Application of Smart Insoles for Recognition of Activities of Daily Living: A Systematic Review

Recent years have witnessed the increasing literature on using smart insoles in health and well-being, and yet, their capability of daily living activity recognition has not been reviewed. This paper addressed this need and provided a systematic review of smart insole-based systems in the recognition of Activities of Daily Living (ADLs). The review followed the PRISMA guidelines, assessing the sensing elements used, the participants involved, the activities recognised, and the algorithms employed. The findings demonstrate the feasibility of using smart insoles for recognising ADLs, showing their high performance in recognising ambulation and physical activities involving the lower body, ranging from 70% to 99.8% of Accuracy, with 13 studies over 95%. The preferred solutions have been those including machine learning. A lack of existing publicly available datasets has been identified, and the majority of the studies were conducted in controlled environments. Furthermore, no studies assessed the impact of different sampling frequencies during data collection, and a trade-off between comfort and performance has been identified between the solutions. In conclusion, real-life applications were investigated showing the benefits of smart insoles over other solutions and placing more emphasis on the capabilities of smart insoles

Analysis of microarray and next generation sequencing data for classification and biomarker discovery in relation to complex diseases

PhDThis thesis presents an investigation into gene expression profiling, using microarray and next generation sequencing (NGS) datasets, in relation to multi-category diseases such as cancer. It has been established that if the sequence of a gene is mutated, it can result in the unscheduled production of protein, leading to cancer. However, identifying the molecular signature of different cancers amongst thousands of genes is complex. This thesis investigates tools that can aid the study of gene expression to infer useful information towards personalised medicine. For microarray data analysis, this study proposes two new techniques to increase the accuracy of cancer classification. In the first method, a novel optimisation algorithm, COA-GA, was developed by synchronising the Cuckoo Optimisation Algorithm and the Genetic Algorithm for data clustering in a shuffle setup, to choose the most informative genes for classification purposes. Support Vector Machine (SVM) and Multilayer Perceptron (MLP) artificial neural networks are utilised for the classification step. Results suggest this method can significantly increase classification accuracy compared to other methods. An additional method involving a two-stage gene selection process was developed. In this method, a subset of the most informative genes are first selected by the Minimum Redundancy Maximum Relevance (MRMR) method. In the second stage, optimisation algorithms are used in a wrapper setup with SVM to minimise the selected genes whilst maximising the accuracy of classification. A comparative performance assessment suggests that the proposed algorithm significantly outperforms other methods at selecting fewer genes that are highly relevant to the cancer type, while maintaining a high classification accuracy. In the case of NGS, a state-of-the-art pipeline for the analysis of RNA-Seq data is investigated to discover differentially expressed genes and differential exon usages between normal and AIP positive Drosophila datasets, which are produced in house at Queen Mary, University of London. Functional genomic of differentially expressed genes were examined and found to be relevant to the case study under investigation. Finally, after normalising the RNA-Seq data, machine learning approaches similar to those in microarray was successfully implemented for these datasets

Multivariate Models and Algorithms for Systems Biology

Rapid advances in high-throughput data acquisition technologies, such as microarraysand next-generation sequencing, have enabled the scientists to interrogate the expression levels of tens of thousands of genes simultaneously. However, challenges remain in developingeffective computational methods for analyzing data generated from such platforms. In thisdissertation, we address some of these challenges. We divide our work into two parts. Inthe first part, we present a suite of multivariate approaches for a reliable discovery of geneclusters, often interpreted as pathway components, from molecular profiling data with replicated measurements. We translate our goal into learning an optimal correlation structure from replicated complete and incomplete measurements. In the second part, we focus on thereconstruction of signal transduction mechanisms in the signaling pathway components. Wepropose gene set based approaches for inferring the structure of a signaling pathway.First, we present a constrained multivariate Gaussian model, referred to as the informed-case model, for estimating the correlation structure from replicated and complete molecular profiling data. Informed-case model generalizes previously known blind-case modelby accommodating prior knowledge of replication mechanisms. Second, we generalize theblind-case model by designing a two-component mixture model. Our idea is to strike anoptimal balance between a fully constrained correlation structure and an unconstrained one.Third, we develop an Expectation-Maximization algorithm to infer the underlying correlation structure from replicated molecular profiling data with missing (incomplete) measurements.We utilize our correlation estimators for clustering real-world replicated complete and incompletemolecular profiling data sets. The above three components constitute the first partof the dissertation. For the structural inference of signaling pathways, we hypothesize a directed signal pathway structure as an ensemble of overlapping and linear signal transduction events. We then propose two algorithms to reverse engineer the underlying signaling pathway structure using unordered gene sets corresponding to signal transduction events. Throughout we treat gene sets as variables and the associated gene orderings as random.The first algorithm has been developed under the Gibbs sampling framework and the secondalgorithm utilizes the framework of simulated annealing. Finally, we summarize our findingsand discuss possible future directions

