Effects of oil palm (elais guineensis) fruit extracts on glucose uptake activity of muscle, adipose and liver cells

The effect of oil palm (Elaeis guineensis) fruit aqueous extract (OPF) on glucose uptake activity of three different cell lines was investigated. The cell lines were incubated with different concentrations of OPF to evaluate the stimulatory effect of OPF towards glucose uptake activity of L6 myotubes, 3T3F442A adipocytes and Chang liver cell line. The glucose uptake activities of all tested cells were enhanced in the presence of OPF extract (basal condition). Nevertheless in combination of OPF extract and 100 nM insulin, the glucose uptake activity was only significantly enhanced in L6 myotubes and 3T3F442A adipocytes cell lines. The extracts enhanced the glucose uptake into cells through either insulin-mimetic or insulin-sensitizing property or combination of these two properties. It can be suggested that the OPF extract exerts its antihyperglycemic action partly by mediated glucose uptake into the glucose-responsive disposal cells, muscle, adipose and liver

Process analytical technology in food biotechnology

Biotechnology is an area where precision and reproducibility are vital. This is due to the fact that products are often in form of food, pharmaceutical or cosmetic products and therefore very close to the human being. To avoid human error during the production or the evaluation of the quality of a product and to increase the optimal utilization of raw materials, a very high amount of automation is desired. Tools in the food and chemical industry that aim to reach this degree of higher automation are summarized in an initiative called Process Analytical Technology (PAT). Within the scope of the PAT, is to provide new measurement technologies for the purpose of closed loop control in biotechnological processes. These processes are the most demanding processes in regards of control issues due to their very often biological rate-determining component. Most important for an automation attempt is deep process knowledge, which can only be achieved via appropriate measurements. These measurements can either be carried out directly, measuring a crucial physical value, or if not accessible either due to the lack of technology or a complicated sample state, via a soft-sensor.Even after several years the ideal aim of the PAT initiative is not fully implemented in the industry and in many production processes. On the one hand a lot effort still needs to be put into the development of more general algorithms which are more easy to implement and especially more reliable. On the other hand, not all the available advances in this field are employed yet. The potential users seem to stick to approved methods and show certain reservations towards new technologies.Die Biotechnologie ist ein Wissenschaftsbereich, in dem hohe Genauigkeit und Wiederholbarkeit eine wichtige Rolle spielen. Dies ist der Tatsache geschuldet, dass die hergestellten Produkte sehr oft den Bereichen Nahrungsmitteln, Pharmazeutika oder Kosmetik angehöhren und daher besonders den Menschen beeinflussen. Um den menschlichen Fehler bei der Produktion zu vermeiden, die Qualität eines Produktes zu sichern und die optimale Verwertung der Rohmaterialen zu gewährleisten, wird ein besonders hohes Maß an Automation angestrebt. Die Werkzeuge, die in der Nahrungsmittel- und chemischen Industrie hierfür zum Einsatz kommen, werden in der Process Analytical Technology (PAT) Initiative zusammengefasst. Ziel der PAT ist die Entwicklung zuverlässiger neuer Methoden, um Prozesse zu beschreiben und eine automatische Regelungsstrategie zu realisieren. Biotechnologische Prozesse gehören hierbei zu den aufwändigsten Regelungsaufgaben, da in den meisten Fällen eine biologische Komponente der entscheidende Faktor ist. Entscheidend für eine erfolgreiche Regelungsstrategie ist ein hohes Maß an Prozessverständnis. Dieses kann entweder durch eine direkte Messung der entscheidenden physikalischen, chemischen oder biologischen Größen gewonnen werden oder durch einen SoftSensor. Zusammengefasst zeigt sich, dass das finale Ziel der PAT Initiative auch nach einigen Jahren des Propagierens weder komplett in der Industrie noch bei vielen Produktionsprozessen angekommen ist. Auf der einen Seite liegt dies mit Sicherheit an der Tatsache, dass noch viel Arbeit in die Generalisierung von Algorithmen gesteckt werden muss. Diese müsse einfacher zu implementieren und vor allem noch zuverlässiger in der Funktionsweise sein. Auf der anderen Seite wurden jedoch auch Algorithmen, Regelungsstrategien und eigne Ansätze für einen neuartigen Sensor sowie einen Soft-Sensors vorgestellt, die großes Potential zeigen. Nicht zuletzt müssen die möglichen Anwender neue Strategien einsetzen und Vorbehalte gegenüber unbekannten Technologien ablegen

Control of Proton Exchange Membrane Fuel Cell System

265 p.In the era of sustainable development, proton exchange membrane (PEM) fuel cell technology has shown significant potential as a renewable energy source. This thesis focuses on improving the performance of the PEM fuel cell system through the use of appropriate algorithms for controlling the power interface. The main objective is to find an effective and optimal algorithm or control law for keeping the stack operating at an adequate power point. Add to this, it is intended to apply the artificial intelligence approach for studying the effect of temperature and humidity on the stack performance. The main points addressed in this study are : modeling of a PEM fuel cell system, studying the effect of temperature and humidity on the PEM fuel cell stack, studying the most common used power converters in renewable energy systems, studying the most common algorithms applied on fuel cell systems, design and implementation of a new MPPT control method for the PEM fuel cell system

A Design for Controllability Methodology for PEM Fuel Cells including the effect of Material Surface Defects on the Dynamic System Performance

