Automatic categorization of diverse experimental information in the bioscience literature

Background: Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM). This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD). We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance. Results: We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI). It is being used in the curation work flow at WormBase for automatic association of newly published papers with ten data types including RNAi, antibody, phenotype, gene regulation, mutant allele sequence, gene expression, gene product interaction, overexpression phenotype, gene interaction, and gene structure correction. Conclusions: Our methods are applicable to a variety of data types with training set containing several hundreds to a few thousand documents. It is completely automatic and, thus can be readily incorporated to different workflow at different literature-based databases. We believe that the work presented here can contribute greatly to the tremendous task of automating the important yet labor-intensive biocuration effort

Improving the text classification using clustering and a novel HMM to reduce the dimensionality

In text classification problems, the representation of a document has a strong impact on the performance of learning systems. The high dimensionality of the classical structured representations can lead to burdensome computations due to the great size of real-world data. Consequently, there is a need for reducing the quantity of handled information to improve the classification process. In this paper, we propose a method to reduce the dimensionality of a classical text representation based on a clustering technique to group documents, and a previously developed Hidden Markov Model to represent them. We have applied tests with the k-NN and SVM classifiers on the OHSUMED and TREC benchmark text corpora using the proposed dimensionality reduction technique. The experimental results obtained are very satisfactory compared to commonly used techniques like InfoGain and the statistical tests performed demonstrate the suitability of the proposed technique for the preprocessing step in a text classification task.European Union | Ref. FP7/REGPOT-2012-2013.1, 316265 BIOCAPSUniversidade de Vigo | Ref. 12VI0

Information retrieval and text mining technologies for chemistry

Efficient access to chemical information contained in scientific literature, patents, technical reports, or the web is a pressing need shared by researchers and patent attorneys from different chemical disciplines. Retrieval of important chemical information in most cases starts with finding relevant documents for a particular chemical compound or family. Targeted retrieval of chemical documents is closely connected to the automatic recognition of chemical entities in the text, which commonly involves the extraction of the entire list of chemicals mentioned in a document, including any associated information. In this Review, we provide a comprehensive and in-depth description of fundamental concepts, technical implementations, and current technologies for meeting these information demands. A strong focus is placed on community challenges addressing systems performance, more particularly CHEMDNER and CHEMDNER patents tasks of BioCreative IV and V, respectively. Considering the growing interest in the construction of automatically annotated chemical knowledge bases that integrate chemical information and biological data, cheminformatics approaches for mapping the extracted chemical names into chemical structures and their subsequent annotation together with text mining applications for linking chemistry with biological information are also presented. Finally, future trends and current challenges are highlighted as a roadmap proposal for research in this emerging field.A.V. and M.K. acknowledge funding from the European Community’s Horizon 2020 Program (project reference: 654021 - OpenMinted). M.K. additionally acknowledges the Encomienda MINETAD-CNIO as part of the Plan for the Advancement of Language Technology. O.R. and J.O. thank the Foundation for Applied Medical Research (FIMA), University of Navarra (Pamplona, Spain). This work was partially funded by Consellería de Cultura, Educación e Ordenación Universitaria (Xunta de Galicia), and FEDER (European Union), and the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684). We thank Iñigo Garciá -Yoldi for useful feedback and discussions during the preparation of the manuscript.info:eu-repo/semantics/publishedVersio

Knowledge mining over scientific literature and technical documentation

Abstract This dissertation focuses on the extraction of information implicitly encoded in domain descriptions (technical terminology and related items) and its usage within a restricted-domain question answering system (QA). Since different variants of the same term can be used to refer to the same domain entity, it is necessary to recognize all possible forms of a given term and structure them, so that they can be used in the question answering process. The knowledge about domain descriptions and their mutual relations is leveraged in an extension to an existing QA system, aimed at the technical maintenance manual of a well-known commercial aircraft. The original version of the QA system did not make use of domain descriptions, which are the novelty introduced by the present work. The explicit treatment of domain descriptions provided considerable gains in terms of efficiency, in particular in the process of analysis of the background document collection. Similar techniques were later applied to another domain (biomedical scientific literature), focusing in particular on protein- protein interactions. This dissertation describes in particular: (1) the extraction of domain specific lexical items which refer to entities of the domain; (2) the detection of relationships (like synonymy and hyponymy) among such items, and their organization into a conceptual structure; (3) their usage within a domain restricted question answering system, in order to facilitate the correct identification of relevant answers to a query; (4) the adaptation of the system to another domain, and extension of the basic hypothesis to tasks other than question answering. Zusammenfassung Das Thema dieser Dissertation ist die Extraktion von Information, welche implizit in technischen Terminologien und ähnlichen Ressourcen enthalten ist, sowie ihre Anwendung in einem Antwortextraktionssystem (AE). Da verschiedene Varianten desselben Terms verwendet werden können, um auf den gleichen Begriff zu verweisen, ist die Erkennung und Strukturierung aller möglichen Formen Voraussetzung für den Einsatz in einem AE-System. Die Kenntnisse über Terme und deren Relationen werden in einem AE System angewandt, welches auf dem Wartungshandbuch eines bekannten Verkehrsflugzeug fokussiert. Die ursprüngliche Version des Systems hatte keine explizite Behandlung von Terminologie. Die explizite Behandlung von Terminologie lieferte eine beachtliche Verbesserung der Effizienz des Systems, insbesondere was die Analyse der zugrundeliegenden Dokumentensammlung betrifft. Ähnliche Methodologien wurden später auf einer anderen Domäne angewandt (biomedizinische Literatur), mit einen besonderen Fokus auf Interaktionen zwischen Proteinen. Diese Dissertation beschreibt insbesondere: (1) die Extraktion der Terminologie (2) die Identifikation der Relationen zwischen Termen (wie z.B. Synonymie und Hyponymie) (3) deren Verwendung in einen AE System (4) die Portierung des Systems auf eine andere Domäne

