Difference-expansion based reversible data hiding and its steganalysis

A novel reversible data embedding method was reported in a recent IEEE journal article. The method was based on difference expansion (DE) technique. It used redundancy in digital images to achieve a high embedding capacity, while keeping visual distortion of the stego-image low. In this thesis, this technique was studied and experimentally evaluated. An effective steganalysis scheme for this DE-based reversible data embedding method was proposed, which used 12-dimensional feature vectors and a Bayes Classifier. The proposed steganalysis scheme steadily achieved a correct classification rate of 99%

High capacity data embedding schemes for digital media

High capacity image data hiding methods and robust high capacity digital audio watermarking algorithms are studied in this thesis. The main results of this work are the development of novel algorithms with state-of-the-art performance, high capacity and transparency for image data hiding and robustness, high capacity and low distortion for audio watermarking.En esta tesis se estudian y proponen diversos métodos de data hiding de imágenes y watermarking de audio de alta capacidad. Los principales resultados de este trabajo consisten en la publicación de varios algoritmos novedosos con rendimiento a la altura de los mejores métodos del estado del arte, alta capacidad y transparencia, en el caso de data hiding de imágenes, y robustez, alta capacidad y baja distorsión para el watermarking de audio.En aquesta tesi s'estudien i es proposen diversos mètodes de data hiding d'imatges i watermarking d'àudio d'alta capacitat. Els resultats principals d'aquest treball consisteixen en la publicació de diversos algorismes nous amb rendiment a l'alçada dels millors mètodes de l'estat de l'art, alta capacitat i transparència, en el cas de data hiding d'imatges, i robustesa, alta capacitat i baixa distorsió per al watermarking d'àudio.Societat de la informació i el coneixemen

Data Security using Reversible Data Hiding with Optimal Value Transfer

In this paper a novel reversible data hiding algorithm is used which can recover image without any distortion. This algorithm uses zero or minimum points of an image and modifies the pixel. It is proved experimentally that the peak signal to noise ratio of the marked image generated by this method and the original image is guaranteed to be above 48 dB this lower bound of peak signal to noise ratio is much higher than all reversible data hiding technique present in the literature. Execution time of proposed system is short. The algorithm has been successfully applied to all types of images

Reversible data hiding in digital images

Nowadays the role of data hiding has become more eminent. The data safety on the Internet is known to be a challenge due to frequent hacker attacks and data tampering during transmission. In addition to encryption schemes, data hiding has an important role in secret message transmission, authentication, and copyright protection. This thesis presents in-depth state-of-the-art data hiding schemes evaluation, and based on the conducted analysis describes the proposed method, which seek the maximum improvement. We utilize a causal predictor and a local activity indicator with two embedding possibilities based on difference expansion and histogram shifting. Moreover, the secret data from Galois field GF(q),q ≤ 2 in order to embed more than one bit per pixel in a single run of the algorithm is considered. We extend our data hiding technique to the transform domain complaint with JPEG coding. In the experimental part, the proposed method is compared with state-of-the-art reversible data hiding schemes on a vast set of test images, where our approach produces better embedding capacity versus image quality performance. We conclude that proposed scheme achieves efficiency in terms of redundancy, which is decreased due to the derived conditions for location map free data embedding, invariability to the choice of predictor, and high payload capacity of more than 1 bit per pixel in a single run of the algorithm

Secure and Privacy-preserving Data Sharing in the Cloud based on Lossless Image Coding

Abstract Image and video processing in the encrypted domain has recently emerged as a promising research area to tackle privacy-related data processing issues. In particular, reversible data hiding in the encrypted domain has been suggested as a solution to store and manage digital images securely in the cloud while preserving their confidentiality. However, although efficiency has been claimed with reversible data hiding techniques in encrypted images (RDHEI), reported results show that the cloud service provider cannot add more than 1 bit per pixel (bpp) of additional data to manage stored images. This paper highlights the weakness of RDHEI as a suggested approach for secure and privacy-preserving cloud computing. In particular, we propose a new, simple, and efficient approach that offers the same level of data security and confidentiality in the cloud without the process of reversible data hiding. The proposed idea is to compress the image via a lossless image coder in order to create space before encryption. This space is then filled with a randomly generated sequence and combined with an encrypted version of the compressed bit stream to form a full resolution encrypted image in the pixel domain. The cloud service provider uses the created room in the encrypted image to add additional data and produces an encrypted image containing additional data in a similar fashion. Assessed with the lossless Embedded Block Coding with Optimized Truncation (EBCOT) algorithm on natural images, the proposed scheme has been shown to exceed the capacity of 3 bpp of additional data while maintaining data security and confidentiality

