Fog Computing in Medical Internet-of-Things: Architecture, Implementation, and Applications

In the era when the market segment of Internet of Things (IoT) tops the chart in various business reports, it is apparently envisioned that the field of medicine expects to gain a large benefit from the explosion of wearables and internet-connected sensors that surround us to acquire and communicate unprecedented data on symptoms, medication, food intake, and daily-life activities impacting one's health and wellness. However, IoT-driven healthcare would have to overcome many barriers, such as: 1) There is an increasing demand for data storage on cloud servers where the analysis of the medical big data becomes increasingly complex, 2) The data, when communicated, are vulnerable to security and privacy issues, 3) The communication of the continuously collected data is not only costly but also energy hungry, 4) Operating and maintaining the sensors directly from the cloud servers are non-trial tasks. This book chapter defined Fog Computing in the context of medical IoT. Conceptually, Fog Computing is a service-oriented intermediate layer in IoT, providing the interfaces between the sensors and cloud servers for facilitating connectivity, data transfer, and queryable local database. The centerpiece of Fog computing is a low-power, intelligent, wireless, embedded computing node that carries out signal conditioning and data analytics on raw data collected from wearables or other medical sensors and offers efficient means to serve telehealth interventions. We implemented and tested an fog computing system using the Intel Edison and Raspberry Pi that allows acquisition, computing, storage and communication of the various medical data such as pathological speech data of individuals with speech disorders, Phonocardiogram (PCG) signal for heart rate estimation, and Electrocardiogram (ECG)-based Q, R, S detection.Comment: 29 pages, 30 figures, 5 tables. Keywords: Big Data, Body Area Network, Body Sensor Network, Edge Computing, Fog Computing, Medical Cyberphysical Systems, Medical Internet-of-Things, Telecare, Tele-treatment, Wearable Devices, Chapter in Handbook of Large-Scale Distributed Computing in Smart Healthcare (2017), Springe

Classification techniques for arrhythmia patterns using convolutional neural networks and Internet of Things (IoT) devices

The rise of Telemedicine has revolutionized how patients are being treated, leading to several advantages such as enhanced health analysis tools, accessible remote healthcare, basic diagnostic of health parameters, etc. The advent of the Internet of Things (IoT), Artificial Intelligence (AI) and their incorporation into Telemedicine extends the potential of health benefits of Telemedicine even further. Therefore, the synergy between AI, IoT, and Telemedicine creates diverse innovative scenarios for integrating cyber-physical systems into medical health to provide remote monitoring and interactive assistance to patients. Data from World Health Organization reports that 7.4 million people died because of Atrial Fibrillation (AF), recognizing the most common arrhythmia associated with human heart rate. Causes like unhealthy diet, smoking, poor resources to go to the doctor and based on research studies, about 12 and 17.9 million of people will be suffering the AF in the USA and Europe, in 2050 and 2060, respectively. The AF as a cardiovascular disease is becoming an important public health issue to tackle. By using a systematic approach, this paper reviews recent contributions related to the acquisition of heart beats, arrhythmia detection, IoT, and visualization. In particular, by analysing the most closely related papers on Convolutional Neural Network (CNN) and IoT devices in heart disease diagnostics, we present a summary of the main research gaps with suggested directions for future research

Advanced Signal Processing in Wearable Sensors for Health Monitoring

Smart, wearables devices on a miniature scale are becoming increasingly widely available, typically in the form of smart watches and other connected devices. Consequently, devices to assist in measurements such as electroencephalography (EEG), electrocardiogram (ECG), electromyography (EMG), blood pressure (BP), photoplethysmography (PPG), heart rhythm, respiration rate, apnoea, and motion detection are becoming more available, and play a significant role in healthcare monitoring. The industry is placing great emphasis on making these devices and technologies available on smart devices such as phones and watches. Such measurements are clinically and scientifically useful for real-time monitoring, long-term care, and diagnosis and therapeutic techniques. However, a pertaining issue is that recorded data are usually noisy, contain many artefacts, and are affected by external factors such as movements and physical conditions. In order to obtain accurate and meaningful indicators, the signal has to be processed and conditioned such that the measurements are accurate and free from noise and disturbances. In this context, many researchers have utilized recent technological advances in wearable sensors and signal processing to develop smart and accurate wearable devices for clinical applications. The processing and analysis of physiological signals is a key issue for these smart wearable devices. Consequently, ongoing work in this field of study includes research on filtration, quality checking, signal transformation and decomposition, feature extraction and, most recently, machine learning-based methods

