A robust framework for medical image segmentation through adaptable class-specific representation

Medical image segmentation is an increasingly important component in virtual pathology, diagnostic imaging and computer-assisted surgery. Better hardware for image acquisition and a variety of advanced visualisation methods have paved the way for the development of computer based tools for medical image analysis and interpretation. The routine use of medical imaging scans of multiple modalities has been growing over the last decades and data sets such as the Visible Human Project have introduced a new modality in the form of colour cryo section data. These developments have given rise to an increasing need for better automatic and semiautomatic segmentation methods. The work presented in this thesis concerns the development of a new framework for robust semi-automatic segmentation of medical imaging data of multiple modalities. Following the specification of a set of conceptual and technical requirements, the framework known as ACSR (Adaptable Class-Specific Representation) is developed in the first case for 2D colour cryo section segmentation. This is achieved through the development of a novel algorithm for adaptable class-specific sampling of point neighbourhoods, known as the PGA (Path Growing Algorithm), combined with Learning Vector Quantization. The framework is extended to accommodate 3D volume segmentation of cryo section data and subsequently segmentation of single and multi-channel greyscale MRl data. For the latter the issues of inhomogeneity and noise are specifically addressed. Evaluation is based on comparison with previously published results on standard simulated and real data sets, using visual presentation, ground truth comparison and human observer experiments. ACSR provides the user with a simple and intuitive visual initialisation process followed by a fully automatic segmentation. Results on both cryo section and MRI data compare favourably to existing methods, demonstrating robustness both to common artefacts and multiple user initialisations. Further developments into specific clinical applications are discussed in the future work section

Multitemporal Feature-Level Fusion on Hyperspectral and LiDAR Data in the Urban Environment

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Novel Markovian Change Detection Models in Computer Vision

In this thesis novel probabilistic models are proposed for three different change detection tasks of computer vision, primarily focusing on applications from video surveillance and aerial exploitation. The surveys are performed in a coherent Markov Random Field (MRF) segmentation framework, but the introduced models face different practical challenges such as shadow effects, image registration errors or presence of noisy and incomplete concept descriptors. Contributions are presented in efficient feature extraction, probabilistic modeling of natural processes and feature integration via local innovations in the model structures. We show by several experiments that the proposed novelties embedded into a strict mathematical toolkit can significantly improve the results in real world test images and videos

Bayesian image restoration and bacteria detection in optical endomicroscopy

Optical microscopy systems can be used to obtain high-resolution microscopic images of tissue cultures and ex vivo tissue samples. This imaging technique can be translated for in vivo, in situ applications by using optical fibres and miniature optics. Fibred optical endomicroscopy (OEM) can enable optical biopsy in organs inaccessible by any other imaging systems, and hence can provide rapid and accurate diagnosis in a short time. The raw data the system produce is difficult to interpret as it is modulated by a fibre bundle pattern, producing what is called the “honeycomb effect”. Moreover, the data is further degraded due to the fibre core cross coupling problem. On the other hand, there is an unmet clinical need for automatic tools that can help the clinicians to detect fluorescently labelled bacteria in distal lung images. The aim of this thesis is to develop advanced image processing algorithms that can address the above mentioned problems. First, we provide a statistical model for the fibre core cross coupling problem and the sparse sampling by imaging fibre bundles (honeycomb artefact), which are formulated here as a restoration problem for the first time in the literature. We then introduce a non-linear interpolation method, based on Gaussian processes regression, in order to recover an interpretable scene from the deconvolved data. Second, we develop two bacteria detection algorithms, each of which provides different characteristics. The first approach considers joint formulation to the sparse coding and anomaly detection problems. The anomalies here are considered as candidate bacteria, which are annotated with the help of a trained clinician. Although this approach provides good detection performance and outperforms existing methods in the literature, the user has to carefully tune some crucial model parameters. Hence, we propose a more adaptive approach, for which a Bayesian framework is adopted. This approach not only outperforms the proposed supervised approach and existing methods in the literature but also provides computation time that competes with optimization-based methods

