Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging

Adaptive imputation of missing values for incomplete pattern classification

In classification of incomplete pattern, the missing values can either play a crucial role in the class determination, or have only little influence (or eventually none) on the classification results according to the context. We propose a credal classification method for incomplete pattern with adaptive imputation of missing values based on belief function theory. At first, we try to classify the object (incomplete pattern) based only on the available attribute values. As underlying principle, we assume that the missing information is not crucial for the classification if a specific class for the object can be found using only the available information. In this case, the object is committed to this particular class. However, if the object cannot be classified without ambiguity, it means that the missing values play a main role for achieving an accurate classification. In this case, the missing values will be imputed based on the K-nearest neighbor (K-NN) and self-organizing map (SOM) techniques, and the edited pattern with the imputation is then classified. The (original or edited) pattern is respectively classified according to each training class, and the classification results represented by basic belief assignments are fused with proper combination rules for making the credal classification. The object is allowed to belong with different masses of belief to the specific classes and meta-classes (which are particular disjunctions of several single classes). The credal classification captures well the uncertainty and imprecision of classification, and reduces effectively the rate of misclassifications thanks to the introduction of meta-classes. The effectiveness of the proposed method with respect to other classical methods is demonstrated based on several experiments using artificial and real data sets

A novel neural network approach to cDNA microarray image segmentation

This is the post-print version of the Article. The official published version can be accessed from the link below. Copyright @ 2013 Elsevier.Microarray technology has become a great source of information for biologists to understand the workings of DNA which is one of the most complex codes in nature. Microarray images typically contain several thousands of small spots, each of which represents a different gene in the experiment. One of the key steps in extracting information from a microarray image is the segmentation whose aim is to identify which pixels within an image represent which gene. This task is greatly complicated by noise within the image and a wide degree of variation in the values of the pixels belonging to a typical spot. In the past there have been many methods proposed for the segmentation of microarray image. In this paper, a new method utilizing a series of artificial neural networks, which are based on multi-layer perceptron (MLP) and Kohonen networks, is proposed. The proposed method is applied to a set of real-world cDNA images. Quantitative comparisons between the proposed method and commercial software GenePix(®) are carried out in terms of the peak signal-to-noise ratio (PSNR). This method is shown to not only deliver results comparable and even superior to existing techniques but also have a faster run time.This work was funded in part by the National Natural Science Foundation of China under Grants 61174136 and 61104041, the Natural Science Foundation of Jiangsu Province of China under Grant BK2011598, the International Science and Technology Cooperation Project of China under Grant No. 2011DFA12910, the Engineering and Physical Sciences Research Council (EPSRC) of the U.K. under Grant GR/S27658/01, the Royal Society of the U.K., and the Alexander von Humboldt Foundation of Germany

A binary self-organizing map and its FPGA implementation

A binary Self Organizing Map (SOM) has been designed and implemented on a Field Programmable Gate Array (FPGA) chip. A novel learning algorithm which takes binary inputs and maintains tri-state weights is presented. The binary SOM has the capability of recognizing binary input sequences after training. A novel tri-state rule is used in updating the network weights during the training phase. The rule implementation is highly suited to the FPGA architecture, and allows extremely rapid training. This architecture may be used in real-time for fast pattern clustering and classification of the binary features