Volcanogenic Turonian and epiclastics of senonian in the Timok magmatic complex between Bor and the Tupižnica mountain, eastern Serbia

In the light of the findings presented in this paper, among the volcanic products of the Upper Cretaceous, referred to as "the first volcanic phase" (Drovenik, 1961), two lithostratigraphic units can be singled out within the Timok Magmatic Complex (TMC): - The lower one, consisting of volcanogenic, subaerial, dominantly hornblende andésite volcaniclastic, formed on land, and less abundant volcanic and sub-volcanic-hypoabyssal rocks. It is the main source of sulfide mine­ralization in Bor. It was formed before the Upper Turonian and consists of hornblende andésite and occasionally low biotite. Minor constituents are biotite-hornblende dacite and some andésite and dacite materials con­taining augite in addition to hornblende and biotite. - The upper one, from the Upper Turonian period when the volcanic activity of the region had ended, is marine deposited and epiclastic. Intercalated with Senonian marls, it is composed of land deposited Turonian volcanogenic material of all generations. Fresh material mostly consisting of hornblende andésite volcanoclastics prevails in it. Fresh epiclastics include ore mineral epiclasts. Epiclastics composed of epiclasts of hydro thermally altered rocks were observed which also include ore epiclasts. The ore epiclasts originate from copper ore. The boundary between the volcanogenic Turonian and the epiclastic deposits is a well-recognized unconformity. Table 1 in the text summarizes the main characteristics of the Turonian volcanogenic rocks, primarily those of volcaniclastics, as well as those of epiclastic deposits

Uticaj molekularnih karakteristika invazivnog duktalnog karcinoma dojke na pojavu lokoregionalnih metastaza

Breast cancer (BC) is the most common malignant tumor in female population and the most common cause of death from malignant diseases in women. The most recent literature data have suggested that there is a small population of cancer stem cells, comprising less than 1% of primary tumors, which are responsible for the development of metastases and disease progression. Breast cancer stem cells (BCSCs) have the ability to self-renew and to create a dominant population of cancer cells. The BCSCs phenotype is specific and characterized by the expression of nuclear and membrane pluripotency factors (molecular markers). In this paper we investigated the expression of markers with stem cell properties (KLF4, SOX2, OCT3/4, EZH2, CD44, CD117) in the cancer cells of invasive ductal breast cancer and their association with clinical-pathological parameters and molecular tumor subtype, aiming to evaluate their impact on the occurrence of locoregional matastases. The results of this study showed that tumor size (T4), higher Ki-67 index, high OCT3/4 and EZH2 expression, increased number of highly expressed nuclear markers, and increased number of altered markers were significantly associated with locoregional disease spread. A high expression of OCT3/4 and EZH2 in invasive ductal breast cancer was predictive of axillary metastases. An increased number of metastatic axillary lymph nodes was significantly associated with reduced ER and PR scores, high expression of OCT3/4, EZH2 and SOX2, with an increased number of nuclear markers with high expression, coexpression of all nuclear markers, coexpression of membrane markers CD44 and CD117, and the increased number of altered markers. Coexpression of all nuclear, as well as CD44 and CD117 markers, was predictive of the increased number of metastatic axillary lymph nodes. T4 stage, reduced ER and PR scores, increased expression of OCT3/4, EZH2 and SOX2 had a significant impact on the increased percentage of metastatic axillary lymph nodes, as well as a greater number of nuclear markers with high expression, coexpression of all nuclear markers, coexpression of highly expressed membrane markers, and a greater number of altered markers. Tumor size, increased number of highly expressed nuclear markers, and CD44 and CD117 coexpression were predictive of a greater percentage of metastatic lymph nodes. Since the development of lymphonodal metastases is a key event in the progression of breast cancer, with a deeper knowledge of primary tumor heterogeneity and using standard and new molecular markers, it is important to identify the patients at risk for the development of metastases

Accordion approach to selected works for accordion and orchestra by Russian authors (Interpretive solutions and problems of symbiosis of accordion and orchestra sound)

