Experimental research state of preventive and therapeutic effect of traditional Chinses medicine on gastrointestinal injury after stress

应激会破坏胃肠道的自稳态,引起胃肠道功能紊乱,轻则出现恶心、呕吐、厌食、腹泻、腹胀,甚则可致应激性溃疡,影响人们的工作生活和健康。单药、经方、自; 拟方和针灸等中医药干预可通过抗胃肠黏膜损伤、调整紊乱的胃肠激素等途径有效改善各种应激后胃肠损伤,文章对此作一综述,并发现迄今为止在中医药预防应激; 后胃肠损伤的抗应激相关机制研究尚显不足,值得进一步研究。Various kinds of stress would destroy gastrointestinal homeostasis and; lead to functional disturbances of gastrointestinal tract, such as; nausea, vomiting, anorexia, diarrhea, abdominal distention and even; stress ulcer, which could influence the work, life and health of people; suffered from stress. Classical prescription, self-made prescription and; acupuncture could ameliorate symptoms and signs of gastrointestinal; stress reaction effectively by protecting from gastrointestinal mucosa; injury and regulating gastrointestinal hormones. This article reviewed; those researches and found that, so far, there were shortages of TCM in; prevention effect and mechanism of anti-stress, which deserved further; study.国家自然科学基金项目; 福建省自然科学基金项

各种应激源对胃肠相关功能影响的研究进展

应激源指对机体构成任何威胁的刺激,包括物理（低温、高温等）、化学、机械、心理、社会等各种刺激。应激源作用于人体产生的非特异性应答反应称为应激。适当的应激可以促进机体逐步适应环境,而过度的应激则使机体正常稳态被破坏,发生一系列非特异性损害。胃肠道是机体与外界接触面积最大的器官,且由于其黏膜血管的解剖特点,在应激状态下更容易受影响,其中,肠道为多器官功能障碍的始动器官。国家自然科学基金项目（No.81302876）; 福建省自然科学基金项目（2013J05123

Separation of terpenes and oxygenated compounds from citrus oil by supercritical CO_2 extraction

以冷榨柑橘精油为原料,采用gC/MS对柑橘精油原料进行定性及定量分析,确定了柑橘精油中的7种萜烯类化合物成分作为分离考察对象。实验探讨了超临界萃取压力、萃取温度、萃取时间和CO2流量等因素对含氧化合物分离效果的影响。实验结果表明,萃取相中萜烯类化合物的回收率总体上随着萃取压力、温度、时间和CO2流量的增大而增大。当萃取压力为12MPA,萃取温度为45℃,萃取时间为4H以及CO2流量为1.0l/MIn时,分离效果最佳,其萃取相中萜烯类化合物的回收率高达90.03%。Supercritical CO2 extraction was employed to separate terpenes and oxygenated compounds from citrus oil.The raw oil,the extract,and the raffinate were qualitatively and quantitatively analyzed by GC/MS,respectively,with the terpenes being represented by seven typical compounds.The influences of several experimental factors including extration pressure,extraction temperature,extraction time and CO2 flow rate on the separation of the oxygenated compounds were studied.The results indicate that the recovery rate of terpenes in the extract generally increases with the increasing of extraction pressure,temperature,time and CO2 flow rate.The optimum conditions for extracting terpenes are as follows: pressure 12 MPa,temperature 45 ℃,extraction time 4 h,and CO2 flow rate 1.0 L/min.Under these optimum conditions,the recovery rate of terpenes in the extract is 90.03%.福建省新世纪人才支持项目(0000-X04157

