スイセンにおけるモノアミン酸化酵素の精製と諸性質

博士(理学)大阪市立大

A method of coastal ecological security management and its application

论述了海岸带生态安全管理的内涵,提出战略环境评价作为一种海岸带生态安全管理的方法,是有效的辅助决策工具,分析了面向海岸带生态安全管理的战略环境评价的对象、主要内容与范围以及评价方法,介绍了自然资源可持续利用评价的一种方法———资源定位法。并以象山港作为实例研究,运用资源定位法进行战略环境评价,评价结果表明象山港的主导功能应是水产养殖,同时兼顾滨海旅游是最佳的选择,港口建设应以小型的民用码头为主。The connotation of the management of coastal ecological security is discussed.Strategic Environmental Assessment is put forward as a method of the management of coastal ecological security which is an effective tool for assistant decision making.The object,main content and range as well as assessment method of Strategic Environmental Assessment are analyzed facing to management of coastal ecological security,and the resources-oriented method is introduced as a assessment method for resource sustainable utilization.By taking Xiangshan Harbor as a case study,the resource-oriented method is applied to the Strategic Environmental Assessment for managing the coastal ecological security of Xiangshan Harbor.Te result shows the main function of resource utilization in Xiangshan Harbor should be aquaculture with compromising the coastal tourism.The port should be constructed to commercial wharf in pocket size.福建省自然科学基金项目(D044005

The Current Situation and Protection Measures of Amphibians and Reptiles Diversity of Huaihe River basin in Anhui

经过调查统计,发现淮河流域(安徽段)现有两栖动物11种,其中古北界2种,东洋界5种,广布种4种;爬行动物23种,属于古北界4种,东洋界13种,广布种6种。区系特点明显,属于古北界向东洋界的过渡区,东洋界和广布种种类分布相对丰富。相似系数分析表明沱湖和女山湖相似系数最高,说明其生境和其他两个保护区相比更为优越。此研究有助于了解该地区两栖爬行动物的多样性现状,为进一步加强资源的保护和可持续利用提供参考。The amphibians and reptiles diversity of Huaihe River basin in Anhui has been investigated and studied.The result indicates that 11 amphibian species have been found,2 of them are pale arctic realm,5 oriental species and 4 widespread species.23 reptile species have been found,4 of them are pale arctic realm,13 oriental species and 6 widespread species.The fauna feature was obvious.The pale arctic species are seldom,the oriental species and the widespread species are rich.Analysis indicates that the similar coefficient of Tuohu and Nvsanhu are the highest.The conclusion is that the diversity of amphibians and reptiles in this area can be illustrated;the environment and wildlife resources can be utilized reasonably after more protection.安徽科技学院重点学科建设基金项目(YZD2004-19)资

乌蔹莓化学成分的初步探究

目的:系统性研究福建道地药材乌蔹莓的有效成分。方法:运用大孔树脂,Sephadex LH-20,ODS及正相硅胶柱等色谱手段对乌蔹莓Cayratia japonica的全草进行分离。结果:从中得到13个化合物,通过多种波谱数据分析鉴定化合物结构,确定其分别为木犀草素(1),芹菜素(2),柠檬酸三乙酯(3),吲哚-3-甲醛(4),秦皮乙素(5),邻苯二甲酸二乙基己酯(6),calendin(7),反式咖啡酸乙酯(8),木犀草素7-O-葡萄糖苷(9),5-hydroxy-3,4-dimethyl-5-pentyl-2(5H)-furanone(10),3,4-二羟基苯甲酸乙酯(11),圣草酚(12),胡萝卜苷(13)。结论:其中3～8及10～12均为首次从乌蔹莓中分离得到

