Loma Linda Nurse - Vol. 27

Contents FEATURES 4 | A Seat at the Table—Discussing the Spectrum of Nursing Care 10 | Andrea Jyn Dizon— The Other Classroom 12 | Justin Bobila— When Nursing Takes Flight LLUSN HIGHLIGHTS 14-19 | ALUMNI NEWS 20-27 | ACADEMICS 28-31 | COMMENCEMENT 32-36 | HOMECOMING 37-39 | FACULTY UPDATEShttps://scholarsrepository.llu.edu/loma-linda-nurse/1023/thumbnail.jp

Edoardo Volterra, Senatus Consulta. A cura di Pierangelo Buongiorno – Annarosa Gallo – Salvatore Marino (Acta Senatus B, Band 1) ; Andrea Raggi – Pierangelo Buongiorno (eds.), Il senatus consultum de Plarasensibus et Aphrodisiensibus del 39 a. C. Edizione, traduzione e commento (Acta Senatus B, Band 7) ; Pierangelo Buongiorno – Giuseppe Camodeca (eds.), Die senatus consulta in den epigraphischen Quellen. Texte und Bezeugungen (Acta senatus B, Band 9). [Book review]

Reviewed works: Edoardo Volterra, Senatus Consulta. A cura di Pierangelo Buongiorno – Annarosa Gallo – Salvatore Marino (Acta Senatus B, Band 1). Franz Steiner Verlag, Stuttgart 2017; Andrea Raggi – Pierangelo Buongiorno (eds.), Il senatus consultum de Plarasensibus et Aphrodisiensibus del 39 a. C. Edizione, traduzione e commento (Acta Senatus B, Band 7). Franz Steiner Verlag, Stuttgart 2020; Pierangelo Buongiorno – Giuseppe Camodeca (eds.), Die senatus consulta in den epigraphischen Quellen. Texte und Bezeugungen (Acta senatus B, Band 9). Franz Steiner Verlag, Stuttgart 2021.Non peer reviewe

Psychiatric Adverse Reactions to Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer: Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System

open7siBackground The development of anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) has improved the survival outcomes of patients with advanced ALK-rearranged non-small-cell lung cancer (NSCLC). The adverse events (AEs) related to ALK inhibitors are fairly well known; notably, about 20% of patients receiving lorlatinib experienced cognitive effects and behavioral alterations in pivotal trials. Therefore, psychiatric disorders could represent AEs of special interest for all ALK TKIs, deserving careful assessment in the post-marketing setting. Objective We conducted a real-world pharmacovigilance study on psychiatric AEs with marketed ALK inhibitors in subjects with advanced NSCLC. Patients and methods We performed an observational, retrospective analysis of spontaneous reports submitted to the Food and Drug Administration Adverse Events Reporting System (FAERS, as of December 2020), selecting psychiatric AEs to ALK TKIs approved in NSCLC (crizotinib, ceritinib, alectinib, brigatinib, lorlatinib). These AEs were independently scrutinized by three oncologists applying predefined exclusion criteria, described in terms of clinical/demographic features and assessed for drug-related causality according to an adaptation of the WHO–UMC system, a standardized probabilistic algorithm. Results Among 584 reported psychiatric AEs, 95 cases were selected as potentially treatment related, with higher reporting frequency for lorlatinib (26, 2.8%), followed by brigatinib (10, 1.2%), alectinib (18, 0.7%), ceritinib (12, 0.6%), and crizo- tinib (29, 0.3%). Reported psychiatric symptoms were mood disorders (39), psychotic disorders (24), and anxiety, agitation, and irritability (25). In the majority (74%) of cases, psychiatric AEs were serious and required hospitalization in about 32% of patients; 15.8% of retained cases were considered as highly probable and 69.5% as probable. Drug discontinuation was recorded in 31.6% of the reported cases, with the highest proportion for lorlatinib (65.4%). Conclusion Notwithstanding limitations, our study found a higher proportion of psychiatric AEs with lorlatinib, but also raised the hypothesis of psychiatric reactions as a class effect of ALK TKIs.openSisi, Monia; Fusaroli, Michele; De Giglio, Andrea; Facchinetti, Francesco; Ardizzoni, Andrea; Raschi, Emanuel; Gelsomino, FrancescoSisi, Monia; Fusaroli, Michele; De Giglio, Andrea; Facchinetti, Francesco; Ardizzoni, Andrea; Raschi, Emanuel; Gelsomino, Francesc

Efficacy of epiphytic bacteria to prevent northern leaf blight caused by Exserohilum turcicum in maize

