Towards dynamical network biomarkers in neuromodulation of episodic migraine

Computational methods have complemented experimental and clinical neursciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.Comment: 13 pages, 5 figure

Enhanced Receivers for Interference Cancellation in 3G Systems

Interference cancellation and multiuser detection in CDMA systems are still actual research topics. These techniques enable us to deal with interference and to increase system capacity. In this paper, a so-called Generalized RAKE receiver, an Uplink generalized multiuser detection and a Blind adaptive multiuser detection are described. These algorithms are compared with conventional receivers and their properties are verified via simulations. The results imply that some of these algorithms are able to overcome the performance of the conventional receivers

MIMO signal processing in offset-QAM based filter bank multicarrier systems

Next-generation communication systems have to comply with very strict requirements for increased flexibility in heterogeneous environments, high spectral efficiency, and agility of carrier aggregation. This fact motivates research in advanced multicarrier modulation (MCM) schemes, such as filter bank-based multicarrier (FBMC) modulation. This paper focuses on the offset quadrature amplitude modulation (OQAM)-based FBMC variant, known as FBMC/OQAM, which presents outstanding spectral efficiency and confinement in a number of channels and applications. Its special nature, however, generates a number of new signal processing challenges that are not present in other MCM schemes, notably, in orthogonal-frequency-division multiplexing (OFDM). In multiple-input multiple-output (MIMO) architectures, which are expected to play a primary role in future communication systems, these challenges are intensified, creating new interesting research problems and calling for new ideas and methods that are adapted to the particularities of the MIMO-FBMC/OQAM system. The goal of this paper is to focus on these signal processing problems and provide a concise yet comprehensive overview of the recent advances in this area. Open problems and associated directions for future research are also discussed.Peer ReviewedPostprint (author's final draft

Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease

The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, tract-based spatial statistics (TBSS) were performed on scans of 40 healthy elders, 19 non-amnestic MCI (MCIna) subjects, 14 amnestic MCI (MCIa) subjects and 9 AD patients. Significantly higher DA was found in MCIna subjects compared to healthy elders in the right posterior cingulum/precuneus. Significantly higher DA was also found in MCIa subjects compared to healthy elders in the left prefrontal cortex, particularly in the forceps minor and uncinate fasciculus. In the MCIa versus MCIna comparison, significantly higher DA was found in large areas of the left prefrontal cortex. For AD patients, the overlap of FA and DR changes and the overlap of FA and MD changes were seen in temporal, parietal and frontal lobes, as well as the corpus callosum and fornix. Analysis of differences between the AD versus MCIna, and AD versus MCIa contrasts, highlighted regions that are increasingly compromised in more severe disease stages. Microstructural damage independent of gross tissue loss was widespread in later disease stages. Our findings suggest a scheme where WM damage begins in the core memory network of the temporal lobe, cingulum and prefrontal regions, and spreads beyond these regions in later stages. DA and MD indices were most sensitive at detecting early changes in MCIa

Official long-term and short-term strategies for preventing the spread of rumors

Recently, public security incidents caused by rumor spreading have frequently occurred, leading to public panic, social chaos and even casualties. Therefore, how governments establish strategies to restrain rumor spreading is important for judging their governance capacity. Herein, we consider one long-term strategy (education) and two short-term strategies (isolation and debunking) for officials to intervene in rumor spreading. To investigate the effects of these strategies, an improved rumor-spreading model and a series of mean-field equations are proposed. Through theoretical analysis, the effective thresholds of three rumor-prevention strategies are obtained, respectively. Finally, through simulation analysis, the effectiveness of these strategies in preventing rumor spreading is investigated. The results indicate that long-term and short-term strategies are effective in suppressing rumor spreading. The greater the efforts of governments to suppress rumors, the smaller the final rumor size. The study also shows that the three strategies are the best when applied simultaneously. The government can adopt corresponding measures to suppress rumor spreading effectively

Oscillator-based neuronal modeling for seizure progression investigation and seizure control strategy

