Development of piezoresistive sensors for biomedical applications

Tese de doutoramento em Engenharia Electrónica Industrial e de ComputadoresIn the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles. In the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles.In the last decades there has been an increase in sensing systems applied in a variety of situations with a large variety of sensor ranges. This represents a growing area with high potential. One of the areas of sensor development that require a great deal of attention is the area of sensor for biomedical applications and biosensors. These sensors have to overcome a number of challenges and limitations inherent to the environment where they are introduced. These difficulties lead to the necessity of using new materials and new techniques for their construction together with the more traditional materials, e.g. silicon based, which have already proven their potential in this area. Among the various materials, polymers have proven to be a good choice, due to a set of advantages such as simple processing, flexibility and facility of being obtained in different shapes. Therefore it is interesting to fabricate polymer based piezoresistive sensors for functional coatings of implantable hip prosthesis. These sensors will allow coating the prosthesis and provide new functionalities to the implants such as the possibility to measure forces and deformations between the prosthesis and the bone and therefore improving the postoperative diagnostic. In this works, a model of hip prosthesis with coated sensors was developed. For this purpose, flexible piezoresistive sensors have been developed that allow being implanted. Strain sensors were fabricated based on thin films of n+-nc-si.H by the technique of hot-wire chemical vapor deposition at a temperature of 150 ºC on a polymeric substrate, using the lithographic technique to construct the various layers of the sensors. The sensor has a gauge factor of -28 for low frequency deformation cycles. Sensors with larger flexibility were also developed though inkjet printing technique. Various configurations and materials were used to evaluate which materials are most appropriate for these types of sensors. Sensors with a gauge factor of approximately 2.5 for an active layer of PeDOT were obtained. A sensor matrix of 4 x 5 sensors was fabricated with an active area of 1.8 x 1.5 mm2 per sensor. These sensors were subjected to a set of electromechanical tests to evaluate its performance in situations close to end use. So the prosthesis was coated with the various sensors, cemented and subjected to deformation cycles for three levels of force according to standard ISO7206. An adaptive system read-out electronic circuit was developed and built that allows reading piezoresistive sensors with different characteristics. This system allows measuring a matrix of 8x8 sensors, but can be scaled to a large number of sensors. The readable range of the system is between 50 Ω and 100 kΩ according to the needs of the sensors being implanted. The total area of the circuit is 135 mm2, according to the requirements of a circuit to be used in in-vivo applications. An energy management system was also implemented that allows to activate and deactivate parts of the circuit when they are not needed, reducing the energy consumption. The system was validated by measuring a matrix of sensors with different characteristics. Finally, simulations were performed in order to evaluate the best options for the development of a wireless communications system. Three possible operation frequency ranges were used for three types of standard antennas. The communication system was introduced into a model simulating the characteristics of the various layers that constitute the human body. These simulations allow evaluate the frequency range most appropriate for implantable devices, the most appropriate antenna and the best location within the body. So the frequency chosen for the implementation was 868 Mhz for a Inverted- F antenna (IFA). In conclusion, the key elements for the implementations of an instrumented hip prosthesis were development and validated. The developed and/or simulated elements, including sensors, circuits for reading and communication system can also be used in other applications due to characteristics.These simulations allow evaluate the frequency range most appropriate for implantable devices, the most appropriate antenna and the best location within the body. So the frequency chosen for the implementation was 868 Mhz for a Inverted- F antenna (IFA). In conclusion, the key elements for the implementations of an instrumented hip prosthesis were development and validated. The developed and/or simulated elements, including sensors, circuits for reading and communication system can also be used in other applications due to characteristics. Neste trabalho foi desenvolvido um modelo de prótese de anca com implementação de sensores. Para atingir esse objectivo, foram desenvolvidos sensores piezoresitivos flexíveis que permitam ser implantados. Assim foram fabricados sensores de deformação baseados em filmes finos de n+-nc-si.H pela técnica de hot-wire chemical vapor deposition a uma temperatura de 150ºC sobre um substrato polimérico. Recorreu-se a técnica de litografia para construir as várias camadas do sensor. Os sensores apresentam um gauge factor de -28, para ciclos de baixa frequência em testes de four-point-bending. Foram ainda desenvolvidos sensores com uma maior flexibilidade através da técnica de inkjet printing. Para esse desenvolvimento foram usadas várias configurações e materiais, para avaliar quais os materiais mais adequados para este tipo de sensores. Na caracterização destes sensores obteve-se um gauge factor de aproximadamente 2.5 para uma camada ativa de PeDOT. Com os melhores sensores obtidos foram construídas matrizes de 4 x 5 sensores que apresentam uma área ativa de 1.8 x 1.5mm2 por sensor. Estes sensores foram sujeitos a um conjunto de ensaios electromecânicos, para avaliar o seu desempenho em situações próximas da utilização final. Desta forma foi revestida uma prótese com os diferentes sensores, cimentada e sujeita a ciclos de deformação para três níveis de força, segundo a norma ISO7206. Foi desenvolvido e construído um sistema de leitura adaptável que permite medir sensores piezoresistivos com diferentes características entre eles. Este sistema permite medir uma matriz de 8x8 sensores, mas pode ser escalada para um número maior de sensores. A gama de leitura do sistema varia entre 50 Ω e 100 kΩ, de acordo com as necessidades dos sensores a serem implementados. A área total deste circuito é de 135 mm2, de acordo com as necessidades de um circuito a ser utilizado em aplicações in-vivo. Foi também implementado um sistema de gestão de energia que permite ativar e desativar partes do circuito quando estas não são necessárias, permitindo, desta forma, reduzir os consumos de energia. O sistema foi validado através da medição de uma matriz de sensores com diferentes características. foram realizadas simulações de forma a avaliar as melhores opções para o desenvolvimento do sistema de comunicação sem fios. Foram usadas três possíveis gamas de frequência de operação para três tipos de antenas standard. O sistema de comunicação foi introduzido num modelo simulando as características das várias camadas que constituem o corpo humano. Estas simulações permitem aferir a gama de frequências mais adequadas para os dispositivos implantáveis, a antena mais adequada e a sua melhor localização, pois foi verificado como as várias camadas que constituem o corpo humano influenciam a comunicação. Assim, a frequência escolhida para a implementação foi de 868 MHz e a antena foi a IFA. Em conclusão, os elementos principais para a implementação de uma prótese de anca instrumentada, foram desenvolvidos e validados. Os elementos desenvolvidos e/ou simulados, incluindo os sensores, circuitos de leitura e sistema de comunicação, poderão igualmente ser utilizados em outras aplicações devido às suas boas características

