Osmaniye ili alüvyal zeminlerin jeoteknik incelemesi

Osmaniye Akdeniz'in doğusunda yer alan ve doğusunda Adana, batısında Hatay illeri ile çevrelenen bir şehrimizdir. Osmaniye yerleşim alanı kil, silt, kum ve çakıllar ile temsil edilen alüvyal zeminlerden oluşmaktadır. Bilindiği üzere alüvyal zeminler yapılaşma açısından oturma, sıvılaşma vb. mühendislik problemlerine neden olabilmektedir. Bu çalışmada Osmaniye kent merkezinin kuzey doğusunda yer alan 7 mahallenin yerel zemin koşulları incelenmiştir. Bu amaç için 2016 yılında Osmaniye belediyesi tarafından 8500 hektar alanın imar planına esas jeolojik-jeoteknik etüd raporunda yer alan verilerin bir bölümü kullanılmıştır. Buna göre çalışma alanında yer alan zeminler killi birimler, siltli birimler, kumlu birimler ve çakıllı birimler olmak üzere dört farklı gruba ayrılmıştır. Çalışma alanı ağırlıklı olarak killi ve çakıllı birimlerden oluşmakta olup, her bir zemin grubunun fiziksel ve mekanik özellikleri ayrı ayrı değerlendirilmiştir. Sıvılaşabilen zeminler çalışma alanında oldukça sınırlı bir alanda gözlenmekte olup, Yeni Mahalle, Dumlupınar, Rızaiye ve Fevzi Çakmak mahallelerinde lokal sıvılaşabilen seviyeler tespit edilmiştir.Osmaniye is a city in southern mediterranean region with alluvial soils which are surrounded by Adana in east and Hatay in west directions. The foundation soils of Osmaniye are characterized by the alluvial mixture of clay, silty, sand and gravel. As generally known, alluvial soils may cause engineering problems such as liquefaction and settlement. In this study, foundation soils of different seven districts which are located north eastern part of Osmaniye are investigated. For this purpose some geotechnical data of engineering geology report prepared by the municipality are used. The foundation soils are classified the four different soils group such as clayey soils, silty soils, sandy soils and gravel. This area is divided into four sections of clay, silt, sand and gravel. The study are mainly consist of clayey and gravely soils and geotechnical properties are evaluated for each different group. Liquefaction soils are observed in a very limited area in the study area and local liquefaction levels were determined in Yeni, Dumlupınar, Rızaiye and Fevzi Çakmak neighborhoods

Evaluation of Vocal Communication in a Robot Collective

In this research, we attempt to design a model in which multiple robots communicate with an artificial proto-language whose symbols are vocally encoded letters of the Morse alphabet. We have shown that, as the robots have limited sensing and acting abilities, the communicated symbols of the proto-language differentiates from their original versions due to copying errors. We check the effects of two distinct environmental factors, namely the positional distance between the robots and the amount of noise in the environment. It is shown that both of these factors affect, in different ways, how accurately the presented proto-language can be accurately transmitted by the robots

AMAMANTANDO AL BAIFO [Material gráfico]

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

P2: Image Analysis and Quantification of 3D Cancer Cell Migration

Metastatic tumors are known for their ability to migrate toward circulatory apparatus and detach from the primary tumor. Generally, metastasis is quantified in vitro using migration assays that are normally measured in two dimensions (2D). Threedimensional (3D) migration assays can better mimic cancers by providing similar microenvironments to those observed in vivo. Imaging 3D cell cultures requires multiple 2D images stacked along a Z-axis; however, imaged cells would be in-focus at varied z-positions at different time points due to the characteristics of cell migration. Our goal in this study was to analyze in-focus cell images and quantify cell migration in 3D in high throughput. Briefly, Hep3B human hepatoma cell line in alginate was printed on top of a layer of chemoattractants in a microwell chip and cultured over time to model hepatocellular carcinoma. Acquired cell images were analyzed using a Fast Fourier Transform (FFT) to create a histogram of pixel brightness variation within an image. We selected a specific frequency range that would correspond to a sharp change in pixel brightness, a spheroid\u27s edge, while the rest was subtracted to delete out-of-focus cells. In-focus cell images were recreated by reverse FFT, and ImageJ macros have been used to calculate the brightness of each corrected image in our 3D culture. By correlating pixel brightness to cell number, it allowed us to calculate the average position of all the cells in our 3D culture, based on brightness and z-position of the cell image. By measuring the change in average position over time, we created a quantifiable method to measure cell migration in 3D.https://engagedscholarship.csuohio.edu/u_poster_2017/1054/thumbnail.jp

Human Activity in Palaeolithic Period in Çanakkale Province

It is acknowledged in the light of today's information that human species first appeared in Africa and spread to other parts of the world. It is one of the most important issues to determine which routes human species took during this process and where their living areas were located. Due to its position between Africa, Asia and Europe, the Anatolian peninsula is a region of critical importance for the investigation of this issue. In Çanakkale province, which is located in a key region in terms of fossil human population spread to Europe, 40 locality where Paleolithic chipped stone finds were found were determined during the surveys carried out between 2014 and 2017. This number is expected to increase as a result of the research to be carried out in the following years. During these researches, 16 caves were found and excavations were initiated in İnkaya Cave, which has an intensive human settlement. In this study, field surveys in Çanakkale province that have been ongoing for 4 seasons and the fossil human traces in the light of the findings obtained from these studies are discussed

Nuclear Factor Erythroid 2-Related Factor (NRF2), Heme Oxygenase 1 (HO-1) and Total Oxidant-Antioxidant Status in Patients with COVID-19

