Compressive Sensing with Low-Power Transfer and Accurate Reconstruction of EEG Signals

Tele-monitoring of EEG in WBAN is essential as EEG is the most powerful physiological parameters to diagnose any neurological disorder. Generally, EEG signal needs to record for longer periods which results in a large volume of data leading to huge storage and communication bandwidth requirements in WBAN. Moreover, WBAN sensor nodes are battery operated which consumes lots of energy. The aim of this research is, therefore, low power transmission of EEG signal over WBAN and its accurate reconstruction at the receiver to enable continuous online-monitoring of EEG and real time feedback to the patients from the medical experts. To reduce data rate and consequently reduce power consumption, compressive sensing (CS) may be employed prior to transmission. Nonetheless, for EEG signals, the accuracy of reconstruction of the signal with CS depends on a suitable dictionary in which the signal is sparse. As the EEG signal is not sparse in either time or frequency domain, identifying an appropriate dictionary is paramount. There are a plethora of choices for the dictionary to be used. Wavelet bases are of interest due to the availability of associated systems and methods. However, the attributes of wavelet bases that can lead to good quality of reconstruction are not well understood. For the first time in this study, it is demonstrated that in selecting wavelet dictionaries, the incoherence with the sensing matrix and the number of vanishing moments of the dictionary should be considered at the same time. In this research, a framework is proposed for the selection of an appropriate wavelet dictionary for EEG signal which is used in tandem with sparse binary matrix (SBM) as the sensing matrix and ST-SBL method as the reconstruction algorithm. Beylkin (highly incoherent with SBM and relatively high number of vanishing moments) is identified as the best dictionary to be used amongst the dictionaries are evaluated in this thesis. The power requirements for the proposed framework are also quantified using a power model. The outcomes will assist to realize the computational complexity and online implementation requirements of CS for transmitting EEG in WBAN. The proposed approach facilitates the energy savings budget well into the microwatts range, ensuring a significant savings of battery life and overall system’s power. The study is intended to create a strong base for the use of EEG in the high-accuracy and low-power based biomedical applications in WBAN

Dictionary selection for Compressed Sensing of EEG signals using sparse binary matrix and spatiotemporal sparse Bayesian learning

Online monitoring of electroencephalogram (EEG) signals is challenging due to the high volume of data and power requirements. Compressed sensing (CS) may be employed to address these issues. Compressed sensing using sparse binary matrix, owing to its low power features, and reconstruction/decompression using spatiotemporal sparse Bayesian learning have been shown to constitute a robust framework for fast, energy efficient and accurate multichannel bio-signal monitoring. EEG signal, however, does not show a strong temporal correlation. Therefore, the use of sparsifying dictionaries has been proposed to exploit the sparsity in a transformed domain instead. Assuming sparsification adds values, a challenge, therefore, in employing this CS framework for the EEG signal is to identify the suitable dictionary. Using real multichannel EEG data from 15 subjects, in this paper, we systematically evaluated the performance of the framework when using various wavelet bases while considering their key attributes of number of vanishing moments and coherence with sensing matrix. We identified Beylkin as the wavelet dictionary leading to the best performance. Using the same dataset, we then compared the performance of Beylkin with discrete cosine basis, often used in the literature, and the case of using no sparsifying dictionary. We further demonstrate that using dictionaries (Beylkin and DCT) may improve performance tangibly only for a high compression ratio (CR) of 80% and with smaller block sizes; as compared to when using no dictionaries

Characterizing the Noise Associated with Sensor Placement and Motion Artifacts and Overcoming its Effects for Body-worn Physiological Sensors

Wearable sensors for continuous physiological monitoring have the potential to change the paradigm for healthcare by providing information in scenarios not covered by the existing clinical model. One key challenge for wearable physiological sensors is that their signal-to-noise ratios are low compared to those of their medical grade counterparts in hospitals. Two primary sources of noise are the sensor-skin contact interface and motion artifacts due to the user’s daily activities. These are challenging problems because the initial sensor placement by the user may not be ideal, the skin conditions can change over time, and the nature of motion artifacts is not predictable. The objective of this research is twofold. The first is to design sensors with reconfigurable contact to mitigate the effects of misplaced sensors or changing skin conditions. The second is to leverage signal processing techniques for accurate physiological parameter estimation despite the presence of motion artifacts. In this research, the sensor contact problem was specifically addressed for dry-contact electroencephalography (EEG). The proposed novel extension to a popular existing EEG electrode design enabled reconfigurable contact to adjust to variations in sensor placement and skin conditions over time. Experimental results on human subjects showed that reconfiguration of contact can reduce the noise in collected EEG signals without the need for manual intervention. To address the motion artifact problem, a particle filter based approach was employed to track the heart rate in cardiac signals affected by the movements of the user. The algorithm was tested on cardiac signals from human subjects running on a treadmill and showed good performance in accurately tracking heart rate. Moreover, the proposed algorithm enables fusion of multiple modalities and is also computationally more efficient compared to other contemporary approaches

