功能的区域性海港、信息港、金融中心和滨海旅游中心,

台湾海峡及厦门湾台风浪场数值模拟

本文利用国际上先进的第三代海浪模式SWAn,在充分考虑风能量输入、白浪效应、水深诱导的波浪破碎、底摩擦、波-波间的非线性相互作用等物理过程。以0604号台风“碧利斯“为例,通过嵌套计算方式,模拟了台湾海峡及厦门湾台风浪场的分布特征。将数值模拟结果与浮标测站实测资料对比分析,结果表明台风浪高模拟值与实际台风资料相符较好,可以为该海域台风浪的模拟提供较好的参考

在福建东南沿海局部地域献血员中检出HTLV-I

[目的 ]进一步阐明福建沿海 HTL V小流行区 HTL V- 的地理分布特点及毒株的基因类型。 [方法 ]对福建东南沿海莆田地区献血员以国产双抗原夹心法 EL ISA试剂筛选 ,对 EL ISA阳性血清用 Western blot(WB)进行确证。对抗体确证阳性者 ,采集外周血分离淋巴细胞用巢式 PCR扩增 HTL V- env区 gp46片段进行序列分析鉴定病毒亚型。 [结果 ]从 1998年 10月至 2 0 0 0年 4月止 ,共检测 45 6 4份标本 ,结果确证出 16例 HTL V- 抗体阳性者 ,感染率为 0 .35 %。HTL V- 抗体阳性者主要分布在某村献血人群中 ,并具有区域集中的特点。笏石秀屿一带某村献血员中感染率高达 4.7%。7例代表性毒株经病毒序列分析为 HTL V- C亚型 (COSMOPOL ITAN)。[结论 ]福建东南沿海某村献血员中发现 HTL V- 流行。提出在对某一地区人群进行 HTL V筛选时 ,既要注意整个地区“面”的筛查 ,又要注重某个村镇“点”的调查

血清一阶导数荧光光谱诊断早期恶性肿瘤

利用Wistar大鼠接种恶性肉瘤模拟人患上癌症。取Wistar大鼠眼静脉血制备血清,并用乙醇简单处理得上层清液,扫描获得其一阶导数荧光光谱,确定上层清液原卟啉发射带(630 nm附近)的峰高,观察到健康Wistar大鼠与癌变大鼠的血清样存在明显差异,10例癌变样假阳性率为0,而20例正常样中仅有1例假阳性达到了恶性肿瘤早期诊断的目的

激光等离子体质谱用于岩样化学成份的分析

在自制的仪器上,记录了一系列岩样的激光等离子体质谱。通过对正负离子质谱的分析,可以确定岩样的化学组成。本文通过对仪器工作原理、实验条件和测试结果的介绍,显示出该测试手段具有分析速度快、分析结果准确可靠、所得信息较为丰富、可进行微区与深度分析等优点。文章还讨论了不足之处及改进方向

Long-term Follow-up Results of 70 Liver Cancer Cases Received Ultrasound Guided Percutaneous PDT

目的　分析光动力治疗肝癌的临床表现和远期疗效 ,探讨疗效影响因素和治疗适应证 ,为临床推广应用提供参考数据。方法　肝癌患者 70例 ,其中小肝癌 2例 ,大肝癌 6 8例。均经B超、CT定位 ,甲胎蛋白 (AFP)定量 ,病理组织学确诊。治疗前 48h ,患者行血卟啉衍生物 (HpD)皮试 ,阴性者按每公斤体重 5mg静脉给药。治疗时 ,在B超引导下 ,用 18G肝穿针经皮穿刺将石英光纤引导入肝肿瘤内进行光辐照。激光器为氩离子激光泵浦染料激光器系统 ,激光波长 6 30nm ,光纤末端为 1cm长柱状弥散头 ,输出功率 30 0～ 35 0mW ,每一照射点能量累积约 2 2 0J,肿瘤内实行多点照射。治疗后 1周 ,检查血常规、肝功能、AFP及B超 ,一个月后 ,行肝穿活检。多次治疗间歇时间为 1个月。结果　 70例肝癌行 170次治疗 ,其中接受 1次治疗 30例 ,多次治疗 40例。 1次治疗组 1年生存率 10 % ,无生存 2年者 ;2次治疗组 1年生存率 5 0 % ,2年以上生存率 8% ;3次以上治疗组 1年生存率 82 % ,2年生存率 5 0 % ,3年生存率 32 % ,其中 3例存活5年以上。全组只有 18%的患者出现治疗后短期内一过性ALT、AST轻度升高 (<5 0U)和TBIL轻度升高 ,余未见明显异常。随访患者 1～ 5年 ,未见肝功能远期受损。病人接受治疗后 ,只有 17%出现低热 3～ 4天 ,30 %的Objective To investigate the long-term follow-up results of ultrasound-guided percutaneous PDT for liver cancer and to evaluate the efficacy and safety of this technique. Methods 70 patients with liver cancers, including 2 small tumors and 68 large tumors, were examined by ultrasound, CT, AFP assay, and diagnosed by histopatholopy of needle biopsy. The patients received injection of hematoporphyrin derivative(HPD) i.v. in a dose of 5 mg/kg body weight 48 h prior to laser irradiation. An argon laser pumped dye laser system was used to give a CW laser beam at 630 nm. The light beam was split and coupled into three optical fibers. An ultrasound-guided percutaneous liver puncture was performed and optical fibers were inserted into the tumors via 18G needles. Efforts were made to ensure that irradiation points were distributed in entire tumor volume and a light output of 300～350 mW for 12 minutes per point was used. The patients were examined with routine blood test, liver functions, AFP assay and USG at one week after treatment. A month later they were reexamined by needle biopsy and received next PDT treatment. Results Total 170 treatments were performed in the 70 patients. Among them 30 cases were treated for only once, 12 cases twice, 12 cases 3 times, and 16 cases 4 times or more. All 70 cases were followed up for 1-5 years. The results showed that multiple treatment is more effective than single treatment. The 1-, 2-and 3-years survival rate was 10%, 0, 0 in the group by single treatment, respectively, 50%, 8% and 8% in the group treated twice, and 82%, 50% and 30% in the group treated by 3 or more time, respectively. Three patients from the last group have already been surviving for longer than 5 years. Slight increase of ALT, AST and total bilirubin occurred in only 18%, and mild fever occurred in 17% of the 70 cases for 3-4 days shortly after PDT treatment. No severe complications due to PDT such as severe hemorrhage after liver puncture, hepatic failure, biliary peritonitis or long-lasting liver dysfunctions were observed in our group. Conclusions Photodynamic therapy is effective and safe for the treatment of liver cancers including those following hepatic resection or those failed after embolic chemotherapy by hepatic artery infusion. However, we would suggest that single PDT treatment is not enough and repeated PDT treatments are recommended in order to obtain a significant therapeutic effect to patients with large liver cancers.福建省“95”重点科技项