ASCNet-ECG: Deep Autoencoder based Attention aware Skip Connection network for ECG filtering

Currently, the telehealth monitoring field has gained huge attention due to its noteworthy use in day-to-day life. This advancement has led to an increase in the data collection of electrophysiological signals. Due to this advancement, electrocardiogram (ECG) signal monitoring has become a leading task in the medical field. ECG plays an important role in the medical field by analysing cardiac physiology and abnormalities. However, these signals are affected due to numerous varieties of noises, such as electrode motion, baseline wander and white noise etc., which affects the diagnosis accuracy. Therefore, filtering ECG signals became an important task. Currently, deep learning schemes are widely employed in signal-filtering tasks due to their efficient architecture of feature learning. This work presents a deep learning-based scheme for ECG signal filtering, which is based on the deep autoencoder module. According to this scheme, the data is processed through the encoder and decoder layer to reconstruct by eliminating noises. The proposed deep learning architecture uses a modified ReLU function to improve the learning of attributes because standard ReLU cannot adapt to huge variations. Further, a skip connection is also incorporated in the proposed architecture, which retains the key feature of the encoder layer while mapping these features to the decoder layer. Similarly, an attention model is also included, which performs channel and spatial attention, which generates the robust map by using channel and average pooling operations, resulting in improving the learning performance. The proposed approach is tested on a publicly available MIT-BIH dataset where different types of noise, such as electrode motion, baseline water and motion artifacts, are added to the original signal at varied SNR levels

Fall Detection from Electrocardiogram (ECG) Signals and Classification by Deep Transfer Learning

Fall is a prominent issue due to its severe consequences both physically and mentally. Fall detection and prevention is a critical area of research because it can help elderly people to depend less on caregivers and allow them to live and move more independently. Using electrocardiograms (ECG) signals independently for fall detection and activity classification is a novel approach used in this paper. An algorithm has been proposed which uses pre-trained convolutional neural networks AlexNet and GoogLeNet as a classifier between the fall and no fall scenarios using electrocardiogram signals. The ECGs for both falling and no falling cases were obtained as part of the study using eight volunteers. The signals are pre-processed using an elliptical filter for signal noises such as baseline wander and power-line interface. As feature extractors, frequency-time representations (scalograms) were obtained by applying a continuous wavelet transform on the filtered ECG signals. These scalograms were used as inputs to the neural network and a significant validation accuracy of 98.08% was achieved in the first model. The trained model is able to distinguish ECGs with a fall activity from an ECG with a no fall activity with an accuracy of 98.02%. For the verification of the robustness of the proposed algorithm, our experimental dataset was augmented by adding two different publicly available datasets to it. The second model can classify fall, daily activities and no activities with an accuracy of 98.44%. These models were developed by transfer learning from the domain of real images to the medical images. In comparison to traditional deep learning approaches, the transfer learning not only avoids "reinventing the wheel," but also presents a lightweight solution to otherwise computationally heavy problems.This research was funded by the research support program of Fb2, Frankfurt University of Applied Sciences. The research of D.G.-U. has been supported in part by the Spanish MICINN under grants PGC2018-096504-B-C33 and RTI2018-100754-B-I00, the European Union under the 2014-2020 ERDF Operational Programme and the Department of Economy, Knowledge, Business and University of the Regional Government of Andalusia (project FEDER-UCA18-108393). The research of I.M.-B. has been supported in part by the European Commission (ERDF), the Spanish Ministry of Science, Innovation and Universities [RTI2018-093608-BC33]

