Entreprenerystės aplinkos Slovakijoje raida

Entrepreneurial environment in Slovakia is monitored and recently demonstrates deteriorative level. Entrepreneurs themselves defined the shortfalls as it was also confirmed by analyses of regional and national agencies. In the Slovak Republic, the small and medium enterprises have an irreplaceable role to play. Entrepreneurs consider levying charges, frequent regulation modifications, difficult exaction of justice, unavailability of loans, ambiguous policies, corrupt practices at magistracies, tax charges, and many others to be the biggest obstacles. Definition and solution of these problems is highly important to support small and medium businesses. It can foster overall conditions of entrepreneurship in Slovakia and also increase Slovakia’s competitiveness. The aim of the article is to point out entrepreneurship and business environment conditions in the Slovak Republic, mainly the organisations oriented towards small and medium enterprises, which have an irreplaceable role predominantly in the field of workplace establishment and regional development.Entreprenerystės aplinka Slovakijoje yra nuolat matuojama ir šiuo metu pastebimos blogėjimo tendencijos. Entrepreneriai patys pripažįsta situacijos blogėjimą bei tai patvirtina regioninių ir nacionalinių agentūrų pateikti duomenys. Slovakijos Respublikoje mažos ir vidutinės įmonės vaidina labai svarbų vaidmenį. Entrepreneriai pripažįsta mokesčių didėjimą, dažnus įstatymų kaitaliojimus, sunkią teisėtvarkos būklę, paskolų trūkumą, ambicingas nepagrįstas politikas, korupciją ir kt. kaip pačias didžiausias kliūtis entreprenerystės plėtrai Slovakijoje. Šių problemų apibrėžimas ir sprendimas yra labai svarbus, siekiant paskatinti smulkiojo ir vidutinio verslo plėtrą. Tai leistų ne tik pagerinti entreprenerystės sąlygas bet ir padidinti Slovakijos konkurencingumą. Straipsnio tikslas yra apibrėžti entreprenerystės ir verslo sąlygas Slovakijoje, turinčias įtakos smulkių ir vidutinių įmonių steigimui, kuris garantuoja naujų darbo vietų kūrimą ir regioninę plėtrą

Inverse cationic ITP for separation of methadone enantiomers with sulfated β-cyclodextrin as chiral selector.

Chiral ITP of the weak base methadone using inverse cationic configurations with H as leading component and multiple isomer sulfated β-CD (S-β-CD) as leading electrolyte (LE) additive, has been studied utilizing dynamic computer simulation, a calculation model based on steady-state values of the ITP zones, and capillary ITP. By varying the amount of acidic S-β-CD in the LE composed of 3-morpholino-2-hydroxypropanesulfonic acid and the chiral selector, and employing glycylglycine as terminating electrolyte (TE), inverse cationic ITP provides systems in which either both enantiomers, only the enantiomer with weaker complexation, or none of the two enantiomers form cationic ITP zones. For the configuration studied, the data reveal that only S-methadone migrates isotachophoretically when the S-β-CD concentration in the LE is between about 0.484 and 1.113 mM. Under these conditions, R-methadone migrates zone electrophoretically in the TE. An S-β-CD concentration between about 0.070 and 0.484 mM results in both S- and R-methadone forming ITP zones. With >1.113 mM and < about 0.050 mM of S-β-CD in the LE both enantiomers are migrating within the TE and LE, respectively. Chiral inverse cationic ITP with acidic S-β-CD in the LE is demonstrated to permit selective ITP trapping and concentration of the less interacting enantiomer of a weak base