我国内蒙古大兴安岭北麓泡状肝包虫种类的研究I.多房棘球绦虫

人兽共患泡状(多房)棘球蚴病的病原种类,一向人们都认为只有多房棘球绦虫一种,其中包含分布在不同地区的2-3个地理株(或亚种)(Vogel,1957;KumaratilakeandThompson,1982;Miyazaki,1991;等)。但在我国内蒙古东北部大兴安岭北麓呼伦贝尔草原,却存在着多房棘球绦虫(EchinococcusmultilocularisLeuckart,1863)的所谓三个“地理株(或亚种)”:欧洲的多房棘球绦虫、冻土地带的西伯利亚棘球绦虫和苏俄的多房棘球绦虫。它们在内蒙古不仅存在于同一流行区,而且成虫常混合感染于同一终宿主沙狐的体内。2001年,作者再次检查呼伦贝尔的沙狐151只,从中检出19只感染有泡状棘球绦虫成虫,其中有9只混合感染上述的不同形态的三虫种。观察了它们成虫的埋蜡连续切片的制片,说明它们的子宫是各有稳定不变的结构。这三虫种经人工感染数百只实验鼠,比较观察了各虫体幼虫期大量的埋蜡连续切片,再次证实此三虫种在中间宿主鼠类体内发育的幼虫期,是各有一定的结构和发育格式。本文着重介绍欧洲型多房棘球绦虫的成虫子宫结构和它幼虫期发育

我国内蒙古大兴安岭北麓泡状肝包虫种类的研究 III.苏俄棘球绦虫(Echinococcus russicensis sp.nov.)

在我国内蒙古大兴安岭北麓草场流行有与在前苏联广泛分布的泡状棘球蚴其成虫具球形子宫相似的病原,过去称之为苏俄的多房棘球绦虫。我们在比较研究了它与欧洲的多房棘球绦虫的全程生活史的发育规律,及成虫和幼虫期的结构之后,发现两者之间有极大差异,认为不能再用多房棘球绦虫称呼之。最近,我们用内蒙古的苏俄型泡状棘球蚴人工感染4只羊羔,全部阴性不能发育,说明内蒙古的本虫种不同于所谓幼虫期可以在牛羊发育的"哈萨克亚种"。为了纪念前苏联学者最早发现和叙述本种成虫,兹暂定名为苏俄棘球绦虫新种(Echinococcus russicensis sp.nov.)

我国内蒙古大兴安岭北麓泡状肝包虫种类的研究 II.西伯利亚棘球绦虫(Echinococcus sibiricensis Rauschet Schiller,1954)

目的Rausch and Schiller(1954)在美国阿拉斯加白令海峡St.Lawrence岛从北极狐(Alopex lagopus)和雪撬狗(sledge dogs)发现西伯利亚棘球绦虫新种(Echinococcus sibiricensis sp.nov.),但诸多学者认为E.sibiricensis Rausch et Schiller,1954是欧洲的多房棘球绦虫(Echinococcus multilocularis Leuckart,1863)的地理株(或亚种)(Vogel,1957;Skrjabin and Abuladze,1964;Kumaratilake and Thompson,1982;Meyajaki,1991等)。于1985-2002年间,作者在我国内蒙古大兴安岭北麓草场多年进行泡状棘球蚴(alveolar Echinococcus)病原的野外调查和实验室鼠类的人工感染试验,结果发现该地区同地点存在有北美西伯利亚棘球绦虫、欧洲多房棘球绦虫及苏俄多房棘球绦虫三种不同"地理株",而且三种成虫常混合感染于同一终宿主沙狐(Vulpes corsac)的体内,它们的幼虫期也存在于当地的布氏田鼠(Microtus brandti)。2001年,作者再次检查当地沙狐151只,从中检出19只感染有泡状棘球绦虫成虫。含成熟虫体的13只阳性沙狐中,感染西伯利亚棘球绦虫有11只,其中2只单独感染此虫种,另9只还混合感染了欧洲多房棘球绦虫及苏俄多房棘球绦虫三虫种。在呼伦贝尔草原的泡状棘球蚴病原中,西伯利亚棘球绦虫是优势种,它在终宿主沙狐和中间宿主的感染率都高过其他虫种。本文着重介绍西伯利亚棘球绦虫的成虫子宫结构和它幼虫期在野外布氏田鼠及人工感染实验鼠体内的发育情况

Analyze the epidemical multidrug-resistant Mycobacterium tuberculosis from Shenzhen by DNA sequencing

