Modeling and Analysis of Drug Permeation Mechanism Based on Blood-Brain Barrier

由于血脑屏障结构的特殊性,脑内疾病的治疗仍然是临床诊疗的一个难点。一般情况下,病人只能通过口服或注射药物来治疗这类疾病。采用理论分析和数值模拟相结合的方法,在控制药物毒性最小的前提下,研究血管和脑组织中游离药物浓度随时间的变化情况。在比较分析未加入超声和加入超声的两个模型后发现：未加入超声时,毛细血管和脑组织中的游离药物浓度在140 min左右达到平衡状态,且平衡点处的药物浓度很低,达不到治疗效果;而加入超声后,在60-70 s就达到了稳定,同时达到稳态时药物浓度也明显增加。由此可见：加入超声大大减少了服药后大脑组织中药物达到治疗浓度所需的时间,且增加了进入脑组织的药物量。Treatment for the intracerebral diseases has been a challenging issue in clinical diagnosis and treatment. Because of the special brain barrier structure,patients generally treat these diseasesonly through oral or injection drugs. In order to make it clear,this paper theoretically and numerically studies the variation laws of free drug concentration in the vascular and brain tissue given minimizing the toxicity of drugs. After comparing two models without and with ultrasound treatments,we find that at the absence of ultrasound treatment it takes about 140 minutes that the concentration of free drugs in capillary and brain tissue reaches the balance state. In this case,drug concentration is greatly low,which does not achieve an ideal therapeutic effect. Otherwise,it only takes approximately 60 to 70 minutes to reach the balance state with ultrasound treatments and drug concentration significantly increases. That greatly reduces the time taken for drugs to reach therapeutic concentration in brain tissue and increases the amount of drugs entering the brain tissue.疾病防控的数学技术与大数据分析山西省重点实验室资助项目（201705D111006）; 山西省动物群发病科技数据服务共享平台项目（201605D121014

25MeV/u40Ar+natAg、209Bi反应中热核的温度和激发能测量

在２５ＭｅＶ／ｕ４０Ａｒ＋ｎａｔＡｇ、２０９Ｂｉ反应中，用４个ＰＰＡＣ和１１组望远镜完成了关联裂变碎片与发射轻粒子的符合测量，角关联描绘为两个被探测到碎片折叠角θ＿（ｆｆ）的函数，线性动量转移（ＬＭＴ）由测量到的角关联推出．将符合测量得到的对应于不同〈ＬＭＴ〉窗的后角轻带电粒子能谱用Ｍａｘｗｅｌｌ分布来拟合其谱的后沿，经过一些修正，由能谱得到热核的初始温度Ｔ＿（ｉｎｔ），在考虑反应Ｑ值和预平衡发射的修正之后，可以得到不同〈ＬＭＴ〉窗所对应的激发能．实验结果表明，在４０Ａｒ＋ｎａｔＡｇ、２０９Ｂｉ反应的中心碰撞中激发能分别为４．２、２．４ＭｅＶ／ｕ，而温度达６．１、５．５ＭｅＶ，在半中心碰撞中激发能为３．５、１．９ＭｅＶ／ｕ，温度可达５．８、４．８ＭｅＶ。国家自然科学基

25MeV／u~（40）Ar＋~（159）Tb反应中等质量碎片的热核蒸发

在２０°至１５５°范围内测量了２５ＭｅＶ／ｕ的４０Ａｒ轰击１５９Ｔｂ靶产生的单举中等质量碎片（３≤Ｚ≤９）能谱．后角区中等质量碎片能谱具有明显的统计蒸发特性，不同元素的能谱可用相同参数的单个运动源模型很好地拟合．拟合提取的源速度和核温度等源参数与非完全熔合所形成热核的反冲速度和核温度近似一致，表明这些不同的中等质量碎片共同起源于热核的统计蒸发．使用统计程序ＧＥＭＩＮＩ计算了碎片角分布和电荷分布．The inclusive energy spectra of intermediate-mass fragments(IMF)(3≤Z≤9)have been measured in the range from 20°to 155°for 40Ar+159Tb reaction at 25MeV/u.At backward angles,the spectra of IMF show a characteristic of statistic evaporation and can be well fitted by a moving source with same parameters.The obtained source velocity and temperature are in agreement with the corresponding values of hot nuclei produced in an incomplete-fusion process.Therefore,it seems that there IMF are statistically evaporated f...国家科委基础研究,国家自然科学基

重离子周边碰撞和中心碰撞引起的不同裂变行为

本实验同时研究了 4 0 Ar+ 2 0 9Bi反应中周边碰撞和中心碰撞两者产生的关联裂变碎片 ,以及其与α粒子的再关联 .对裂变碎片质量分布和能量分布随热裂变核初始温度演化的系统分析 ,发现中心碰撞和周边碰撞所形成的热核存在着不同的裂变行为

干旱内陆河灌区节水农业综合技术体系研究与集成

本课题从工程节水、农艺节水、管理节水三个方面,集成了农业高效节水、水肥盐调控、生态保护、监测与管理等关键技术,提出了干旱内陆河灌区农业节水技术集成体系与应用模式。提出了仅需根据水流推进过程确定土壤入渗参数和田面糙率系数的新方法,简化了地面灌溉设计。提出了根据土壤剖面含水率变化估算柽柳生长条件下潜水蒸发的理论方法与数学模型,为解决天然植被实际生态耗水问题提供了简易可行的方法

绿洲农业高效用水技术集成与示范

简要技术说明： 该成果围绕棉花、葡萄、小麦3大作物,从干旱绿洲区作物高效用水和提高作物水分生产效率的目标出发,研究形成了棉花高效用水技术模式3套、葡萄高效用水技术模式1套、小麦优化灌溉节水及配套栽培技术模式1套、干旱绿洲区农业高效用水管理技术模式1套,开发了15项农业节水关键技术和1套“农业灌溉决策支持系统”,筛选出节水配套抗旱小麦品种2个、抗旱棉花品种1个,制定了农业高效用水技术规程7项,研发了专利产品1项、软件著作权登记1项,人才培养12名、发表论文45篇。通过对高效灌溉技术、农艺高效用水技术、高效用水管理技术等3方面的关键技术的集成与创新,研究形成了干旱绿洲区特色作物(棉花、葡萄、..

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies