Graphene-based wearable temperature sensors: A review

The paper presents a comprehensive review of the use of graphene to develop wearable temperature sensors. The detection of temperature over a wide range has been a growing interest in multidisciplinary sectors in the sensing world. Different kinds of flexible temperature sensors have been fabricated with a range of polymers and nanomaterials. With the additional attribute of wearable nature, these temperature sensors are used ubiquitously to determine the effect of physiochemical variations happening in the environment of the chosen biomedical and industrial applications. Graphene, owing to its exceptional electrical, mechanical, and thermal properties, has been extensively used for the development of wearable temperature sensors. The prototypes have been deployed with certain wireless communication protocols to transfer the experimental data obtained under both controlled environments and real-time scenarios. This paper underlines some of the significant works done on the use of graphene to fabricate and implement wearable temperature sensors, along with the possible remedial steps that can be considered to deal with the challenges existing in the current literature

Development of piezoresistive sensors for biomedical applications

Tese de doutoramento em Engenharia Electrónica Industrial e de ComputadoresIn the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles. In the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles.In the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles. Sensors with larger flexibility were also developed though inkjet printing technique. Various configurations and materials were used to evaluate which materials are most appropriate for these types of sensors. Sensors with a gauge factor of approximately 2.5 for an active layer of PeDOT were obtained. A sensor matrix of 4 x 5 sensors was fabricated with an active area of 1.8 x 1.5 mm2 per sensor. These sensors were subjected to a set of electromechanical tests to evaluate its performance in situations close to end use. So the prosthesis was coated with the various sensors, cemented and subjected to deformation cycles for three levels of force according to standard ISO7206. An adaptive system read-out electronic circuit was developed and built that allows reading piezoresistive sensors with different characteristics. This system allows measuring a matrix of 8x8 sensors, but can be scaled to a large number of sensors. The readable range of the system is between 50 Ω and 100 kΩ according to the needs of the sensors being implanted. The total area of the circuit is 135 mm2, according to the requirements of a circuit to be used in in-vivo applications. An energy management system was also implemented that allows to activate and deactivate parts of the circuit when they are not needed, reducing the energy consumption. The system was validated by measuring a matrix of sensors with different characteristics. Finally, simulations were performed in order to evaluate the best options for the development of a wireless communications system. Three possible operation frequency ranges were used for three types of standard antennas. The communication system was introduced into a model simulating the characteristics of the various layers that constitute the human body. These simulations allow evaluate the frequency range most appropriate for implantable devices, the most appropriate antenna and the best location within the body. So the frequency chosen for the implementation was 868 Mhz for a Inverted- F antenna (IFA). In conclusion, the key elements for the implementations of an instrumented hip prosthesis were development and validated. The developed and/or simulated elements, including sensors, circuits for reading and communication system can also be used in other applications due to characteristics.These simulations allow evaluate the frequency range most appropriate for implantable devices, the most appropriate antenna and the best location within the body. So the frequency chosen for the implementation was 868 Mhz for a Inverted- F antenna (IFA). In conclusion, the key elements for the implementations of an instrumented hip prosthesis were development and validated. The developed and/or simulated elements, including sensors, circuits for reading and communication system can also be used in other applications due to characteristics. Neste trabalho foi desenvolvido um modelo de prótese de anca com implementação de sensores. Para atingir esse objectivo, foram desenvolvidos sensores piezoresitivos flexíveis que permitam ser implantados. Assim foram fabricados sensores de deformação baseados em filmes finos de n+-nc-si.H pela técnica de hot-wire chemical vapor deposition a uma temperatura de 150ºC sobre um substrato polimérico. Recorreu-se a técnica de litografia para construir as várias camadas do sensor. Os sensores apresentam um gauge factor de -28, para ciclos de baixa frequência em testes de four-point-bending. Foram ainda desenvolvidos sensores com uma maior flexibilidade através da técnica de inkjet printing. Para esse desenvolvimento foram usadas várias configurações e materiais, para avaliar quais os materiais mais adequados para este tipo de sensores. Na caracterização destes sensores obteve-se um gauge factor de aproximadamente 2.5 para uma camada ativa de PeDOT. Com os melhores sensores obtidos foram construídas matrizes de 4 x 5 sensores que apresentam uma área ativa de 1.8 x 1.5mm2 por sensor. Estes sensores foram sujeitos a um conjunto de ensaios electromecânicos, para avaliar o seu desempenho em situações próximas da utilização final. Desta forma foi revestida uma prótese com os diferentes sensores, cimentada e sujeita a ciclos de deformação para três níveis de força, segundo a norma ISO7206. Foi desenvolvido e construído um sistema de leitura adaptável que permite medir sensores piezoresistivos com diferentes características entre eles. Este sistema permite medir uma matriz de 8x8 sensores, mas pode ser escalada para um número maior de sensores. A gama de leitura do sistema varia entre 50 Ω e 100 kΩ, de acordo com as necessidades dos sensores a serem implementados. A área total deste circuito é de 135 mm2, de acordo com as necessidades de um circuito a ser utilizado em aplicações in-vivo. Foi também implementado um sistema de gestão de energia que permite ativar e desativar partes do circuito quando estas não são necessárias, permitindo, desta forma, reduzir os consumos de energia. O sistema foi validado através da medição de uma matriz de sensores com diferentes características. foram realizadas simulações de forma a avaliar as melhores opções para o desenvolvimento do sistema de comunicação sem fios. Foram usadas três possíveis gamas de frequência de operação para três tipos de antenas standard. O sistema de comunicação foi introduzido num modelo simulando as características das várias camadas que constituem o corpo humano. Estas simulações permitem aferir a gama de frequências mais adequadas para os dispositivos implantáveis, a antena mais adequada e a sua melhor localização, pois foi verificado como as várias camadas que constituem o corpo humano influenciam a comunicação. Assim, a frequência escolhida para a implementação foi de 868 MHz e a antena foi a IFA. Em conclusão, os elementos principais para a implementação de uma prótese de anca instrumentada, foram desenvolvidos e validados. Os elementos desenvolvidos e/ou simulados, incluindo os sensores, circuitos de leitura e sistema de comunicação, poderão igualmente ser utilizados em outras aplicações devido às suas boas características