Predmet doktorskog umetničkog projekta jeste akordeonistički pristup izabranim delima za harmoniku i orkestar ruskih autora koji ukazuje na interpretativna rešenja i problematiku simbioze zvuka harmonike i orkestra. Rad je usko povezan sa umetničkim delom doktorskog umetničkog projekta koji uključuje izvođenje tri kompozicije eminentnih autora: Koncertna simfonija br. 1 za harmoniku i simfonijski orkestar Vladislava Zolotarjova, Fahwerk Sofije Gubajduline za harmoniku, perkusije i gudački orkestar i Viva Voce, koncert broj 1 za harmoniku i gudački orkestar Jefrema Podgajca. Cilj doktorskog umetničkog projekta jeste afirmacija dela za harmoniku i orkestar i njihovo implementiranje u akordeonističku, ali i celokupnu umetničku koncertnu aktivnost. Cilj rada sagledava se kroz analitičko-interpretativni pristup pomenutim delima kompozitora koji su u mladosti i tokom obrazovanja i sami bili akordeonisti, ali i onih kompozitora koji se nisu praktično bavili harmonikom i izučavali je kao instrument iz ugla izvođača. Primenom istorijsko-analitičkog metoda, kao i metoda intervjua, kao posebno značajnog u procesu sagledavanja savremene kompozitorske misli, napravljen je uvid u najsitnije relacije muzičko-stilskog izraza ruskih kompozitora, ali i pokazan razvojni put harmonike kao instrumenta. Takođe, sadejstvo primene pomenutih metoda rezultiralo je značajnim informacijama koje se odnose na sam pristup interpretaciji izabranih dela za potrebe doktorskog umetničkog projekta, kao i usvajanjem korisnih smernica u domenu interpretativnih rešenja u realizaciji zvučne slike harmonike i orkestra u zajedničkom nastupu. U radu je prezentovana autentičnost zvuka harmonike u odnosu na gudački orkestar kroz njene solističke deonice, ali i situacijama gde je pažnja naročito usmerena ka usaglašavanju njihovog istovremenog zvučanja, tačnije njihov simultani zvuk i originalnost zvuka harmonike u takvom muzičkom sklopu. Komparacijom različitih načina interpretacije i tembralnosti najupečatljivijih delova kompozicija izvedeni su zaključci koji se tiču statusa harmonike kao solističkog instrumenta u orkestru, njenih tehničkih mogućnosti u odnosu na orkestar, kao i načina na koji su predstavljne njene prednosti i nedostaci u odnosu na druge solističke instrumente. Rezultati istraživanja pokazali su, takođe, da je od izuzetne je važnosti istaći činjenicu da kompozitori koji su i sami izvođači na instrumentu za koji pišu muziku to čine znatno „pažljivije”, odnosno da je izvođenje njihove muzike izuzetno pogodno i „pod rukom”. Ukoliko kompozitori, sa druge strane, ne sviraju instrument za koji stvaraju, potreban je intenzivan odnos na relaciji kompozitor-izvođač, koji je od izuzetnog, primarnog značaja kada se ima u vidu iskorišćavanje potpunog tehničkog i zvučnog potencijala harmonike.The subject of the doctoral art project is the accordionist approach to selected works for accordion and orchestra by Russian authors, which points to interpretive solutions and the problem of the symbiosis of the sound of the accordion and orchestra. The work is closely connected with the artistic part of the doctoral art project, which includes the performance of three compositions by eminent authors: Concert Symphony no. 1 for accordion and symphony orchestra by Vladislav Zolotaryov, Fahwerk by Sofia Gubajdulina for accordion, percussion and string orchestra and Viva Voce, concert number 1 for accordion and string orchestra by Jefrem Podgajc. The goal of the doctoral art project is the affirmation of works for accordion and orchestra and their implementation in the accordion, but also the entire artistic concert activity. The aim of the work is seen through an analytical-interpretative approach to the mentioned works of composers who were accordionists in their youth and education, but also those composers who did not practice the accordion and studied it as an instrument from the performer's point of view. By applying the historical-analytical method, as well as the interview method, as especially important in the process of perceiving contemporary composer's thought, an insight was made into the smallest relations of musical-stylistic expression of Russian composers, but also showed the development of the accordion as an instrument. Also, the cooperation of the mentioned methods resulted in important information related to the approach to the interpretation of selected works for the needs of the doctoral art project, as well as the adoption of useful guidelines in the field of interpretive solutions in the realization of the sound image of accordion and orchestra. The paper presents the authenticity of the accordion sound in relation to the string orchestra through its solo sections, but also situations where attention is especially focused on harmonizing the simultaneity of their sound, more precisely their simultaneous sound and originality of the accordion sound in such a musical composition. By comparing different ways of interpretation and timbreliness of the most impressive parts of the compositions, conclusions were drawn regarding the status of the accordion as a solo instrument in an orchestra, its technical capabilities in relation to the orchestra, and the way in which its advantages and disadvantages in relation to other solo instruments are presented. The results of the research also showed that it is extremely important to point out the fact that composers who are themselves performers on the instrument for which they write music do it much „carefully”, ie that performing their music is extremely convenient and „at hand”. If composers, on the other way, do not play the instrument for which they create, an intensive relationship between the composer and the performer is needed, which is of exceptional, primary importance when considering the full technical and sound potential of the accordion

