A droplet routing technique for fault-tolerant digital microfluidic devices

Abstract—Efficient droplet routing is one of the key approaches for realizing fault-tolerant microfluidic biochips. It requires that run-time diagnosis and fault recovery can be made possible in such systems. This paper describes a droplet routing technique for a fault-tolerant digital microfluidic platform. This technique features handling of many microfluidic operations simultaneously and uses on-chip sensors for diagnosis at run-time.\ud Once a fault is detected during the droplet routing, recovery procedures will be started-up immediately. Faulty units on the chip will be marked and isolated from the array so that the remaining droplets can still be routed along a fault-free path to their destinations. This method guarantees a non-stop fault-tolerant operation for very large microfluidic arrays.\u

BioScript: programming safe chemistry on laboratories-on-a-chip

This paper introduces BioScript, a domain-specific language (DSL) for programmable biochemistry which executes on emerging microfluidic platforms. The goal of this research is to provide a simple, intuitive, and type-safe DSL that is accessible to life science practitioners. The novel feature of the language is its syntax, which aims to optimize human readability; the technical contributions of the paper include the BioScript type system and relevant portions of its compiler. The type system ensures that certain types of errors, specific to biochemistry, do not occur, including the interaction of chemicals that may be unsafe. The compiler includes novel optimizations that place biochemical operations to execute concurrently on a spatial 2D array platform on the granularity of a control flow graph, as opposed to individual basic blocks. Results are obtained using both a cycle-accurate microfluidic simulator and a software interface to a real-world platform

Digital Microfluidics as a Reconfiguration Mechanism for Antennas

This dissertation work concentrates on novel reconfiguration technologies, including design, microfabrication, and characterization aspects with an emphasis on their applications to multifunctional reconfigurable antennas. In the literature, reconfigurable antennas have made use of various reconfiguration techniques. The most common techniques utilized revolved around switching mechanisms. Other techniques such as the incorporation of variable capacitors, varactors, and physical structure manipulation surfaced recently to overcome many problems faced in using switches and their biasing. Usage of fluids (micro-fluidic or otherwise) in antennas provides a conceptually easy reconfiguration mechanism in the aspect of physical alteration. However, a requirement of pumps, valves, etc. for liquid transportation makes the antenna implementations rather impractical for the real-life scenarios. This work reports on design and experiments conducted to evaluate the electrowetting on dielectric (EWOD) driven digital microfluidics as a reconfiguration mechanism for antennas

Reconfigurable pixel antennas for communications

Premi extraordinari doctorat curs 2012-2013, àmbit Enginyeria de les TICThe explosive growth of wireless communications has brought new requirements in terms of compactness, mobility and multi-functionality that pushes antenna research. In this context, recon gurable antennas have gained a lot of attention due to their ability to adjust dynamically their frequency and radiation properties, providing multiple functionalities and being able to adapt themselves to a changing environment. A pixel antenna is a particular type of recon gurable antenna composed of a grid of metallic patches interconnected by RF-switches which can dynamically reshape its active surface. This capability provides pixel antennas with a recon guration level much higher than in other recon gurable architectures. Despite the outstanding recon guration capabilities of pixel antennas, there are important practical issues related to the performance-complexity balance that must be addressed before they can be implemented in commercial systems. This doctoral work focuses on the minimization of the pixel antenna complexity while maximizing its recon guration capabilities, contributing to the development of pixel antennas from a conceptual structure towards a practical recon gurable antenna architecture. First, the conceptualization of novel pixel geometries is addressed. It is shown that antenna complexity can be signi cantly reduced by using multiple-sized pixels. This multi-size technique allows to design pixel antennas with a number of switches one order of magnitude lower than in common pixel structures, while preserving high multiparameter recon gurability. A new conceptual architecture where the pixel surface acts as a parasitic layer is also proposed. The parasitic nature of the pixel layer leads to important advantages regarding the switch biasing and integration possibilities. Secondly, new pixel recon guration technologies are explored. After investigating the capabilities of semiconductors and RF-MEMS switches, micro uidic technology is proposed as a new technology to create and remove liquid metal pixels rather than interconnecting them. Thirdly, the full multi-parameter recon guration capabilities of pixel antennas is explored, which contrasts with the partial explorations available in the literature. The maximum achievable recon guration ranges (frequency range, beam-steering angular range and polarization modes) as well as the linkage between the di erent parameter under recon guration are studied. Finally, the performance of recon gurable antennas in beam-steering applications is analyzed. Figures-of-merit are derived to quantify radiation pattern recon gurability, enabling the evaluation of the performance of recon gurable antennas, pixel antennas and recon guration algorithms.Award-winningPostprint (published version