The coupled oscillator model has previously been used for the simulation of neuronal activities in in vitro rat hippocampal slice seizure data and the evaluation of seizure suppression algorithms. Each model unit can be described as either an oscillator which can generate action potential spike trains without inputs, or a threshold-based unit. With the change of only one parameter, each unit can either be an oscillator or a threshold-based spiking unit. This would eliminate the need for a new set of equations for each type of unit. Previous analysis has suggested that long kernel duration and imbalance of inhibitory feedback can cause the system to intermittently transition into and out of ictal activities. The state transitions of seizure-like events were investigated here; specifically, how the system excitability may change when the system undergoes transitions in the preictal and postictal processes. Analysis showed that the area of the excitation kernel is positively correlated with the mean firing rate of the ictal activity. The kernel duration is also correlated to the amount of ictal activity. The transition into ictal activity involved the escape from the saddle point foci in the state space trajectory identified by using Newton\u27s method. The ability to accurately anticipate and suppress seizures is an important endeavor that has tremendous impact on improving the quality of lives for epileptic patients. The stimulation studies have suggested that an electrical stimulation strategy that uses the intrinsic high complexity dynamics of the biological system may be more effective in reducing the duration of seizure-like activities in the computer model. In this research, we evaluate this strategy on an in vitro rat hippocampal slice magnesium-free model. Simulated postictal field potential data generated by an oscillator-based hippocampal network model was applied to the CA1 region of the rat hippocampal slices through a multi-electrode array (MEA) system. It was found to suppress and delay the onset of future seizures temporarily. The average inter-seizure time was found to be significantly prolonged after postictal stimulation when compared to the negative control trials and bipolar square wave signals. The result suggests that neural signal-based stimulation related to resetting may be suitable for seizure control in the clinical environment

Transceiver design and system optimization for ultra-wideband communications

This dissertation investigates the potential promises and proposes possible solutions to the challenges of designing transceivers and optimizing system parameters in ultra-wideband (UWB) systems. The goal is to provide guidelines for UWB transceiver implementations under constraints by regulation, existing interference, and channel estimation. New UWB pulse shapes are invented that satisfy the Federal Communications Commission spectral mask. Parameters are designed to possibly implement the proposed pulses. A link budget is quantified based on an accurate frequency-dependent path loss calculation to account for variations across the ultra-wide bandwidth of the signal. Achievable information rates are quantified as a function of transmission distance over additive white Gaussian noise and multipath channels under specific UWB constraints: limited power spectral density, specific modulation formats, and a highly dispersive channel. The effect of self-interference (SI) and inter-symbol interference (ISI) on channel capacity is determined, and modulation formats that mitigate against this effect is identified. Spreading gains of familiar UWB signaling formats are evaluated, and UWB signals are proved to be spread spectrum. Conditions are formulated for trading coding gain with spreading gain with only a small impact on performance. Numerical results are examined to demonstrate that over a frequency-selective channel, the spreading gain may be beneficial in reducing the SI and ISI resulting in higher information rates. A reduced-rank adaptive filtering technique is applied to the problem of interference suppression and optimum combining in UWB communications. The reduced-rank combining method, in particular the eigencanceler, is proposed and compared with a minimum mean square error Rake receiver. Simulation results are evaluated to show that the performance of the proposed method is superior to the minimum mean square error when the correlation matrix is estimated from limited data. Impact of channel estimation on UWB system performance is investigated when path delays and path amplitudes are jointly estimated. Cramér-Rao bound (CRB) expressions for the variance of path delay and amplitude estimates are formulated using maximum likelihood estimation. Using the errors obtained from the CRB, the effective signal-to-noise ratio for UWB Rake receivers employing maximum ratio combining (MRC) is devised in the presence of channel path delay and amplitude errors. An exact expression of the bit error rate (BER) for UWB Rake receivers with MRC is derived with imperfect estimates of channel path delays and amplitudes. Further, this analysis is applied to design optimal transceiver parameters. The BER is used as part of a binary symmetric channel and the achievable information rates are evaluated. The optimum power allocation and number of symbols allocated to the pilot are developed with respect to maximizing the information rate. The optimal signal bandwidth to be used for UWB communications is determined in the presence of imperfect channel state information. The number of multipath components to be collected by Rake receivers is designed to optimize performance with non-ideal channel estimation