Sleep Stage Classification: A Deep Learning Approach

Sleep occupies significant part of human life. The diagnoses of sleep related disorders are of great importance. To record specific physical and electrical activities of the brain and body, a multi-parameter test, called polysomnography (PSG), is normally used. The visual process of sleep stage classification is time consuming, subjective and costly. To improve the accuracy and efficiency of the sleep stage classification, automatic classification algorithms were developed. In this research work, we focused on pre-processing (filtering boundaries and de-noising algorithms) and classification steps of automatic sleep stage classification. The main motivation for this work was to develop a pre-processing and classification framework to clean the input EEG signal without manipulating the original data thus enhancing the learning stage of deep learning classifiers. For pre-processing EEG signals, a lossless adaptive artefact removal method was proposed. Rather than other works that used artificial noise, we used real EEG data contaminated with EOG and EMG for evaluating the proposed method. The proposed adaptive algorithm led to a significant enhancement in the overall classification accuracy. In the classification area, we evaluated the performance of the most common sleep stage classifiers using a comprehensive set of features extracted from PSG signals. Considering the challenges and limitations of conventional methods, we proposed two deep learning-based methods for classification of sleep stages based on Stacked Sparse AutoEncoder (SSAE) and Convolutional Neural Network (CNN). The proposed methods performed more efficiently by eliminating the need for conventional feature selection and feature extraction steps respectively. Moreover, although our systems were trained with lower number of samples compared to the similar studies, they were able to achieve state of art accuracy and higher overall sensitivity

Hardware Implementation of Deep Network Accelerators Towards Healthcare and Biomedical Applications

With the advent of dedicated Deep Learning (DL) accelerators and neuromorphic processors, new opportunities are emerging for applying deep and Spiking Neural Network (SNN) algorithms to healthcare and biomedical applications at the edge. This can facilitate the advancement of the medical Internet of Things (IoT) systems and Point of Care (PoC) devices. In this paper, we provide a tutorial describing how various technologies ranging from emerging memristive devices, to established Field Programmable Gate Arrays (FPGAs), and mature Complementary Metal Oxide Semiconductor (CMOS) technology can be used to develop efficient DL accelerators to solve a wide variety of diagnostic, pattern recognition, and signal processing problems in healthcare. Furthermore, we explore how spiking neuromorphic processors can complement their DL counterparts for processing biomedical signals. After providing the required background, we unify the sparsely distributed research on neural network and neuromorphic hardware implementations as applied to the healthcare domain. In addition, we benchmark various hardware platforms by performing a biomedical electromyography (EMG) signal processing task and drawing comparisons among them in terms of inference delay and energy. Finally, we provide our analysis of the field and share a perspective on the advantages, disadvantages, challenges, and opportunities that different accelerators and neuromorphic processors introduce to healthcare and biomedical domains. This paper can serve a large audience, ranging from nanoelectronics researchers, to biomedical and healthcare practitioners in grasping the fundamental interplay between hardware, algorithms, and clinical adoption of these tools, as we shed light on the future of deep networks and spiking neuromorphic processing systems as proponents for driving biomedical circuits and systems forward.Comment: Submitted to IEEE Transactions on Biomedical Circuits and Systems (21 pages, 10 figures, 5 tables

Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression

Combining electroencephalogram (EEG) recording and functional magnetic resonance imaging (fMRI) offers the potential for imaging brain activity with high spatial and temporal resolution. This potential remains limited by the significant ballistocardiogram (BCG) artifacts induced in the EEG by cardiac pulsation-related head movement within the magnetic field. We model the BCG artifact using a harmonic basis, pose the artifact removal problem as a local harmonic regression analysis, and develop an efficient maximum likelihood algorithm to estimate and remove BCG artifacts. Our analysis paradigm accounts for time-frequency overlap between the BCG artifacts and neurophysiologic EEG signals, and tracks the spatiotemporal variations in both the artifact and the signal. We evaluate performance on: simulated oscillatory and evoked responses constructed with realistic artifacts; actual anesthesia-induced oscillatory recordings; and actual visual evoked potential recordings. In each case, the local harmonic regression analysis effectively removes the BCG artifacts, and recovers the neurophysiologic EEG signals. We further show that our algorithm outperforms commonly used reference-based and component analysis techniques, particularly in low SNR conditions, the presence of significant time-frequency overlap between the artifact and the signal, and/or large spatiotemporal variations in the BCG. Because our algorithm does not require reference signals and has low computational complexity, it offers a practical tool for removing BCG artifacts from EEG data recorded in combination with fMRI.National Institutes of Health (U.S.) (Award DP1-OD003646)National Institutes of Health (U.S.) (Award TR01-GM104948)National Institutes of Health (U.S.) (Grant R44NS071988)National Institute of Neurological Diseases and Stroke (U.S.) (Grant Grant R44NS071988

