Models and Analysis of Vocal Emissions for Biomedical Applications

The International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications (MAVEBA) came into being in 1999 from the particularly felt need of sharing know-how, objectives and results between areas that until then seemed quite distinct such as bioengineering, medicine and singing. MAVEBA deals with all aspects concerning the study of the human voice with applications ranging from the newborn to the adult and elderly. Over the years the initial issues have grown and spread also in other fields of research such as occupational voice disorders, neurology, rehabilitation, image and video analysis. MAVEBA takes place every two years in Firenze, Italy. This edition celebrates twenty-two years of uninterrupted and successful research in the field of voice analysis

Advances in Computational Intelligence Applications in the Mining Industry

This book captures advancements in the applications of computational intelligence (artificial intelligence, machine learning, etc.) to problems in the mineral and mining industries. The papers present the state of the art in four broad categories: mine operations, mine planning, mine safety, and advances in the sciences, primarily in image processing applications. Authors in the book include both researchers and industry practitioners

Information-theoretic causal inference of lexical flow

This volume seeks to infer large phylogenetic networks from phonetically encoded lexical data and contribute in this way to the historical study of language varieties. The technical step that enables progress in this case is the use of causal inference algorithms. Sample sets of words from language varieties are preprocessed into automatically inferred cognate sets, and then modeled as information-theoretic variables based on an intuitive measure of cognate overlap. Causal inference is then applied to these variables in order to determine the existence and direction of influence among the varieties. The directed arcs in the resulting graph structures can be interpreted as reflecting the existence and directionality of lexical flow, a unified model which subsumes inheritance and borrowing as the two main ways of transmission that shape the basic lexicon of languages. A flow-based separation criterion and domain-specific directionality detection criteria are developed to make existing causal inference algorithms more robust against imperfect cognacy data, giving rise to two new algorithms. The Phylogenetic Lexical Flow Inference (PLFI) algorithm requires lexical features of proto-languages to be reconstructed in advance, but yields fully general phylogenetic networks, whereas the more complex Contact Lexical Flow Inference (CLFI) algorithm treats proto-languages as hidden common causes, and only returns hypotheses of historical contact situations between attested languages. The algorithms are evaluated both against a large lexical database of Northern Eurasia spanning many language families, and against simulated data generated by a new model of language contact that builds on the opening and closing of directional contact channels as primary evolutionary events. The algorithms are found to infer the existence of contacts very reliably, whereas the inference of directionality remains difficult. This currently limits the new algorithms to a role as exploratory tools for quickly detecting salient patterns in large lexical datasets, but it should soon be possible for the framework to be enhanced e.g. by confidence values for each directionality decision

Information-theoretic causal inference of lexical flow

This volume seeks to infer large phylogenetic networks from phonetically encoded lexical data and contribute in this way to the historical study of language varieties. The technical step that enables progress in this case is the use of causal inference algorithms. Sample sets of words from language varieties are preprocessed into automatically inferred cognate sets, and then modeled as information-theoretic variables based on an intuitive measure of cognate overlap. Causal inference is then applied to these variables in order to determine the existence and direction of influence among the varieties. The directed arcs in the resulting graph structures can be interpreted as reflecting the existence and directionality of lexical flow, a unified model which subsumes inheritance and borrowing as the two main ways of transmission that shape the basic lexicon of languages

Development of novel mass spectrometric methods for point-of-care mucosal diagnostics

