Subset-Based Ant Colony Optimisation for the Discovery of Gene-Gene Interactions in Genome Wide Association Studies

In this paper an ant colony optimisation approach for the discovery of gene-gene interactions in genome-wide association study (GWAS) data is proposed. The subset-based approach includes a novel encoding mechanism and tournament selection to analyse full scale GWAS data consisting of hundreds of thousands of variables to discover associations between combinations of small DNA changes and Type II diabetes. The method is tested on a large established database from the Wellcome Trust Case Control Consortium and is shown to discover combinations that are statistically significant and biologically relevant within reasonable computational time.The work contained in this paper was supported by an EPSRC First Grant (EP/J007439/1). This study makes use of data generated by the Wellcome Trust Case Control Consortium. A full list of the inves- tigators who contributed to the generation of the data is available from http://www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113

Hybridization of Biologically Inspired Algorithms for Discrete Optimisation Problems

In the field of Optimization Algorithms, despite the popularity of hybrid designs, not enough consideration has been given to hybridization strategies. This paper aims to raise awareness of the benefits that such a study can bring. It does this by conducting a systematic review of popular algorithms used for optimization, within the context of Combinatorial Optimization Problems. Then, a comparative analysis is performed between Hybrid and Base versions of the algorithms to demonstrate an increase in optimization performance when hybridization is employed

Self-adaptive hybrid genetic algorithm using an ant-based algorithm

The pheromone trail metaphor is a simple and effective way to accumulate the experience of the past solutions in solving discrete optimization problems. Ant-based optimization algorithms have been successfully employed to solve hard optimization problems. The problem of achieving an optimal utilization of a hybrid genetic algorithm search time is actually a problem of finding its optimal set of control parameters. In this paper, a novel form of hybridization between an ant-based algorithm and a genetic-local hybrid algorithm is proposed. An ant colony optimization algorithm is used to monitor the behavior of a genetic-local hybrid algorithm and dynamically adjust its control parameters to optimize the exploitation-exploration balance according to the fitness landscape

Evolutionary population dynamics and multi-objective optimisation problems

Griffith Sciences, School of Information and Communication TechnologyFull Tex

Optimal Control of SOAs with Artificial Intelligence for Sub-Nanosecond Optical Switching

Novel approaches to switching ultra-fast semiconductor optical amplifiers using artificial intelligence algorithms (particle swarm optimisation, ant colony optimisation, and a genetic algorithm) are developed and applied both in simulation and experiment. Effective off-on switching (settling) times of 542 ps are demonstrated with just 4.8% overshoot, achieving an order of magnitude improvement over previous attempts described in the literature and standard dampening techniques from control theory.Comment: This manuscript was accepted for publication in the IEEE/OSA Journal of Lightwave Technology on 21st June 2020. Open access code: https://github.com/cwfparsonson/soa_driving Open access data: https://doi.org/10.5522/04/12356696.v

Hybrid Meta-heuristic Algorithms for Static and Dynamic Job Scheduling in Grid Computing

The term ’grid computing’ is used to describe an infrastructure that connects geographically distributed computers and heterogeneous platforms owned by multiple organizations allowing their computational power, storage capabilities and other resources to be selected and shared. Allocating jobs to computational grid resources in an efficient manner is one of the main challenges facing any grid computing system; this allocation is called job scheduling in grid computing. This thesis studies the application of hybrid meta-heuristics to the job scheduling problem in grid computing, which is recognized as being one of the most important and challenging issues in grid computing environments. Similar to job scheduling in traditional computing systems, this allocation is known to be an NPhard problem. Meta-heuristic approaches such as the Genetic Algorithm (GA), Variable Neighbourhood Search (VNS) and Ant Colony Optimisation (ACO) have all proven their effectiveness in solving different scheduling problems. However, hybridising two or more meta-heuristics shows better performance than applying a stand-alone approach. The new high level meta-heuristic will inherit the best features of the hybridised algorithms, increasing the chances of skipping away from local minima, and hence enhancing the overall performance. In this thesis, the application of VNS for the job scheduling problem in grid computing is introduced. Four new neighbourhood structures, together with a modified local search, are proposed. The proposed VNS is hybridised using two meta-heuristic methods, namely GA and ACO, in loosely and strongly coupled fashions, yielding four new sequential hybrid meta-heuristic algorithms for the problem of static and dynamic single-objective independent batch job scheduling in grid computing. For the static version of the problem, several experiments were carried out to analyse the performance of the proposed schedulers in terms of minimising the makespan using well known benchmarks. The experiments show that the proposed schedulers achieved impressive results compared to other traditional, heuristic and meta-heuristic approaches selected from the bibliography. To model the dynamic version of the problem, a simple simulator, which uses the rescheduling technique, is designed and new problem instances are generated, by using a well-known methodology, to evaluate the performance of the proposed hybrid schedulers. The experimental results show that the use of rescheduling provides significant improvements in terms of the makespan compared to other non-rescheduling approaches

Comparison between five stochastic global search algorithms for optimizing thermoelectric generator designs

In this study, the best settings of five heuristics are determined for solving a mixed-integer non-linear multi-objective optimization problem. The algorithms treated in the article are: ant colony optimization, genetic algorithm, particle swarm optimization, differential evolution, and teaching-learning basic algorithm. The optimization problem consists in optimizing the design of a thermoelectric device, based on a model available in literature. Results showed that the inner settings can have different effects on the algorithm performance criteria depending on the algorithm. A formulation based on the weighted sum method is introduced for solving the multiobjective optimization problem with optimal settings. It was found that the five heuristic algorithms have comparable performances. Differential evolution generated the highest number of non-dominated solutions in comparison with the other algorithms

Hybrid meta-heuristic algorithms for independent job scheduling in grid computing

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.The term ’grid computing’ is used to describe an infrastructure that connects geographically distributed computers and heterogeneous platforms owned by multiple organizations allowing their computational power, storage capabilities and other resources to be selected and shared. The job scheduling problem is recognized as being one of the most important and challenging issues in grid computing environments. This paper proposes two strongly coupled hybrid meta-heuristic schedulers. The first scheduler combines Ant Colony Optimisation and Variable Neighbourhood Search in which the former acts as the primary algorithm which, during its execution, calls the latter as a supporting algorithm, while the second merges the Genetic Algorithm with Variable Neighbourhood Search in the same fashion. Several experiments were carried out to analyse the performance of the proposed schedulers in terms of minimizing the makespan using well known benchmarks. The experiments show that the proposed schedulers achieved impressive results compared to other selected approaches from the bibliography