Variations in surface export fluxes of POC during ice-melting in the Arctic Ocean

运用210Po/210Pb不平衡法和234Th/238U不平衡法分别在中国第四次和第五次北极科学考察期间估算了楚科奇海和加拿大海盆的POC输出通量及其随时间的变化情况，同时评估了过去20年来北冰洋的POC输出通量的变化情况。研究结果显示，在第四次北极科学考察期间（2010年7~9月），研究区域真光层中颗粒态210Po的停留时间在-14.92a~1.52a，高于溶解态210Po的停留时间-7.17a~-0.70a，所有测站中溶解态210Po存在明显的过剩，210Po/210Pb的平均值为1.91±0.20。采用两种计算方法（E法和B法）估算了真光层POC输出通量，结果显示从南到北呈现出下降趋势。...Export fluxes of particulate organic carbon (POC) were derived from 210Po/210Pb disequilibrium method and 234Th/238U disequilibrium method during the 4Th and 5Th Chinese National Arctic Research Expedition (CHINARE-4, July 1~September 28, 2010, and CHINARE-5 ), respectively. In 2010,the average residence time of particulate 210Po were in the range of -14.92 a~1.52 a, which is higher than that of ...学位：理学博士院系专业：海洋与地球学院_海洋化学学号：2242009015325

FICM干预对急性运动大鼠抗氧化能力的影响

目的:探讨远红外陶瓷微珠对大鼠一次性力竭运动后血清SOD、GSH-Px、MDA含量的影响。方法:将88只雄性SD大鼠分为安静对照组(A组)、模型组(B组)、模型+热水组(C组)、(模型+陶瓷微珠组D组)。B、C、D组大鼠利用下坡跑跑台一次性运动至力竭。各组大鼠分别于安静时与运动后即刻、24h、48h、72h取心脏血,分离血清测定SOD、GSH-Px、MDA含量。结果:D组运动后各时相血清SOD、GSH-Px含量均高于B组与C组同时相(P <0. 05),D组运动后各时相血清MDA含量均低于B组与C组同时相(P <0. 05)。结论:陶瓷微珠干预手段具有抑制急性运动后机体氧自由基生成,减少过氧化损伤的作用。福建省科技厅省自然科学基金项目(2016J01404);;莆田学院育苗基金项目(2017014);莆田学院国家基金预研项目(2016076);;国家体育总局科技服务项目(2017HT008

卤原子取代苯并噻二唑聚合物给体材料的合成及其光伏性能研究

通过对苯并噻二唑单元进行氟、氯等卤原子取代,并同时调节烷基侧链的长度,设计合成了一系列基于苯并噻二唑四噻吩类的聚合物太阳电池材料.不同卤原子取代以及烷基侧链的长度都会影响聚合物的结晶性和薄膜聚集形貌从而改变其带隙和电荷传输性质.氟、氯原子的引入可调节聚合物的能级结构,而且相对于氟原子而言,具有更大原子半径的氯原子的引入可在更大尺度下调节能级结构,从而大幅提高相应太阳电池的开路电压,同时通过侧链的优化可进一步调节聚合物的微观聚集结构,改善器件能量转换效率.结果表明,在氯原子和氟原子共同作用的情况下,引入较长的侧链有利于提升聚合物的开路电压和短路电流,从而获得较好的器件性能.其中,以氯、氟共同取代的聚合物PCFBT4T-2OD与PC71BM为活性层的器件性能最佳,能量转换效率可达8.84%.国家自然科学基金(基金号51773087,21733005);;广东省自然科学基金(基金号2016A030313637);;深圳市孔雀团队(项目号KQTD20140630110339343)资助项

远红外陶瓷微珠干预对急性损伤大鼠LZM、MPO、IL-8和IL-10指标影响的研究

利用远红外陶瓷微珠作为干预手段,对大鼠肌肉急性损伤后进行恢复治疗,探讨其对骨骼肌血清炎症指标LZM、MPO和免疫学IL-10、IL-8指标的影响.将88只SD雄性大鼠分为A组安静对照组; B组模型组; C组模型+热水组; D组模型+陶瓷微珠组,大鼠急性损伤造模成功后自然休息48 h后,各组实验大鼠按照设计分别取干预后第3 d、4 d、6 d、7 d时相点数据进行组内、组间分析.结果:(1)干预后第3 d,D组血LZM、IL-10恢复后各时相水平均显著高于自然恢复B组与模型C组(P <0. 05);(2)干预后7 d,D组血MPO、IL-8恢复水平均显著低于自然恢复B组与模型C组(P <0. 01).结论:(1)远红外陶瓷微珠干预下,发现降低了MPO水平而提升了LZM水平,说明干预后急性损伤炎性细胞对损伤肌肉的破坏进一步减小;(2)远红外陶瓷微珠干预可提升IL-10浓度水平和降低IL-8的浓度水平,验证其影响炎症反应过程,促进急性损伤的快速恢复.福建省自然科学基金资助项目(2016J01404);;莆田学院育苗基金资助项目(2017014);莆田学院国家基金预研资助项目(2016076);;国家体育总局科技服务资助项目(2017HT008

Bone Proteomic Analysis About Chinese Medicine Action On Rat Ovariectomy Model of Osteoporosis.

