11,887 research outputs found

    PERANCANGAN ALAT PERMAINAN EDUKATIF (APE) MENGENAL ANGGOTA TUBUH (PUZZLE WAJAH) KEPADA SISWA PAUD MENGGUNAKAN METODE KANSEI ENGINEERING

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    PERANCANGAN ALAT PERMAINAN EDUKATIF (APE) MENGENAL ANGGOTA TUBUH (PUZZEL GAMBAR) KEPADA SISWA PAUD MENGGUNAKAN METODE KANSEI ENGINEERING NUGRAHA RAMADHANI 11652100936 Jurusan Teknik Industri Fakultas Sains dan Teknologi Universitas Islam Negeri Sultan Syarif Kasim Riau Jalan. H.R Soebrantas No. 155 Pekanbaru ABSTRAK Pendidikan sangat penting dalam mewujudkan bangsa yang kuat dan maju. Jadi, prosesnya harus dilakukan sejak dini. Oleh karena itu, Pendidikan Anak Usia Dini merupakan pondasi utama bagi perkembangan generasi bangsa. Sedangkan standar PAUD belum merata, ternyata masih banyak yang kurang, terutama pada media pembelajaran Alat Permainan Edukatif (APE). Tujuan dari penelitian ini yakni untuk merancang alat permainan edukatif mengenal anggota tubuh (puzzel gambar) yang lebih ekonomis. Hasil penelitian ini yaitu spesifikasi dari alat permainan sesuai dengan yang diminta, yaitu alat permainan yang terbuat dari papan kayu, berwarna terang dan berbentuk unik, serta kansei word yang terpilih adalah bentuk unik, bentuk simpel, berwarna, rapi, harga layak, ramah lingkungan, ramah anak, produk halus, desain menarik, moderen mudah dibawa, tahan lama, mudah digunakan, dan bahan standar. Kata Kunci : Alat Permainan Edukatif, Kansei Engineering, Kansei Word, PAU

    The Use of E Voting in the General Election System in Indonesia

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    Sebagai bangsa yang menganut konsep demokrasi, Indonesia diharapkan dapat menyelenggarakan pemilihan umum yang jujur dan adil yang sesuai dengan cita-cita langsung, umum, bebas, dan rahasia. Agar hasil pemilihan umum dan kepala daerah dapat menimbulkan kepercayaan semua pihak, keterbukaan dan akuntabilitas harus menjadi acuan dalam kontes ini. Membangun arsitektur jaringan yang memungkinkan pelaksanaan pemilu yang transparan itu sendiri merupakan salah satu aspek yang paling menantang dalam membangun partai demokrasi. Penelitian ini bermaksud untuk mengkaji penggunaan electronic voting di masa depan dalam sistem pemilu Indonesia. Penelitian ini menggunakan metodologi deskriptif kualitatif. Dalam upaya meningkatkan partisipasi pemilih, mengurangi dampak kecurangan dalam penghitungan suara, mengurangi biaya, dan mempersingkat waktu pelaksanaan, hasilnya menunjukkan bahwa pemilihan elektronik dapat digunakan sebagai metode alternatif pemilihan umum karena putusan Mahkamah Konstitusi nomor 147/ PUU-VII/2009. Mengingat situasi pemilu 2019 yang banyak memakan korban. Selain berdampak positif, pelaksanaan e-voting juga tidak lepas dari masalah seperti waktu persiapan yang singkat, masalah anggaran, kesiapan sarana dan prasarana seperti ketersediaan internet yang tidak merata dan terakhir kesiapan sumber daya. Keywords: General Election, E Voting, Democracy

    A direct-laser-written heart-on-a-chip platform for generation and stimulation of engineered heart tissues