Design and Implementation of Metamaterial Based Strain Sensor Using Aperture Coupled Antenna

Strain sensors are used to convert the physical measured quantity of strain into an electrical signal suitable for processing by electronic equipment. Traditional strain sensors are comprised of a thin flexible film with a resistive pattern traced on the surface. As the sensor is deformed, the electrical resistance changes proportionally, giving a direct measure of the strain incurred. Metamaterials, particularly split ring resonators (SRR), lend themselves as a valuable tool for sensing applications due to their highly resonant nature and their very narrow bandwidth (high Q-factor). Due to very high field localization effects, they are extremely sensitive to both the dielectric properties of the materials they are deposited on and in close proximity to, allowing for a high degree of tunability. The benefit of using metamaterials as a sensor lies in the fact that as a microwave device, they can be used to realize passive wireless sensors as compared to the current technology which requires supporting circuitry to measure and transmit data. This thesis will address the feasibility of implementing a metamaterial based strain sensor that exploits the tunable nature of the SRR as it is calibrated with a traditional resistive strain sensor and then applied to quantify the strain incurred on a loaded cantilever beam

Graphene-based wearable temperature sensors: A review

The paper presents a comprehensive review of the use of graphene to develop wearable temperature sensors. The detection of temperature over a wide range has been a growing interest in multidisciplinary sectors in the sensing world. Different kinds of flexible temperature sensors have been fabricated with a range of polymers and nanomaterials. With the additional attribute of wearable nature, these temperature sensors are used ubiquitously to determine the effect of physiochemical variations happening in the environment of the chosen biomedical and industrial applications. Graphene, owing to its exceptional electrical, mechanical, and thermal properties, has been extensively used for the development of wearable temperature sensors. The prototypes have been deployed with certain wireless communication protocols to transfer the experimental data obtained under both controlled environments and real-time scenarios. This paper underlines some of the significant works done on the use of graphene to fabricate and implement wearable temperature sensors, along with the possible remedial steps that can be considered to deal with the challenges existing in the current literature

