A survey of simulation techniques in commerce and defence

Despite the developments in Modelling and Simulation (M&S) tools and techniques over the past years, there has been a gap in the M&S research and practice in healthcare on developing a toolkit to assist the modellers and simulation practitioners with selecting an appropriate set of techniques. This study is a preliminary step towards this goal. This paper presents some results from a systematic literature survey on applications of M&S in the commerce and defence domains that could inspire some improvements in the healthcare. Interim results show that in the commercial sector Discrete-Event Simulation (DES) has been the most widely used technique with System Dynamics (SD) in second place. However in the defence sector, SD has gained relatively more attention. SD has been found quite useful for qualitative and soft factors analysis. From both the surveys it becomes clear that there is a growing trend towards using hybrid M&S approaches

Applications of lean thinking: a briefing document

This report has been put together by the Health and Care Infrastructure Research and Innovation Centre (HaCIRIC) at the University of Salford for the Department of Health. The need for the report grew out of two main simple questions, o Is Lean applicable in sectors other than manufacturing? o Can the service delivery sector learn from the success of lean in manufacturing and realise the benefits of its implementation?The aim of the report is to list together examples of lean thinking as it is evidenced in the public and private service sector. Following a review of various sources a catalogue of evidence is put together in an organised manner which demonstrates that Lean principles and techniques, when applied rigorously and throughout an entire organization/unit, they can have a positive impact on productivity, cost, quality, and timely delivery of services

Data-driven through-life costing to support product lifecycle management solutions in innovative product development

Innovative product usually refers to product that comprises of creativity and new ideas. In the development of such a new product, there is often a lack of historical knowledge and data available to be used to perform cost estimation accurately. This is due to the fact that traditional cost estimation methods are used to predict costs only after a product model has been built, and not at an early design stage when there is little data and information available. In light of this, original equipment manufacturers are also facing critical challenges of becoming globally competitive and increasing demands from customer for continuous innovation. To alleviate these situations this research has identified a new approach to cost modelling with the inclusion of product lifecycle management solutions to address innovative product development.The aim of this paper, therefore, is to discuss methods of developing an extended-enterprise data-driven through-life cost estimating method for innovative product development

Pathophysiology, histopathology and therapeutic of SARS-CoV-2

The rapid transmission of SARS-CoV-2 through the world has induced the scientist to understand the histopathology of the virus and then to find an effective drug. However, many of the point associated with the virus pathogenicity still unknown and need more studies. In this chapter the pathophysiology, histopathology and therapeutic of SARS-CoV-2 has been reviewed. It was appeared that pathogenicity of SARS-CoV-2 is belonging to the viral with genome structure which acting by blocking the host innate immune response. Both chloroquine and hydroxyl-chloroquine have similar structure and mechanism action and they are among the most effective antiviral for treating the patents with the SARS-CoV-2. Chloroquine works by inhibition the intracellular organism by increasing the pH

Sustainability in the Aerospace, Naval, and Automotive Supply Chain 4.0: Descriptive Review

The search for sustainability in the Supply Chain (SC) is one of the tasks that most concerns business leaders in all manufacturing sectors because of the importance that the Supply Chain has as a transversal tool and due to the leading role that it has been playing lately. Of all the manufacturing sectors, this study focuses on the aerospace, shipbuilding, and automotive sectors identified as transport. The present study carries out a descriptive review of existing publications in these three sectors in relation to the sustainability of the Supply Chain in its 4.0 adaptation as an update in matters that are in constant evolution. Among the results obtained, Lean practices are common to the three sectors, as well as different technologies focused on sustainability. Furthermore, the results show that the automotive sector is the one that makes the greatest contribution in this sense through collaborative programs that can be very useful to the other two sectors, thus benefiting from the consequent applicable advantages. Meanwhile, the Aerospace and Shipbuilding sectors do not seem to be working on promoting a sustainable culture in the management of the Supply Chain or on including training programs for their personnel in matters related to Industry 4.0

