ART in Europe, 2016 : results generated from European registries by ESHRE

STUDY QUESTION: What are the reported data on cycles in ART, IUI and fertility preservation (FP) interventions in 2016 as compared to previous years, as well as the main trends over the years? SUMMARY ANSWER: The 20th ESHRE report on ART and IUI shows a progressive increase in reported treatment cycle numbers in Europe, with a decrease in the number of transfers with more than one embryo causing a reduction of multiple delivery rates (DR), as well as higher pregnancy rates and DR after frozen embryo replacement (FER) compared to fresh IVF and ICSI cycles, while the outcomes for IUI cycles remained stable. WHAT IS KNOWN ALREADY: Since 1997, ART aggregated data generated by national registries, clinics or professional societies have been collected, analysed by the European IVF-monitoring Consortium (EIM) and reported in 19 manuscripts published in Human Reproduction and Human Reproduction Open. STUDY DESIGN, SIZE, DURATION: Yearly collection of European medically assisted reproduction (MAR) data by EIM for ESHRE. The data on treatments performed between 1 January and 31 December 2016 in 40 European countries were provided by either National Registries or registries based on personal initiatives of medical associations and scientific organizations. PARTICIPANTS/MATERIALS, SETTING, METHODS: In all, 1347 clinics offering ART services in 40 countries reported a total of 918 159 treatment cycles, involving 156 002 with IVF, 407 222 with ICSI, 248 407 with FER, 27 069 with preimplantation genetic testing, 73 927 with egg donation (ED), 654 with IVM of oocytes and 4878 cycles with frozen oocyte replacement (FOR). European data on IUI using husband/partner’s semen (IUI-H) and donor semen (IUI-D) were reported from 1197 institutions offering IUI in 29 and 24 countries, respectively. A total of 162 948 treatments with IUI-H and 50 467 treatments with IUI-D were included. A total of 13 689 FP interventions from 11 countries including oocyte, ovarian tissue, semen and testicular tissue banking in pre-and postpubertal patients were reported. MAIN RESULTS AND THE ROLE OF CHANCE: In 20 countries (18 in 2015) with a total population of approximately 325 million inhabitants, in which all ART clinics reported to the registry, a total of 461 401 treatment cycles were performed, corresponding to a mean of 1410 cycles per million inhabitants (range 82–3088 per million inhabitants). In the 40 reporting countries, after IVF the clinical pregnancy rates (PR) per aspiration and per transfer in 2016 were similar to those observed in 2015 (28.0% and 34.8% vs 28.5% and 34.6%, respectively). After ICSI, the corresponding rates were also similar to those achieved in 2015 (25% and 33.2% vs 26.2% and 33.2%). After FER with own embryos, the PR per thawing is still on the rise, from 29.2% in 2015 to 30.9% in 2016. After ED, the PR per fresh embryo transfer was 49.4% (49.6% in 2015) and per FOR 43.6% (43.4% in 2015). In IVF and ICSI together, the trend towards the transfer of fewer embryos continues with the transfer of 1, 2, 3 and 4 embryos in 41.5%, 51.9%, 6.2% and 0.4% of all treatments, respectively (corresponding to 37.7%, 53.9%, 7.9% and 0.5% in 2015). This resulted in a proportion of singleton, twin and triplet DRs of 84.8%, 14.9% and 0.3%, respectively (compared to 83.1%, 16.5% and 0.4%, respectively in 2015). Treatments with FER in 2016 resulted in twin and triplet DR of 11.9% and 0.2%, respectively (vs 12.3% and 0.3% in 2015). After IUI, the DRs remained similar at 8.9% after IUI-H (7.8% in 2015) and at 12.4% after IUI-D (12.0% in 2015). Twin and triplet DRs after IUI-H were 8.8% and 0.3%, respectively (in 2015: 8.9% and 0.5%) and 7.7% and 0.4% after IUI-D (in 2015: 7.3% and 0.6%). The majority of FP interventions included the cryopreservation of ejaculated sperm (n¼7877 from 11 countries) and of oocytes (n¼4907 from eight countries). LIMITATIONS, REASONS FOR CAUTION: As the methods of data collection and levels of completeness of reported data vary among European countries, the results should be interpreted with caution. A number of countries failed to provide adequate data about the number of initiated cycles and deliveries. WIDER IMPLICATIONS OF THE FINDINGS: The 20th ESHRE report on ART and IUI shows a continuous increase of reported treatment numbers and MAR-derived livebirths in Europe. Being already the largest data collection on MAR in Europe, continuous efforts to stimulate data collection and reporting strive for future quality control of the data, transparency and vigilance in the field of reproductive medicine.The study has no external funding and all costs were covered by ESHRE.peer-reviewe

