An application protocol for CAD to CAD transfer of electronic information

The exchange of Computer Aided Design (CAD) information between dissimilar CAD systems is a problem. This is especially true for transferring electronics CAD information such as multi-chip module (MCM), hybrid microcircuit assembly (HMA), and printed circuit board (PCB) designs. Currently, there exists several neutral data formats for transferring electronics CAD information. These include IGES, EDIF, and DXF formats. All these formats have limitations for use in exchanging electronic data. In an attempt to overcome these limitations, the Navy's MicroCIM program implemented a project to transfer hybrid microcircuit design information between dissimilar CAD systems. The IGES (Initial Graphics Exchange Specification) format is used since it is well established within the CAD industry. The goal of the project is to have a complete transfer of microelectronic CAD information, using IGES, without any data loss. An Application Protocol (AP) is being developed to specify how hybrid microcircuit CAD information will be represented by IGES entity constructs. The AP defines which IGES data items are appropriate for describing HMA geometry, connectivity, and processing as well as HMA material characteristics

A New Method for Variant Design Technology in ECAD

One of the most important approaches to enable cost and time reduction with respect to Computer-AidedDesign for electrical/electromechanical engineering (ECAD/ECAE) is to develop, generate, and handle designvariants in an efficient manner. The objective of this paper is to present a generic variant design technologyapproach that has a high potential for the efficient reusability of existing projects. More precisely, the paperwill present the procedure to allow the new methodology in variant design technology to be implementedwithin an arbitrary ECAD environment. The method presented automatically generates a complete technicaldocumentation of an electrical installation on the basis of a placed order specification. This involves threemajor steps. Firstly, a product variant of an installation is configured on the basis of existing standardisedmodules. Secondly, based upon the corresponding configuration file, a set of commands describing thegeneration of a typical ECAD project containing the configured modules is automatically compiled. This is akey novelty, as all commands are expressed in a non-system specific meta-language, which can then beautomatically translated into a macro programming language of a specific ECAD system and stored as a file.Thirdly, the specific ECAD system can import and process the file to create a practical ECAD project ofrealistic complexity

Protecting entanglement from correlated amplitude damping channel using weak measurement and quantum measurement reversal

Based on the quantum technique of weak measurement, we propose a scheme to protect the entanglement from correlated amplitude damping decoherence. In contrast to the results of memoryless amplitude damping channel, we show that the memory effects play a significant role in the suppression of entanglement sudden death and protection of entanglement under severe decoherence. Moreover, we find that the initial entanglement could be drastically amplified by the combination of weak measurement and quantum measurement reversal even under the correlated amplitude damping channel. The underlying mechanism can be attributed to the probabilistic nature of weak measurements.Comment: 11 pages, 5 figures, accepted by Quantum Information Processin

Collective and single cell behavior in epithelial contact inhibition

Control of cell proliferation is a fundamental aspect of tissue physiology central to morphogenesis, wound healing and cancer. Although many of the molecular genetic factors are now known, the system level regulation of growth is still poorly understood. A simple form of inhibition of cell proliferation is encountered in vitro in normally differentiating epithelial cell cultures and is known as "contact inhibition". The study presented here provides a quantitative characterization of contact inhibition dynamics on tissue-wide and single cell levels. Using long-term tracking of cultured MDCK cells we demonstrate that inhibition of cell division in a confluent monolayer follows inhibition of cell motility and sets in when mechanical constraint on local expansion causes divisions to reduce cell area. We quantify cell motility and cell cycle statistics in the low density confluent regime and their change across the transition to epithelial morphology which occurs with increasing cell density. We then study the dynamics of cell area distribution arising through reductive division, determine the average mitotic rate as a function of cell size and demonstrate that complete arrest of mitosis occurs when cell area falls below a critical value. We also present a simple computational model of growth mechanics which captures all aspects of the observed behavior. Our measurements and analysis show that contact inhibition is a consequence of mechanical interaction and constraint rather than interfacial contact alone, and define quantitative phenotypes that can guide future studies of molecular mechanisms underlying contact inhibition

The knowledge economy, hub airports and accessibility. A location based perspective.

The airplane is gradually creating a completely new spatial pattern as did other kinds of transportation modes in the past. Successively, international airports have gone through a morphogenesis from original pure infrastructure facilities into multimodal and multilayered spatial growth poles and center of competences. Landside infrastructure investments have converted airports and their hinterland into spaces of highest accessibility. The airports unique locational advantages and the growing segment of non-aviation activities on the part of the airport operators have made airports an advantageous business location for knowledge-intensive industries. At the same time airports have become a crucial asset for city-regions especially those competing on a European or international spatial level for future-oriented enterprises and highly skilled employees. The paper asks about the general interplay between airports, air transport and the knowledge economy. What are the contributions of the knowledge economy that explain the economic effects of airports on the spatial structure? What kinds of knowledge economy linked locational patterns have already emerged around airports? What is their spatial relationship to more traditional locations for example within the core cities? Why does an array of knowledge-based companies relocate their business activities at spaces of highest accessibility such as international airports? This paper analyzes aviation induced spatial patterns and processes of specialization around European airports, especially around those with hub function. First results show that airports and their vicinities have become attractive sites for real estate developments and property-led capital accumulation. Locations directly at or close by international airports are notably in demand among highly globalized sectors characterized by their need for frequent face-to-face interaction, high value products and services. As the traditional role of airports is redefined a new spatial quality and entity within the city regions is evolving.

Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

To maintain tissue integrity during epithelial morphogenesis, adherens junctions (AJs) must resist the mechanical stresses exerted by dynamic tissue movements. Junctional stability is dependent on actomyosin contractility within the actin ring. Here we describe a novel function for the axon guidance receptor, Neogenin, as a key component of the actin nucleation machinery governing junctional stability. Loss of Neogenin perturbs AJs and attenuates junctional tension. Neogenin promotes actin nucleation at AJs by recruiting the Wave regulatory complex (WRC) and Arp2/3. A direct interaction between the Neogenin WIRS domain and the WRC is crucial for the spatially restricted recruitment of the WRC to the junction. Thus, we provide the first example of a functional WIRS-WRC interaction in epithelia. We further show that Neogenin regulates cadherin recycling at the AJ. In summary, we identify Neogenin as a pivotal component of the AJ, where it influences both cadherin dynamics and junctional tension