Multivariate Models and Algorithms for Systems Biology

Rapid advances in high-throughput data acquisition technologies, such as microarraysand next-generation sequencing, have enabled the scientists to interrogate the expression levels of tens of thousands of genes simultaneously. However, challenges remain in developingeffective computational methods for analyzing data generated from such platforms. In thisdissertation, we address some of these challenges. We divide our work into two parts. Inthe first part, we present a suite of multivariate approaches for a reliable discovery of geneclusters, often interpreted as pathway components, from molecular profiling data with replicated measurements. We translate our goal into learning an optimal correlation structure from replicated complete and incomplete measurements. In the second part, we focus on thereconstruction of signal transduction mechanisms in the signaling pathway components. Wepropose gene set based approaches for inferring the structure of a signaling pathway.First, we present a constrained multivariate Gaussian model, referred to as the informed-case model, for estimating the correlation structure from replicated and complete molecular profiling data. Informed-case model generalizes previously known blind-case modelby accommodating prior knowledge of replication mechanisms. Second, we generalize theblind-case model by designing a two-component mixture model. Our idea is to strike anoptimal balance between a fully constrained correlation structure and an unconstrained one.Third, we develop an Expectation-Maximization algorithm to infer the underlying correlation structure from replicated molecular profiling data with missing (incomplete) measurements.We utilize our correlation estimators for clustering real-world replicated complete and incompletemolecular profiling data sets. The above three components constitute the first partof the dissertation. For the structural inference of signaling pathways, we hypothesize a directed signal pathway structure as an ensemble of overlapping and linear signal transduction events. We then propose two algorithms to reverse engineer the underlying signaling pathway structure using unordered gene sets corresponding to signal transduction events. Throughout we treat gene sets as variables and the associated gene orderings as random.The first algorithm has been developed under the Gibbs sampling framework and the secondalgorithm utilizes the framework of simulated annealing. Finally, we summarize our findingsand discuss possible future directions

Predictive Modelling Approach to Data-Driven Computational Preventive Medicine

This thesis contributes novel predictive modelling approaches to data-driven computational preventive medicine and offers an alternative framework to statistical analysis in preventive medicine research. In the early parts of this research, this thesis presents research by proposing a synergy of machine learning methods for detecting patterns and developing inexpensive predictive models from healthcare data to classify the potential occurrence of adverse health events. In particular, the data-driven methodology is founded upon a heuristic-systematic assessment of several machine-learning methods, data preprocessing techniques, models’ training estimation and optimisation, and performance evaluation, yielding a novel computational data-driven framework, Octopus. Midway through this research, this thesis advances research in preventive medicine and data mining by proposing several new extensions in data preparation and preprocessing. It offers new recommendations for data quality assessment checks, a novel multimethod imputation (MMI) process for missing data mitigation, a novel imbalanced resampling approach, and minority pattern reconstruction (MPR) led by information theory. This thesis also extends the area of model performance evaluation with a novel classification performance ranking metric called XDistance. In particular, the experimental results show that building predictive models with the methods guided by our new framework (Octopus) yields domain experts' approval of the new reliable models’ performance. Also, performing the data quality checks and applying the MMI process led healthcare practitioners to outweigh predictive reliability over interpretability. The application of MPR and its hybrid resampling strategies led to better performances in line with experts' success criteria than the traditional imbalanced data resampling techniques. Finally, the use of the XDistance performance ranking metric was found to be more effective in ranking several classifiers' performances while offering an indication of class bias, unlike existing performance metrics The overall contributions of this thesis can be summarised as follow. First, several data mining techniques were thoroughly assessed to formulate the new Octopus framework to produce new reliable classifiers. In addition, we offer a further understanding of the impact of newly engineered features, the physical activity index (PAI) and biological effective dose (BED). Second, the newly developed methods within the new framework. Finally, the newly accepted developed predictive models help detect adverse health events, namely, visceral fat-associated diseases and advanced breast cancer radiotherapy toxicity side effects. These contributions could be used to guide future theories, experiments and healthcare interventions in preventive medicine and data mining