通讯作者: 杨慧( yh2009cn@y ahoo.com.cn)[中文文摘]目的了解深圳市耐多药结核分枝杆菌(multidrug-resistant Mycobacterium tuberculosis,MDR-TB)的分子流行病学特征。方法参照WHO/I UATLD标准,使用L-J药敏培养基,采用1%比例法药敏试验筛选出敏感株和异烟肼(isoniazid,INH)、利福平(rifampicin,RFP)双耐药临床分离株,通过DNA测序检测深圳地区153株敏感株与132株MDR-TB的INH耐药基因katG、inhA、oxyR-ahpC基因间区域及RFP耐药基因rpoB碱基排列顺序,运用DNASTAR和blastn进行序列分析。结果 153株敏感株突变率为27.5%(42/153)。132株MDR-TB突变率为98.5%(130/132),其中katG基因突变率为73.5%(97/132),68.9%(91/132)为katG315位突变;inhA基因突变率为18.2%(24/132),11.4%(15/132)为启动子区域突变,未发现inhA94特异突变株;ahpC基因突变率为16.7%(22/132),10.6%(14/132)为启动子区域突变;rpoB基因81 bp核心区域突变率为93.2%(123/132)。结论 katG315、inhA启动子区域、ahpC启动子区域以及rpoB 81 bp核心区域突变为深圳地区耐多药结核分枝杆菌主要突变类型,与其他国家和地区差异无统计学意义;但深圳地区未见inhA94突变株。[英文文摘]Objective To investigate the epidemiologic characteristic of mult idrug-resistant (MDR) Mycobacterium tuberculosis (MTB) in Shenzhen. Methods According to the standard of WHO, International Union Against Tuberculosis and Lung Disease (IU ATLD) ,drug-susceptive and MDR MTB strains were collected by drug suscept ibility test (DST) of 1% proportion method.kat G, inh A, intergenic region of oxy R-ahp C and 81bp core region of rpo B genes in 153 drug-sus-ceptive strains and 132 MDR strains were analyzed by DNA sequencing. Results 27.5%(42/153) of drug-susceptive strains and 98.5% (130/132) of MDR strains showed gene mutat ions. Of 132 MDR strains, 73.5%( 97/132) had ka t G mutat ions, and 68.9% (91/132) of kat G mutations were at codon 315; 18.2% (24/132) had in h A mutations, and none specific mutations were found at codon 94 of in h A; 11.4% (15/132) had mutations at inh A-promoter region; 16.7% (22/132) had ahp C mutat ions, 10.6% (14/132) had mutations at interg enic region of oxyR-ah p C; 93.2%( 123/132) had mutations at the 81bp core region of rpoB. Conclusion The codon 315 of kat G, promoter region of inh A, ahp C and the 81bp core region of rpoB play predominant roles in MDR-T B in Shenzhen.艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2008ZX10003-004

First Sagittarius A* Event Horizon Telescope Results. VIII. Physical Interpretation of the Polarized Ring

In a companion paper, we present the first spatially resolved polarized image of Sagittarius A* on event horizon scales, captured using the Event Horizon Telescope, a global very long baseline interferometric array operating at a wavelength of 1.3 mm. Here we interpret this image using both simple analytic models and numerical general relativistic magnetohydrodynamic (GRMHD) simulations. The large spatially resolved linear polarization fraction (24%–28%, peaking at ∼40%) is the most stringent constraint on parameter space, disfavoring models that are too Faraday depolarized. Similar to our studies of M87*, polarimetric constraints reinforce a preference for GRMHD models with dynamically important magnetic fields. Although the spiral morphology of the polarization pattern is known to constrain the spin and inclination angle, the time-variable rotation measure (RM) of Sgr A* (equivalent to ≈46° ± 12° rotation at 228 GHz) limits its present utility as a constraint. If we attribute the RM to internal Faraday rotation, then the motion of accreting material is inferred to be counterclockwise, contrary to inferences based on historical polarized flares, and no model satisfies all polarimetric and total intensity constraints. On the other hand, if we attribute the mean RM to an external Faraday screen, then the motion of accreting material is inferred to be clockwise, and one model passes all applied total intensity and polarimetric constraints: a model with strong magnetic fields, a spin parameter of 0.94, and an inclination of 150°. We discuss how future 345 GHz and dynamical imaging will mitigate our present uncertainties and provide additional constraints on the black hole and its accretion flow