Mining the Medical and Patent Literature to Support Healthcare and Pharmacovigilance

Recent advancements in healthcare practices and the increasing use of information technology in the medical domain has lead to the rapid generation of free-text data in forms of scientific articles, e-health records, patents, and document inventories. This has urged the development of sophisticated information retrieval and information extraction technologies. A fundamental requirement for the automatic processing of biomedical text is the identification of information carrying units such as the concepts or named entities. In this context, this work focuses on the identification of medical disorders (such as diseases and adverse effects) which denote an important category of concepts in the medical text. Two methodologies were investigated in this regard and they are dictionary-based and machine learning-based approaches. Futhermore, the capabilities of the concept recognition techniques were systematically exploited to build a semantic search platform for the retrieval of e-health records and patents. The system facilitates conventional text search as well as semantic and ontological searches. Performance of the adapted retrieval platform for e-health records and patents was evaluated within open assessment challenges (i.e. TRECMED and TRECCHEM respectively) wherein the system was best rated in comparison to several other competing information retrieval platforms. Finally, from the medico-pharma perspective, a strategy for the identification of adverse drug events from medical case reports was developed. Qualitative evaluation as well as an expert validation of the developed system's performance showed robust results. In conclusion, this thesis presents approaches for efficient information retrieval and information extraction from various biomedical literature sources in the support of healthcare and pharmacovigilance. The applied strategies have potential to enhance the literature-searches performed by biomedical, healthcare, and patent professionals. The applied strategies have potential to enhance the literature-searches performed by biomedical, healthcare, and patent professionals. This can promote the literature-based knowledge discovery, improve the safety and effectiveness of medical practices, and drive the research and development in medical and healthcare arena

Biomedical concept association and clustering using word embeddings

Indiana University-Purdue University Indianapolis (IUPUI)Biomedical data exists in the form of journal articles, research studies, electronic health records, care guidelines, etc. While text mining and natural language processing tools have been widely employed across various domains, these are just taking off in the healthcare space. A primary hurdle that makes it difficult to build artificial intelligence models that use biomedical data, is the limited amount of labelled data available. Since most models rely on supervised or semi-supervised methods, generating large amounts of pre-processed labelled data that can be used for training purposes becomes extremely costly. Even for datasets that are labelled, the lack of normalization of biomedical concepts further affects the quality of results produced and limits the application to a restricted dataset. This affects reproducibility of the results and techniques across datasets, making it difficult to deploy research solutions to improve healthcare services. The research presented in this thesis focuses on reducing the need to create labels for biomedical text mining by using unsupervised recurrent neural networks. The proposed method utilizes word embeddings to generate vector representations of biomedical concepts based on semantics and context. Experiments with unsupervised clustering of these biomedical concepts show that concepts that are similar to each other are clustered together. While this clustering captures different synonyms of the same concept, it also captures the similarities between various diseases and the symptoms that those diseases are symptomatic of. To test the performance of the concept vectors on corpora of documents, a document vector generation method that utilizes these concept vectors is also proposed. The document vectors thus generated are used as an input to clustering algorithms, and the results show that across multiple corpora, the proposed methods of concept and document vector generation outperform the baselines and provide more meaningful clustering. The applications of this document clustering are huge, especially in the search and retrieval space, providing clinicians, researchers and patients more holistic and comprehensive results than relying on the exclusive term that they search for. At the end, a framework for extracting clinical information that can be mapped to electronic health records from preventive care guidelines is presented. The extracted information can be integrated with the clinical decision support system of an electronic health record. A visualization tool to better understand and observe patient trajectories is also explored. Both these methods have potential to improve the preventive care services provided to patients