Eight potential biological control agents (BCAs) were evaluated in planta in order toassess their effectiveness in reducing disease severity of northern leaf blight caused by Exserohilumturcicum. The assay was carried out in greenhouse. Twenty-six-day-old plants, V4 phenologicalstage, were inoculated with antagonists by foliar spray. Only one biocontrol agent wasused per treatment. Ten days after this procedure, all treatments were inoculated with E. turcicumby foliar application. Treatments performed were: C-Et: control of E. turcicum; T1: isolate1 (Enterococcus genus) + E. turcicum; T2: isolate 2 (Corynebacterium genus) + E. turcicum; T3:isolate 3 (Pantoea genus) + E. turcicum; T4: isolate 4 (Corynebacterium genus) + E. turcicum; T5:isolate 5 (Pantoea genus) + E. turcicum; T6: isolate 6 (Bacillus genus) + E. turcicum; T7: isolate 7(Bacillus genus) + E. turcicum; T8: isolate 8 (Bacillus genus) + E. turcicum. Monitoring of antagonistson the phyllosphere was performed at different times. Furthermore, the percentage ofinfected leaves and, plant and leaf incidence were determined. Foliar application of differentbacteria significantly reduced the leaf blight between 30---78% and 39---56% at 20 and 39 daysrespectively. It was observed that in the V10 stage of maize plants, isolate 8 (Bacillus spp.)caused the greatest effect on reducing the severity of northern leaf blight. Moreover, isolate 8was the potential BCA that showed more stability in the phyllosphere. At 39 days, all potentialbiocontrol agents had a significant effect on controlling the disease caused by E. turcicum.Se evaluó a 8 potenciales agentes de control biológico (ACB) en un ensayo in planta, con el objetivo de probar su efectividad en la reducción del daño provocado por Exserohilum turcicum, agente causal del tizón foliar del maíz. El ensayo se llevó a cabo en invernadero. Plantas de maíz de 26 días, en estadio fenológico V4, se inocularon con los potenciales antagonistas por aplicación foliar como espray. Solo un agente de biocontrol fue usado por tratamiento y todos los tratamientos se inocularon con E. turcicum 10 días después, también por aplicación foliar. Los tratamientos desarrollados fueron los siguientes: C-Et: control de E. turcicum; T1: aislamiento 1 (género Enterococcus) + E. turcicum; T2: aislamiento 2 (género Corynebacterium) + E. turcicum; T3: aislamiento 3 (género Pantoea) + E. turcicum; T4: aislamiento 4 (género Corynebacterium) + E. turcicum; T5: aislamiento 5 (género Pantoea) + E. turcicum; T6: aislamiento 6 (género Bacillus) + E. turcicum; T7: aislamiento 7 (género Bacillus) + E. turcicum; T8: aislamiento 8 (género Bacillus) + E. turcicum. La monitorización en la filosfera de los antagonistas se llevó a cabo a diferentes tiempos. Además, se determinó el porcentaje de hojas infectadas y la incidencia en plantas y hojas. La aplicación foliar de diferentes bacterias redujo significativamente la gravedad del tizón del maíz: entre el 30 y el 78% a los 20 días y entre el 39 y el 56% a los 39 días. En el estadio V10 de las plantas de maíz se observó que el aislamiento 8 (Bacillus spp.) causó el mayor efecto de reducción del tizón foliar. Además, dicho aislamiento fue el potencial agente de biocontrol que mostró mayor estabilidad en la filosfera. A los 39 días, todos los potenciales agentes de biocontrol demostraban un efecto significativo sobre el control de la enfermedad causada por E. turcicum.Fil: Sartori, Melina Victoria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Nesci, Andrea Verónica. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: García, Julián. Oro Verde, Servicios Fitosanitarios; ArgentinaFil: Passone, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaFil: Montemarani, Analía Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; ArgentinaFil: Etcheverry, Miriam Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología e Inmunología; Argentin

Mutations in the EXT1 and EXT2 genes in Spanish patients with multiple osteochondromas

Multiple osteochondromas is an autosomal dominant skeletal disorder characterized by the formation of multiple cartilage-capped tumours. Two causal genes have been identified, EXT1 and EXT2, which account for 65% and 30% of cases, respectively. We have undertaken a mutation analysis of the EXT1 and EXT2 genes in 39 unrelated Spanish patients, most of them with moderate phenotype, and looked for genotype-phenotype correlations. We found the mutant allele in 37 patients, 29 in EXT1 and 8 in EXT2. Five of the EXT1 mutations were deletions identified by MLPA. Two cases of mosaicism were documented. We detected a lower number of exostoses in patients with missense mutation versus other kinds of mutations. In conclusion, we found a mutation in EXT1 or in EXT2 in 95% of the Spanish patients. Eighteen of the mutations were novel.Fil: Sarrión, P.. Universidad de Barcelona; EspañaFil: Sangorrin, A.. Hospital Sant Joan de Déu; EspañaFil: Urreizti, R.. Universidad de Barcelona; EspañaFil: Delgado, María Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Artuch, R.. Hospital Sant Joan de Déu; EspañaFil: Martorell, L.. Hospital Sant Joan de Déu; EspañaFil: Armstrong, J.. Hospital Sant Joan de Déu; EspañaFil: Anton, J.. Hospital Sant Joan de Déu; EspañaFil: Torner, F.. Hospital Sant Joan de Déu; EspañaFil: Vilaseca, M. A.. Hospital Sant Joan de Déu; EspañaFil: Nevado, J.. Hospital Universitario La Paz; EspañaFil: Lapunzina, P.. Hospital Universitario La Paz; EspañaFil: Asteggiano, Carla Gabriela. Universidad Nacional de Córdoba; Argentina. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Balcells, S.. Universidad de Barcelona; EspañaFil: Grinberg, D.. Universidad de Barcelona; Españ