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    In this dissertation, we first develop a versatile microfluidic heart-on-a-chip model to generate 3D-engineered human cardiac microtissues in highly-controlled microenvironments. The platform, which is enabled by direct laser writing (DLW), has tailor-made attachment sites for cardiac microtissues and comes with integrated strain actuators and force sensors. Application of external pressure waves to the platform results in controllable time-dependent forces on the microtissues. Conversely, oscillatory forces generated by the microtissues are transduced into measurable electrical outputs. After characterization of the responsivity of the transducers, we demonstrate the capabilities of this platform by studying the response of cardiac microtissues to prescribed mechanical loading and pacing. Next, we tune the geometry and mechanical properties of the platform to enable parametric studies on engineered heart tissues. We explore two geometries: a rectangular seeding well with two attachment sites, and a stadium-like seeding well with six attachment sites. The attachment sites are placed symmetrically in the longitudinal direction. The former geometry promotes uniaxial contraction of the tissues; the latter additionally induces diagonal fiber alignment. We systematically increase the length for both configurations and observe a positive correlation between fiber alignment at the center of the microtissues and tissue length. However, progressive thinning and “necking” is also observed, leading to the failure of longer tissues over time. We use the DLW technique to improve the platform, softening the mechanical environment and optimizing the attachment sites for generation of stable microtissues at each length and geometry. Furthermore, electrical pacing is incorporated into the platform to evaluate the functional dynamics of stable microtissues over the entire range of physiological heart rates. Here, we typically observe a decrease in active force and contraction duration as a function of frequency. Lastly, we use a more traditional ?TUG platform to demonstrate the effects of subthreshold electrical pacing on the rhythm of the spontaneously contracting cardiac microtissues. Here, we observe periodic M:N patterns, in which there are ? cycles of stimulation for every ? tissue contractions. Using electric field amplitude, pacing frequency, and homeostatic beating frequencies of the tissues, we provide an empirical map for predicting the emergence of these rhythms

    Therapeutic effect of mesenchymal stem cell derived extracellular vesicles on 3D model of oligocortical spheroids

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    Extracellular vesicles (EVs) are released by nearly every cell type and are an important structure in inter-cellular communication. Abnormal EV signaling is found in many conditions including ischemia, Alzheimer’s Disease (AD) and Down Syndrome (DS). However, EVs from stem cells from healthy animals have recently emerged as a possible therapeutic intervention to address a variety of neurological conditions. Mesenchymal stromal cell-derived (MSCs) extracellular vesicles from the bone marrow of young healthy monkeys contain microRNAs and proteins and previous studies have shown that MSC-EV treatment mitigates inflammation and oxidative stress, promotes myelination, and improves functional recovery in a rhesus monkey model of cortical injury. EVs have also been shown to reduce AD pathology in mouse models by promoting anti-inflammatory processes and slowing the progression of AD. While AD currently effects over 6 million people in the United States, individuals with DS are disproportionately affected by early onset AD. Therefore, investigating the efficacy of MSC-EVs as a potential therapeutic to mitigate AD like pathology in DS is critical. Accordingly, the current study aims to explore the application of EVs on 3D human brain models of DS, ischemia, and oxygen glucose deprivation (OGD). We generated human oligocortical spheroids (OLS) containing neurons, astrocytes and oligodendrocytes allowing investigation of the effects of the EVs in human, physiologically relevant conditions. First, with OLS in ischemic conditions results were insufficient in demonstrating the recapitulation of cell death and oxidative damage associated with ischemia in vivo. Consequently, the inconsistency of the model prevented us from comprehensive evaluation of the therapeutic potential of EVs in OGD model in OLS. However, we next used DS-derived OLS generated from isogenic induced pluripotent stem cell (iPSCs) lines to evaluate the efficacy of EV treatment in DS. Trisomic OLS display significantly higher levels of amyloid beta (Aβ40 and Aβ42) depositions in both the soluble and insoluble fractions. Additionally, trisomic OLS are consistently smaller than their euploid counterparts, and have elevated levels of cleaved-caspase 3 (CC3) detection indicating more cell death. When treated with EVs, trisomic OLS demonstrated greater preserved cortical volume, significantly decreased levels of Aβ40 and Aβ42 in both fractions, and significant reduction in cell death compared to the untreated trisomic OLS. These results suggest that EVs alleviated the AD-related pathology in DS-derived OLS. Evaluation of the markers of cortical layer neurons demonstrated significantly higher counts of neurons expressing deep and superficial layer markers, suggesting that EVs contributed to greater preserved cortical volume of trisomic OLS by promoting neurogenesis and alleviating trisomy-induced deficits. Our studies show for the first time the efficacy of MSC-EVs in mitigating DS and AD-related cellular phenotypes and pathological depositions in human OLS. Furthermore, oligocortical spheroids present a unique tool for a target validation of potential therapeutics

