Development of grid frameworks for clinical trials and epidemiological studies

E-Health initiatives such as electronic clinical trials and epidemiological studies require access to and usage of a range of both clinical and other data sets. Such data sets are typically only available over many heterogeneous domains where a plethora of often legacy based or in-house/bespoke IT solutions exist. Considerable efforts and investments are being made across the UK to upgrade the IT infrastructures across the National Health Service (NHS) such as the National Program for IT in the NHS (NPFIT) [1]. However, it is the case that currently independent and largely non-interoperable IT solutions exist across hospitals, trusts, disease registries and GP practices – this includes security as well as more general compute and data infrastructures. Grid technology allows issues of distribution and heterogeneity to be overcome, however the clinical trials domain places special demands on security and data which hitherto the Grid community have not satisfactorily addressed. These challenges are often common across many studies and trials hence the development of a re-usable framework for creation and subsequent management of such infrastructures is highly desirable. In this paper we present the challenges in developing such a framework and outline initial scenarios and prototypes developed within the MRC funded Virtual Organisations for Trials and Epidemiological Studies (VOTES) project [2]

Initial experiences in developing e-health solutions across Scotland

The MRC funded Virtual Organisations for Trials and Epidemiological Studies (VOTES) project is a collaborative effort between e-Science, clinical and ethical research centres across the UK including the universities of Oxford, Glasgow, Imperial, Nottingham and Leicester. The project started in September 2005 and is due to run for 3 years. The primary goal of VOTES is to develop a reusable Grid framework through which a multitude of clinical trials and epidemiological studies can be supported. The National e-Science Centre (NeSC) at the University of Glasgow are looking at developing the Scottish components of this framework. This paper presents the initial experiences in developing this framework and in accessing and using existing data sets, services and software across the NHS in Scotland

Towards data grids for microarray expression profiles

The UK DTI funded Biomedical Research Informatics Delivered by Grid Enabled Services (BRIDGES) project developed a Grid infrastructure through which research into the genetic causes of hypertension could be supported by scientists within the large Wellcome Trust funded Cardiovascular Functional Genomics project. The BRIDGES project had a focus on developing a compute Grid and a data Grid infrastructure with security at its heart. Building on the work within BRIDGES, the BBSRC funded Grid enabled Microarray Expression Profile Search (GEMEPS) project plans to provide an enhanced data Grid infrastructure to support richer queries needed for the discovery and analysis of microarray data sets, also based upon a fine-grained security infrastructure. This paper outlines the experiences gained within BRIDGES and outlines the status of the GEMEPS project, the open challenges that remain and plans for the future

Extensions to the self protecting object model to facilitate integrity in stationary and mobile hosts

M.Sc. (Computer Science)In this dissertation we propose extensions to the Self Protecting Object (SPO) model to facilitate the sharing of information in a more effective manner. We see the sharing ofinformation as the sharing of objects that provide services. Sharing objects effectively is allowing the objects to be used in a secure environment, independent of their location, in a manner usage was intended. The SPO model proposed by Olivier [32] allows for objects in a federated database to be moved from one site to another and ensures that the security policy of the object will always be respected and implemented, regardless of its location. Although the SPO model does indeed allow for objects (information) to be shared effectively, it fails to address issues of maintaining integrity within objects. We therefore define the notion of maintaining integrity within the spa model and propose a model to achieve it. We argue that ensuring an SPO is only used in a way usage was intended does not suffice to ensure integrity. The model we propose is based on ensuring that modifications to an SPO are only executed if the modification does not violate the constraints defined for the Sf'O, The model" allows for an spa to maintain its unique identity in addition to maintaining its integrity. The SPO model is designed to be used in a federated database on sites that are stationary. Therefore, having addressed the issue of maintaining integrity within SPOs on stationary sites in the federated database, we then introduce the notion of a mobile site: a site that will eventually disconnect from the federated database and become unreachable for some time. Introducing the mobile site into the federated database allows us to propose the Mobile Self Protecting Object (MSPO) and its associated architecture. Because of the nature of mobile sites, the original model for maintaining integrity can not be applied to the MSPO architecture. We therefore propose a mechanism (to be implemented in unison with the original model) to ensure the integrity of MSPOs on mobile sites. We then discuss the JASPO prototype. The aim of the prototype was to determine if the Self Protecting Object model was feasible using current development technologies. We examine the requirements identified in order for the prototype to be successful and discuss how these were satisfied. Several modifications were made to the original spa model, including the addition of a new module and the exclusion of others, we discuss these modifications and examine why they were necessary

Myriad: Design and implementation of a federated database prototype

This paper describes our experiences in the design and implementation of Myriad, and in the project management. Special emphasis is given to discussing design alternatives and their impact on Myriad. This paper also presents the software engineering principles and the project management techniques we used in developing Myriad and the lessons we learned. We believe these lessons would be useful for practitioners who wish to develop a similar syste

Designing privacy for scalable electronic healthcare linkage

A unified electronic health record (EHR) has potentially immeasurable benefits to society, and the current healthcare industry drive to create a single EHR reflects this. However, adoption is slow due to two major factors: the disparate nature of data and storage facilities of current healthcare systems and the security ramifications of accessing and using that data and concerns about potential misuse of that data. To attempt to address these issues this paper presents the VANGUARD (Virtual ANonymisation Grid for Unified Access of Remote Data) system which supports adaptive security-oriented linkage of disparate clinical data-sets to support a variety of virtual EHRs avoiding the need for a single schematic standard and natural concerns of data owners and other stakeholders on data access and usage. VANGUARD has been designed explicit with security in mind and supports clear delineation of roles for data linkage and usage

Multimodal integration of disparate information sources with attribution

Cover title.Includes bibliographical references (p. [9]-[10]).Thomas Y. Lee & Stephane Bressan