Human mucosal surfaces act as key interfaces between microbiota and host. As such, mucosal sampling using medical swabs is performed for diagnostic purposes that most commonly rely upon subsequent microscopy, culture or molecular-based assays. These approaches are limited in providing information on host response, which is a critical facet of pathology. In this thesis, I sought to test the hypothesis that both presence of specific microbes as well as their interactions with the human host are reflected in the mucosal metabolome and that this information could be exploited for mucosal diagnostic applications. The study aimed to develop a method for rapid, direct metabolic profiling from swabs using desorption electrospray ionisation mass spectrometry (DESI-MS). Method optimisation was conducted to elucidate optimal instrumental and geometrical conditions essential for the swab analysis. The application of the method for mucosal diagnostics was then assessed by characterising the metabolic profile of multiple bodysites (oral, nasal and vaginal mucosa), vaginal mucosa during two different physiological states (non-pregnant vs pregnant) and to detect a pathological state (bacterial vaginosis). Correlation of DESI-MS vaginal metabolic profiles with matched vaginal microbiota composition (VMC) characterised by 16S rRNA-based metataxonomics during pregnancy enabled to robustly predict a Lactobacillus dominant from depleted state but also major vaginal community states types (CST). The predictive performance of DESI-MS based models was comparable to “gold standard” LC-MS based models. Additionally, bacterial metabolite markers predictive of specific microbial genera were identified through matching to a spectral database constructed using pure cultures of commensal and pathogenic microbes often observed in the vaginal microbiome. In summary, DESI-MS has the potential to revolutionise the current way of mucosal based diagnostic by reducing significantly the time-demand needed for the characterisation of VMC, drug or inflammatory response to only few minutes and therefore could enable a faster decision making on patient’s treatment.Open Acces

Attitudes towards old age and age of retirement across the world: findings from the future of retirement survey

The 21st century has been described as the first era in human history when the world will no longer be young and there will be drastic changes in many aspects of our lives including socio-demographics, financial and attitudes towards the old age and retirement. This talk will introduce briefly about the Global Ageing Survey (GLAS) 2004 and 2005 which is also popularly known as “The Future of Retirement”. These surveys provide us a unique data source collected in 21 countries and territories that allow researchers for better understanding the individual as well as societal changes as we age with regard to savings, retirement and healthcare. In 2004, approximately 10,000 people aged 18+ were surveyed in nine counties and one territory (Brazil, Canada, China, France, Hong Kong, India, Japan, Mexico, UK and USA). In 2005, the number was increased to twenty-one by adding Egypt, Germany, Indonesia, Malaysia, Poland, Russia, Saudi Arabia, Singapore, Sweden, Turkey and South Korea). Moreover, an additional 6320 private sector employers was surveyed in 2005, some 300 in each country with a view to elucidating the attitudes of employers to issues relating to older workers. The paper aims to examine the attitudes towards the old age and retirement across the world and will indicate some policy implications

Applying safe flooring in housing environments related to the independent elderly : evaluating suitability flooring technology to absorb impact in the event of a fall