Development of an unsupervised remote sensing methodology of detect surface leakage from terrestrial CO2 storage sites

Imperial Users onl

Review on Active and Passive Remote Sensing Techniques for Road Extraction

Digital maps of road networks are a vital part of digital cities and intelligent transportation. In this paper, we provide a comprehensive review on road extraction based on various remote sensing data sources, including high-resolution images, hyperspectral images, synthetic aperture radar images, and light detection and ranging. This review is divided into three parts. Part 1 provides an overview of the existing data acquisition techniques for road extraction, including data acquisition methods, typical sensors, application status, and prospects. Part 2 underlines the main road extraction methods based on four data sources. In this section, road extraction methods based on different data sources are described and analysed in detail. Part 3 presents the combined application of multisource data for road extraction. Evidently, different data acquisition techniques have unique advantages, and the combination of multiple sources can improve the accuracy of road extraction. The main aim of this review is to provide a comprehensive reference for research on existing road extraction technologies.Peer reviewe

A statistical multi-experts approach to image classification and segmentation

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1995.Includes bibliographical references (leaves 170-177).by Lik Mui.M.Eng

Texture representation using wavelet filterbanks

Texture analysis is a fundamental issue in image analysis and computer vision. While considerable research has been carried out in the texture analysis domain, problems relating to texture representation have been addressed only partially and active research is continuing. The vast majority of algorithms for texture analysis make either an explicit or implicit assumption that all images are captured under the same measurement conditions, such as orientation and illumination. These assumptions are often unrealistic in many practical applications;This dissertation addresses the viewpoint-invariance problem in texture classification by introducing a rotated wavelet filterbank. The proposed filterbank, in conjunction with a standard wavelet filterbank, provides better freedom of orientation tuning for texture analysis. This allows one to obtain texture features that are invariant with respect to texture rotation and linear grayscale transformation. In this study, energy estimates of channel outputs that are commonly used as texture features in texture classification are transformed into a set of viewpoint-invariant features. Texture properties that have a physical connection with human perception are taken into account in the transformation of the energy estimates;Experiments using natural texture image sets that have been used for evaluating other successful approaches were conducted in order to facilitate comparison. We observe that the proposed feature set outperformed methods proposed by others in the past. A channel selection method is also proposed to minimize the computational complexity and improve performance in a texture segmentation algorithm. Results demonstrating the validity of the approach are presented using experimental ultrasound tendon images