The design and development of a planar coil sensor for angular displacements

The increased prevalence of wearable sensing devices is accelerating the development of personalised medical devices for monitoring the human condition. The measurement of joint posture and kinematics is particularly relevant in areas of physiotherapy and in the management of diseases. Existing sensors for performing these tasks are however, either inaccurate or too technically complex and obtrusive. A novel approach has been taken to develop a new type of sensor for angular displacement sensing. This thesis describes the development of a series of novel inductive planar coil sensors for measuring angular displacement. The small profile of these sensors makes them ideal for integration into garments as part of wearable devices. The main objective of this work was to design a planar coil topology, based on an inductive methodology, suitable for measuring angular displacements typically observed in finger articulation. Finite Element Method software was initially employed to determine the feasibility of various coil topologies. The planar coils were subsequently manufactured on several types of substrate including rigid printed circuit boards and flexible polyester films incorporating an iron-based amorphous ribbon as the inductive element. A series of experimental investigations involving inductance and stray field measurements, were performed on a range of coil topologies and layered configurations. The resulting data provided information relating sensor performance to positioning of the amorphous element and its overall angular displacement. The main findings showed that inductance change was not frequency dependent in the range (20 – 100) kHz but decreased by up to 15% for large angular displacements when utilising a figure-of-eight coil design. The sensors developed in this work provide significantly better accuracy than current resistive-based flexible sensors. Further refinements to coil design and optimisation of the inductive element’s magnetic properties is expected to yield further improvements in sensor performance providing an excellent platform for future wearable technologies

Studies on Spinal Fusion from Computational Modelling to ‘Smart’ Implants

Low back pain, the worldwide leading cause of disability, is commonly treated with lumbar interbody fusion surgery to address degeneration, instability, deformity, and trauma of the spine. Following fusion surgery, nearly 20% experience complications requiring reoperation while 1 in 3 do not experience a meaningful improvement in pain. Implant subsidence and pseudarthrosis in particular present a multifaceted challenge in the management of a patient’s painful symptoms. Given the diversity of fusion approaches, materials, and instrumentation, further inputs are required across the treatment spectrum to prevent and manage complications. This thesis comprises biomechanical studies on lumbar spinal fusion that provide new insights into spinal fusion surgery from preoperative planning to postoperative monitoring. A computational model, using the finite element method, is developed to quantify the biomechanical impact of temporal ossification on the spine, examining how the fusion mass stiffness affects loads on the implant and subsequent subsidence risk, while bony growth into the endplates affects load-distribution among the surrounding spinal structures. The computational modelling approach is extended to provide biomechanical inputs to surgical decisions regarding posterior fixation. Where a patient is not clinically pre-disposed to subsidence or pseudarthrosis, the results suggest unilateral fixation is a more economical choice than bilateral fixation to stabilise the joint. While finite element modelling can inform pre-surgical planning, effective postoperative monitoring currently remains a clinical challenge. Periodic radiological follow-up to assess bony fusion is subjective and unreliable. This thesis describes the development of a ‘smart’ interbody cage capable of taking direct measurements from the implant for monitoring fusion progression and complication risk. Biomechanical testing of the ‘smart’ implant demonstrated its ability to distinguish between graft and endplate stiffness states. The device is prepared for wireless actualisation by investigating sensor optimisation and telemetry. The results show that near-field communication is a feasible approach for wireless power and data transfer in this setting, notwithstanding further architectural optimisation required, while a combination of strain and pressure sensors will be more mechanically and clinically informative. Further work in computational modelling of the spine and ‘smart’ implants will enable personalised healthcare for low back pain, and the results presented in this thesis are a step in this direction

