Nucleation and growth control in protein crystallization

The five topics summarized in this final report are as follows: (1) a technique for the expedient, semi-automated determination of protein solubilities as a function of temperature and application of this technique to proteins other than lysozyme; (2) a small solution cell with adjustable temperature gradients for the growth of proteins at a predetermined location through temperature programming; (3) a microscopy system with image storage and processing capability for high resolution optical studies of temperature controlled protein growth and etching kinetics; (4) growth experiments with lysozyme in thermosyphon flow ; and (5) a mathematical model for the evolution of evaporation/diffusion induced concentration gradients in the hanging drop protein crystallization technique

Studies of the effects of gravitational and inertial forces on cardiovascular and respiratory dynamics Semiannual status report, period ending 1 Oct. 1968

Gravitational and inertial force environment effects on cardiovascular and respiratory functions in dogs and chimpanzee

Proto-type installation of a double-station system for the optical-video-detection and orbital characterisation of a meteor/fireball in South Korea

We give a detailed description of the installation and operation of a double-station meteor detection system which formed part of a research & education project between Korea Astronomy Space Science Institute and Daejeon Science Highschool. A total of six light-sensitive CCD cameras were installed with three cameras at SOAO and three cameras at BOAO observatory. A double-station observation of a meteor event enables the determination of the three-dimensional orbit in space. This project was initiated in response to the Jinju fireball event in March 2014. The cameras were installed in October/November 2014. The two stations are identical in hardware as well as software. Each station employes sensitive Watec-902H2 cameras in combination with relatively fast f/1.2 lenses. Various fields of views were used for measuring differences in detection rates of meteor events. We employed the SonotaCo UFO software suite for meteor detection and their subsequent analysis. The system setup as well as installation/operation experience is described and first results are presented. We also give a brief overview of historic as well as recent meteor (fall) detections in South Korea. For more information please consult http://meteor.kasi.re.kr .Comment: Technical/instrumentation description of a professional meteor detection system, 23 pages, 20 figures (color/monochrome), 5 tables, submitted to the Journal of Korean Astronomical Society (JKAS, http://jkas.kas.org/, http://jkas.kas.org/history.html

The NASA SBIR product catalog

The purpose of this catalog is to assist small business firms in making the community aware of products emerging from their efforts in the Small Business Innovation Research (SBIR) program. It contains descriptions of some products that have advanced into Phase 3 and others that are identified as prospective products. Both lists of products in this catalog are based on information supplied by NASA SBIR contractors in responding to an invitation to be represented in this document. Generally, all products suggested by the small firms were included in order to meet the goals of information exchange for SBIR results. Of the 444 SBIR contractors NASA queried, 137 provided information on 219 products. The catalog presents the product information in the technology areas listed in the table of contents. Within each area, the products are listed in alphabetical order by product name and are given identifying numbers. Also included is an alphabetical listing of the companies that have products described. This listing cross-references the product list and provides information on the business activity of each firm. In addition, there are three indexes: one a list of firms by states, one that lists the products according to NASA Centers that managed the SBIR projects, and one that lists the products by the relevant Technical Topics utilized in NASA's annual program solicitation under which each SBIR project was selected

Astronomical use of television-type image sensors

Conference on using TV type image sensors in astronomical photometr

Marshall Space Flight Center Research and Technology Report 2019

Today, our calling to explore is greater than ever before, and here at Marshall Space Flight Centerwe make human deep space exploration possible. A key goal for Artemis is demonstrating and perfecting capabilities on the Moon for technologies needed for humans to get to Mars. This years report features 10 of the Agencys 16 Technology Areas, and I am proud of Marshalls role in creating solutions for so many of these daunting technical challenges. Many of these projects will lead to sustainable in-space architecture for human space exploration that will allow us to travel to the Moon, on to Mars, and beyond. Others are developing new scientific instruments capable of providing an unprecedented glimpse into our universe. NASA has led the charge in space exploration for more than six decades, and through the Artemis program we will help build on our work in low Earth orbit and pave the way to the Moon and Mars. At Marshall, we leverage the skills and interest of the international community to conduct scientific research, develop and demonstrate technology, and train international crews to operate further from Earth for longer periods of time than ever before first at the lunar surface, then on to our next giant leap, human exploration of Mars. While each project in this report seeks to advance new technology and challenge conventions, it is important to recognize the diversity of activities and people supporting our mission. This report not only showcases the Centers capabilities and our partnerships, it also highlights the progress our people have achieved in the past year. These scientists, researchers and innovators are why Marshall and NASA will continue to be a leader in innovation, exploration, and discovery for years to come