Recent Advances in Signal Processing

The signal processing task is a very critical issue in the majority of new technological inventions and challenges in a variety of applications in both science and engineering fields. Classical signal processing techniques have largely worked with mathematical models that are linear, local, stationary, and Gaussian. They have always favored closed-form tractability over real-world accuracy. These constraints were imposed by the lack of powerful computing tools. During the last few decades, signal processing theories, developments, and applications have matured rapidly and now include tools from many areas of mathematics, computer science, physics, and engineering. This book is targeted primarily toward both students and researchers who want to be exposed to a wide variety of signal processing techniques and algorithms. It includes 27 chapters that can be categorized into five different areas depending on the application at hand. These five categories are ordered to address image processing, speech processing, communication systems, time-series analysis, and educational packages respectively. The book has the advantage of providing a collection of applications that are completely independent and self-contained; thus, the interested reader can choose any chapter and skip to another without losing continuity

STED Nanoscopy to Illuminate New Avenues in Cancer Research – From Live Cell Staining and Direct Imaging to Decisive Preclinical Insights for Diagnosis and Therapy

Molecular imaging is established as an indispensable tool in various areas of cancer research, ranging from basic cancer biology and preclinical research to clinical trials and medical practice. In particular, the field of fluorescence imaging has experienced exceptional progress during the last three decades with the development of various in vivo technologies. Within this field, fluorescence microscopy is primarily of experimental use since it is especially qualified for addressing the fundamental questions of molecular oncology. As stimulated emission depletion (STED) nanoscopy combines the highest spatial and temporal resolutions with live specimen compatibility, it is best-suited for real-time investigations of the differences in the molecular machineries of malignant and normal cells to eventually translate the acquired knowledge into increased diagnostic and therapeutic efficacy. This thesis presents the application of STED nanoscopy to two acute topics in cancer research of direct or indirect clinical interest. The first project has investigated the structure of telomeres, the ends of the linear eukaryotic chromosomes, in intact human cells at the nanoscale. To protect genome integrity, a telomere can mask the chromosome end by folding back and sequestering its single-stranded 3’-overhang in an upstream part of the double-stranded DNA repeat region. The formed t-loop structure has so far only been visualized by electron microscopy and fluorescence nanoscopy with cross-linked mammalian telomeric DNA after disruption of cell nuclei and spreading. For the first time, this work demonstrates the existence of t-loops within their endogenous nuclear environment in intact human cells. The identification of further telomere conformations has laid the groundwork for distinguishing cancerous cells that use different telomere maintenance mechanisms based on their individual telomere populations by a combined STED nanoscopy and deep learning approach. The population difference was essentially attributed to the promyelocytic leukemia (PML) protein that significantly perturbs the organization of a subpopulation of telomeres towards an open conformation in cancer cells that employ a telomerase-independent, alternative telomere lengthening mechanism. Elucidating the nanoscale topology of telomeres and associated proteins within the nucleus has provided new insight into telomere structure-function relationships relevant for understanding the deregulation of telomere maintenance in cancer cells. After understanding the molecular foundations, this newly gained knowledge can be exploited to develop novel or refined diagnostic and treatment strategies. The second project has characterized the intracellular distribution of recently developed prostate cancer tracers. These novel prostate-specific membrane antigen (PSMA) inhibitors have revolutionized the treatment regimen of prostate cancer by enabling targeted imaging and therapy approaches. However, the exact internalization mechanism and the subcellular fate of these tracers have remained elusive. By combining STED nanoscopy with a newly developed non-standard live cell staining protocol, this work confirmed cell surface clustering of the targeted membrane antigen upon PSMA inhibitor binding, subsequent clathrin-dependent endocytosis and endosomal trafficking of the antigen-inhibitor complex. PSMA inhibitors accumulate in prostate cancer cells at clinically relevant time points, but strikingly and in contrast to the targeted antigen itself, they eventually distribute homogenously in the cytosol. This project has revealed the subcellular fate of PSMA/PSMA inhibitor complexes for the first time and provides crucial knowledge for the future application of these tracers including the development of new strategies in the field of prostate cancer diagnostics and therapeutics. Relying on the photostability and biocompatibility of the applied fluorophores, the performance of live cell STED nanoscopy in the field of cancer research is boosted by the development of improved fluorophores. The third project in this thesis introduces a biocompatible, small molecule near-infrared dye suitable for live cell STED imaging. By the application of a halogen dance rearrangement, a dihalogenated fluorinatable pyridinyl rhodamine could be synthesized at high yield. The option of subsequent radiolabeling combined with excellent optical properties and a non-toxic profile renders this dye an appropriate candidate for medical and bioimaging applications. Providing an intrinsic and highly specific mitochondrial targeting ability, the radiolabeled analogue is suggested as a vehicle for multimodal (positron emission tomography and optical imaging) medical imaging of mitochondria for cancer diagnosis and therapeutic approaches in patients and biopsy tissue. The absence of cytotoxicity is not only a crucial prerequisite for clinically used fluorophores. To guarantee the generation of meaningful data mirroring biological reality, the absence of cytotoxicity is likewise a decisive property of dyes applied in live cell STED nanoscopy. The fourth project in this thesis proposes a universal approach for cytotoxicity testing based on characterizing the influence of the compound of interest on the proliferation behavior of human cell lines using digital holographic cytometry. By applying this approach to recently developed live cell STED compatible dyes, pronounced cytotoxic effects could be excluded. Looking more closely, some of the tested dyes slightly altered cell proliferation, so this project provides guidance on the right choice of dye for the least invasive live cell STED experiments. Ultimately, live cell STED data should be exploited to extract as much biological information as possible. However, some information might be partially hidden by image degradation due the dynamics of living samples and the deliberate choice of rather conservative imaging parameters in order to preserve sample viability. The fifth project in this thesis presents a novel image restoration method in a Bayesian framework that simultaneously performs deconvolution, denoising as well as super-resolution, to restore images suffering from noise with mixed Poisson-Gaussian statistics. Established deconvolution or denoising methods that consider only one type of noise generally do not perform well on images degraded significantly by mixed noise. The newly introduced method was validated with live cell STED telomere data proving that the method can compete with state-of-the-art approaches. Taken together, this thesis demonstrates the value of an integrated approach for STED nanoscopy imaging studies. A coordinated workflow including sample preparation, image acquisition and data analysis provided a reliable platform for deriving meaningful conclusions for current questions in the field of cancer research. Moreover, this thesis emphasizes the strength of iteratively adapting the individual components in the operational chain and it particularly points towards those components that, if further improved, optimize the significance of the final results rendering live cell STED nanoscopy even more powerful