Reconfigurable pixel antennas for communications

The explosive growth of wireless communications has brought new requirements in terms of compactness, mobility and multi-functionality that pushes antenna research. In this context, recon gurable antennas have gained a lot of attention due to their ability to adjust dynamically their frequency and radiation properties, providing multiple functionalities and being able to adapt themselves to a changing environment. A pixel antenna is a particular type of recon gurable antenna composed of a grid of metallic patches interconnected by RF-switches which can dynamically reshape its active surface. This capability provides pixel antennas with a recon guration level much higher than in other recon gurable architectures. Despite the outstanding recon guration capabilities of pixel antennas, there are important practical issues related to the performance-complexity balance that must be addressed before they can be implemented in commercial systems. This doctoral work focuses on the minimization of the pixel antenna complexity while maximizing its recon guration capabilities, contributing to the development of pixel antennas from a conceptual structure towards a practical recon gurable antenna architecture. First, the conceptualization of novel pixel geometries is addressed. It is shown that antenna complexity can be signi cantly reduced by using multiple-sized pixels. This multi-size technique allows to design pixel antennas with a number of switches one order of magnitude lower than in common pixel structures, while preserving high multiparameter recon gurability. A new conceptual architecture where the pixel surface acts as a parasitic layer is also proposed. The parasitic nature of the pixel layer leads to important advantages regarding the switch biasing and integration possibilities. Secondly, new pixel recon guration technologies are explored. After investigating the capabilities of semiconductors and RF-MEMS switches, micro uidic technology is proposed as a new technology to create and remove liquid metal pixels rather than interconnecting them. Thirdly, the full multi-parameter recon guration capabilities of pixel antennas is explored, which contrasts with the partial explorations available in the literature. The maximum achievable recon guration ranges (frequency range, beam-steering angular range and polarization modes) as well as the linkage between the di erent parameter under recon guration are studied. Finally, the performance of recon gurable antennas in beam-steering applications is analyzed. Figures-of-merit are derived to quantify radiation pattern recon gurability, enabling the evaluation of the performance of recon gurable antennas, pixel antennas and recon guration algorithms

Additively Manufactured Shape-changing RF Devices Enabled by Origami-inspired Structures

The work to be presented in this dissertation explores the possibility of implementing origami-inspired shape-changing structures into RF designs to enable continuous performance tunability as well as deployability. The research not only experimented novel structures that have unique mechanical behaviour, but also developed automated additive manufacturing (AM) fabrication process that pushes the boundary of realizable frequency from Sub-6 GHz to mm-wave. High-performance origami-inspired reconfigurable frequency selective surfaces (FSSs) and reflectarray antennas are realized for the first time at mm-wave frequencies via AM techniques. The research also investigated the idea of combining mechanical tuning and active tuning methods in a hybrid manner to realize the first truly conformal beam-forming phased array antenna that can be applied onto any arbitrary surface and can be re-calibrated with a 3D depth camera.Ph.D