Introduction: Studies on nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) levels in COVID-19 patients are limited. This study aimed to investigate the relationship between some biomarkers of oxidant-antioxidant status with COVID-19 disease. Material and methods: The patients older than 18 years of age who tested positive for SARS CoV-2 PCR (polymerase chain reaction) with clinical symptoms and signs were included in this study. Total antioxidant status (TAS), total antioxidant status (TOS), oxidative stress index (OSI) and HO-1 and Nrf2 levels were analyzed from serum samples taken before and after treatment. Results: In this study, 16 patients followed up with the diagnosis of COVID-19 were included. 9 (56.3%) of the patients were female and 7 (43.8%) were male. The mean age was 33.75 ± 17.03 years. All patients were symptomatic and were hospitalized to be followed up. It was determined that Nrf2 and HO-1 values increased significantly after treatment. Moreover, there was a significant positive correlation between Nrf2 and TAS values and TAS increases significantly in parallel to an increase in Nrf2, and there was a significant but negative correlation between Nrf2 and TOS and OSI values, and thus an increase in Nrf2 led to a decrease in TOS and OSI values. There was a significant positive correlation between HO-1 and TAS, and TAS increased significantly, as HO-1 increased. Conclusions: The decrease in TOS and OSI and the increase in Nrf2 and HO-1 during the follow-up period in COVID-19 patients suggest that the body tries to prevent ROS-related oxidative stress via Nrf2 and HO-1 and that oxidative stress may have a key role in the pathophysiology of COVID-19

Role of pyroptosis in COVID-19

Aim: In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis. Material and Methods: This study was carried out with 58 participants, 28 (48.28%) of whom were diagnosis with COVID-19, and 30 (51.72%) of whom were healthy volunteers (control group). Results: There were no statistically significant differences between the gasdermin-D, caspase-1, IL-1β, and NLRP3 levels as a result of all statistical comparisons performed. However, IL-1β values both during the discharge period and during the hospitalization period were considerably higher than those of the control group. At the discharge period, IL-1β values of the patients with severe COVID-19 category had higher than moderate patients, and the patients with moderate than the patients with mild patients. Conclusion: It was observed that IL-1β, which is one of the cytokines released as a result of cell death in the pyroptosis mechanism, was higher in the COVID-19 patients in both the hospitalization and discharge periods compared to the control group. Although not statistically significant these results could support the relationship between pyroptosis and COVID-19

Unsustainable harvest of water frogs in southern Turkey for the European market

Frogs have been harvested from the wild for the last 40 years in Turkey. We analysed the population dynamics of Anatolian water frogs (Pelophylax spp.) in the Seyhan and Ceyhan Deltas during 2013–2015. We marked a total of 13,811 individuals during 3 years, estimated population sizes, simulated the dynamics of a harvested population over 50 years, and collated frog harvest and export statistics from the region and for Turkey as a whole. Our capture estimates indicated a population reduction of c. 20% per year, and our population modelling showed that, if overharvesting continues at current rates, the harvested populations will decline rapidly. Simulations with a model of harvested population dynamics resulted in a risk of extinction of > 90% within 50 years, with extinction likely in c. 2032. Our interviews with harvesters revealed their economic dependence on the frog harvest. However, our results also showed that reducing harvest rates would not only ensure the viability of these frog populations but would also provide a source of income that is sustainable in the long term. Our study provides insights into the position of Turkey in the ‘extinction domino’ line, in which harvest pressure shifts among countries as frog populations are depleted and harvest bans are effected. We recommend that harvesting of wild frogs should be banned during the mating season, hunting and exporting of frogs < 30 g should be banned, and harvesters should be trained on species knowledge and awareness of regulations

Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience

Background/Aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population.Material and Methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received ledipasvir (LDV) and sofosbuvir (SOF)+/- ribavirin (RBV) ombitasvir/paritaprevir/ritonavir +/- dasabuvir (PrOD)+/- RBV for 12 or 24 weeks. Sustained virologic response (SVR) rates, factors affecting SVR, safety profile, and hepatocellular cancer (HCC) occurrence were analyzed.Results: SVR12 was achieved in 92.8% of the patients (4,040/4,352) according to intention-to-treat and in 98.3% of the patients (4,040/4,108) according to per-protocol analysis. The SVR12 rates were similar between the treatment regimens (97.2%-100%) and genotypes (95.6%-100%). Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase (ALT) levels (50.90 +/- 54.60 U/L to 17.00 +/- 14.50 U/L) and model for end-stage liver disease (MELD) scores (7.51 +/- 4.54 to 7.32 +/- 3.40) (p<0.05). Of the patients, 2 were diagnosed with HCC during the treatment and 14 were diagnosed with HCC 37.0 +/- 16.0 weeks post-treatment. Higher initial MELD score (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.22-2.38; p=0.023]), higher hepatitis C virus (HCV) RNA levels (OR: 1.44, 95% CI: 1.31-2.28; p=0.038), and higher serum ALT levels (OR: 1.38, 95% CI: 1.21-1.83; p=0.042) were associated with poor SVR12. The most common adverse events were fatigue (12.6%), pruritis (7.3%), increased serum ALT (4.7%) and bilirubin (3.8%) levels, and anemia (3.1%).Conclusion: LDV/SOF or PrOD +/- RBV were effective and tolerable treatments for patients with CHC and with or without advanced liver disease before and after liver transplantation. Although HCV eradication improves the liver function, there is a risk of developing HCC.Turkish Association for the Study of The Liver (TASL