Towards higher sense of presence: a 3D virtual environment adaptable to confusion and engagement

Virtual Reality scenarios where emitters convey information to receptors can be used as a tool for distance learning and to enable virtual visits to company physical headquarters. However, immersive Virtual Reality setups usually require visualization interfaces such as Head-mounted Displays, Powerwalls or CAVE systems, supported by interaction devices (Microsoft Kinect, Wii Motion, among others), that foster natural interaction but are often inaccessible to users. We propose a virtual presentation scenario, supported by a framework, that provides emotion-driven interaction through ubiquitous devices. An experiment with 3 conditions was designed involving: a control condition; a less confusing text script based on its lexical, syntactical, and bigram features; and a third condition where an adaptive lighting system dynamically acted based on the user’s engagement. Results show that users exposed to the less confusing script reported higher sense of presence, albeit without statistical significance. Users from the last condition reported lower sense of presence, which rejects our hypothesis without statistical significance. We theorize that, as the presentation was given orally and the adaptive lighting system impacts the visual channel, this conflict may have overloaded the users’ cognitive capacity and thus reduced available resources to address the presentation content.info:eu-repo/semantics/publishedVersio

A Novel ILP Framework for Summarizing Content with High Lexical Variety

Summarizing content contributed by individuals can be challenging, because people make different lexical choices even when describing the same events. However, there remains a significant need to summarize such content. Examples include the student responses to post-class reflective questions, product reviews, and news articles published by different news agencies related to the same events. High lexical diversity of these documents hinders the system's ability to effectively identify salient content and reduce summary redundancy. In this paper, we overcome this issue by introducing an integer linear programming-based summarization framework. It incorporates a low-rank approximation to the sentence-word co-occurrence matrix to intrinsically group semantically-similar lexical items. We conduct extensive experiments on datasets of student responses, product reviews, and news documents. Our approach compares favorably to a number of extractive baselines as well as a neural abstractive summarization system. The paper finally sheds light on when and why the proposed framework is effective at summarizing content with high lexical variety.Comment: Accepted for publication in the journal of Natural Language Engineering, 201

Performance analysis of NOMA in 5G systems with HPA nonlinearities

LISBOA-01-0145-FEDER-0307095-PTDC/EEITEL/30709/2017 PTDC/EEI-TEL/30588/20 UIDB/50008/2020In this paper, we provide an analytical performance assessment of downlink non-orthogonal multiple access (NOMA) systems over Nakagami-m fading channels in the presence of nonlinear high-power amplifiers (HPAs). By modeling the distortion of the HPA by a nonlinear polynomial model, we evaluate the performance the NOMA scheme in terms of outage probability (OP) and ergodic sum rate. Hence, we derive a new closed-form expression for the exact OP, taking into account the undesirable effects of HPA. Furthermore, to characterize the diversity order of the considered system, the asymptotic OP in the high signal-to-noise (SNR) regime is derived. Moreover, the ergodic sum rate is investigated, resulting in new upper and lower bounds. Our numerical results demonstrate that the performance loss in presence of nonlinear distortions is very substantial at high data rates. In particular, it is proved that in presence of HPA distortion, the ergodic sum rate cannot exceed a determined threshold which limits its performance compared to the ideal hardware case. Monte-Carlo simulations are conducted and their results agree well with the analytical results.publishersversionpublishe

European policies on same-sex relationships, adoption and assisted reproduction

Same-sex civil union, marriage, adoption and access to assisted reproduction have progressively been more accepted worldwide. However, many differences exist in national legislation regarding the matter. This work is a review of current national policies of 31 European countries, including all the European Union, Iceland, Norway, Switzerland and the United Kingdom. At the moment, many European countries recognize same-sex civil unions, marriage and adoption, as well as the access of single women and lesbian couples to assisted reproduction, specially the northern and western countries. However, there is still an important number of countries where there is no official recognition of gay partnerships and adoption, and fertility treatments are exclusive to heterosexual couples. In addition, given the need to surrogacy, male couples have quite limited options concerning assisted reproduction in Europe. Europe is progressively allowing same-sex couples to legalize their relationship and to open adoption and assisted reproduction to everyone, regardless of gender, sexual orientation or marital status

Conversational OLAP

The democratization of data access and the adoption of OLAP in scenarios requiring hand-free interfaces push towards the creation of smart OLAP interfaces. In this paper, we describe COOL, a framework devised for COnversational OLap applications. COOL interprets and translates a natural language dialog into an OLAP session that starts with a GPSJ (Generalized Projection, Selection, and Join) query and continues with the application of OLAP operators. The interpretation relies on a formal grammar and on a repository storing metadata and values from a multidimensional cube. In case of ambiguous text description, COOL can obtain the correct query either through automatic inference or user interactions to disambiguate the text