Editorial: Formal Ontologies meet Industry

The Formal Ontologies meet Industry (FOMI) workshop series is a scientific initiative supported by the International Association for Ontology and its Applications (IAOA) aimed at bringing together academics and practitioners interested in ontologies for industry. FOMI addresses research and application topics concerning, e.g., the design of domain-specific ontologies, the development of ontology-based information systems, or the investigation of the theoretical underpinnings of formal ontology when tuned to engineering applications

AGILE Paradigm: The next generation collaborative MDO for the development of aeronautical systems

The research and innovation EU funded AGILE project has developed the next generation of aircraft Multidisciplinary Design and Optimization (MDO) processes, which target significant reductions in aircraft development costs and time to market, leading to more cost-effective and greener aircraft solutions. 19 industry, research and academia partners from Europe, Canada and Russia have developed solutions to cope with the challenges of collaborative design and optimization of complex aeronautical products. In order to accelerate the deployment of large-scale, collaborative multidisciplinary design and optimization, a novel approach, the so-called “AGILE Paradigm”, has been conceived. The AGILE Paradigm is defined as a “blueprint for MDO”, accelerating the deployment and the operations of collaborative “MDO systems” and enabling the development of complex products practiced by multi-site and cross-organizational design teams, having heterogeneous expertise. A set of technologies has been developed by the AGILE consortium to enable the implementation of the AGILE Paradigm principles, thus delivering not only an abstract formalization of the approach, but also an applicable framework. The collection of all the technologies constitutes the so-called “AGILE Framework”, which has been applied for the design and the optimization of multiple aircraft configurations. The ambition of the AGILE Paradigm was set to reduce the lead time of 40% with respect to the current state-of-the-art. This work reviews the evolution of the MDO systems, underlines the open challenges tackled by the AGILE project, and introduces the main architectural concepts behind the AGILE Paradigm. Thereafter, an overview of the application design cases is presented, focusing of the main challenges and achievements. The AGILE technologies enabled the consortium to formulate and to solve in 15 months 7 MDO applications in parallel for the development of 7 novel aircraft configurations, demonstrating time savings beyond the 40% goal

Collaborative Design of a Business Jet Family Using the AGILE 4.0 MBSE Environment

This paper presents the collaborative model-based design of a business jet family. In family design, a trade-off is made between aircraft performance, reducing fuel burn, and commonality, reducing manufacturing costs. The family is designed using Model-Based Systems Engineering (MBSE) methods developed in the AGILE 4.0 project. The EC-funded AGILE 4.0 project extends the scope of the preliminary aircraft design process to also include systems engineering phases and new design domains like manufacturing, maintenance, and certification. Stakeholders, needs, requirements, and architecture models of the business jet family are presented. Then, the collaborative Multidisciplinary Design Analysis and Optimization (MDAO) capabilities are used to integrate various aircraft design disciplines, including overall aircraft design, onboard systems design, wing structural sizing, tailplane sizing, mission analysis, and cost estimation. Decisions regarding the degree of commonality are implemented by optionally fixing the design of a shared component when sizing an aircraft

Dynamic vs dedicated automation systems - a study in large structure assembly

The manufacturing industry needs to increase productivity and flexibility to stay competitive. This requires more adaptable and versatile production capabilities. It is expected that dynamic systems, consisting of mobile robots, will be particularly prominent in manufacturing environments where it is difficult to move components and products in a flexible manner. This paper compares the relative advantages of a dynamic, mobile robot-based system with traditional dedicated automation systems. The study uses simulations to evaluate several representative scenarios with different product supply bottlenecks, interference among mobile robots and mixes of products inspired by the aerospace industry. The results show that mobility enables higher resource utilisation and increased flexibility. This highlights the potential operational advantages mobile robot-based systems would offer and gives clear justification to continue the development of dynamic, self-organising production systems based on mobile robots