Separation and purification of auraptene from peels of grapefruit

Abstract

目前,癌症已经成为危害人类生命健康的一大杀手,对于癌症的治疗工作已经刻不容缓,但是由于除紫杉醇外无其他有明显治疗作用的药物,给肿瘤的治疗带来了很大的困难。近年来国外科学家陆续从天然柑橘类果实中提取到一种天然抗癌药物——橙油素(Auraptene),他们发现橙油素能够抑制癌细胞增生,促使癌细胞凋亡,对于大肠癌、子宫癌、食道癌等具有明显疗效,因此提纯橙油素对于癌症的治疗具有积极的意义。 本文先采用静态法测定橙油素在超临界CO2中的相平衡数据,然后采用超临界萃取技术(Supercriticalfluidextraction)从漳州产蜜柚果皮中提取蜜柚精油,利用高效液相色谱技术(HPLC)分析精油中...At present, cancers have become the leading killer to human health, it’s important to cure that, but there are a lot of difficulties for no effective drug except taxol. In recent years foreign scientists found a kind of natural anticancer drug named auraptene (7-geranyloxycoumarin) from citrus which could restrain cancer cells hyperplasia and prompt cancer cells apoptosis, auraptene has obvious cu...学位:工学硕士院系专业:化学化工学院化学工程与生物工程系_化学工程学号:2062008115159

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