Biomechatronics: Harmonizing Mechatronic Systems with Human Beings

This eBook provides a comprehensive treatise on modern biomechatronic systems centred around human applications. A particular emphasis is given to exoskeleton designs for assistance and training with advanced interfaces in human-machine interaction. Some of these designs are validated with experimental results which the reader will find very informative as building-blocks for designing such systems. This eBook will be ideally suited to those researching in biomechatronic area with bio-feedback applications or those who are involved in high-end research on manmachine interfaces. This may also serve as a textbook for biomechatronic design at post-graduate level

XXII International Conference on Mechanics in Medicine and Biology - Abstracts Book

This book contain the abstracts presented the XXII ICMMB, held in Bologna in September 2022. The abstracts are divided following the sessions scheduled during the conference

Advances in materials strategies, circuit designs, and informatics for wearable, flexible and stretchable electronics with medical and robotic applications

The future of medical electronics should be flexible, stretchable and skin-integrated. While modern electronics become increasing smaller, faster and energy efficient, the designs remain bulky and rigid due to materials and processing limitations. The miniaturization of health monitoring devices in wearable form resembles a significant progress towards the next-generation medical electronics. However, there are still key challenges in these wearable electronics associated with medical-grade sensing precision, reliable wireless powering, and materials strategy for skin-integration. Here, I present a series of systematic studies from materials strategies, circuit design to signal processing on skin-mounted electronic wearable devices. Several types of Epidermal Electronic Systems (EES) develop applications in dermatology, cardiology, rehabilitation, and wireless powering. For skin hydration measurement, fundamental studies of electrode configurations and skin-electrode impedance reveal the optimal sensor design. Furthermore, wireless operation of hydration sensor was made possible with direct integration on skin, and on porous substrates that collect and analyze sweats. Additionally, I present an epidermal multi-functional sensing platform that could provide a control-feedback loop through electromyogram and current stimulation; and a mechano-acoustic device that could capture vibrations from muscle, heart, and throat as diagnostic tools or human-machine interface. I developed a modularized epidermal radio-frequency energy transfer epidermal device to eliminate batteries and power cables for wearable electronics. Finally, I present a clinical study that validates a commercialized ESS on patients with nerve disorders for electromyography monitoring during peripheral nerve and spinal cord surgeries

Intelligent Biosignal Processing in Wearable and Implantable Sensors

This reprint provides a collection of papers illustrating the state-of-the-art of smart processing of data coming from wearable, implantable or portable sensors. Each paper presents the design, databases used, methodological background, obtained results, and their interpretation for biomedical applications. Revealing examples are brain–machine interfaces for medical rehabilitation, the evaluation of sympathetic nerve activity, a novel automated diagnostic tool based on ECG data to diagnose COVID-19, machine learning-based hypertension risk assessment by means of photoplethysmography and electrocardiography signals, Parkinsonian gait assessment using machine learning tools, thorough analysis of compressive sensing of ECG signals, development of a nanotechnology application for decoding vagus-nerve activity, detection of liver dysfunction using a wearable electronic nose system, prosthetic hand control using surface electromyography, epileptic seizure detection using a CNN, and premature ventricular contraction detection using deep metric learning. Thus, this reprint presents significant clinical applications as well as valuable new research issues, providing current illustrations of this new field of research by addressing the promises, challenges, and hurdles associated with the synergy of biosignal processing and AI through 16 different pertinent studies. Covering a wide range of research and application areas, this book is an excellent resource for researchers, physicians, academics, and PhD or master students working on (bio)signal and image processing, AI, biomaterials, biomechanics, and biotechnology with applications in medicine

Acoustic and videoendoscopic techniques to improve voice assessment via relative fundamental frequency