Growth of binary oxides on Si substrates:solid solutions of SiO2-GeO2 and HfO2-ZrO2

Functional oxides are materials with interesting properties for electronic applications. In this thesis, we investigate the growth of thin films of two types of oxides: mixtures of silicon oxide and germanium oxide, and mixtures of hafnium oxide and zirconium oxide. These mixtures can have varying amounts of their components, which we can use to change their properties. Silicon and germanium oxide can adopt the alpha-quartz structure, which is piezoelectric (that is, they can convert electrical stimuli to a mechanical response, and vice versa). This is an important property for communications components. To make devices that operate at higher frequencies (5G and beyond), we would like to make ever smaller quartz elements. To do this, we grow silicon and germanium oxide thin films in a non-crystalline, thus non-piezoelectric state. We can do this by alternating layers of pure silicon oxide with layers of pure germanium oxide using a chemistry-based method (Atomic Layer Deposition), or by growing a mix of the two using a physics-based method (Pulsed Laser Deposition). Then, we guide them into the correct crystalline form in a high temperature furnace. Hafnium and zirconium oxide are peculiar in that they can be ferroelectric (which has applications in memory storage) but only when they are grown in very thin films. We investigate their behavior when these films are grown by Pulsed Laser Deposition on silicon substrates (the most common substrate type in industry). In both cases, we investigate the results using various techniques, mainly based on X-ray diffraction and electron microscopy

An Energy-Efficient and Reliable Data Transmission Scheme for Transmitter-based Energy Harvesting Networks

Energy harvesting technology has been studied to overcome a limited power resource problem for a sensor network. This paper proposes a new data transmission period control and reliable data transmission algorithm for energy harvesting based sensor networks. Although previous studies proposed a communication protocol for energy harvesting based sensor networks, it still needs additional discussion. Proposed algorithm control a data transmission period and the number of data transmission dynamically based on environment information. Through this, energy consumption is reduced and transmission reliability is improved. The simulation result shows that the proposed algorithm is more efficient when compared with previous energy harvesting based communication standard, Enocean in terms of transmission success rate and residual energy.This research was supported by Basic Science Research Program through the National Research Foundation by Korea (NRF) funded by the Ministry of Education, Science and Technology(2012R1A1A3012227)