Selective Catalytic Hydrogenation of Cinnamaldehyde to Hydrocinnamaldehyde

采用煤质活性炭作载体,分别用HNO3、H2O2和(NH4)2S2O8进行预处理,然后用浸渍法负载PdCl2,在H2流中还原得到Pd/C催化剂,用于肉桂醛(CAL)选择加氢制氢化肉桂醛(HCAL)的反应。考查了Pd负载量,反应温度和压力对加氢反应的影响,优化了反应条件。进一步考查了助剂Fe、Co、Ni[1]对反应的影响。最终,CAL转化率为98%,HCAL选择性为88%。Coal-based activated carbon was pretreated with HNO_3,H_2O_2 and(NH_4)_2S_2O_8 before selected as support.A series of Pd/C catalysts were prepared by means of impregnation and with PdCl_2 as precursor.It was reduced in H_2 stream,and applied to selective hydrogenation of cinnamaldehyde to hydrocinnamaldehyde.Effects of Pd-loading,reaction temperature and pressure were discussed.In addition,promoters of Fe,Co,Ni were introduced to the catalysts.At last proper conditions for the reaction were found,and 88% selectivity to HCAL at 98% conversion of CAL was obtained.国家自然科学基金(No.20203014

激光等离子体源飞行时间质谱计

本文介绍了自行研制的一台激光等离子体源飞行时间质谱计.该义器以高能量密度的脉冲激光作用于固体样品,产生的高温等离子体由原位的飞行时间质谱计作质谱分析.该装置具有能同时记录正负离子质谱,智能化程度高、质量分辨好等优点.而且具有较强的研究能力,既能用于原子簇离子的激光产生与质谱研究,又可以对各种无机和有机样品进行结构研究与分析测式

Ultrasound Guided Percutaneous PDT For Advanced Liver Cancer A Report of 30 Cases

为探讨治疗中晚期肝癌的理想方法，扩大和发展光动力疗法，自1994年6月起，我们应用光动力疗法（PdT）治疗中晚期肝癌30例，其中肝细胞癌28例、腺癌2例。肿瘤直径7~10CM的13例、10CM以上至16CM的17例。伴肺转移5例、骨转移5例、门静脉或腔静脉浸润4例。首次治疗19例、其他方法治疗无效或复发者11例。本研究采用氩激光泵浦染料激光器系统，获得630nM波长的连续波治疗光。光敏剂选用血卟啉衍生物（HPd）。治疗时通过b超引导经皮肝穿，将光纤导入肿瘤组织中布点照射。治疗后未见肝功能明显损伤，未出现肝穿出血、腹膜炎等严重并发症，没有一个月内病情恶化者。有14例患者只作一次治疗，其中5例出院后失访；另9例肿瘤部分缓解率为22%。16例患者接受二、三次治疗，肿瘤部分缓解率达到62%。随访病例中有8例已存活1年以上。patients with advanced liver cancer were treated by interstitial photodynamic therapy (PDT).These included 28 hepatocellular carcinoma and two adenocarcinoma, 19 primary tumors and 11 recurred Following other treatments.The diameter of tumors were 7 10 cm in 13 cases and 10 16 cm in 17 cases.In this study, an argon laser pumped dye laser system was used to give a CW laser beam at 630 nm which was split and coupled into three optical Fibers.The patients received injection of photosensitizer of hematoporphyrin derivative (HpD) i.v.at a dose of 5 mg/kg body weight 48 h prior to laser irradiation.Then the Fibers were inserted into tumor by ultrasonic visualization guided percutaneous liver puncture.The inserted irradiation points were spaced in entire tumor volume and the tumor was irradiated with a light output power of 300 mW For 12 minuts per point.Totally 52 treatments were perFormed in 30 patients.Among them, 14 cases were treated by only one time and 16 cases 2 or 3 times.The Follow up were carried out in 25 cases For 3 18 months.The results show that signiFicant remission was 22% (2/9) in those patients by only one treatment and 62% (10/16) in those by 2 or 3 treatments.The reduction rate of tumor size was over 90% in Five out of six cases aFter 3 treatments.8 patients have been surviving over one year.No obvious change was Found in all patients examined by liver Function test, renal Function test and blood routine examination.The level of AFP depicted a descending tendency aFter PDT.Our Findings indicate that PDT is eFFective and saFe For the treatment of large liver cancers including those recurred Following hepatic resection and those Failed in hepatic artery inFusion embolic chemotherapy.福建省“八五”攻关资