A Deep Learning Classifier for Detecting Atrial Fibrillation in Hospital Settings Applicable to Various Sensing Modalities

Cardiac signals provide variety of information related to the patient\u27s health. One of the most important is for medical experts to diagnose the functionality of a patient’s heart. This information helps the medical experts monitor heart disease such as atrial fibrillation and heart failure. Atrial fibrillation (AF) is one of the most major diseases that are threatening patients’ health. Medical experts measure cardiac signals usng the Electrocardiogram (ECG or EKG), the Photoplethysmogram (PPG), and more recently the Videoplethysmogram (VPG). Then they can use these measurements to analyze the heart functionality to detect heart diseases. In this study, these three major cardiac signals were used with different classification methodologies such as Basic Thresholding Classifiers (BTC), Machine Learning (SVM) classifiers, and deep learning classifiers based on Convolutional Neural Networks (CNN) to detect AF. To support the work, cardiac signals were acquired from forty-six AF subjects scheduled for cardioversion who were enrolled in a clinical study that was approved by the Internal Review Committees to protect human subjects at the University of Rochester Medical Center (URMC, Rochester, NY), and the Rochester Institute of Technology (RIT, Rochester, NY). The study included synchronized measurements of 5 minutes and 30 seconds of ECG, PPG, VPG 180Hz (High-quality camera), VPG 30 Hz (low quality webcam), taken before and after cardioversion of AF subjects receiving treatment at the AF Clinic of URMC. These data are subjected to BTC, SVM, and CNN classifiers to detect AF and compare the result for each classifier depending on the signal type. We propose a deep learning approach that is applicable to different kinds of cardiac signals to detect AF in a similar manner. By building this technique for different sensors we aim to provide a framework to implement a technique that can be used for most devices, such as, phones, tablets, PCs, ECG devices, and wearable PPG sensors. This conversion of the different sensing platforms provides a single AF detection classifier that can support a complete monitoring cycle that is referring to screen the patient whether at a hospital or home. By using that, the risk factor of heart attack, stroke, or other kind of heart complications can be reduced to a low level to prevent major dangers, since increasing monitoring AF patients helps to predict the disease at an early stage as well as track its progress. We show that the proposed approach provides around 99% accuracy for each type of classifier on the test dataset, thereby helping generalize AF detection by simplifying implementation using a sensor-agnostic deep learning model

Unsupervised Heart-rate Estimation in Wearables With Liquid States and A Probabilistic Readout

Heart-rate estimation is a fundamental feature of modern wearable devices. In this paper we propose a machine intelligent approach for heart-rate estimation from electrocardiogram (ECG) data collected using wearable devices. The novelty of our approach lies in (1) encoding spatio-temporal properties of ECG signals directly into spike train and using this to excite recurrently connected spiking neurons in a Liquid State Machine computation model; (2) a novel learning algorithm; and (3) an intelligently designed unsupervised readout based on Fuzzy c-Means clustering of spike responses from a subset of neurons (Liquid states), selected using particle swarm optimization. Our approach differs from existing works by learning directly from ECG signals (allowing personalization), without requiring costly data annotations. Additionally, our approach can be easily implemented on state-of-the-art spiking-based neuromorphic systems, offering high accuracy, yet significantly low energy footprint, leading to an extended battery life of wearable devices. We validated our approach with CARLsim, a GPU accelerated spiking neural network simulator modeling Izhikevich spiking neurons with Spike Timing Dependent Plasticity (STDP) and homeostatic scaling. A range of subjects are considered from in-house clinical trials and public ECG databases. Results show high accuracy and low energy footprint in heart-rate estimation across subjects with and without cardiac irregularities, signifying the strong potential of this approach to be integrated in future wearable devices.Comment: 51 pages, 12 figures, 6 tables, 95 references. Under submission at Elsevier Neural Network