    The place where curses are manufactured : four poets of the Vietnam War

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    The Vietnam War was unique among American wars. To pinpoint its uniqueness, it was necessary to look for a non-American voice that would enable me to articulate its distinctiveness and explore the American character as observed by an Asian. Takeshi Kaiko proved to be most helpful. From his novel, Into a Black Sun, I was able to establish a working pair of 'bookends' from which to approach the poetry of Walter McDonald, Bruce Weigl, Basil T. Paquet and Steve Mason. Chapter One is devoted to those seemingly mismatched 'bookends,' Walt Whitman and General William C. Westmoreland, and their respective anthropocentric and technocentric visions of progress and the peculiarly American concept of the "open road" as they manifest themselves in Vietnam. In Chapter, Two, I analyze the war poems of Walter McDonald. As a pilot, writing primarily about flying, his poetry manifests General Westmoreland's technocentric vision of the 'road' as determined by and manifest through technology. Chapter Three focuses on the poems of Bruce Weigl. The poems analyzed portray the literal and metaphorical descent from the technocentric, 'numbed' distance of aerial warfare to the world of ground warfare, and the initiation of a 'fucking new guy,' who discovers the contours of the self's interior through a set of experiences that lead from from aerial insertion into the jungle to the degradation of burning human feces. Chapter Four, devoted to the thirteen poems of Basil T. Paquet, focuses on the continuation of the descent begun in Chapter Two. In his capacity as a medic, Paquet's entire body of poems details his quotidian tasks which entail tending the maimed, the mortally wounded and the dead. The final chapter deals with Steve Mason's JohnnY's Song, and his depiction of the plight of Vietnam veterans back in "The World" who are still trapped inside the interior landscape of their individual "ghettoes" of the soul created by their war-time experiences

    Access To Justice of Citizenship Rights for Stateless Indonesian Migrant Workers’ Children In Sarawak, Malaysia

