Use of a Checklist to Facilitate the Recognition of a Transfusion Associated Adverse Event

Transfusions are the most common procedure that hospitalized patients undergo. One of the risks associated with a transfusion is a transfusion related adverse event (TAAE). Transfusion associated adverse events can occur in any patient receiving a transfusion. Some patients are at risk of certain TAAEs (e.g., heart failure patients at risk of transfusion associated circulatory overload) while other events (e.g., allergic reactions) cannot always be anticipated. The severity of a TAAE can range from mildly uncomfortable to life threatening. Nurses need to be able to identify the signs and symptoms of a possible TAAE and intervene immediately by stopping the infusion of the blood product, taking immediate action to stabilize the patient and contacting the provider and transfusion medicine services/blood bank. This experimental study describes how the use of a transfusion checklist could facilitate the recognition and management of TAAEs for all clinicians and in particular, student nurses

Can a Checklist Facilitate Recognition of a Transfusion Associated Adverse Event by Prelicensure Nurses

https://scholarlycommons.libraryinfo.bhs.org/nurs_presentations2023/1029/thumbnail.jp

Transfusion-associated adverse events incidence and severity after the implementation of an active hemovigilance program with 24 h follow-up. A prospective cohort study

Background: Hemovigilance (HV) is usually based on voluntary reports (passive HV). Our aim is to ascertain credible incidence, severity, and mortality of transfusion-associated adverse events (TAAEs) using an active HV program. Study Design and Methods: Prospective cohort study to estimate transfusion risk after 46,488 transfusions in 5830 patients, using an active HV program with follow-up within the first 24 h after transfusion. We compared these results to those with the previously established passive HV program during the same 30 months of the study. We explored factors associated with the occurrence of TAAEs using generalized estimating equations models. Results: With the active HV program TAAEs incidence was 57.3 (95% CI, 50.5–64.2) and mortality 1.1 (95% CI, 0.13–2.01) per 10,000 transfusions. Incidence with the new surveillance model was 14.0 times higher than with the passive. Most events occurred when transfusions had already finished (60.2%); especially pulmonary events (80.4%). Three out of five deaths and 50.3% of severe TAAEs were pulmonary. In the multivariate analysis surgical patients had half TAAEs risk when compared to medical patients (OR, 0.53; 95% CI, 0.34–0.78) and women had nearly twice the risk of a pulmonary event compared to men (OR, 1.84; 95% CI, 1.03–3.32). Patient's age, blood component type, or blood component shelf-life were unrelated to TAAEs risk. Discussion: Active hemovigilance programs provide additional data which may lead to better recognition and understanding of TAAEs and their frequency and severit

John D. Feerick to Richard Poff

Letter from John D. Feerick to Representative Richard Poff, regarding language and scope of proposed amendment. Letter discusses legislative history and strategy.https://ir.lawnet.fordham.edu/twentyfifth_amendment_correspondence/1031/thumbnail.jp