Restoration of Atmospheric Turbulence Degraded Video using Kurtosis Minimization and Motion Compensation

In this thesis work, the background of atmospheric turbulence degradation in imaging was reviewed and two aspects are highlighted: blurring and geometric distortion. The turbulence burring parameter is determined by the atmospheric turbulence condition that is often unknown; therefore, a blur identification technique was developed that is based on a higher order statistics (HOS). It was observed that the kurtosis generally increases as an image becomes blurred (smoothed). Such an observation was interpreted in the frequency domain in terms of phase correlation. Kurtosis minimization based blur identification is built upon this observation. It was shown that kurtosis minimization is effective in identifying the blurring parameter directly from the degraded image. Kurtosis minimization is a general method for blur identification. It has been tested on a variety of blurs such as Gaussian blur, out of focus blur as well as motion blur. To compensate for the geometric distortion, earlier work on the turbulent motion compensation was extended to deal with situations in which there is camera/object motion. Trajectory smoothing is used to suppress the turbulent motion while preserving the real motion. Though the scintillation effect of atmospheric turbulence is not considered separately, it can be handled the same way as multiple frame denoising while motion trajectories are built.Ph.D.Committee Chair: Mersereau, Russell; Committee Co-Chair: Smith, Mark; Committee Member: Lanterman, Aaron; Committee Member: Wang, May; Committee Member: Tannenbaum, Allen; Committee Member: Williams, Dougla

Optical and X-Ray Technology Synergies Enabling Diagnostic and Therapeutic Applications in Medicine

X-ray and optical technologies are the two central pillars for human imaging and therapy. The strengths of x-rays are deep tissue penetration, effective cytotoxicity, and the ability to image with robust projection and computed-tomography methods. The major limitations of x-ray use are the lack of molecular specificity and the carcinogenic risk. In comparison, optical interactions with tissue are strongly scatter dominated, leading to limited tissue penetration, making imaging and therapy largely restricted to superficial or endoscopically directed tissues. However, optical photon energies are comparable with molecular energy levels, thereby providing the strength of intrinsic molecular specificity. Additionally, optical technologies are highly advanced and diversified, being ubiquitously used throughout medicine as the single largest technology sector. Both have dominant spatial localization value, achieved with optical surface scanning or x-ray internal visualization, where one often is used with the other. Therapeutic delivery can also be enhanced by their synergy, where radio-optical and optical-radio interactions can inform about dose or amplify the clinical therapeutic value. An emerging trend is the integration of nanoparticles to serve as molecular intermediates or energy transducers for imaging and therapy, requiring careful design for the interaction either by scintillation or Cherenkov light, and the nanoscale design is impacted by the choices of optical interaction mechanism. The enhancement of optical molecular sensing or sensitization of tissue using x-rays as the energy source is an important emerging field combining x-ray tissue penetration in radiation oncology with the molecular specificity and packaging of optical probes or molecular localization. The ways in which x-rays can enable optical procedures, or optics can enable x-ray procedures, provide a range of new opportunities in both diagnostic and therapeutic medicine. Taken together, these two technologies form the basis for the vast majority of diagnostics and therapeutics in use in clinical medicine

LOFAR Observations of Substructure Within a Traveling Ionospheric Disturbance at Mid-Latitude

The large scale morphology and finer sub-structure within a slowly propagating traveling ionospheric disturbance (TID) are studied using wide band trans-ionospheric radio observations with the LOw Frequency ARray (LOFAR; van Haarlem et al., 2013, https://doi.org/10.1051/0004-6361/201220873). The observations were made under geomagnetically quiet conditions, between 0400 and 0800 on 7 January 2019, over the UK. In combination with ionograms and Global Navigation Satellite System Total Electron Content anomaly data we estimate the TID velocity to ∼60 ms−1, in a North-westerly direction. Clearly defined substructures with oscillation periods of ∼300 s were identified within the TID, corresponding to scale sizes of 20 km. At the geometries and observing wavelengths involved, the Fresnel scale is between 3 and 4 km, hence these substructures contribute significant refractive scattering to the received LOFAR signal. The refractive scattering is strongly coherent across the LOFAR bandwidth used here (25–64 MHz). The size of these structures distinguishes them from previously identified ionospheric scintillation with LOFAR in Fallows et al. (2020), https://doi.org/10.1051/swsc/2020010, where the scale sizes of the plasma structure varied from ∼500 m to 5 km