Separation and identification of auraptene from grapefruit peel oil

橙油素是广泛存在于柑橘类果实中的天然抗癌活性成分。选用SP70大孔吸附树脂分离纯化葡萄柚精油中的橙油素,该树脂对于橙油素的吸附容量和解吸率分别达到14.53 Mg/g和83.32%,并成功地从树脂床层的洗脱液中结晶分离出橙油素晶体。对所得晶体分别采用差示扫描量热仪(dSC)、紫外吸收光谱(uV)、红外吸收光谱(Ir)、电喷雾质谱(ESI-MS)进行定性分析,分析结果与橙油素标准品相符合。进一步采用高效液相色谱(HPlC)对所得晶体进行定量分析,结果表明所得晶体中橙油素的质量分数可达85%。Auraptene exists widely in the peels and juice sacs of citrus species and is reported to be an effective inhibitor of chemical carcinogenesis in some rodent models.The separation and purification of auraptene from the grapefruit peel oil was performed by SP70 macroporous resin adsorption.The amount adsorbed and the recovery of auraptene were 14.53 mg/g and 83.32% respectively.Auraptene was crystallized out from the concentrated eluate of macroporous resin bed successfully.Differential scanning calorimetric(DSC),ultraviolet spectrum(UV),infrared spectroscopy(IR) and electrospray ionization mass spectroscopy(ESI-MS) were all used to analyze the obtained crystals qualitatively.The analytical results are in accordance with that of auraptene standard.Furthermore,high performance liquid chromatography(HPLC) was utilized to quantify auraptene of the crystals obtained.The mass fraction of auraptene in the obtained crystals can reach 85%.福建省新世纪人才支持项目(0000-X04157

Separation and purification of auraptene from peels of grapefruit

目前，癌症已经成为危害人类生命健康的一大杀手，对于癌症的治疗工作已经刻不容缓，但是由于除紫杉醇外无其他有明显治疗作用的药物，给肿瘤的治疗带来了很大的困难。近年来国外科学家陆续从天然柑橘类果实中提取到一种天然抗癌药物——橙油素（Auraptene），他们发现橙油素能够抑制癌细胞增生，促使癌细胞凋亡，对于大肠癌、子宫癌、食道癌等具有明显疗效，因此提纯橙油素对于癌症的治疗具有积极的意义。 本文先采用静态法测定橙油素在超临界CO2中的相平衡数据，然后采用超临界萃取技术（Supercriticalfluidextraction）从漳州产蜜柚果皮中提取蜜柚精油，利用高效液相色谱技术（HPLC）分析精油中...At present, cancers have become the leading killer to human health, it’s important to cure that, but there are a lot of difficulties for no effective drug except taxol. In recent years foreign scientists found a kind of natural anticancer drug named auraptene (7-geranyloxycoumarin) from citrus which could restrain cancer cells hyperplasia and prompt cancer cells apoptosis, auraptene has obvious cu...学位：工学硕士院系专业：化学化工学院化学工程与生物工程系_化学工程学号：2062008115159

test purpose description for model-based testing of concurrent systems

提出了带约束事件的时序逻辑TLCE,用于描述系统运行中输入/输出事件之间的时序关系以及对事件参数的数据相关性约束.阐述了一种基于模型的并发系统测试框架,采用TLCE描述测试目的以引导测试用例生成.缓存一致性协议和会议协议的实例研究中所生成的测试用例集显著优于随机测试用例集.这说明了TLCE作为测试目的描述的有效性.National Natural Science Foundation of China; Public Administration and Civil Service Bureau of Macau SAR; Companhia de Telecomunicacoes de Macau S.A.R.L.; Macau SAR Government Tourist Offic

WDM网络中的一种基于BFP-Tree方法的负载平衡路由机制

文章提出一种基于数据包频率模式-树结构（BFP-Tree）方法的负载平衡路由机制,该机制首先统计所有路径节点的使用频度;然后选取使用频度最高的节点路径,按照网络中各链路使用波长数的统计方差最小的原则,对业务请求进行路由选择。仿真结果表明:该方法在阻塞概率和传输延迟性能方面都优于BFP-Tree路由机制

WDM网络中基于分簇的静态业务量疏导算法

针对大多数文献中报道的静态业务量疏导技术不适用于大型光网络的问题,文章基于分簇思想提出了一种有效的静态业务量疏导算法。该方法将大型光网络划分为若干个相互独立的簇,并在每个簇中选择一个节点作为簇头节点来负责簇内和簇间的业务量疏导。仿真结果表明:该算法与已知的静态业务量疏导算法相比具有更好的性能