Design and Implementation of Metamaterial Based Strain Sensor Using Aperture Coupled Antenna

Strain sensors are used to convert the physical measured quantity of strain into an electrical signal suitable for processing by electronic equipment. Traditional strain sensors are comprised of a thin flexible film with a resistive pattern traced on the surface. As the sensor is deformed, the electrical resistance changes proportionally, giving a direct measure of the strain incurred. Metamaterials, particularly split ring resonators (SRR), lend themselves as a valuable tool for sensing applications due to their highly resonant nature and their very narrow bandwidth (high Q-factor). Due to very high field localization effects, they are extremely sensitive to both the dielectric properties of the materials they are deposited on and in close proximity to, allowing for a high degree of tunability. The benefit of using metamaterials as a sensor lies in the fact that as a microwave device, they can be used to realize passive wireless sensors as compared to the current technology which requires supporting circuitry to measure and transmit data. This thesis will address the feasibility of implementing a metamaterial based strain sensor that exploits the tunable nature of the SRR as it is calibrated with a traditional resistive strain sensor and then applied to quantify the strain incurred on a loaded cantilever beam

System Integration of Flexible and Multifunctional Thin Film Sensors for Structural Health Monitoring

Greater information is needed on the state of civil infrastructure to ensure public safety and cost-efficient management. Lack of infrastructure investment and foreseeable funding challenges mandate a more intelligent approach to future maintenance of infrastructure systems. Much of the technology currently utilized to assess structural performance is based on discrete sensors. While such sensors can provide valuable data, they can lack sufficient resolution to accurately identify damage through inverse methods. Alternatively, technologies have shown promise for distributed, direct damage detection with flexible thin film and multifunctional polymer-nanocomposite materials. However, challenges remain as significant past work has focused on material optimization as opposed to sensing systems for damage detection. This dissertation offers novel methods for direct and distributed strain sensing by providing a fabrication methodology for broadly enabling thin film sensing technologies in structural health monitoring (SHM) applications. This fabrication methodology is presented initially as a set of materials and processes which are illustrated in analog circuit primitive forms including flexible, thin film capacitors, resistors, and inductors. Three sensing systems addressing specific SHM challenges are developed from this base of components and processes as specific illustrations of the broader fabrication approach. The first system developed is a fully integrated strain sensing system designed to enable the use of multifunctional materials in sensing applications. This is achieved through the development of an optimized fabrication approach applicable to many multifunctional materials. A layer-by-layer (LbL) deposited nanocomposite is incorporated with a lithography process to produce a sensing system. To illustrate the process, a strain sensing platform consisting of a nanocomposite film within an amplified Wheatstone bridge circuit is presented. The study reveals the material process is highly repeatable to produce fully integrated strain sensors with high linearity and sensitivity. The thin film strain sensors are robust and are capable of high strain measurements beyond 3,000 μϵ. The second system developed is an array of resistive distributed strain sensors and an associated algorithm to provide an alternative to electrical impedance tomography for spatial strain sensing. An LbL deposited polymer composite thin film is utilized as the piezoresistive sensing material. An inverse algorithm is presented and utilized for determining the resistance of array elements by electrically stimulating boundary nodes. Two polymer nanocomposite arrays are strain tested under cyclic loading. Both arrays functioned as networks of strain sensors confirming the viability of the approach and computational benefits for SHM. The third system developed is a thin film wireless threshold strain sensor for measuring strain in implanted and embedded applications. The wireless sensing system is comprised of two thin film, inductor-capacitor circuits, one of which included a fuse element. The sensor is fabricated on polyimide with metal layers used to pattern inductive antennas and a strain sensitive parallel plate capacitor. A titanium thin film fuse is designed to fail, or have a large resistance increase, when a strain threshold is exceeded. Three prototype systems are interrogated wirelessly while under increasing tensile strain. One of two sensor resonant peaks disappear at a strain threshold as designed, validating the sensing approach and thin film form for use in SHM systems. The fuse approach provides a platform for various systems and sensing elements. The reference peak remains intact and is used for continuous real-time strain sensing with a sensitivity of 0.5 and a noise floor below 50 microstrain.PHDCivil EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/144183/1/arburt_1.pd

