Programa de educación para la salud para formar personas ileostomizadas expertas.

Las personas ileostomizadas sufren, en un breve período de tiempo, cambios físicos y biológicos, que les producen inseguridad, incertidumbre y bajo nivel de autoestima. Estos cambios influyen decisivamente en su calidad de vida, siendo fundamental una buena educación para la adaptación al estoma y lo que conlleva. Está demostrado que la educación grupal es beneficiosa para los pacientes, y que, cuando esta educación se hace de igual a igual (Programa de Paciente Experto), fomenta las conductas positivas y el autocuidado, mejorando el bienestar y disminuyendo el gasto sanitario. Objetivo: A través de un programa de educación, aumentar el conocimiento de personas ileostomizadas y darles herramientas de trabajo para que la educación sea efectiva y así se mejore la calidad de vida del colectivo de ileostomizados. Método: Apoyándose en una revisión bibliográfica, se ha diseñado un Programa de Educación para la Salud, cuya población diana son 10 personas ileostomizadas de Palencia con, al menos, 1 año de experiencia. Para lograr el objetivo se han propuesto diferentes actividades, que se evalúan mediante un conjunto de talleres y cuestionarios. Todo esto tendrá lugar en el Hospital Río Carrión durante el mes de septiembre. Conclusión: Debido a la importancia que adquiere este tipo de educación, resulta interesante aplicarla a otros colectivos de personas, de manera que se aumente la calidad de vida de la población y disminuya el gasto sanitario.Grado en Enfermerí

Influence of pH on the adsorption-desorption of doxycycline, enrofloxacin, and sulfamethoxypyridazine in soils with variable surface charge

Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGIn this research, the adsorption/desorption of the antibiotics doxycycline (DC), enrofloxacin (ENR), and sulfamethoxypyradazine (SMP) was studied in 6 agricultural soils with predominance of variable charge, both before and after removing organic matter by calcination. DC adsorption was high at acidic pH, and decreased at pH values above 8. Removal of organic matter with calcination caused just a slight decrease in adsorption, and even in some soils adsorption was similar to that in non-calcined samples. The adsorption coefficients (Kd) were higher for the DC− species compared to DC+, DC0 and DC2−. Regarding DC desorption, the values were very low throughout the pH range covered in the study (2–12), both in the calcined samples and in those not subjected to calcination. ENR showed a similar behavior to DC regarding the effect of pH, since ENR adsorption also decreased at basic pH, but the effect of removing organic matter was different, as it caused a clear decrease in ENR adsorption. The species with the highest Kd was in this case ENR0, although ENR+ is also quantitatively important as regards Kd value in calcined samples. For this antibiotic, no differences in desorption were observed between calcined and non-calcined samples. Finally, SMP adsorption also decreased as pH increased, and, in addition, similarly to what happened with ENR, in general, there was a strong decrease in SMP adsorption when organic matter was removed. The species with the highest Kd in this case was SMP+ in non-calcined samples, but SMP0 and SMP− become more relevant in calcined samples. The percentages of SMP desorption were higher than those for the other two antibiotics, and an increase occurs at intermediate pH values, being higher for calcined samples. These results can be considered relevant in terms of increasing the knowledge as regards the possible evolution and fate of the three antibiotics studied. Specifically, for different pH conditions and with different organic matter contents, when they reach soils and other environmental compartments after being discharged as contaminants. This could have important repercussions on public health and the overall environmentMinisterio de Economía y Competitividad | Ref. CGL2015-67333-C2-1-RMinisterio de Economía y Competitividad | Ref. CGL2015-67333-C2-2-

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T patients and Atm−/− mouse models are particularly predisposed to develop lymphoid cancers derived from deficient repair of RAG-induced DSBs during V(D)J recombination. Here, we unexpectedly find that specifically disturbing the repair of DSBs produced by DNA topoisomerase II (TOP2) by genetically removing the highly specialised repair enzyme TDP2 increases the incidence of thymic tumours in Atm−/− mice. Furthermore, we find that TOP2 strongly colocalizes with RAG, both genome-wide and at V(D)J recombination sites, resulting in an increased endogenous chromosomal fragility of these regions. Thus, our findings demonstrate a strong causal relationship between endogenous TOP2-induced DSBs and cancer development, confirming these lesions as major drivers of ATM-deficient lymphoid malignancies, and potentially other conditions and cancer types.Junta de Andalucía SAF2010-21017, SAF2013-47343-P, SAF2014-55532-R, SAF2017-89619-R, CVI-7948European Research Council ERC-CoG-2014-64735

Proyecto de recualificación del área del mercado de Xipamanine y reasentamiento de la población afectada (Maputo, Mozambique)