Electric power has become indispensable for the development of society. Our quality of life is entirely dependent on the availability of electric energy in the industrial, commercial, and residential sectors. Most of this energy is currently obtained from non-renewable sources (oil, natural gas, and coal mainly). Unfortunately, the continuous combustion of these fuels has severely impacted the environment due to the continuous emissions of greenhouse gases. Therefore, the need to explore alternative energy sources in a wide array of applications is essential for the sustainability of our way of life. Hydrogen is one of the promising fuels of the future, which would allow a transition to a cleaner generation matrix. Although hydrogen is mostly obtained from reforming of natural gas, different pathways from renewable resources are developed and being researched. Therefore, the study of devices operating with hydrogen contributes to the construction of a sustainable future. Fuel cells are one of the most effective ways to transform hydrogen into electrical power. By definition, a fuel cell is an electrochemical device capable of producing electrical energy from a fuel and an oxidant. For Proton Exchange Membrane (PEM) fuel cells the fuel is hydrogen, which is supplied to the anode, and the oxidant agent is oxygen (or air) supplied to the cathode. In this research, a methodology is developed for the selection of fuel cells materials, considering how their properties influence the cell dynamic response. To achieve this, a test bench was designed and constructed to characterize the PEM fuel cells dynamic response, and laboratory tests were developed to perform defect characterization. Different membrane assemblies were tested to analyze the impact of their properties on the cell settling time, and therefore, determine its effect on the controllability of the system

Gasification for Practical Applications

Although there were many books and papers that deal with gasification, there has been only a few practical book explaining the technology in actual application and the market situation in reality. Gasification is a key technology in converting coal, biomass, and wastes to useful high-value products. Until renewable energy can provide affordable energy hopefully by the year 2030, gasification can bridge the transition period by providing the clean liquid fuels, gas, and chemicals from the low grade feedstock. Gasification still needs many upgrades and technology breakthroughs. It remains in the niche market, not fully competitive in the major market of electricity generation, chemicals, and liquid fuels that are supplied from relatively cheap fossil fuels. The book provides the practical information for researchers and graduate students who want to review the current situation, to upgrade, and to bring in a new idea to the conventional gasification technologies

Electric Power Conversion and Micro-Grids

This edited volume is a collection of reviewed and relevant research chapters offering a comprehensive overview of recent achievements in the field of micro-grids and electric power conversion. The book comprises single chapters authored by various researchers and is edited by a group of experts in such research areas. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on electric power conversion, micro-grids, and their up-to-the-minute technological advances and opens new possible research paths for further novel developments

Advanced Control and Estimation Concepts, and New Hardware Topologies for Future Mobility

According to the National Research Council, the use of embedded systems throughout society could well overtake previous milestones in the information revolution. Mechatronics is the synergistic combination of electronic, mechanical engineering, controls, software and systems engineering in the design of processes and products. Mechatronic systems put “intelligence” into physical systems. Embedded sensors/actuators/processors are integral parts of mechatronic systems. The implementation of mechatronic systems is consistently on the rise. However, manufacturers are working hard to reduce the implementation cost of these systems while trying avoid compromising product quality. One way of addressing these conflicting objectives is through new automatic control methods, virtual sensing/estimation, and new innovative hardware topologies

A Review of physics-based and data-driven models for real-time control of polymer electrolyte membrane fuel cells

The real-time model-based control of polymer electrolyte membrane (PEM) fuel cells requires a computationally efficient and sufficiently accurate model to predict the transient and long-term performance under various operational conditions, involving the pressure, temperature, humidity, and stoichiometry ratio. In this article, recent progress on the development of PEM fuel cell models that can be used for real-time control is reviewed. The major operational principles of PEM fuel cells and the associated mathematical description of the transport and electrochemical phenomena are described. The reduced-dimensional physics-based models (pseudo-two-dimensional, one-dimensional numerical and zero dimensional analytical models) and the non-physics-based models (zero-dimensional empirical and data-driven models) have been systematically examined, and the comparison of these models has been performed. It is found that the current trends for the real-time control models are (i) to couple the single cell model with balance of plants to investigate the system performance, (ii) to incorporate aging effects to enable long-term performance prediction, (iii) to increase the computational speed (especially for one-dimensional numerical models), and (iv) to develop data-driven models with artificial intelligence/machine learning algorithms. This review will be beneficial for the development of physics or non-physics based models with sufficient accuracy and computational speed to ensure the real-time control of PEM fuel cells.Toyota Motor Engineering & Manufacturing North America || Natural Sciences and Engineering Research Council of Canad

Entropy generation analysis of wildfire propagation

Entropy generation is commonly applied to describe the evolution of irreversible processes, such as heat transfer and turbulence. These are both dominating phenomena in fire propagation. In this paper, entropy generation analysis is applied to a grassland fire event, with the aim of finding possible links between entropy generation and propagation directions. The ultimate goal of such analysis consists in helping one to overcome possible limitations of the models usually applied to the prediction of wildfire propagation. These models are based on the application of the superimposition of the effects due to wind and slope, which has proven to fail in various cases. The analysis presented here shows that entropy generation allows a detailed analysis of the landscape propagation of a fire and can be thus applied to its quantitative descriptio

Energy management control strategies for energy storage systems of hybrid electric vehicle : A review

Continuous efforts to preserve the environment and to reduce gaseous emissions due to the massive growth of urban economic development and heightened concerns over crude oil depletion have accelerated researchers to find long-term solutions, particularly in the transportation sector with the focus on powertrain electrification. This article delivers a comprehensive overview of electric vehicle architectures, energy storage systems, and motor traction power. Subsequently, it emphasizes different charge equalization methodologies of the energy storage system. This work's contribution can be identified in two points: first, providing an overview of different energy management methods to researchers and scholars. Second, to highlight the state-of-the-art leanings in major components and to highlight promising approaches to hybrid electric vehicle future development