Aplicat embargament des de la data de defensa fins el dia 3/6/2022This research has been developed with the intention of investigating a different generation of pavements. Most of the current pavements have the same basic standard characteristics and this ensures that living conditions are comfortable, safe, and pleasant for the majority of citizens. But a small group of pavements is designed with a specific purpose: to reduce injuries related to people's falls to the ground; They are called CF (compliant flooring in English). A detailed study of CF flooring systems is warranted to assess their usability for vulnerable groups such as the elderly. This study is structured in six chapters. The first chapter has dealt mainly with bibliographic studies and statistical data consulted on official and international websites. This section evaluates the importance of the increase in the elderly population, life expectancy, and threats to the safety and health of the elderly, especially, and their secondary effects. The scope of the research has been carried out internationally, in Europe and within Spain, and finally, specifically for Catalonia. The second chapter presents a brief overview of the interior flooring, specifically considering its comfort and safety during use. The importance and direct relationship between the sole of the foot and the gait mechanism with respect to the type of pavement have been verified. Many factors that influence this have been investigated, such as the physics and biomechanics of the body when walking, the kinematics of falls, and the dynamics of impact. In addition, a general description of the behavior of materials for use in pavements has been made to better understand the behavior of CF systems. In addition, the most suitable strategies to cope with falls and reduce injuries are discussed. Examining other products with appreciable energy-absorbing and shock-reducing capabilities has been helpful in the proposed pre-designs, all of which have been made based on numerical analysis and related standards. The third chapter is already dedicated to the study of technology and research on the most suitable CF systems; studies from academic, commercial, and architecture departments, in general, are included. In this section, some standard tests related to the various selected materials are developed and several examples of similar products are studied. The fourth chapter includes field research (on-site) and analysis of case studies. Several notable flooring companies around the world were contacted by mail, specifically examining those products whose manufacturers claimed to be shock absorbers. This part of the investigation was slowed down by the delay in shipments. Once they arrived, a real environment was sought where they could obtain the opinion of the elderly and the personnel assigned to their care. All the practice tests were carried out in a residence for the elderly in Barcelona for about two months, focusing on the study of the current pavements of the center and the current derived problems related to users.This entire process was completed by interviewing users and caregivers with predefined questionnaires. It should be noted that this allowed us to contrast the quantitative characteristics of the study in combination with the elements of qualitative research. Chapter Five deals with the results, discussions, suggestions for installation and improvement of pavement safety in risk areas. Simulations were also carried out on a possible base structure of the pavements with the finite element method (FEM). Chapter six presents guidelines for future developments. The author further investigated the materials and their structure and is presented them as a basis for future technical developments.The author considers that, with more detailed studies, it would be possible to use as CF system other materials, either natural or recycled based on agricultural products, which would increase the diversity of the CF system offer and promote more sustainable architectureEsta investigación se ha desarrollado con la intención de investigar una generación diferente de pavimentos. La mayoría de los actuales pavimentos tienen las mismas características básicas estándar y ello garantiza que las condiciones de vida sean cómodas, seguras y agradables para la mayoría de los ciudadanos. Pero un grupo reducido de pavimentos está diseñado con un propósito específico: reducir las lesiones relacionadas con las caídas al suelo de las personas; son los denominados CF (compliant flooring en inglés). Un estudio detallado de los sistemas de pavimentos CF está justificado para evaluar su posibilidad de uso para grupos vulnerables como los ancianos. Este estudio se estructura en seis capítulos. En el primer capítulo se han abordado principalmente los estudios bibliográficos y datos estadísticos consultados en sitios web oficiales e internacionales. En esta sección se evalúa la importancia del aumento de la población anciana. El ámbito de la investigación se ha realizado a nivel internacional, en Europa y dentro de España, y finalmente, específicamente para Cataluña. El segundo capítulo se presenta una breve panorámica del pavimento interior. Se ha constatado la importancia y relación directa entre la planta del pie y el mecanismo de andar con respecto al tipo de pavimento. Se han investigado muchos factores que influyen en ello. Además, se ha realizado una descripción general del comportamiento de los materiales al uso en pavimentos para comprender mejor el comportamiento de los sistemas de CF. Además, se discuten las estrategias más idóneas para hacer frente a las caídas y reducir las lesiones. Examinar otros productos con apreciables capacidades de amortiguación de energía y reducción de impactos ha sido de gran ayuda en los prediseños propuestos, todos los cuales se han realizado sobre la base de análisis numérico y los estándares relacionados. El tercer capítulo está dedicado ya al estudio de la tecnología y la investigación sobre los sistemas de C más idóneos; se incluyen estudios procedentes de departamentos académicos, comerciales y de arquitectura en general. En esta sección se desarrollan algunas pruebas estándar relacionadas con los diversos materiales seleccionados y se estudian varios ejemplos de productos similares. El cuarto capítulo incluye investigación de campo (in situ) y análisis de estudios de casos. Se contactó por correo con varias empresas notables de pavimentos en todo el mundo, y se examinaron específicamente aquellos productos cuyos fabricantes afirmaban ser amortiguadores. Esta parte de la investigación se vio ralentizada por la demora en los envíos. Una vez llegados se buscó un ámbito real donde poder recabar la opinión de las personas mayores y del personal adscrito a su cuidado. Todas las pruebas prácticas se realizaron en una residencia de ancianos de Barcelona durante unos dos meses, centrándose en el estudio de los actuales pavimentos del centro y los problemas actuales derivados relacionados con los usuarios. Todo este proceso se completó mediante entrevistas a usuarios y cuidadores con cuestionarios predefinidos. El Capítulo Cinco se refiere a los resultados, discusiones, sugerencias para la instalación y mejora de la seguridad del pavimento en áreas de riesgo. También se realizaron simulaciones sobre una posible estructura base de los pavimentos con el método elemento finito (FEM). El capítulo seis presenta directrices para desarrollos futuros. El autor investigó más a fondo sobre los materiales y su estructura, y se presenta como una base para desarrollos técnicos futuros. El autor considera que, con estudios más detallados, sería posible utilizar como CF otros materiales, bien naturales o reciclados a base de productos agrícolas, lo cual aumentaría la diversidad de la oferta de CF y fomentaría la arquitectura más sostenible.Postprint (published version