Imaging neural correlates of syntactic complexity in a naturalistic context

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 2008.Includes bibliographical references (p. 253-280).The aim of this thesis, and the research project within which it is embedded, is to delineate a neural model of grammatical competence. For this purpose, we develop here a novel integrated, multi-disciplinary experimental paradigm that endorses the fundamental premise of generative grammar, that the study of language is in essence, the study of the mind. We use functional Magnetic Resonance Imaging (fMRI) to monitor brain activation while subjects listen to short narratives. The texts have been written so as to introduce various syntactic complexities (relative clauses, embedded questions, etc.) not usually found (in such density) in actual corpora. We have calculated a number of complexity measures (both at the level of the single word and at that of the phrase) based on current linguistic and psycholinguistic theory and with the use of a computationally implemented probabilistic parser. By correlating these measures with observed brain activity, we are able to identify the different brain networks that support linguistic processing and characterize their particular function. Conversely, we use the rich brain data to inform our cognitive, and linguistic, theory. We report here the neural correlates of surprisal (based on contextual predictions), syntactic complexity, structural ambiguity and disambiguation, Theory of Mind and non-local dependencies. This work made use of novel solutions to compute numerical predictions for these linguistic dimensions, which are often tested only qualitatively, and of a novel parametric fMRI design that allowed for the use of single subject unaveraged data as the dependent variable. The thesis ends with a synthesis of the results in the form of a blue print for a neural model of grammatical competence.by Asaf Bachrach.Ph.D

Modern Views of Machine Learning for Precision Psychiatry

In light of the NIMH's Research Domain Criteria (RDoC), the advent of functional neuroimaging, novel technologies and methods provide new opportunities to develop precise and personalized prognosis and diagnosis of mental disorders. Machine learning (ML) and artificial intelligence (AI) technologies are playing an increasingly critical role in the new era of precision psychiatry. Combining ML/AI with neuromodulation technologies can potentially provide explainable solutions in clinical practice and effective therapeutic treatment. Advanced wearable and mobile technologies also call for the new role of ML/AI for digital phenotyping in mobile mental health. In this review, we provide a comprehensive review of the ML methodologies and applications by combining neuroimaging, neuromodulation, and advanced mobile technologies in psychiatry practice. Additionally, we review the role of ML in molecular phenotyping and cross-species biomarker identification in precision psychiatry. We further discuss explainable AI (XAI) and causality testing in a closed-human-in-the-loop manner, and highlight the ML potential in multimedia information extraction and multimodal data fusion. Finally, we discuss conceptual and practical challenges in precision psychiatry and highlight ML opportunities in future research

Contributions to the study of Austism Spectrum Brain conectivity

164 p.Autism Spectrum Disorder (ASD) is a largely prevalent neurodevelopmental condition with a big social and economical impact affecting the entire life of families. There is an intense search for biomarkers that can be assessed as early as possible in order to initiate treatment and preparation of the family to deal with the challenges imposed by the condition. Brain imaging biomarkers have special interest. Specifically, functional connectivity data extracted from resting state functional magnetic resonance imaging (rs-fMRI) should allow to detect brain connectivity alterations. Machine learning pipelines encompass the estimation of the functional connectivity matrix from brain parcellations, feature extraction and building classification models for ASD prediction. The works reported in the literature are very heterogeneous from the computational and methodological point of view. In this Thesis we carry out a comprehensive computational exploration of the impact of the choices involved while building these machine learning pipelines

Artificial intelligence methods for security and cyber security systems

This research is in threat analysis and countermeasures employing Artificial Intelligence (AI) methods within the civilian domain, where safety and mission-critical aspects are essential. AI has challenges of repeatable determinism and decision explanation. This research proposed methods for dense and convolutional networks that provided repeatable determinism. In dense networks, the proposed alternative method had an equal performance with more structured learnt weights. The proposed method also had earlier learning and higher accuracy in the Convolutional networks. When demonstrated in colour image classification, the accuracy improved in the first epoch to 67%, from 29% in the existing scheme. Examined in transferred learning with the Fast Sign Gradient Method (FSGM) as an analytical method to control distortion of dissimilarity, a finding was that the proposed method had more significant retention of the learnt model, with 31% accuracy instead of 9%. The research also proposed a threat analysis method with set-mappings and first principle analytical steps applied to a Symbolic AI method using an algebraic expert system with virtualized neurons. The neural expert system method demonstrated the infilling of parameters by calculating beamwidths with variations in the uncertainty of the antenna type. When combined with a proposed formula extraction method, it provides the potential for machine learning of new rules as a Neuro-Symbolic AI method. The proposed method uses extra weights allocated to neuron input value ranges as activation strengths. The method simplifies the learnt representation reducing model depth, thus with less significant dropout potential. Finally, an image classification method for emitter identification is proposed with a synthetic dataset generation method and shows the accurate identification between fourteen radar emission modes with high ambiguity between them (and achieved 99.8% accuracy). That method would be a mechanism to recognize non-threat civil radars aimed at threat alert when deviations from those civilian emitters are detected

Applications of Artificial Intelligence in Medicine Practice

This book focuses on a variety of interdisciplinary perspectives concerning the theory and application of artificial intelligence (AI) in medicine, medically oriented human biology, and healthcare. The list of topics includes the application of AI in biomedicine and clinical medicine, machine learning-based decision support, robotic surgery, data analytics and mining, laboratory information systems, and usage of AI in medical education. Special attention is given to the practical aspect of a study. Hence, the inclusion of a clinical assessment of the usefulness and potential impact of the submitted work is strongly highlighted

Generative Adversarial Network (GAN) for Medical Image Synthesis and Augmentation

Medical image processing aided by artificial intelligence (AI) and machine learning (ML) significantly improves medical diagnosis and decision making. However, the difficulty to access well-annotated medical images becomes one of the main constraints on further improving this technology. Generative adversarial network (GAN) is a DNN framework for data synthetization, which provides a practical solution for medical image augmentation and translation. In this study, we first perform a quantitative survey on the published studies on GAN for medical image processing since 2017. Then a novel adaptive cycle-consistent adversarial network (Ad CycleGAN) is proposed. We respectively use a malaria blood cell dataset (19,578 images) and a COVID-19 chest X-ray dataset (2,347 images) to test the new Ad CycleGAN. The quantitative metrics include mean squared error (MSE), root mean squared error (RMSE), peak signal-to-noise ratio (PSNR), universal image quality index (UIQI), spatial correlation coefficient (SCC), spectral angle mapper (SAM), visual information fidelity (VIF), Frechet inception distance (FID), and the classification accuracy of the synthetic images. The CycleGAN and variant autoencoder (VAE) are also implemented and evaluated as comparison. The experiment results on malaria blood cell images indicate that the Ad CycleGAN generates more valid images compared to CycleGAN or VAE. The synthetic images by Ad CycleGAN or CycleGAN have better quality than those by VAE. The synthetic images by Ad CycleGAN have the highest accuracy of 99.61%. In the experiment on COVID-19 chest X-ray, the synthetic images by Ad CycleGAN or CycleGAN have higher quality than those generated by variant autoencoder (VAE). However, the synthetic images generated through the homogenous image augmentation process have better quality than those synthesized through the image translation process. The synthetic images by Ad CycleGAN have higher accuracy of 95.31% compared to the accuracy of the images by CycleGAN of 93.75%. In conclusion, the proposed Ad CycleGAN provides a new path to synthesize medical images with desired diagnostic or pathological patterns. It is considered a new approach of conditional GAN with effective control power upon the synthetic image domain. The findings offer a new path to improve the deep neural network performance in medical image processing