Status of the differential transformation method

Further to a recent controversy on whether the differential transformation method (DTM) for solving a differential equation is purely and solely the traditional Taylor series method, it is emphasized that the DTM is currently used, often only, as a technique for (analytically) calculating the power series of the solution (in terms of the initial value parameters). Sometimes, a piecewise analytic continuation process is implemented either in a numerical routine (e.g., within a shooting method) or in a semi-analytical procedure (e.g., to solve a boundary value problem). Emphasized also is the fact that, at the time of its invention, the currently-used basic ingredients of the DTM (that transform a differential equation into a difference equation of same order that is iteratively solvable) were already known for a long time by the "traditional"-Taylor-method users (notably in the elaboration of software packages --numerical routines-- for automatically solving ordinary differential equations). At now, the defenders of the DTM still ignore the, though much better developed, studies of the "traditional"-Taylor-method users who, in turn, seem to ignore similarly the existence of the DTM. The DTM has been given an apparent strong formalization (set on the same footing as the Fourier, Laplace or Mellin transformations). Though often used trivially, it is easily attainable and easily adaptable to different kinds of differentiation procedures. That has made it very attractive. Hence applications to various problems of the Taylor method, and more generally of the power series method (including noninteger powers) has been sketched. It seems that its potential has not been exploited as it could be. After a discussion on the reasons of the "misunderstandings" which have caused the controversy, the preceding topics are concretely illustrated.Comment: To appear in Applied Mathematics and Computation, 29 pages, references and further considerations adde

Mathematical Modeling of Biological Systems

Mathematical modeling is a powerful approach supporting the investigation of open problems in natural sciences, in particular physics, biology and medicine. Applied mathematics allows to translate the available information about real-world phenomena into mathematical objects and concepts. Mathematical models are useful descriptive tools that allow to gather the salient aspects of complex biological systems along with their fundamental governing laws, by elucidating the system behavior in time and space, also evidencing symmetry, or symmetry breaking, in geometry and morphology. Additionally, mathematical models are useful predictive tools able to reliably forecast the future system evolution or its response to specific inputs. More importantly, concerning biomedical systems, such models can even become prescriptive tools, allowing effective, sometimes optimal, intervention strategies for the treatment and control of pathological states to be planned. The application of mathematical physics, nonlinear analysis, systems and control theory to the study of biological and medical systems results in the formulation of new challenging problems for the scientific community. This Special Issue includes innovative contributions of experienced researchers in the field of mathematical modelling applied to biology and medicine