The Protein-Protein Interaction tasks of BioCreative III: classification/ranking of articles and linking bio-ontology concepts to full text

BACKGROUND: Determining usefulness of biomedical text mining systems requires realistic task definition and data selection criteria without artificial constraints, measuring performance aspects that go beyond traditional metrics. The BioCreative III Protein-Protein Interaction (PPI) tasks were motivated by such considerations, trying to address aspects including how the end user would oversee the generated output, for instance by providing ranked results, textual evidence for human interpretation or measuring time savings by using automated systems. Detecting articles describing complex biological events like PPIs was addressed in the Article Classification Task (ACT), where participants were asked to implement tools for detecting PPI-describing abstracts. Therefore the BCIII-ACT corpus was provided, which includes a training, development and test set of over 12,000 PPI relevant and non-relevant PubMed abstracts labeled manually by domain experts and recording also the human classification times. The Interaction Method Task (IMT) went beyond abstracts and required mining for associations between more than 3,500 full text articles and interaction detection method ontology concepts that had been applied to detect the PPIs reported in them.RESULTS:A total of 11 teams participated in at least one of the two PPI tasks (10 in ACT and 8 in the IMT) and a total of 62 persons were involved either as participants or in preparing data sets/evaluating these tasks. Per task, each team was allowed to submit five runs offline and another five online via the BioCreative Meta-Server. From the 52 runs submitted for the ACT, the highest Matthew's Correlation Coefficient (MCC) score measured was 0.55 at an accuracy of 89 and the best AUC iP/R was 68. Most ACT teams explored machine learning methods, some of them also used lexical resources like MeSH terms, PSI-MI concepts or particular lists of verbs and nouns, some integrated NER approaches. For the IMT, a total of 42 runs were evaluated by comparing systems against manually generated annotations done by curators from the BioGRID and MINT databases. The highest AUC iP/R achieved by any run was 53, the best MCC score 0.55. In case of competitive systems with an acceptable recall (above 35) the macro-averaged precision ranged between 50 and 80, with a maximum F-Score of 55. CONCLUSIONS: The results of the ACT task of BioCreative III indicate that classification of large unbalanced article collections reflecting the real class imbalance is still challenging. Nevertheless, text-mining tools that report ranked lists of relevant articles for manual selection can potentially reduce the time needed to identify half of the relevant articles to less than 1/4 of the time when compared to unranked results. Detecting associations between full text articles and interaction detection method PSI-MI terms (IMT) is more difficult than might be anticipated. This is due to the variability of method term mentions, errors resulting from pre-processing of articles provided as PDF files, and the heterogeneity and different granularity of method term concepts encountered in the ontology. However, combining the sophisticated techniques developed by the participants with supporting evidence strings derived from the articles for human interpretation could result in practical modules for biological annotation workflows

Semi-Supervised Learning For Identifying Opinions In Web Content

Thesis (Ph.D.) - Indiana University, Information Science, 2011Opinions published on the World Wide Web (Web) offer opportunities for detecting personal attitudes regarding topics, products, and services. The opinion detection literature indicates that both a large body of opinions and a wide variety of opinion features are essential for capturing subtle opinion information. Although a large amount of opinion-labeled data is preferable for opinion detection systems, opinion-labeled data is often limited, especially at sub-document levels, and manual annotation is tedious, expensive and error-prone. This shortage of opinion-labeled data is less challenging in some domains (e.g., movie reviews) than in others (e.g., blog posts). While a simple method for improving accuracy in challenging domains is to borrow opinion-labeled data from a non-target data domain, this approach often fails because of the domain transfer problem: Opinion detection strategies designed for one data domain generally do not perform well in another domain. However, while it is difficult to obtain opinion-labeled data, unlabeled user-generated opinion data are readily available. Semi-supervised learning (SSL) requires only limited labeled data to automatically label unlabeled data and has achieved promising results in various natural language processing (NLP) tasks, including traditional topic classification; but SSL has been applied in only a few opinion detection studies. This study investigates application of four different SSL algorithms in three types of Web content: edited news articles, semi-structured movie reviews, and the informal and unstructured content of the blogosphere. SSL algorithms are also evaluated for their effectiveness in sparse data situations and domain adaptation. Research findings suggest that, when there is limited labeled data, SSL is a promising approach for opinion detection in Web content. Although the contributions of SSL varied across data domains, significant improvement was demonstrated for the most challenging data domain--the blogosphere--when a domain transfer-based SSL strategy was implemented