MakerFluidics: low cost microfluidics for synthetic biology

Recent advancements in multilayer, multicellular, genetic logic circuits often rely on manual intervention throughout the computation cycle and orthogonal signals for each chemical “wire”. These constraints can prevent genetic circuits from scaling. Microfluidic devices can be used to mitigate these constraints. However, continuous-flow microfluidics are largely designed through artisanal processes involving hand-drawing features and accomplishing design rule checks visually: processes that are also inextensible. Additionally, continuous-flow microfluidic routing is only a consideration during chip design and, once built, the routing structure becomes “frozen in silicon,” or for many microfluidic chips “frozen in polydimethylsiloxane (PDMS)”; any changes to fluid routing often require an entirely new device and control infrastructure. The cost of fabricating and controlling a new device is high in terms of time and money; attempts to reduce one cost measure are, generally, paid through increases in the other. This work has three main thrusts: to create a microfluidic fabrication framework, called MakerFluidics, that lowers the barrier to entry for designing and fabricating microfluidics in a manner amenable to automation; to prove this methodology can design, fabricate, and control complex and novel microfluidic devices; and to demonstrate the methodology can be used to solve biologically-relevant problems. Utilizing accessible technologies, rapid prototyping, and scalable design practices, the MakerFluidics framework has demonstrated its ability to design, fabricate and control novel, complex and scalable microfludic devices. This was proven through the development of a reconfigurable, continuous-flow routing fabric driven by a modular, scalable primitive called a transposer. In addition to creating complex microfluidic networks, MakerFluidics was deployed in support of cutting-edge, application-focused research at the Charles Stark Draper Laboratory. Informed by a design of experiments approach using the parametric rapid prototyping capabilities made possible by MakerFluidics, a plastic blood--bacteria separation device was optimized, demonstrating that the new device geometry can separate bacteria from blood while operating at 275% greater flow rate as well as reduce the power requirement by 82% for equivalent separation performance when compared to the state of the art. Ultimately, MakerFluidics demonstrated the ability to design, fabricate, and control complex and practical microfluidic devices while lowering the barrier to entry to continuous-flow microfluidics, thus democratizing cutting edge technology beyond a handful of well-resourced and specialized labs

Reconfigurable antennas and radio wave propagation at millimeter-wave frequencies

For the last decades we have been witnessing the evolution of wireless radio networks. Since new devices appear and the mobile traffic, as well as the number of users, grows rapidly, there is a great demand in high capacity communications with better coverage, high transmission quality, and more efficient use of the radio spectrum. In this thesis, reconfigurable antennas at micro- and millimeter-wave frequencies and peculiar properties of radio wave propagation at mm-wave frequencies are studied. Reconfigurable antennas can improve radio link performance. Recently, many different concepts have been developed in the reconfigurable antenna design to control the antenna bandwidth, resonant frequency, polarization, and radiation properties. In the first part of the thesis, we investigate mechanically tunable antennas operating at microwave frequencies with the ability to change the shape of the conductor element and, consequently, to control the radiation properties of the antenna. Also in the first part, we study conformal antenna arraysfor 60 GHz applications based on cylindrical structures. Beam switching technology is implemented by realizing several antenna arrays around the cylinder with a switching network.Scanning angles of +34˚/-32˚ are achieved. Moreover, it is vital to study radio wave propagation peculiarities at mm-wave frequencies in indoor and outdoor environments to be able to deploy wireless networks effectively. The propagation part of the thesis focuses on several aspects. First, we investigate how the estimation of optimum antenna configurations in indoor environment can be done usingrealistic propagation models at 60 GHz. Ray tracing simulations are performed and realistic human blockage models are considered. Second, we present the results from a measurement campaign where reflection and scattering properties of two different built surfaces are studied in the millimeter-wave E-band (71-76 and 81-86 GHz). Next, we present a geometry based channel model for a street canyon scenario, using angular-domain measurement results to calculate realistic power angular spectra in the azimuth and elevation planes. Then, we evaluate propagation effects on the radio channel on the rooftop of the buildings bymeasurements and simulations. We have used unmanned aerial vehicles and photogrammetrytechnique to create a highly accurate 3D model of the environment. Based on a comparison of the measured and simulated power delay profiles, we show that the highly accurate 3D modelsare beneficial in radio wave propagation planning at mm-wave frequencies instead of using simple geometrical models

Advances in Optofluidics

Optofluidics a niche research field that integrates optics with microfluidics. It started with elegant demonstrations of the passive interaction of light and liquid media such as liquid waveguides and liquid tunable lenses. Recently, the optofluidics continues the advance in liquid-based optical devices/systems. In addition, it has expanded rapidly into many other fields that involve lightwave (or photon) and liquid media. This Special Issue invites review articles (only review articles) that update the latest progress of the optofluidics in various aspects, such as new functional devices, new integrated systems, new fabrication techniques, new applications, etc. It covers, but is not limited to, topics such as micro-optics in liquid media, optofluidic sensors, integrated micro-optical systems, displays, optofluidics-on-fibers, optofluidic manipulation, energy and environmental applciations, and so on