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    As one of the countries that ratified the United Nations Convention on the Rights of the Child in 1990 which was subsequently promulgated into the Child Protection Act, Indonesia is still unsuccessful in protecting children. This mainly occurs in the context of protection illegal migrant workers’ children who were born in the country where their parents work. In Sarawak, Malaysia, for instance, there are 43,445 stateless children. This study aims to portray the stateless children in Sarawak, Malaysia, and the efforts of the Indonesian government to protect their right to access justice. This research is normative-qualitative with observations and in-depth interviews with consultant general staff and Indonesian volunteers In Sarawak as one of the main research methods. The results of this study indicate that stateless condition makes it possible for the children to get other rights, such as education. Meanwhile, the Indonesian government has already made regulations and efforts to provide access to basic human rights for children of stateless migrant workers, including itsbat nikah abroad to legalize unregistered marriage among workers. However, it has not been fully successful because the problems are so complex that it needs to involve several parties, especially the Malaysian government, and plantation owners as employers of the migrant workers. Likewise, harder and more coordinated efforts are also needed to fulfill their citizenship right. (Sebagai salah satu negara yang meratifikasi Konvensi PBB tentang Hak Anak pada 1990 dan kemudian dikristalkan menjadi Undang-undang Perlidungan Anak, Indonesia ternyata belum sepenuhnya berhasil melindungi hak-hak anak. Ini utamanya berlaku dalam konteks perlindungan terhadap anak para buruh migran yang lahir dan tinggal di negara tempat orang tuanya bekerja. Di Sarawak, Malaysia, ada 43.445 anak-anak tanpa kewarganegaraan. Penelitian ini bertujuan memotret kondisi anak buruh migran ilegal tanpa kewarganegaraan di Serawak, Malaysia, serta menjelaskan upaya pemerintah Indonesia untuk melindungi hak-hak mereka. Penelitian ini bersifat normatif-kualitatif dengan observasi dan wawancara mendalam kepada pegawai Konsulat Jenderal dan relawan Indonesia sebagai salah satu metode penggalian data utamanya. Hasil dari penelitian ini menunjukkan bahwa status tanpa kewarganegaraan menghalangi anak-anak tersebut mengakses hak-haknya yang lain, semisal pendidikan. Sementara itu, pemerintah Indonesia sudah memiliki beberapa aturan tertulis dan berupaya memberikan akses keadilan bagi anak para buruh migran tersebut, termasuk melalui program itsbat nikah di luar negeri. Namun demikian, situasi belum sepenuhnya terkendali karena permasalahan yang begitu kompleks dan mengharuskan keterlibatan banyak pihak, utamanya pemerintah Malaysia dan para pemilik perkebunan. Perlu juga dilakukan upaya yang lebih keras dan terkordinasi agar hak-hak tersebut dapat terpenuhi.)Indonesia salah satu negara yang meratifikasi United Nations Convention on The Rights of the Child tahun 1990, yang selanjutnya diundangkan menjadi Undang-undang Perlidungan Anak. Namun demikian, Indonesia masih belum cukup berhasil dalam memberikan proteksi kepada anak-anak. Salah satunya adalah memberikan perlindungan pada anak-anak buruh migrant illegal yang lahir di negara tempat mereka bekerja. Tercatat 43.445 anak-anak tanpa kewarganegaraan di Sarawak Malaysia. Karena tidak memiliki kewarganegaraan, mereka menjadi tidak memiliki akses untuk mendapatkan hak yang paling pendasar seperti Pendidikan.                Metode penelitian yang digunakan  memadukan dua metode yaitu yuridis normative dan socio legal research. Tujuannya  untuk melihat apakah hukum  yang tertulis dalam pakteknya dapat memberikan perlindungan hukum bagi anak buruh migran penyandang stateless atau tidak.  Penelitian ini dapat mengidentifikasi kendala yang dihadapi agar  memperoleh solusi yang tepat.                  Hasil dari penelitian ini menunjukkan bahwa pemerintah Indonesia sudah memiliki aturan tertulis dan sudah melakukan upaya memberikan akses keadilan bagi anak buruh migran yang berstatus stateless, namun belum sepenuhnya berhasil karena permasalahannya yang begitu kompleks dan harus melibatkan beberapa pihak terutama bekerjasama dengan pemerintah Malaysia dan para pemilik perkebunan.  Perlu upaya yang lebih keras dan terkordinasi, agar hak  atas hak memiliki identitas negara bagi anak buruh migran dapat terpenuhi

    Problems of Democratic and Dignified Election in Indonesian Simultaneously Electoral Era

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    This research was motivated by the section material in Act No. 7 of 2017 concerning General Election that not arranged in a structured, systematic and massive, so it appears the section material that overlaps with Constitutional Court and the Constitution of 1945. The purpose of this study is to analyze the problems of simultaneous elections in 2019 in order to bring democracy with dignity and integrity in the next election. The research type is a literature study. This research uses laws and conceptual approach. The main data of this study is obtained from primary and secondary law materials. The result showed that the problems in the section material of Electoral Lawimplicate to the practice, namely the chaos in updating of the voter list led to manipulation fraudulent of the voters list,10,520 polling stations had a shortage of election supplies, ballot boxes Voting Organizing Group received thatnot sealed as many as 6,474 polling stations, ballot papers that exchanged between Electoral District as many 3,411 Voting place and 527 Voting Organizing Group officer died and 11 239 sick

    Investigating the mechanism of human beta defensin-2-mediated protection of skin barrier in vitro