Quantitative measures of laryngeal muscle tension are needed to improve assessment and track clinical progress. Although relative fundamental frequency (RFF) shows promise as an acoustic estimate of laryngeal muscle tension, it is not yet transferable to the clinic. The purpose of this work was to refine algorithmic estimation of RFF, as well as to enhance the knowledge surrounding the physiological underpinnings of RFF. The first study used a large database of voice samples collected from 227 speakers with voice disorders and 256 typical speakers to evaluate the effects of fundamental frequency estimation techniques and voice sample characteristics on algorithmic RFF estimation. By refining fundamental frequency estimation using the Auditory Sawtooth Waveform Inspired Pitch Estimator—Prime (Auditory-SWIPE′) algorithm and accounting for sample characteristics via the acoustic measure, pitch strength, algorithmic errors related to the accuracy and precision of RFF were reduced by 88.4% and 17.3%, respectively. The second study sought to characterize the physiological factors influencing acoustic outputs of RFF estimation. A group of 53 speakers with voice disorders and 69 typical speakers each produced the utterance, /ifi/, while simultaneous recordings were collected using a microphone and flexible nasendoscope. Acoustic features calculated via the microphone signal were examined in reference to the physiological initiation and termination of vocal fold vibration. The features that corresponded with these transitions were then implemented into the RFF algorithm, leading to significant improvements in the precision of the RFF algorithm to reflect the underlying physiological mechanisms for voicing offsets (p < .001, V = .60) and onsets (p < .001, V = .54) when compared to manual RFF estimation. The third study further elucidated the physiological underpinnings of RFF by examining the contribution of vocal fold abduction to RFF during intervocalic voicing offsets. Vocal fold abductory patterns were compared to RFF values in a subset of speakers from the second study, comprising young adults, older adults, and older adults with Parkinson’s disease. Abductory patterns were not significantly different among the three groups; however, vocal fold abduction was observed to play a significant role in measures of RFF at voicing offset. By improving algorithmic estimation and elucidating aspects of the underlying physiology affecting RFF, this work adds to the utility of RFF for use in conjunction with current clinical techniques to assess laryngeal muscle tension.2021-09-29T00:00:00

Southwest Research Institute assistance to NASA in biomedical areas of the technology utilization program

The activities are reported of the NASA Biomedical Applications Team at Southwest Research Institute between 25 August, 1972 and 15 November, 1973. The program background and methodology are discussed along with the technology applications, and biomedical community impacts

Models and Analysis of Vocal Emissions for Biomedical Applications

The International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications (MAVEBA) came into being in 1999 from the particularly felt need of sharing know-how, objectives and results between areas that until then seemed quite distinct such as bioengineering, medicine and singing. MAVEBA deals with all aspects concerning the study of the human voice with applications ranging from the neonate to the adult and elderly. Over the years the initial issues have grown and spread also in other aspects of research such as occupational voice disorders, neurology, rehabilitation, image and video analysis. MAVEBA takes place every two years always in Firenze, Italy