Doprinos analizi vremenskih nizova sa celobrojnim vrednostima

New thinning operators are defined as differences of two negative binomial thinning operators. On the basis of such defined operators, time series with discrete Laplace marginals are defined. Some important features of all introduced models are determined. Estimators of unknown parameters are derived and their asimptotic behaviour are discussed. All models are checked on simulated data and compared with some of existing models. An application in real-life situations are presented. Also, a method for identification of latent components of the models are give

Neki primeri numeričke simulacije ravanskih tokova

U ovom radu se govori o mogućnostima primene ravanskih računskih modela u hidrotehničkoj praksi. Prikazan je jedan od takvih modela, baziran na jednačinama koje su dobijene osrednjavanjem po dubini toka, a koje se regavaju pomoću eksplicitne MacCormack-ove sheme konačnih razlika. Ova shema razdvojenih operatora je zadnjih godina u svetu veoma aktuelna, jer omogućava istovremeno obuhvatanje različitih režima tečenja i dobru reprodukciju talasa sa strmim čelom. Mogućnost korišćenja ovog modela u praksi je ilustrovana sa nekoliko primera koji obuhvataju probleme rušenja brane, tečenja kroz suženje i tečenja u blizini napera.The possibilities of application of depth-averaged two dimensional numerical models in hydraulic engineering are discussed in this paper. One of such models, based on the explicit time-splitting MacCormack finite-difference scheme, has been briefly described. In the last few years, this particular scheme has become very popular in open-channel hydraulics due to its good shock capturing capabilities and the fact that different flow regimes, which might simultaneously occur in different parts of the channel can be treated in the same time. Several practical examples are used for illustration, including dam-break flow, flow through constriction and flow in the vicinity of groynes

DATA ANALYSIS OF ENVIRONMENTAL CONDITIONS INFLUENCING THE WORK OF LABORATORY EQUIPMENT AND APPLICATION OF MACHINE LEARNING MODELS FOR CLASSIFICATION OF POOR CONDITIONS

Environmental conditions can have a crucial impact on the functioning of laboratory equipment. Electric components are sensitive to the influence of certain environmental factors such as temperature, humidity, vibrations, etc. Environmental factors should, therefore, be monitored to avoid their negative influence on the system and potential faults and failures they could cause. Unlike the traditional approaches which required the presence of special staff to monitor environmental factors and react if they are poor, the rise of the Internet of Things enhanced the application of intelligent solutions where human factor is not necessary. In this paper, research on data analysis, preprocessing and intelligent classification of environmental conditions has been conducted. The data was collected by sensors connected to Raspberry Pi. The applied monitoring system setup enabled long-distance monitoring of laboratory conditions through the internet and full applicability of fundamental IoT concepts. Since data preparation is an important step in the process of designing machine learning models, the collected data was analyzed and preprocessed in Python. Intelligent classification of environmental conditions was performed using machine learning models k-Nearest Neighbors and Random Forest. Grid search was used for model selection, and the performances of k-Nearest Neighbors and Random Forest machine learning models were compared. Experimental results show that these machine learning models can be successfully used for intelligent classification of environmental conditions