Machine learning techniques for sensor-based household activity recognition and forecasting

Thanks to the recent development of cheap and unobtrusive smart-home sensors, ambient assisted living tools promise to offer innovative solutions to support the users in carrying out their everyday activities in a smoother and more sustainable way. To be effective, these solutions need to constantly monitor and forecast the activities of daily living carried out by the inhabitants. The Machine Learning field has seen significant advancements in the development of new techniques, especially regarding deep learning algorithms. Such techniques can be successfully applied to household activity signal data to benefit the user in several applications. This thesis therefore aims to produce a contribution that artificial intelligence can make in the field of activity recognition and energy consumption. The effective recognition of common actions or the use of high-consumption appliances would lead to user profiling, thus enabling the optimisation of energy consumption in favour of the user himself or the energy community in general. Avoiding wasting electricity and optimising its consumption is one of the main objectives of the community. This work is therefore intended as a forerunner for future studies that will allow, through the results in this thesis, the creation of increasingly intelligent systems capable of making the best use of the user's resources for everyday life actions. Namely, this thesis focuses on signals from sensors installed in a house: data from position sensors, door sensors, smartphones or smart meters, and investigates the use of advanced machine learning algorithms to recognize and forecast inhabitant activities, including the use of appliances and the power consumption. The thesis is structured into four main chapters, each of which represents a contribution regarding Machine Learning or Deep Learning techniques for addressing challenges related to the aforementioned data from different sources. The first contribution highlights the importance of exploiting dimensionality reduction techniques that can simplify a Machine Learning model and increase its efficiency by identifying and retaining only the most informative and predictive features for activity recognition. In more detail, it is presented an extensive experimental study involving several feature selection algorithms and multiple Human Activity Recognition benchmarks containing mobile sensor data. In the second contribution, we propose a machine learning approach to forecast future energy consumption considering not only past consumption data, but also context data such as inhabitants’ actions and activities, use of household appliances, interaction with furniture and doors, and environmental data. We performed an experimental evaluation with real-world data acquired in an instrumented environment from a large user group. Finally, the last two contributions address the Non-Intrusive-Load-Monitoring problem. In one case, the aim is to identify the operating state (on/off) and the precise energy consumption of individual electrical loads, considering only the aggregate consumption of these loads as input. We use a Deep Learning method to disaggregate the low-frequency energy signal generated directly by the new generation smart meters being deployed in Italy, without the need for additional specific hardware. In the other case, driven by the need to build intelligent non-intrusive algorithms for disaggregating electrical signals, the work aims to recognize which appliance is activated by analyzing energy measurements and classifying appliances through Machine Learning techniques. Namely, we present a new way of approaching the problem by unifying Single Label (single active appliance recognition) and Multi Label (multiple active appliance recognition) learning paradigms. This combined approach, supplemented with an event detector, which suggests the instants of activation, would allow the development of an end-to-end NILM approach

Signal Processing Using Non-invasive Physiological Sensors

Non-invasive biomedical sensors for monitoring physiological parameters from the human body for potential future therapies and healthcare solutions. Today, a critical factor in providing a cost-effective healthcare system is improving patients' quality of life and mobility, which can be achieved by developing non-invasive sensor systems, which can then be deployed in point of care, used at home or integrated into wearable devices for long-term data collection. Another factor that plays an integral part in a cost-effective healthcare system is the signal processing of the data recorded with non-invasive biomedical sensors. In this book, we aimed to attract researchers who are interested in the application of signal processing methods to different biomedical signals, such as an electroencephalogram (EEG), electromyogram (EMG), functional near-infrared spectroscopy (fNIRS), electrocardiogram (ECG), galvanic skin response, pulse oximetry, photoplethysmogram (PPG), etc. We encouraged new signal processing methods or the use of existing signal processing methods for its novel application in physiological signals to help healthcare providers make better decisions