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    The human skin barrier is a biological imperative. Chronic inflammatory skin diseases, such as Atopic Dermatitis (AD), are characterised by a reduction in skin barrier function and an increased number of secondary infections. Staphyloccocus aureus (S. aureus) has an increased presence on AD lesional skin and contributes significantly to AD pathology. It was previously demonstrated that the damage induced by a virulence factor of S. aureus, V8 protease, which causes further breakdown in skin barrier function, can be reduced by induction of human β- defensin (HBD)2 (by IL-1β) or exogenous HBD2 application. Induction of this defensin is impaired in AD skin. This thesis examines the mechanism of HBD2-mediated barrier protection in vitro; demonstrating that in this system, HBD2 was not providing protection through direct protease inhibition, nor was it altering keratinocyte proliferation or migration, or exhibiting specific localisation within the monolayer. Proteomics data demonstrated that HBD2 did not induce expression of known antiproteases but suggested that HBD2 stimulation may function by modulating expression of extracellular matrix proteins, specifically collagen- IVι2 and Laminin-β-1. Alternative pathways of protection initiated by IL-1β and TNFι stimulation were also investigated, as well as their influence over generalised wound healing. Finally, novel 3D human skin epidermal models were used to better recapitulate the structure of human epidermis and examine alterations to skin barrier function in a more physiological system. These data validate the barrier-protective properties of HBD2 and extended our knowledge of the consequences of exposure to this peptide in this context

    The Impact of a Play Intervention on the Social-Emotional Development of Preschool Children in Riyadh, Saudi Arabia

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    Practitioners working with children have emphasized that play is vital to children’s development, Links between children’s social-emotional development and play have been widely documented. However, rigorous research evidence of these links remains limited. This study’s objectives were to measure the impact of play on children’s social-emotional development in the kingdom of Saudi Arabia; identify teachers’ viewpoints around the use of play intervention; and understand the children’s experience of play intervention. Fifty-nine children aged between five and six years, with mean age of 5.5 (SD 3.376) and eight teachers participated in the study. The study used a mixed-method strategy including questionnaires, interviews, and focus group discussions. Children’s social-emotional development was measured by using the Strengths and Difficulties Questioner (SDQ). A pre-/post-test counterbalanced design was used to measure the impact of the play intervention on children’s development. Teachers’ perspectives on play were obtained by interviewing eight teachers. Children’s views were gathered through focus group discussions. Repeated measures ANOVA was conducted to determine the differences in the SDQ score over three time points. Results showed that using unstructured loose parts play had positively impacted children’s social-emotional development. After participation in the play intervention, scores from the SDQ indicated that children demonstrated significantly less problematic emotional, conduct and peer relationship issues. They also scored significantly higher in their positive prosocial behaviour. These positive effects were sustained after six weeks of stopping the intervention. The play intervention did not however impact children’s hyperactivity level. The interviews analysis illustrates four main themes: concept and characteristics of play, play functions, developmental benefits of play, and play and practice. Regarding children’s discussion, affordance emerged as a main theme; this includes emotional, social, and functional affordances. Unstructured loose parts play intervention was demonstrated to have positive impacts on children’s social-emotional development. The study’s findings support the view that play is a way to increase children’s development

    JESUS AND THE VISIBILITY OF GOD: SIGHT AND BELIEF IN THE FOURTH GOSPEL

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    This thesis establishes the value of the physical incarnation of God for belief. It asserts that the theological nature of belief derives from a God who can make himself physically visible in the world. While scholars have often debated the relationship between the empirical senses and belief in John, few have queried the presuppositions about God’s invisibility that inform their positions. In response, this thesis argues across six chapters that unless God becomes physically visible in Jesus, belief does not obtain. Chapter 1 shows that God himself is ultimately the cause, content, and consequence of the belief that John 20:30-31 describes as the purpose of the Gospel. It establishes the theological nature of belief and thus the fact that the Gospel endeavours to draw humanity close to God via faith in Jesus. The remaining five chapters argue that seeing God in Jesus is both possible and desirable. Chapter 2 re-evaluates the metaphysics of divine visibility in Early Judaism and in John and concludes that God can be physically visible in Jesus’s body. John does not regard divinity as invisible in itself; rather, he claims that seeing Jesus is seeing God. Two long chapters follow and substantiate the claims of Chapter 2. They point up the entwined nature of divine presence and material reality by arguing that Jesus’s body is a divine place. This fact – coupled with John’s depiction of Jesus as a man in divine places – stresses his divinity on earth even as it reveals his localized humanity. Chapter 5 argues that sight itself is the primary catalyst for belief in John. Although human hearts occlude proper vision, seeing remains key to human apprehension of God and belief in him. Chapter 6 draws the foregoing together by arguing that seeing Jesus is seeing God across the Johannine narratives, both despite and because of their deeply counterintuitive climax in the crucifixion
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