Real-time signal detection and classification algorithms for body-centered systems

El principal motivo por el cual los sistemas de comunicación en el entrono corporal se desean con el objetivo de poder obtener y procesar señales biométricas para monitorizar e incluso tratar una condición médica sea ésta causada por una enfermedad o el rendimiento de un atleta. Dado que la base de estos sistemas está en la sensorización y el procesado, los algoritmos de procesado de señal son una parte fundamental de los mismos. Esta tesis se centra en los algoritmos de tratamiento de señales en tiempo real que se utilizan tanto para monitorizar los parámetros como para obtener la información que resulta relevante de las señales obtenidas. En la primera parte se introduce los tipos de señales y sensores en los sistemas en el entrono corporal. A continuación se desarrollan dos aplicaciones concretas de los sistemas en el entorno corporal así como los algoritmos que en las mismas se utilizan. La primera aplicación es el control de glucosa en sangre en pacientes con diabetes. En esta parte se desarrolla un método de detección mediante clasificación de patronones de medidas erróneas obtenidas con el monitor contínuo comercial "Minimed CGMS". La segunda aplicacióin consiste en la monitorizacióni de señales neuronales. Descubrimientos recientes en este campo han demostrado enormes posibilidades terapéuticas (por ejemplo, pacientes con parálisis total que son capaces de comunicarse con el entrono gracias a la monitorizacióin e interpretación de señales provenientes de sus neuronas) y también de entretenimiento. En este trabajo, se han desarrollado algoritmos de detección, clasificación y compresión de impulsos neuronales y dichos algoritmos han sido evaluados junto con técnicas de transmisión inalámbricas que posibiliten una monitorización sin cables. Por último, se dedica un capítulo a la transmisión inalámbrica de señales en los sistemas en el entorno corporal. En esta parte se estudia las condiciones del canal que presenta el entorno corporal para la transmisión de sTraver Sebastiá, L. (2012). Real-time signal detection and classification algorithms for body-centered systems [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/16188Palanci

EEG To FMRI Synthesis: Is Deep Learning a Candidate?

Advances on signal, image and video generation underly major breakthroughs on generative medical imaging tasks, including Brain Image Synthesis. Still, the extent to which functional Magnetic Ressonance Imaging (fMRI) can be mapped from the brain electrophysiology remains largely unexplored. This work provides the first comprehensive view on how to use state-of-the-art principles from Neural Processing to synthesize fMRI data from electroencephalographic (EEG) data. Given the distinct spatiotemporal nature of haemodynamic and electrophysiological signals, this problem is formulated as the task of learning a mapping function between multivariate time series with highly dissimilar structures. A comparison of state-of-the-art synthesis approaches, including Autoencoders, Generative Adversarial Networks and Pairwise Learning, is undertaken. Results highlight the feasibility of EEG to fMRI brain image mappings, pinpointing the role of current advances in Machine Learning and showing the relevance of upcoming contributions to further improve performance. EEG to fMRI synthesis offers a way to enhance and augment brain image data, and guarantee access to more affordable, portable and long-lasting protocols of brain activity monitoring. The code used in this manuscript is available in Github and the datasets are open source

Sensors for Vital Signs Monitoring

Sensor technology for monitoring vital signs is an important topic for various service applications, such as entertainment and personalization platforms and Internet of Things (IoT) systems, as well as traditional medical purposes, such as disease indication judgments and predictions. Vital signs for monitoring include respiration and heart rates, body temperature, blood pressure, oxygen saturation, electrocardiogram, blood glucose concentration, brain waves, etc. Gait and walking length can also be regarded as vital signs because they can indirectly indicate human activity and status. Sensing technologies include contact sensors such as electrocardiogram (ECG), electroencephalogram (EEG), photoplethysmogram (PPG), non-contact sensors such as ballistocardiography (BCG), and invasive/non-invasive sensors for diagnoses of variations in blood characteristics or body fluids. Radar, vision, and infrared sensors can also be useful technologies for detecting vital signs from the movement of humans or organs. Signal processing, extraction, and analysis techniques are important in industrial applications along with hardware implementation techniques. Battery management and wireless power transmission technologies, the design and optimization of low-power circuits, and systems for continuous monitoring and data collection/transmission should also be considered with sensor technologies. In addition, machine-learning-based diagnostic technology can be used for extracting meaningful information from continuous monitoring data