Inductively Coupled Passive Resonance Sensors: Readout Methods and Applications

Measurement systems are used to acquire information from the surrounding world. The requirements of the measurement system depend on the application, and the acquired information is used in different ways. For example, measurements are taken as part of the control systems of industrial processes. Alternatively, the information obtained from the measurements can be used to provide answers to scientific questions. Each measurement has a case-specific importance for the user and a certain cost in terms of time and money. Therefore, the same measurement approach is not optimal in every case. The design process of the measurement systems always includes a compromise between performance, viability, and cost. These factors are, in turn, strongly dependent on the implementation of the measurement system in each separate case. Inductively coupled passive resonance sensors provide a measurement method that has two notable benefits: the simple structure of the sensors and the possibility to take short-range wireless measurements. However, the limitations of the available readout devices have often impeded the use and development of these sensors in many demanding applications. In addition, uncertainty in the measurement results due to inductive coupling hinders the use of this method.This work concerns the development and implementation of a measurement system based on inductively coupled passive resonance sensors. A custom-made readout device to improve the feasibility of the readout in applications where continuous field measurements are performed was both specified and produced. The readout device was implemented using a simplified version of the method used in conventional impedance analyzers. In addition, signal processing methods were developed which can extract resonance characteristics from the measured data. A special algorithm was developed to compensate for the effects of the changes in the inductive coupling when the measurement distance varies. The operation of the developed readout methods was studied using simulations, and several realistic measurement configurations were tested. Competing readout methods published in the literature were also simulated. The accuracy of all the studied methods depended on the configuration of the measurement system. The inductive coupling coefficient also had a significant influence on the accuracy of the tested methods.The newly-developed readout methods and the inductively coupled passive resonance sensor were then utilized in a medical application to monitor the pressure between the skin and compression garments. These garments are used, for example, to improve the healing of burns and reduce swelling in the legs. Effective medical treatment of such conditions requires that the appropriate pressure is applied. With this system, the pressure reading under the compression garment can be obtained by using simple disposable sensors that can be read wirelessly through a thin fabric. Using our inductive coupling compensation method, the sensor enabled the monitoring of the pressure with the required level of precision.Inductively coupled resonance sensors can also be used to monitor the properties of the materials around the sensor. This monitoring is possible because the permittivity of the environment near to the sensor affects the sensor’s resonance characteristics. This method was tested in two applications. In the first application, the manufacturing process of ceramic slurry was monitored by a sensor that was installed inside the container where the slurry was mixed. The resonance characteristics of the sensor were measured as the manufacturing process was incrementally carried out. The results indicated that the method could be used to control the composition of the slurry. In the second application, the inductively coupled sensors were tested in monitoring the degradation processes of two different polymers during hydrolysis. In this application, the sensors were encapsulated into the tested polymers. The polymer samples were kept inside containers filled with buffer solution and the resonance characteristics of the encapsulated sensors were then measured wirelessly from outside. The results showed a clear difference in degradation profiles between the tested polymers. The method may provide a novel way to continuously monitor the degradation processes of certain materials.In summary, the developed readout methods improved the applicability of inductive coupled passive resonance sensors in the tested applications and created novel ways to acquire information. This new technology provides a good starting point for the development of a new generation of inductively coupled passive resonance sensors