目的:用蛋白质组学的方法对绝经后骨质疏松症和中药作用机理进行研究,有利于临床防治该疾病。方法:建立去卵巢大鼠骨质疏松症模型,设立中药治疗组及假手术对照组,6周后骨质疏松症模型成功,行骨形态学检查,提取骨组织蛋白质样品,双向电泳分离,得到各组骨组织总蛋白质分子解剖图谱,用图像分析软件,分析各组间差异蛋白质点,MADITOF/MS质谱分析,结合蛋白质生物信息库(Matrix science Ltd database),对各蛋白质初步鉴定。结论:鉴定了3个差异蛋白,分别为P1硫氧还蛋白过氧化酶1(Thioredoxin peroxidase 1),P2为阻凝蛋白轻链肽2(Myosin light polypeptide 2),P3为泛素化酶E2-17KD(ubiquitin-conjugating enzyme E2-17kD)。初步认为这三种蛋白质在绝经后骨质疏松症的发病及中药治疗过程中发挥着重要调控作用。Objective:To study the mechanism about osteoporosis of OVX(ovariectomy) and Chinese Medicine action on osteoporosis in proteomics,it is of benefit to prevent and cure this disease.Methods:Bilateal OVX in rats was performed as osteoporosis model.Rat was randomly divided into three groups:control group,osteoporosis model group and Chinese Medicine therapy group.The pathology of bone was examined after 6 weeks.In the present proteomic study,we characterized the protential effects of OVX and Chinese Medicine on protein expression in rat bones.Using two-dimensional gel electrophoresis,mass spectrometry,and Matrix science Ltd database,we elementarily identified three variational proteins.Conclusions:Three proteins were identified as proteins similar to thioredoxin peroxidase 1,Myosin light polypeptide 2 and ubiquitin-conjugating enzyme E2-17kD.These proteins have been demonstrated to be postmenopausal proteins.These results can provide valuable experimental evidences for the research for the molecular mechanism of osteoporosis which was response to OVX and Chinese Medicine in bone.国家自然科学基金项目(基金号:30400606); 广东省自然科学基金项目(基金号:04010036);; 广东省科技厅项目(基金号:粤科社字2004,139号);; 广州中医药大学创新基金项目(基金号:K004044

房室结慢径消融电生理特性与临床疗效关系探讨

【目的】探讨房室结折返性心动过速(AVNRT)慢径消融时心内电生理改变与临床疗效的关系。【方法】对94 例慢-快型AVNRT 病人采用射频消融慢径治疗, 分析消融前后电生理特征、消融时心内电生理改变和消融终点。【结果】94 例均消融成功, 其中75 例(80 %)慢径阻断, 19 例(20 %)慢径未阻断, 其中2 例(2 %)慢径未阻断者并有1 ～ 2 个心房回波;术 后随访(28 ±17)月, 4 例术后1～ 5 月复发, 经再次消融成功。术中5 例消融时呈持续交界心律, 经消融后仍然有心动过速发 作, 调整靶点后消融成功;4 例放电时有房室传导阻滞先兆, 用时间滴定法消融成功。【结论】慢径路消融的理想终点应该是 电刺激诱发的心动过速消失;消融时出现持续交界心律是安全的, 部分患者需调整消融靶点提高消融成功率;有房室传导阻 滞先兆者采用时间滴定法, 可避免永久性房室传导阻滞发生

