Responsible Research and Innovation between \u201cnew governance\u201d and fundamental rights

This chapter frames RRI as an emerging governance approach in the EU regulatory context. We argue that reference to fundamental rights makes RRI a distinctive approach to responsibility compared to other existing paradigms and that human rights, in particular those laid down in the Charter of Fundamental Rights of the European Union, are not necessarily a constraint but can instead be a catalyst of innovation. Eventually we maintain that a governance framework based on the complementarity between legal norms and voluntary commitments might successfully combine the respect of fundamental rights with the openness and flexibility of the innovation process

Approximation with Random Bases: Pro et Contra

In this work we discuss the problem of selecting suitable approximators from families of parameterized elementary functions that are known to be dense in a Hilbert space of functions. We consider and analyze published procedures, both randomized and deterministic, for selecting elements from these families that have been shown to ensure the rate of convergence in $L_2$ norm of order $O(1/N)$, where $N$ is the number of elements. We show that both randomized and deterministic procedures are successful if additional information about the families of functions to be approximated is provided. In the absence of such additional information one may observe exponential growth of the number of terms needed to approximate the function and/or extreme sensitivity of the outcome of the approximation to parameters. Implications of our analysis for applications of neural networks in modeling and control are illustrated with examples.Comment: arXiv admin note: text overlap with arXiv:0905.067

Policy options for including LULUCF in the EU reduction commitment and policy instruments for increasing GHG mitigation efforts in the LULUCF and agriculture sectors

Land use, land-use change and forestry (LULUCF) is an inventory sector defined by the Intergovern-mental Panel on Climate Change (IPCC) that covers anthropogenic emissions and removals of GHGs resulting from changes in terrestrial carbon stocks. The EU has committed unilaterally to reduce its overall greenhouse gas (GHG) emissions to 20 % be-low 1990 levels by 2020, and to 30 % below 1990 levels if conditions are right

Developing a cellular automata model of urban growth to inform spatial policy for flood mitigation:A case study in Kampala, Uganda

Urban growth may intensify local flooding problems. Understanding the spatially explicit flood consequences of possible future land cover patterns contributes to inform policy for mitigating these impacts. A cellular automata model has been coupled with the openLISEM integrated flood modeling tool to simulate scenarios of urban growth and their consequent flood; the urban growth model makes use of a continuous response variable (the percentage of built-up area) and a spatially explicit simulation of supply for urban development. The models were calibrated for Upper Lubigi (Kampala, Uganda), a sub-catchment that experienced rapid urban growth during 2004–2010; this data scarce environment was chosen in part to test the model's performance with data inputs that introduced important uncertainty. The cellular automata model was validated in Nalukolongo (Kampala, Uganda). The calibrated modeling ensemble was then used to simulate urban growth scenarios of Upper Lubigi for 2020. Two scenarios, trend conditions and a policy of strict protection of existing wetlands, were simulated. The results of simulated scenarios for Upper Lubigi show how a policy of only protecting wetlands is ineffective; further, a substantial increase of flood impacts, attributable to urban growth, should be expected by 2020. The coupled models are operational with regard to the simulation of dynamic feedbacks between flood and suitability for urban growth. The tool proved useful in generating meaningful scenarios of land cover change and comparing their policy drivers as flood mitigation measures in a data scarce environment

Working Notes from the 1992 AAAI Spring Symposium on Practical Approaches to Scheduling and Planning

The symposium presented issues involved in the development of scheduling systems that can deal with resource and time limitations. To qualify, a system must be implemented and tested to some degree on non-trivial problems (ideally, on real-world problems). However, a system need not be fully deployed to qualify. Systems that schedule actions in terms of metric time constraints typically represent and reason about an external numeric clock or calendar and can be contrasted with those systems that represent time purely symbolically. The following topics are discussed: integrating planning and scheduling; integrating symbolic goals and numerical utilities; managing uncertainty; incremental rescheduling; managing limited computation time; anytime scheduling and planning algorithms, systems; dependency analysis and schedule reuse; management of schedule and plan execution; and incorporation of discrete event techniques

Autonomía Indígena y Justicia para Mujeres Indígenas Latinoamericanas

My paper deals with indigenous peoples’ rights, focusing on Latin American case-law related to gender issues. Latin American Courts have faced cases related to sexual crimes or domestic violence among indigenous people and have to choose between giving pre-eminence to women’s rights or indigenous autonomy. On deciding those cases, the tools provided by the proportionality test are paramount in order to analyse the case-law. The indigenous rights regimes (ILO-169, UNDRIP) may prevail or not against other human rights systems (which specially protect women or children) according to the facts of the case, but also according to domestic legal cultures modelled by the country’s historical evolution.Este trabajo analiza los derechos de los pueblos indígenas, centrándose en la jurisprudencia latinoamericana relacionada con cuestiones de género. Los tribunales latinoamericanos han enfrentado casos relacionados con crímenes sexuales o violencia intra-familiar entre indígenas y tienen que decidir entre dar preeminencia a los derechos de las mujeres o la autonomía indígena. Al resolver estos casos, las herramientas proporcionadas por el test de proporcionalidad son esenciales para analizar la jurisprudencia. Los regímenes de derechos indígenas (ILO-169, UNDRIP) pueden prevalecer o no contra otros sistemas de derechos humanos (que protegen especialmente a las mujeres o los niños) de acuerdo con los hechos del caso, pero también de acuerdo con la cultura jurídica modeladas por la diversa evolución histórica de cada país

Treatment Effect Quantification for Time-to-event Endpoints -- Estimands, Analysis Strategies, and beyond

A draft addendum to ICH E9 has been released for public consultation in August 2017. The addendum focuses on two topics particularly relevant for randomized confirmatory clinical trials: estimands and sensitivity analyses. The need to amend ICH E9 grew out of the realization of a lack of alignment between the objectives of a clinical trial stated in the protocol and the accompanying quantification of the "treatment effect" reported in a regulatory submission. We embed time-to-event endpoints in the estimand framework, and discuss how the four estimand attributes described in the addendum apply to time-to-event endpoints. We point out that if the proportional hazards assumption is not met, the estimand targeted by the most prevalent methods used to analyze time-to-event endpoints, logrank test and Cox regression, depends on the censoring distribution. We discuss for a large randomized clinical trial how the analyses for the primary and secondary endpoints as well as the sensitivity analyses actually performed in the trial can be seen in the context of the addendum. To the best of our knowledge, this is the first attempt to do so for a trial with a time-to-event endpoint. Questions that remain open with the addendum for time-to-event endpoints and beyond are formulated, and recommendations for planning of future trials are given. We hope that this will provide a contribution to developing a common framework based on the final version of the addendum that can be applied to design, protocols, statistical analysis plans, and clinical study reports in the future.Comment: 37 page