Studies on Spinal Fusion from Computational Modelling to ‘Smart’ Implants

Low back pain, the worldwide leading cause of disability, is commonly treated with lumbar interbody fusion surgery to address degeneration, instability, deformity, and trauma of the spine. Following fusion surgery, nearly 20% experience complications requiring reoperation while 1 in 3 do not experience a meaningful improvement in pain. Implant subsidence and pseudarthrosis in particular present a multifaceted challenge in the management of a patient’s painful symptoms. Given the diversity of fusion approaches, materials, and instrumentation, further inputs are required across the treatment spectrum to prevent and manage complications. This thesis comprises biomechanical studies on lumbar spinal fusion that provide new insights into spinal fusion surgery from preoperative planning to postoperative monitoring. A computational model, using the finite element method, is developed to quantify the biomechanical impact of temporal ossification on the spine, examining how the fusion mass stiffness affects loads on the implant and subsequent subsidence risk, while bony growth into the endplates affects load-distribution among the surrounding spinal structures. The computational modelling approach is extended to provide biomechanical inputs to surgical decisions regarding posterior fixation. Where a patient is not clinically pre-disposed to subsidence or pseudarthrosis, the results suggest unilateral fixation is a more economical choice than bilateral fixation to stabilise the joint. While finite element modelling can inform pre-surgical planning, effective postoperative monitoring currently remains a clinical challenge. Periodic radiological follow-up to assess bony fusion is subjective and unreliable. This thesis describes the development of a ‘smart’ interbody cage capable of taking direct measurements from the implant for monitoring fusion progression and complication risk. Biomechanical testing of the ‘smart’ implant demonstrated its ability to distinguish between graft and endplate stiffness states. The device is prepared for wireless actualisation by investigating sensor optimisation and telemetry. The results show that near-field communication is a feasible approach for wireless power and data transfer in this setting, notwithstanding further architectural optimisation required, while a combination of strain and pressure sensors will be more mechanically and clinically informative. Further work in computational modelling of the spine and ‘smart’ implants will enable personalised healthcare for low back pain, and the results presented in this thesis are a step in this direction

Interface Circuits for Microsensor Integrated Systems

ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [Recent advances in sensing technologies, especially those for Microsensor Integrated Systems, have led to several new commercial applications. Among these, low voltage and low power circuit architectures have gained growing attention, being suitable for portable long battery life devices. The aim is to improve the performances of actual interface circuits and systems, both in terms of voltage mode and current mode, in order to overcome the potential problems due to technology scaling and different technology integrations. Related problems, especially those concerning parasitics, lead to a severe interface design attention, especially concerning the analog front-end and novel and smart architecture must be explored and tested, both at simulation and prototype level. Moreover, the growing demand for autonomous systems gets even harder the interface design due to the need of energy-aware cost-effective circuit interfaces integrating, where possible, energy harvesting solutions. The objective of this Special Issue is to explore the potential solutions to overcome actual limitations in sensor interface circuits and systems, especially those for low voltage and low power Microsensor Integrated Systems. The present Special Issue aims to present and highlight the advances and the latest novel and emergent results on this topic, showing best practices, implementations and applications. The Guest Editors invite to submit original research contributions dealing with sensor interfacing related to this specific topic. Additionally, application oriented and review papers are encouraged.

NASA Tech Briefs, May 1994

Topics covered include: Robotics/Automation; Electronic Components and Circuits; Electronic Systems; Physical Sciences; Materials; Computer Programs; Mechanics; Machinery/Automation; Manufacturing/Fabrication; Mathematics and Information Sciences; Life Sciences; Books and Reports

Enhanced Living Environments

This open access book was prepared as a Final Publication of the COST Action IC1303 “Algorithms, Architectures and Platforms for Enhanced Living Environments (AAPELE)”. The concept of Enhanced Living Environments (ELE) refers to the area of Ambient Assisted Living (AAL) that is more related with Information and Communication Technologies (ICT). Effective ELE solutions require appropriate ICT algorithms, architectures, platforms, and systems, having in view the advance of science and technology in this area and the development of new and innovative solutions that can provide improvements in the quality of life for people in their homes and can reduce the financial burden on the budgets of the healthcare providers. The aim of this book is to become a state-of-the-art reference, discussing progress made, as well as prompting future directions on theories, practices, standards, and strategies related to the ELE area. The book contains 12 chapters and can serve as a valuable reference for undergraduate students, post-graduate students, educators, faculty members, researchers, engineers, medical doctors, healthcare organizations, insurance companies, and research strategists working in this area