Valor predictivo de la candidiasis oral como marcador de evolución a SIDA

Objetivo: Determinar la validez de la candidiasis oral (CO) como marcador clinico de evolucion en los pacientes infectados por el Virus de la Inmunodeficiencia Humana. Diseno del estudio: En 1992, se efectuo una exploracion oral a un colectivo de 200 pacientes infectados por VIH, con una edad media de 36,8'}7 anos (rango 25-46 anos) para establecer el diagnostico de CO. Se registraron las variables edad, sexo, tiempo de evolucion de la enfermedad, conducta de riesgo, numero de linfocitos CD4/'ÊL, estadio clinico y tratamiento antirretroviral. De los 200 pacientes del grupo de estudio, 157 no cumplian criterios de SIDA en el momento de la exploracion basal y a estos se les efectuo un seguimiento semestral hasta que cumplieron dichos criterios, concluyendo el estudio al final de 2001. Resultados: De los 157 pacientes seleccionados, 71 (45,2%) no presentaron CO y de estos el 28,7% evoluciono a SIDA durante el periodo de seguimiento. De los 86 (54,8%) pacientes con CO, el 48,2% evoluciono a SIDA (RR=2,71). Al trasladar el origen del estudio al ano 1997 cuando se inicio la administracion de la terapia antirretroviral de alta eficacia (TAAE), no se observaron diferencias en el porcentaje de pacientes que evolucionaron a SIDA en relacion a la existencia o no de CO en la exploracion basal. El analisis multivariante demostro que la asociacion de la variable de exposicion CO con la evolucion a SIDA no alcanzo un valor predictivo. Conclusiones: El valor pronostico a largo plazo de la CO, no se ha determinado en pacientes que reciben terapia antirretroviral de alta eficacia (TAAE). La recuperacion inmunologica y la disminucion de enfermedades oportunistas observadas tras la administracion de TAAE, hacen que muchos pacientes que alcanzaron la condicion de SIDA no cumplan en la actualidad dichos criterios, lo que obliga a renovar la propia definición del síndrome para poder evaluar marcadores de pronóstico.Objective: To determine the validity of oral candidiasis (OC) as a clinical marker of progression in patients with human immunodeficiency virus infection. Study design: In 1992, an oral examination was carried out on a group of 200 HIV-infected patients with a mean age of 36.8 ± 7 years (range 25-46 years) to establish the diagnosis of OC. The following variables were recorded: age, sex, duration of the disease, risk behaviour, CD4 lymphocyte count, clinical stage and antiretroviral treatment. Of the 200 patients in the group evaluated, 157 did not fulfil the criteria for AIDS at the time of the baseline examination; these patients constitute the study group and underwent 6-monthly follow-up until they fulfilled these criteria. The study was concluded at the end of 2001. Results: Of the 157 patients selected, 71 (45.2%) did not present OC and, of these, 28.7% progressed to AIDS during the followup period. Of the 86 (54.8%) patients with OC, 48.2% progressed to AIDS (RR= 2.71). If the start date of the study was taken as 1997, when highly active antiretroviral therapy (HAART) was introduced, no differences were found in the percentage of patients who progressed to AIDS with respect to the presence or absence of OC at the baseline examination. Multivariate analysis demonstrated that the association of the presence of OC with progression to AIDS did not reach a predictive value. Conclusions: The long-term prognostic value of OC has not been established in patients receiving highly active antiretroviral therapy (HAART). The immunological recovery and the reduction in the number of opportunistic diseases observed after the administration of HAART means that many patients who developed AIDS do not currently satisfy these criteria, making a review of the definition of the syndrome itself a necessity in order to be able to evaluate prognostic markers

Antimicrobial screening of Terminalia avicennoides and Acalypha wilkesiana

The antimicrobial activities of extracts of Terminalia avicennoides (Mexican tea) and Acalypha wilkesiana (copper leaf) were screened against Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli, Klebsiella, Salmonella typhi, Staphyloccus aureus and Candida albicans. The extracts showed a better activity against all organisms but T. avicennoides showed high activity against C. albicans. The antimicrobial activities for both plant extracts were more pronounced at a high concentration than at low concentration of the extracts. The extracts of the two plants can be used in the treatment of diseases where the test organisms are implicated.Keywords: Antimicrobial activities, Terminalia avicennoides, Acalypha wilkesian

Board of Trustees Meeting Minutes 2017-10-12

The official meeting minutes of Bowling Green State University\u27s Board of Trustees

Treebanking User-Generated Content: A Proposal for a Unified Representation in Universal Dependencies

The paper presents a discussion on the main linguistic phenomena of user-generated texts found in web and social media, and proposes a set of annotation guidelines for their treatment within the Universal Dependencies (UD) framework. Given on the one hand the increasing number of treebanks featuring user-generated content, and its somewhat inconsistent treatment in these resources on the other, the aim of this paper is twofold: (1) to provide a short, though comprehensive, overview of such treebanks - based on available literature - along with their main features and a comparative analysis of their annotation criteria, and (2) to propose a set of tentative UD-based annotation guidelines, to promote consistent treatment of the particular phenomena found in these types of texts. The main goal of this paper is to provide a common framework for those teams interested in developing similar resources in UD, thus enabling cross-linguistic consistency, which is a principle that has always been in the spirit of UD

Evaluation of the screening efficiency of the Johnston group pure tone test as compared with the individual Sweepcheck test with 1500 pupils in the public schools of Taunton, Massachusetts.

Thesis (Ed.M.)--Boston Universit