A Silent-Speech Interface using Electro-Optical Stomatography

Sprachtechnologie ist eine große und wachsende Industrie, die das Leben von technologieinteressierten Nutzern auf zahlreichen Wegen bereichert. Viele potenzielle Nutzer werden jedoch ausgeschlossen: Nämlich alle Sprecher, die nur schwer oder sogar gar nicht Sprache produzieren können. Silent-Speech Interfaces bieten einen Weg, mit Maschinen durch ein bequemes sprachgesteuertes Interface zu kommunizieren ohne dafür akustische Sprache zu benötigen. Sie können außerdem prinzipiell eine Ersatzstimme stellen, indem sie die intendierten Äußerungen, die der Nutzer nur still artikuliert, künstlich synthetisieren. Diese Dissertation stellt ein neues Silent-Speech Interface vor, das auf einem neu entwickelten Messsystem namens Elektro-Optischer Stomatografie und einem neuartigen parametrischen Vokaltraktmodell basiert, das die Echtzeitsynthese von Sprache basierend auf den gemessenen Daten ermöglicht. Mit der Hardware wurden Studien zur Einzelworterkennung durchgeführt, die den Stand der Technik in der intra- und inter-individuellen Genauigkeit erreichten und übertrafen. Darüber hinaus wurde eine Studie abgeschlossen, in der die Hardware zur Steuerung des Vokaltraktmodells in einer direkten Artikulation-zu-Sprache-Synthese verwendet wurde. Während die Verständlichkeit der Synthese von Vokalen sehr hoch eingeschätzt wurde, ist die Verständlichkeit von Konsonanten und kontinuierlicher Sprache sehr schlecht. Vielversprechende Möglichkeiten zur Verbesserung des Systems werden im Ausblick diskutiert.:Statement of authorship iii Abstract v List of Figures vii List of Tables xi Acronyms xiii 1. Introduction 1 1.1. The concept of a Silent-Speech Interface . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2. Structure of this work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. Fundamentals of phonetics 7 2.1. Components of the human speech production system . . . . . . . . . . . . . . . . . . . 7 2.2. Vowel sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3. Consonantal sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.4. Acoustic properties of speech sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.5. Coarticulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 2.6. Phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2.7. Summary and implications for the design of a Silent-Speech Interface (SSI) . . . . . . . 21 3. Articulatory data acquisition techniques in Silent-Speech Interfaces 25 3.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2. Scope of the literature review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.3. Video Recordings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.4. Ultrasonography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3.5. Electromyography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 3.6. Permanent-Magnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 3.7. Electromagnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 3.8. Radio waves . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 3.9. Palatography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 3.10.Conclusion and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 4. Electro-Optical Stomatography 55 4.1. Contact sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 4.2. Optical distance sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 4.3. Lip sensor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 4.4. Sensor Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 4.5. Control Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 4.6. Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 5. Articulation-to-Text 99 5.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.2. Command word recognition pilot study . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.3. Command word recognition small-scale study . . . . . . . . . . . . . . . . . . . . . . . . 102 6. Articulation-to-Speech 109 6.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.2. Articulatory synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.3. The six point vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 6.4. Objective evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 116 6.5. Perceptual evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 120 6.6. Direct synthesis using EOS to control the vocal tract model . . . . . . . . . . . . . . . . 125 6.7. Pitch and voicing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132 7. Summary and outlook 145 7.1. Summary of the contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 7.2. Outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146 A. Overview of the International Phonetic Alphabet 151 B. Mathematical proofs and derivations 153 B.1. Combinatoric calculations illustrating the reduction of possible syllables using phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 B.2. Signal Averaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 B.3. Effect of the contact sensor area on the conductance . . . . . . . . . . . . . . . . . . . . 155 B.4. Calculation of the forward current for the OP280V diode . . . . . . . . . . . . . . . . . . 155 C. Schematics and layouts 157 C.1. Schematics of the control unit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158 C.2. Layout of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 C.3. Bill of materials of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 C.4. Schematics of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 C.5. Layout of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 C.6. Bill of materials of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 D. Sensor unit assembly 169 E. Firmware flow and data protocol 177 F. Palate file format 181 G. Supplemental material regarding the vocal tract model 183 H. Articulation-to-Speech: Optimal hyperparameters 189 Bibliography 191Speech technology is a major and growing industry that enriches the lives of technologically-minded people in a number of ways. Many potential users are, however, excluded: Namely, all speakers who cannot easily or even at all produce speech. Silent-Speech Interfaces offer a way to communicate with a machine by a convenient speech recognition interface without the need for acoustic speech. They also can potentially provide a full replacement voice by synthesizing the intended utterances that are only silently articulated by the user. To that end, the speech movements need to be captured and mapped to either text or acoustic speech. This dissertation proposes a new Silent-Speech Interface based on a newly developed measurement technology called Electro-Optical Stomatography and a novel parametric vocal tract model to facilitate real-time speech synthesis based on the measured data. The hardware was used to conduct command word recognition studies reaching state-of-the-art intra- and inter-individual performance. Furthermore, a study on using the hardware to control the vocal tract model in a direct articulation-to-speech synthesis loop was also completed. While the intelligibility of synthesized vowels was high, the intelligibility of consonants and connected speech was quite poor. Promising ways to improve the system are discussed in the outlook.:Statement of authorship iii Abstract v List of Figures vii List of Tables xi Acronyms xiii 1. Introduction 1 1.1. The concept of a Silent-Speech Interface . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2. Structure of this work . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. Fundamentals of phonetics 7 2.1. Components of the human speech production system . . . . . . . . . . . . . . . . . . . 7 2.2. Vowel sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3. Consonantal sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2.4. Acoustic properties of speech sounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.5. Coarticulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 2.6. Phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2.7. Summary and implications for the design of a Silent-Speech Interface (SSI) . . . . . . . 21 3. Articulatory data acquisition techniques in Silent-Speech Interfaces 25 3.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 3.2. Scope of the literature review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.3. Video Recordings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 3.4. Ultrasonography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3.5. Electromyography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 3.6. Permanent-Magnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 3.7. Electromagnetic Articulography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 3.8. Radio waves . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 3.9. Palatography . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 3.10.Conclusion and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 4. Electro-Optical Stomatography 55 4.1. Contact sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 4.2. Optical distance sensors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 4.3. Lip sensor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 4.4. Sensor Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84 4.5. Control Unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 4.6. Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 5. Articulation-to-Text 99 5.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.2. Command word recognition pilot study . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 5.3. Command word recognition small-scale study . . . . . . . . . . . . . . . . . . . . . . . . 102 6. Articulation-to-Speech 109 6.1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.2. Articulatory synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 6.3. The six point vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 6.4. Objective evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 116 6.5. Perceptual evaluation of the vocal tract model . . . . . . . . . . . . . . . . . . . . . . . . 120 6.6. Direct synthesis using EOS to control the vocal tract model . . . . . . . . . . . . . . . . 125 6.7. Pitch and voicing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132 7. Summary and outlook 145 7.1. Summary of the contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 7.2. Outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 146 A. Overview of the International Phonetic Alphabet 151 B. Mathematical proofs and derivations 153 B.1. Combinatoric calculations illustrating the reduction of possible syllables using phonotactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153 B.2. Signal Averaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 B.3. Effect of the contact sensor area on the conductance . . . . . . . . . . . . . . . . . . . . 155 B.4. Calculation of the forward current for the OP280V diode . . . . . . . . . . . . . . . . . . 155 C. Schematics and layouts 157 C.1. Schematics of the control unit. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 158 C.2. Layout of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163 C.3. Bill of materials of the control unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 164 C.4. Schematics of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 C.5. Layout of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 C.6. Bill of materials of the sensor unit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 D. Sensor unit assembly 169 E. Firmware flow and data protocol 177 F. Palate file format 181 G. Supplemental material regarding the vocal tract model 183 H. Articulation-to-Speech: Optimal hyperparameters 189 Bibliography 19

Wearable and Nearable Biosensors and Systems for Healthcare

Biosensors and systems in the form of wearables and “nearables” (i.e., everyday sensorized objects with transmitting capabilities such as smartphones) are rapidly evolving for use in healthcare. Unlike conventional approaches, these technologies can enable seamless or on-demand physiological monitoring, anytime and anywhere. Such monitoring can help transform healthcare from the current reactive, one-size-fits-all, hospital-centered approach into a future proactive, personalized, decentralized structure. Wearable and nearable biosensors and systems have been made possible through integrated innovations in sensor design, electronics, data transmission, power management, and signal processing. Although much progress has been made in this field, many open challenges for the scientific community remain, especially for those applications requiring high accuracy. This book contains the 12 papers that constituted a recent Special Issue of Sensors sharing the same title. The aim of the initiative was to provide a collection of state-of-the-art investigations on wearables and nearables, in order to stimulate technological advances and the use of the technology to benefit healthcare. The topics covered by the book offer both depth and breadth pertaining to wearable and nearable technology. They include new biosensors and data transmission techniques, studies on accelerometers, signal processing, and cardiovascular monitoring, clinical applications, and validation of commercial devices