"A corazón abierto" plantea la regeneración del centro de barrio, el gran Mercado Xipamanine, Maputo, Mozambique. Mozambique es un país localizado al sudeste de áfrica. El 78% de la población se encuentra en la pobreza y mas de la mitad de la población en pobreza absoluta. Dentro de Maputo, Xamanculo es un barrio que destaca por su actividad comercial . Ahí se localiza el Mercado sobre el que actúa el proyecto. Se trabaja en un solar que incluye un mercado informal, viviendas auto-construidas dispersas, barracas y una terminal de transporte. Se analiza la orografía del terreno, planteando un proyecto en el que se evita el riesgo por inundaciones por lo que se redistribuyen los equipamientos en el solar tratando de aglutinarlos según programa y las circulaciones que generan dejando un espacio vacío en el centro que funciona como espacio público. Se plantea un proyecto por fases llegando a una fusión entre lo formal y lo informal basándose en el planteamiento de aceptar las pre-existencias y que sean generadoras de proyecto

La marca como intangible estratégico una reflexión crítica sobre su consideración como tema de interés para la empresa : A marca como intangível estratégicouma reflexão crítica sobre a sua consideração como tema de interesse para a empresa

El artículo consiste en una reflexión teórica general crítica sobre la consideración que se ha venido haciendo de la marca, y en general de los intangibles, por parte del mundo empresarial. Se proponen cuatro etapas en cuanto a la consideración y visión de la marca por parte del mundo económico y empresarial, que van desde la nula atención y gestión, hasta su integración en los cuadros de mando como asunto estratégico del management contemporáneo en la nueva economía. Finalmente, el artículo sugiere que puede ser el Dircom, por sus habilidades y conocimientos, quien se implique en la gestión de la marca corporativa, bajo la perspectiva de los los stakeholders, complementando la perspectiva comercial de las marcas de productos y servicios de las compañías

A marca como intangível estratégico uma reflexão crítica sobre a sua consideração como tema de interesse para a empresa

El artículo consiste en una reflexión teórica general crítica sobre la consideración que se ha venido haciendo de la marca, y en general de los intangibles, por parte del mundo empresarial. Se proponen cuatro etapas en cuanto a la consideración y visión de la marca por parte del mundo económico y empresarial, que van desde la nula atención y gestión, hasta su integración en los cuadros de mando como asunto estratégico del management contemporáneo en la nueva economía. Finalmente, el artículo sugiere que puede ser el Dircom, por sus habilidades y conocimientos, quien se implique en la gestión de la marca corporativa, bajo la perspectiva de los los stakeholders, complementando la perspectiva comercial de las marcas de productos y servicios de las compañías.O artigo consiste em uma reflexão teórica e crítica geral sobre a consideração dada à marca e, em geral, aos intangíveis, pelo mundo dos negócios ao longo da história recente. São propostos quatro estágios, em termos de consideração e visão da marca pelo mundo econômico e empresarial, que vão desde a falta de atenção e gestão até sua integração nos painéis de controle como uma questão estratégica da gestão contemporânea na nova economia. Por fim, o artigo sugere que o Dircom, por suas habilidades e conhecimentos, pode se envolver na gestão de marcas corporativas, sob a perspectiva dos stakeholders, complementando a perspectiva comercial das marcas de produtos e serviços das empresas

Occurrence of tetracyclines and sulfonamides in manures, agricultural soils and crops from different areas in Galicia (NW Spain)

Antibiotics released to the environment are causing public health and sustainability concerns. Taking that into account, we studied the presence of tetracyclines (Tetracycline, Oxytetracycline, Chlortetracycline and Doxycycline) and sulfonamides (Sulfadiazine, Sulfamethazine, Sulfachlorpyridazine and Sulfamethoxypyridazine) in manures, soils and crops from Galicia (Spain), where a high number of cattle, pig and poultry farms exist. We used the HPLC-MS/MS technique to analyze 40 samples of cattle, pig and poultry manure, as well as 65 soil samples, and 27 vegetation samples. The presence of antibiotics was detected in 42% of the manures, 17% of the soils and 44% of crop samples, with maximum concentrations of 106.0 mg kg−1 for individual antibiotics in manures and 0.6 mg kg−1 in soils and plants. The simultaneous presence of several antibiotics was infrequent in soils (only three soils presented two or three antibiotics), and more common in manures and plants, some of them with up to five antibiotics. Pig slurries showed the highest antibiotic concentrations, as well as the highest number of different antibiotics. Crops fertilized with these slurries also showed the highest number of different antibiotics. Antibiotics were detected in 71% of grass and corn samples, and in 33% of wheat grain samples, while they were not detected in potato samples. These results can be very relevant taking into account potential environmental and public health repercussions of antibiotics in soil and water, as well as antibiotics uptake and accumulation in plants, and subsequent incorporation to the food chain.This work was supported by the Spanish Ministry of Economy and Competitiveness [grant numbers CGL2015-67333-C2-1-R and CGL2015-67333-C2-2-R]. M. Conde-Cid holds a pre-doctoral contract (FPU15/0280, Spanish Government). The sponsor had not involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report, and in the decision to submit the article for publication.S