Interface Circuits for Microsensor Integrated Systems

ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [Recent advances in sensing technologies, especially those for Microsensor Integrated Systems, have led to several new commercial applications. Among these, low voltage and low power circuit architectures have gained growing attention, being suitable for portable long battery life devices. The aim is to improve the performances of actual interface circuits and systems, both in terms of voltage mode and current mode, in order to overcome the potential problems due to technology scaling and different technology integrations. Related problems, especially those concerning parasitics, lead to a severe interface design attention, especially concerning the analog front-end and novel and smart architecture must be explored and tested, both at simulation and prototype level. Moreover, the growing demand for autonomous systems gets even harder the interface design due to the need of energy-aware cost-effective circuit interfaces integrating, where possible, energy harvesting solutions. The objective of this Special Issue is to explore the potential solutions to overcome actual limitations in sensor interface circuits and systems, especially those for low voltage and low power Microsensor Integrated Systems. The present Special Issue aims to present and highlight the advances and the latest novel and emergent results on this topic, showing best practices, implementations and applications. The Guest Editors invite to submit original research contributions dealing with sensor interfacing related to this specific topic. Additionally, application oriented and review papers are encouraged.

Development of Solution Blow Spun Nanofibers as Electrical and Whole Cell Biosensing Interfaces

Infectious pathogens place a huge burden on the US economy with more than $120 billion spent annually for direct and indirect costs for the treatment of infectious diseases. Rapid detection schemes continue to evolve in order to meet the demand of early diagnosis. In chronic wound infections, bacterial load is capable of impeding the healing process. Additionally, bacterial virulence production works coherently with bacterial load to produce toxins and molecules that prolongs the healing cycle. This work examines the use of nonwoven polymeric conductive and non-conductive nanofiber mats as synthetic biosensor scaffolds, drug delivery and biosensor interface constructs. A custom-made nanofiber platform was built to produce solution blow spun nanofibers of various polymer loading. Antimicrobial nanofiber mats were made with the use of an in-situ silver chemical reduction method. Ceria nanoparticles were incorporated to provide an additional antioxidative property. Conductivity properties were examined by using silver and multi-walled carbon nanotubes (MWCNT) as a filler material. SBS parameters were adjusted to analyze electrical conductivity properties. Nanofiber mats were used to detect bacteria concentrations in vitro. Protein adhesion to conductive nanofibers was studied using fluorescent antibodies and BCA assay. Anti-rabbit and streptavidin Alexa Flour 594 was used to examine the adsorption properties of SBS nanofiber mats. Enhancements were made to further improve interface design for specificity. SBS nanofiber electrodes were fabricated to serve as scaffold and detection site for spike protein detection. Bacteria virulence production was examined by the detection of pyocyanin and quorum sensing molecules. The opportunistic pathogen, Pseudomonas aeruginosa is a nosocomial iii pathogen found in immunocompromised patients with such as those with chronic wounds and cystic fibrosis. Pyocyanin is one of four quorum sensing molecules that the pathogen produces which can be detected electrochemically due to its inherent redox-active activity. SBS has been used to develop a sensing scheme to detect pyocyanin. This work also examines the use of a synthetic biosensor with a LasR based system capable of detecting homoserine lactone produced by P. aeruginosa and other common gram-negative pathogens. Genetic modifications were made to biosensor in order to replace a green, fluorescent reporter with a chromoprotein based reporter system for visual readout. Additionally, work related to community service and outreach regarding the encouragement of middle school students to pursue Science, Technology, Engineering and Math (STEM) was conducted. Results from outreach program showed an increase in the STEM interest among a group of middle school students. There was a general trend with STEM career knowledge, STEM self-efficacy and the level of interest in STEM careers and activities. Military research was also done with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) to develop several assays for the detection of several highly infectious viruses and bacteria. Due to confidentiality, the work cannot be published in this manuscript