室房间期差值对间隔部旁道与快径逆传心动过速的鉴别诊断价值

【目的】研究间隔部旁道参与的和房室结功能连续曲线性快径逆传的室上性心动过速的电生理特征, 为射频治 疗提供准确的定位依据。【方法】选择10 例间隔旁道介导的房室折返性心动过速(AVRT, 旁道组)与10 例房室结功能连续曲 线的房室结折返性心动过速(AVNRT, 房室结组)病人, 分别在与心动过速相同的频率起搏右心室及心动过速发作时, 测量希氏 束(HBE)、冠状窦近端(CS9 -10)导联记录的室房传导间期(VAVP和VASVT)及两者差值ΔVA(VAVP -VASVT)。【结果】①房室结组 心室起搏与心动过速时VA 间期差异显著(P 0.05);②心室起搏时旁道组与房室结组 的VAVP相比差异无显著性(P >0.05);③心动过速时VA 间期旁道组明显长于房室结组, 两者相比VASVT差异显著(P < 0.001);④旁道组ΔVA 与房室结组比较差异显著(P ≤0.001)。【结论】CS9-10导联ΔVA 是鉴别隐性间隔部旁道介导的AVRT 与AVNRT 的重要参考指标, 特别对房室结功能连续曲线性房室结折返性心动过速的鉴别有较高价值

Removal of Iron During Copper Sulfate Production from Bioleaching Reextraction Solution

［中文文摘］利用三种方法分别对某铜矿山生物浸铜反萃液生产饲料级五水硫酸铜的重要步骤———除铁工艺进行了深入研究,结果表明:采用黄铵铁矾法除铁,控制温度在95℃、pH=1 6,除铁率可以达到91 2%;采用氢氧化铁沉淀法,于70℃,pH=3 8的条件下,除铁率可达98 1%。但上述方法除+、Na+和Ca2+等杂质带入硫酸铜溶液;采用一步结晶法,控制结晶温度在60℃、结铁过程会将NH4晶时间为6h,除铁率可以达98 5%,该工艺操作简单,产品符合饲料级硫酸铜的国家标准。［英文文摘］Iron removal is crucial to the process of feed-additive copper sulfate pentahydrate production from bioleaching reextraction solution.In this paper,three iron removal methods were examined.A series of experiments were conducted in different conditions and the results indicated that when iron was removed by precipitating in the form of ammonium jarosite(95 ℃,pH=1.6),the iron removal efficiency was 91.2%,while by precipitating in the form of ferric hydroxide(70 ℃,pH=3.8),the iron removal efficiency was 98.1% However ,by these two methods ,the use of oxidant and neutralization reagents introduced unwanted NH+4 ,Na + ,Ca2 + into copper sulfate solution. Crystallizating copper sulfate from reextraction solution ,a simple process ,could remove iron effectively without adding any additives and the iron removal efficiency could reach 98.5% under the condition of 60 ℃and 6 h ,and the quality of copper sulfate met national standards of feed additive.福建紫金矿业股份有限公司资助项

Bone Proteomic Analysis About Chinese Medicine Action on Rat Glucocorticoid-induced Model of Osteonecrsis.

目的:用蛋白质组学的研究方法进行激素性骨坏死的病理和中药作用机理的研究,有利于临床治激素性骨坏死。方法:按照常用激素性骨坏死的造模方法,建立大鼠坏死模型,并设立中药治疗组及空白对照组,经过6周处理后经骨形态学检查,确定骨坏死造模成功,处死动物取股骨和肱骨,提取骨组织蛋白质样品,双向电泳分离,得到各组骨组织总蛋白质分子解剖图谱,用图像分析软件,找到各组间差异蛋白质点,进一步行胶内酶切,M AD ITOF/M S质谱分析,得到各差异点的蛋白质肽指纹图谱,结合蛋白质生物信息库(M atrix sc ience L td database),对各蛋白质进行初步鉴定。结论:初步鉴定了3个差异蛋白,分别为阻凝蛋白重链ⅡB、磷脂谷胱甘肽过氧分酶及泛素化酶E 2(MW:17 kd),初步认为这三种蛋白质在激素性骨坏死的发病及中药治疗过程中发挥着重要调控作用。Objective:To study the mechanism about glucocorticoid-induced osteonecrosis and Chinese Medicine action on osteonecrosis in proteomics,it is beneficial to prevention and cure this disease.Methods:Rat was randomly divided into three groups:cortrol group,osteonecrosis model group and Chinese Medicine therapy group.In the present proteomic study ,we characterized the potential effects of glucocorticoids and Chinese Medicine on protein expression in rat bone.Using two-dimensional gel electrophoresis,mass spectrometry,and Matrix science Ltd database,we elementarily identified three variational proteins.Conclusion:Three proteins were identified as proteins similar to Myosin heavy chain ⅡB,Phospholipid hydroperoxide glutathione peroxidase and ubiquitin-conjugating enzyme E2-17kD.These proteins have been documented to be glucocorticoid-relted proteins.These results can provide valuable experimental evidences for the research of the molecular mechanism of osteonecrosis response to glucocorticoids and Chinese Medicine in bone.获得国家自然科学基金资助(30273631,3010244);; 广东省自然科学基金(020778);; 广东省教育厅基金(Z02011