Feature extraction and classification for hyperspectral remote sensing images

Recent advances in sensor technology have led to an increased availability of hyperspectral remote sensing data at very high both spectral and spatial resolutions. Many techniques are developed to explore the spectral information and the spatial information of these data. In particular, feature extraction (FE) aimed at reducing the dimensionality of hyperspectral data while keeping as much spectral information as possible is one of methods to preserve the spectral information, while morphological profile analysis is the most popular methods used to explore the spatial information. Hyperspectral sensors collect information as a set of images represented by hundreds of spectral bands. While offering much richer spectral information than regular RGB and multispectral images, the high dimensional hyperspectal data creates also a challenge for traditional spectral data processing techniques. Conventional classification methods perform poorly on hyperspectral data due to the curse of dimensionality (i.e. the Hughes phenomenon: for a limited number of training samples, the classification accuracy decreases as the dimension increases). Classification techniques in pattern recognition typically assume that there are enough training samples available to obtain reasonably accurate class descriptions in quantitative form. However, the assumption that enough training samples are available to accurately estimate the class description is frequently not satisfied for hyperspectral remote sensing data classification, because the cost of collecting ground-truth of observed data can be considerably difficult and expensive. In contrast, techniques making accurate estimation by using only small training samples can save time and cost considerably. The small sample size problem therefore becomes a very important issue for hyperspectral image classification. Very high-resolution remotely sensed images from urban areas have recently become available. The classification of such images is challenging because urban areas often comprise a large number of different surface materials, and consequently the heterogeneity of urban images is relatively high. Moreover, different information classes can be made up of spectrally similar surface materials. Therefore, it is important to combine spectral and spatial information to improve the classification accuracy. In particular, morphological profile analysis is one of the most popular methods to explore the spatial information of the high resolution remote sensing data. When using morphological profiles (MPs) to explore the spatial information for the classification of hyperspectral data, one should consider three important issues. Firstly, classical morphological openings and closings degrade the object boundaries and deform the object shapes, while the morphological profile by reconstruction leads to some unexpected and undesirable results (e.g. over-reconstruction). Secondly, the generated MPs produce high-dimensional data, which may contain redundant information and create a new challenge for conventional classification methods, especially for the classifiers which are not robust to the Hughes phenomenon. Last but not least, linear features, which are used to construct MPs, lose too much spectral information when extracted from the original hyperspectral data. In order to overcome these problems and improve the classification results, we develop effective feature extraction algorithms and combine morphological features for the classification of hyperspectral remote sensing data. The contributions of this thesis are as follows. As the first contribution of this thesis, a novel semi-supervised local discriminant analysis (SELD) method is proposed for feature extraction in hyperspectral remote sensing imagery, with improved performance in both ill-posed and poor-posed conditions. The proposed method combines unsupervised methods (Local Linear Feature Extraction Methods (LLFE)) and supervised method (Linear Discriminant Analysis (LDA)) in a novel framework without any free parameters. The underlying idea is to design an optimal projection matrix, which preserves the local neighborhood information inferred from unlabeled samples, while simultaneously maximizing the class discrimination of the data inferred from the labeled samples. Our second contribution is the application of morphological profiles with partial reconstruction to explore the spatial information in hyperspectral remote sensing data from the urban areas. Classical morphological openings and closings degrade the object boundaries and deform the object shapes. Morphological openings and closings by reconstruction can avoid this problem, but this process leads to some undesirable effects. Objects expected to disappear at a certain scale remain present when using morphological openings and closings by reconstruction, which means that object size is often incorrectly represented. Morphological profiles with partial reconstruction improve upon both classical MPs and MPs with reconstruction. The shapes of objects are better preserved than classical MPs and the size information is preserved better than in reconstruction MPs. A novel semi-supervised feature extraction framework for dimension reduction of generated morphological profiles is the third contribution of this thesis. The morphological profiles (MPs) with different structuring elements and a range of increasing sizes of morphological operators produce high-dimensional data. These high-dimensional data may contain redundant information and create a new challenge for conventional classification methods, especially for the classifiers which are not robust to the Hughes phenomenon. To the best of our knowledge the use of semi-supervised feature extraction methods for the generated morphological profiles has not been investigated yet. The proposed generalized semi-supervised local discriminant analysis (GSELD) is an extension of SELD with a data-driven parameter. In our fourth contribution, we propose a fast iterative kernel principal component analysis (FIKPCA) to extract features from hyperspectral images. In many applications, linear FE methods, which depend on linear projection, can result in loss of nonlinear properties of the original data after reduction of dimensionality. Traditional nonlinear methods will cause some problems on storage resources and computational load. The proposed method is a kernel version of the Candid Covariance-Free Incremental Principal Component Analysis, which estimates the eigenvectors through iteration. Without performing eigen decomposition on the Gram matrix, our approach can reduce the space complexity and time complexity greatly. Our last contribution constructs MPs with partial reconstruction on nonlinear features. Traditional linear features, on which the morphological profiles usually are built, lose too much spectral information. Nonlinear features are more suitable to describe higher order complex and nonlinear distributions. In particular, kernel principal components are among the nonlinear features we used to built MPs with partial reconstruction, which led to significant improvement in terms of classification accuracies. The experimental analysis performed with the novel techniques developed in this thesis demonstrates an improvement in terms of accuracies in different fields of application when compared to other state of the art methods