Sintering of fly ash based composites with zeolite and bentonite addition for application in construction materials

Due to pozzolanic characteristics, fly ash is commonly used as a cement replacement in construction composites. Addition of natural clays with sorption ability (i.e. zeolite and bentonite) in to the fly ash based construction materials is of both scientific and industrial interest. Namely, due to the application of sorptive clay minerals, it is possible to immobilize toxic heavy metals from the composite structure. The thermal compatibility of fly ash and zeolite, as well as fly ash and bentonite, within the composite was observed during sintering procedure. The starting components were used in 1:1 ratio and they were applied without additional mechanical treatment. The used compaction pressure for the tablets was 2 t•cm-2. The sintering process was conducted at 1000ºC and 1200ºC for two hours in the air atmosphere. The mineralogical phase composition of the non-treated and sintered samples was analyzed using X-ray diffraction method. Scanning electron microscopy was applied in the analysis of the microstructure of starting and sintered samples. The thermal behavior was observed via DTA method. The influence of temperature on the properties of fly ash-zeolite and fly ash-bentonite composites was investigate

ADSORPTION OF PLANT EXTRACTS ON CATIONIZED COTTON

Cotton, like most textile fibers, is negative charged in neutral and alkali aqueous solutions. Dyestuffs, optical brighteners and finishing agents in aqueous solution have the same electrical charge as cotton. Therefore, adsorption processes are difficult due to these repulsive forces. This paper studies the application of water extraction plants of St. Johns wart, marigold and hibiscus for the finishing of modified cotton by mercerization and cationization. The mercerization is the oldest modification since 19th century, while the cationization is researched in last 10 years. In this paper cationization of cotton fabric for achieving electropositive charge and better adsorption properties was carried out with cationic compound, quaternary ammonium salt during the mercerization well as with commercial product for cationization Denimcol Fix-GF (Bezema). The cotton electrokinetic phenomena after modifications were determined by zeta potential, isoelectric point, point of zero charge and specific amount of surface charge. The adsorption ability of plant extracts with and without mordant was investigated

Influence of Mechanical Activation on the Constituents of the MgO-Al2O3-SiO2-MoO3 System

Cordierite, 2MgO•2Al2O3•5SiO2 (MAS), is high-temperature ceramic material. Cordierite is commonly used material because of outstanding electrical properties, low temperature expansion coefficient and low dielectric constant. In order to accelerate the process of sintering, 5.00 mass% MoO3 has been added to the starting mixtures. The mechanical activation of the starting mixtures was performed in a high energy ball mill during 0-160 minutes. All starting mixtures were sintered at 1100°C, 1200°C and 1300°C for 2h. The particle size analysis (PSA) was employed in order to determine the changes in the particle size of the mechanically treated powders. The phase composition of the starting powders was analyzed by the X-ray diffraction method. Differential thermal (DTA) and thermogravimetric (TG) analysis were used in order to determine characteristic temperatures within the system during heating. Based on the obtained DTA results, it was established that mechanical activation with additive MoO3, has influence on decreasing sintering temperatures for about 150°C

Plovni putevi i pristaništa kroz rešene primere

Knjiga Plovni putevi i pristaništa kroz rešene primere je udžbenik iz istoimenog predmeta na Građevinskom fakultetu u Beogradu. Do akreditacije 2021. godine ovo je bio obavezan predmet najpre na osnovnim, a potom na master akademskim studijama. Od akreditacije 2021. godine postaje izborni predmet uprkos činjenicama da kroz Republiku Srbiju prolaze tri međunarodna plovna puta - reke Dunav, Sava i Tisa i da Republika Srbija u skladu sa potpisanim međunarodnim sporazumima ima obavezu da osigura bezbednu plovidbu duž sektora koji prolaze kroz njenu teritoriju