Le Domus de janas del Logudoro-Mejlogu

Nel Logudoro-Meilogu, regione geografica della Sardegna nordoccidentale, è stata rilevata la presenza di 253 ipogei alcuni dei quali molto noti, sia per la complessità delle strutture (S. Andrea Priu di Bonorva), sia per i motivi di carattere sacro (protomi, corna, spirali, figurine antropomorfe) dipinti, scolpiti od incisi (Mandra Antine di Thiesi, Enas de Cannuia di Bessude e Moseddu di Cheremule). Vengono esaminate: - le tipologie planimetriche, risultate nella maggior parte dei casi di tipo monocellulare (42%) anche se è stata notata una certa diffusione di impianti pluricellulari (30%) e bicellulari (21%); - il rapporto tra i monumenti ed il territorio circostante prendendo soprattutto in considerazione gli aspetti geomorfologico ed altimetrico. In base a tale indagine è emersa la tendenza a collocare gli ipogei su costoni rocciosi (39%), per lo più di natura calcarea (68%), nella fascia altimetrica compresa tra i 300-600 metri (85%). - i particolari architettonici (pilastri, colonne, lesene, fasce in rilievo, focolari) e i vari segni decorativo-cultuali

KONTEN MALE GENDER ROLE DALAM NOVEL AYAH KARYA ANDREA HIRATA

Penelitian ini bertujuan mendeskripsikan male gender role (peran gender pria) dalam novel Ayah karya Andrea Hirata. Metode penelitian ini menggunakan metode deskriptif kualitatif. Adapun yang menjadi sumber data pada penelitian ini adalah teks novel Ayah karya Andrea Hirata. Langkah analisis data dalam penelitian ini adalah mengidentifikasi, mengklasifikasikan, menganalisis, menginterpretasi, dan menyimpulkan novel. Berdasarkan hasil dan pembahasan, novel Ayah karya Andrea Hirata mendapat 12 jenis male gender role (peran gender pria) dengan jumlah 103 kutipan, diantaranya scholar (cendekia/sarjana) 11 kutipan, be the best you can (jadilah terbaik yang kamu bisa) 4 kutipan, good Samaritan (orang Samaria yang baik hati) 28 kutipan, technician (teknisi) 1 kutipan, work ethic (etos kerja) 5 kutipan, law (hukum) 5 kutipan, breadwinner (pencari nafkah) 4 kutipan, nurturer (pemelihara) 39 kutipan, sportsman (olahragawan) 1 kutipan, be like your father (jadilah seperti ayahmu) 3 kutipan, stoic (tabah) 1 kutipan, dan tough guy (pria tangguh) 1 kutipan

1987 Statistics

1987 Women\u27s Basketball Statistics, George Fox Universit

Evaluation of Bacillus thuringiensis subsp. Israelensis and Bacillus sphaericus combination against Culex pipiens in highly vegetated ditches

9openInternationalItalian coauthor/editorAmong the few mosquito larvicides available in the market, Bacillus thuringiensis subsp. israelensis (Bti) and B. sphaericus (Bs) represent the most environmentally safe alternatives. The combination of the 2 products is known to overcome their specific limitations by producing a synergistic effect. The aim of the study was to assess the effect and persistence of a single treatment with a granular Bti + Bs formulation on highly vegetated ditches in northeastern Italy that represents the primary rural larval sites for Culex pipiens, the primary vector of the West Nile virus in Europe. The analysis takes into account the nonlinear temporal effects on the population dynamics of larvae and pupae. The results showed a dramatic reduction in mosquito larval abundance 24 h posttreatment (93%) and was effective against larvae up to 22 days (100%). The residual effect after 28 days was 99.5%, and a limited residual effect was observed after 39 days (31.2%). A reduction in pupal density was observed after 4 days (70%) and was >98% from days 14 to 28 posttreatment, persisting for up to 39 days (84% after 39 days). The results demonstrate the effective use of the Bti + Bs formulation against Cx. pipiens in vegetated ditches in rural areas. Our modeling framework provides a flexible statistical approach to predict the residual effect of the product over time, in order to plan a seasonal intervention scheme.openVirgillito, Chiara; Manica, Mattia; Marini, Giovanni; Rosà, Roberto; Della Torre, Alessandra; Martini, Simone; Drago, Andrea; Baseggio, Alberto; Caputo, BeniaminoVirgillito, C.; Manica, M.; Marini, G.; Rosà, R.; Della Torre, A.; Martini, S.; Drago, A.; Baseggio, A.; Caputo, B