Occurrence of tetracyclines and sulfonamides in manures, agricultural soils and crops from different areas in Galicia (NW Spain)

Antibiotics released to the environment are causing public health and sustainability concerns. Taking that into account, we studied the presence of tetracyclines (Tetracycline, Oxytetracycline, Chlortetracycline and Doxycycline) and sulfonamides (Sulfadiazine, Sulfamethazine, Sulfachlorpyridazine and Sulfamethoxypyridazine) in manures, soils and crops from Galicia (Spain), where a high number of cattle, pig and poultry farms exist. We used the HPLC-MS/MS technique to analyze 40 samples of cattle, pig and poultry manure, as well as 65 soil samples, and 27 vegetation samples. The presence of antibiotics was detected in 42% of the manures, 17% of the soils and 44% of crop samples, with maximum concentrations of 106.0 mg kg−1 for individual antibiotics in manures and 0.6 mg kg−1 in soils and plants. The simultaneous presence of several antibiotics was infrequent in soils (only three soils presented two or three antibiotics), and more common in manures and plants, some of them with up to five antibiotics. Pig slurries showed the highest antibiotic concentrations, as well as the highest number of different antibiotics. Crops fertilized with these slurries also showed the highest number of different antibiotics. Antibiotics were detected in 71% of grass and corn samples, and in 33% of wheat grain samples, while they were not detected in potato samples. These results can be very relevant taking into account potential environmental and public health repercussions of antibiotics in soil and water, as well as antibiotics uptake and accumulation in plants, and subsequent incorporation to the food chain.Ministerio de Economía y Competitividad | Ref. CGL2015-67333-C2-1-RMinisterio de Economía y Competitividad | Ref. CGL2015-67333-C2-2-

Participatory visioning for building disruptive future scenarios for transport and land use planning

Participatory visioning in transport scenario building can be particularly useful to anticipate and examine unexpected outcomes over long-term future timelines, providing broad legitimacy to today's decision-making processes. However, the strategic value of participatory approaches is increasingly being contested due to the difficulty to operationalize non-linear thinking, resulting in long-term visions similar to business-as-usual projections. To address this challenge, we developed and implemented a novel participatory visioning approach based on using semi-structured interviews that incorporate two types of wild cards &- low probability and high impact processes &- as disruptive visioning triggers: imaginable and unimaginable processes. A group of experts evaluated the level of disruptive thinking in the generated future visions. The Henares Corridor in the Metropolitan Area of Madrid, Spain provided the empirical focus. The results present a total of seven 2050 visions: one desired common vision plus six wild card visions. Higher levels of disruptive thinking were mainly present in those future visions generated by unimaginable processes, as such processes initiate highly diverging participant future views. It was also noted that smaller and specific groups of participants can visualize 2050 futures more disruptively. Conclusions and reflections on the strengths and weakness of the presented approach are drawn

Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs

Bioprinting is a promising tool to fabricate well-organized cell-laden constructs for repair and regener- ation of articular cartilage. The selection of a suitable bioink, in terms of composition and mechanical properties, is crucial for the development of viable cartilage substitutes. In this study, we focused on the use of one of the main cartilage components, hyaluronic acid (HA), to design and formulate a new bioink for cartilage tissue 3D bioprinting. Major characteristics required for this application such as printabil- ity, biocompatibility, and biodegradability were analyzed. To produce cartilage constructs with optimal mechanical properties, HA-based bioink was co-printed with polylactic acid (PLA). HA-based bioink was found to improve cell functionality by an increase in the expression of chondrogenic gene markers and specific matrix deposition and, therefore, tissue formation. These results indicate that it is a promising bioink candidate for cartilage tissue engineering based in 3D bioprinting.This work was partially supported by MINECO MAT2016-78778-R and PCIN-2015-051 projects (Spain), European Regional Development Fund (ERDF), by the Consejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía and European Regional Development Fund (ERDF), ref. SOMM17/6109/UGR and by the Ministerio de Economía, Industria y Competitividad ( FEDER funds, project RTC-2016-5451-1 ) (to JA.M and P.G-M)