Emotion and Stress Recognition Related Sensors and Machine Learning Technologies

This book includes impactful chapters which present scientific concepts, frameworks, architectures and ideas on sensing technologies and machine learning techniques. These are relevant in tackling the following challenges: (i) the field readiness and use of intrusive sensor systems and devices for capturing biosignals, including EEG sensor systems, ECG sensor systems and electrodermal activity sensor systems; (ii) the quality assessment and management of sensor data; (iii) data preprocessing, noise filtering and calibration concepts for biosignals; (iv) the field readiness and use of nonintrusive sensor technologies, including visual sensors, acoustic sensors, vibration sensors and piezoelectric sensors; (v) emotion recognition using mobile phones and smartwatches; (vi) body area sensor networks for emotion and stress studies; (vii) the use of experimental datasets in emotion recognition, including dataset generation principles and concepts, quality insurance and emotion elicitation material and concepts; (viii) machine learning techniques for robust emotion recognition, including graphical models, neural network methods, deep learning methods, statistical learning and multivariate empirical mode decomposition; (ix) subject-independent emotion and stress recognition concepts and systems, including facial expression-based systems, speech-based systems, EEG-based systems, ECG-based systems, electrodermal activity-based systems, multimodal recognition systems and sensor fusion concepts and (x) emotion and stress estimation and forecasting from a nonlinear dynamical system perspective

Mining Heterogeneous Urban Data at Multiple Granularity Layers

The recent development of urban areas and of the new advanced services supported by digital technologies has generated big challenges for people and city administrators, like air pollution, high energy consumption, traffic congestion, management of public events. Moreover, understanding the perception of citizens about the provided services and other relevant topics can help devising targeted actions in the management. With the large diffusion of sensing technologies and user devices, the capability to generate data of public interest within the urban area has rapidly grown. For instance, different sensors networks deployed in the urban area allow collecting a variety of data useful to characterize several aspects of the urban environment. The huge amount of data produced by different types of devices and applications brings a rich knowledge about the urban context. Mining big urban data can provide decision makers with knowledge useful to tackle the aforementioned challenges for a smart and sustainable administration of urban spaces. However, the high volume and heterogeneity of data increase the complexity of the analysis. Moreover, different sources provide data with different spatial and temporal references. The extraction of significant information from such diverse kinds of data depends also on how they are integrated, hence alternative data representations and efficient processing technologies are required. The PhD research activity presented in this thesis was aimed at tackling these issues. Indeed, the thesis deals with the analysis of big heterogeneous data in smart city scenarios, by means of new data mining techniques and algorithms, to study the nature of urban related processes. The problem is addressed focusing on both infrastructural and algorithmic layers. In the first layer, the thesis proposes the enhancement of the current leading techniques for the storage and elaboration of Big Data. The integration with novel computing platforms is also considered to support parallelization of tasks, tackling the issue of automatic scaling of resources. At algorithmic layer, the research activity aimed at innovating current data mining algorithms, by adapting them to novel Big Data architectures and to Cloud computing environments. Such algorithms have been applied to various classes of urban data, in order to discover hidden but important information to support the optimization of the related processes. This research activity focused on the development of a distributed framework to automatically aggregate heterogeneous data at multiple temporal and spatial granularities and to apply different data mining techniques. Parallel computations are performed according to the MapReduce paradigm and exploiting in-memory computing to reach near-linear computational scalability. By exploring manifold data resolutions in a relatively short time, several additional patterns of data can be discovered, allowing to further enrich the description of urban processes. Such framework is suitably applied to different use cases, where many types of data are used to provide insightful descriptive and predictive analyses. In particular, the PhD activity addressed two main issues in the context of urban data mining: the evaluation of buildings energy efficiency from different energy-related data and the characterization of people's perception and interest about different topics from user-generated content on social networks. For each use case within the considered applications, a specific architectural solution was designed to obtain meaningful and actionable results and to optimize the computational performance and scalability of algorithms, which were extensively validated through experimental tests

Smart Sensors for Healthcare and Medical Applications

This book focuses on new sensing technologies, measurement techniques, and their applications in medicine and healthcare. Specifically, the book briefly describes the potential of smart sensors in the aforementioned applications, collecting 24 articles selected and published in the Special Issue “Smart Sensors for Healthcare and Medical Applications”. We proposed this topic, being aware of the pivotal role that smart sensors can play in the improvement of healthcare services in both acute and chronic conditions as well as in prevention for a healthy life and active aging. The articles selected in this book cover a variety of topics related to the design, validation, and application of smart sensors to healthcare