Fusion of Visualization Induced SOM

In this study ensemble techniques have been applied in the frame of topology preserving mappings with visualization purposes. A novel extension of the ViSOM (Visualization Induced SOM) is obtained by the use of the ensemble meta-algorithm and a later fusion process. This main fusion algorithm has two different variants, considering two different criteria for the similarity of nodes. These criteria are Euclidean distance and similarity on Voronoi polygons. The goal of this upgrade is to improve the quality and robustness of the single model. Some experiments performed over different datasets applying the two variants of the fusion and other simpler models are included for comparison purposes

WeVoS-ViSOM: an ensemble summarization algorithm for enhanced data visualization

This study presents a novel version of the Visualization Induced Self-Organizing Map based on the application of a new fusion algorithm for summarizing the results of an ensemble of topology-preserving mapping models. The algorithm is referred to as Weighted Voting Superposition (WeVoS). Its main feature is the preservation of the topology of the map, in order to obtain the most accurate possible visualization of the data sets under study. To do so, a weighted voting process between the units of the maps in the ensemble takes place, in order to determine the characteristics of the units of the resulting map. Several different quality measures are applied to this novel neural architecture known as WeVoS-ViSOM and the results are analyzed, so as to present a thorough study of its capabilities. To complete the study, it has also been compared with the well-know SOM and its fusion version, with the WeVoS-SOM and with two other previously devised fusion Fusion by Euclidean Distance and Fusion by Voronoi Polygon Similarity—based on the analysis of the same quality measures in order to present a complete analysis of its capabilities. All three summarization methods were applied to three widely used data sets from the UCI Repository. A rigorous performance analysis clearly demonstrates that the novel fusion algorithm outperforms the other single and summarization methods in terms of data sets visualizationThis research has been partially supported through projects CIT-020000-2008-2 and CIT-020000-2009-12 of the Spanish Ministry of Education and Innovation and project BUO06A08 of the Junta of Castilla and Leon. The authors would also like to thank the manufacturer of components for vehicle interiors, Grupo Antolin Ingenieria, S.A. within the framework of the MAGNO2008-1028 CENIT project, funded by the Spanish Ministry of Science and Innovatio

Quality of Adaptation of Fusion ViSOM

This work presents a research on the performance capabilities of an extension of the ViSOM (Visualization Induced SOM) algorithm by the use of the ensemble meta-algorithm and a later fusion process. This main fusion process has two different variants, considering two different criteria for the similarity of nodes. These criteria are Euclidean distance and similarity on Voronoi polygons. The capabilities, strengths and weakness of the different variants of the model are discussed and compared more deeply in the present work. The details of several experiments performed over different datasets applying the variants of the fusion to the ViSOM algorithm along with same variants of fusion with the SOM are included for this purpose

A combined measure for quantifying and qualifying the topology preservation of growing self-organizing maps

The Self-OrganizingMap (SOM) is a neural network model that performs an ordered projection of a high dimensional input space in a low-dimensional topological structure. The process in which such mapping is formed is defined by the SOM algorithm, which is a competitive, unsupervised and nonparametric method, since it does not make any assumption about the input data distribution. The feature maps provided by this algorithm have been successfully applied for vector quantization, clustering and high dimensional data visualization processes. However, the initialization of the network topology and the selection of the SOM training parameters are two difficult tasks caused by the unknown distribution of the input signals. A misconfiguration of these parameters can generate a feature map of low-quality, so it is necessary to have some measure of the degree of adaptation of the SOM network to the input data model. The topologypreservation is the most common concept used to implement this measure. Several qualitative and quantitative methods have been proposed for measuring the degree of SOM topologypreservation, particularly using Kohonen's model. In this work, two methods for measuring the topologypreservation of the Growing Cell Structures (GCSs) model are proposed: the topographic function and the topology preserving ma

Hacia el modelado 3d de tumores cerebrales mediante endoneurosonografía y redes neuronales

Las cirugías mínimamente invasivas se han vuelto populares debido a que implican menos riesgos con respecto a las intervenciones tradicionales. En neurocirugía, las tendencias recientes sugieren el uso conjunto de la endoscopia y el ultrasonido, técnica llamada endoneurosonografía (ENS), para la virtualización 3D de las estructuras del cerebro en tiempo real. La información ENS se puede utilizar para generar modelos 3D de los tumores del cerebro durante la cirugía. En este trabajo, presentamos una metodología para el modelado 3D de tumores cerebrales con ENS y redes neuronales. Específicamente, se estudió el uso de mapas auto-organizados (SOM) y de redes neuronales tipo gas (NGN). En comparación con otras técnicas, el modelado 3D usando redes neuronales ofrece ventajas debido a que la morfología del tumor se codifica directamente sobre los pesos sinápticos de la red, no requiere ningún conocimiento a priori y la representación puede ser desarrollada en dos etapas: entrenamiento fuera de línea y adaptación en línea. Se realizan pruebas experimentales con maniquíes médicos de tumores cerebrales. Al final del documento, se presentan los resultados del modelado 3D a partir de una base de datos ENS.Minimally invasive surgeries have become popular because they reduce the typical risks of traditional interventions. In neurosurgery, recent trends suggest the combined use of endoscopy and ultrasound (endoneurosonography or ENS) for 3D virtualization of brain structures in real time. The ENS information can be used to generate 3D models of brain tumors during a surgery. This paper introduces a methodology for 3D modeling of brain tumors using ENS and unsupervised neural networks. The use of self-organizing maps (SOM) and neural gas networks (NGN) is particularly studied. Compared to other techniques, 3D modeling using neural networks offers advantages, since tumor morphology is directly encoded in synaptic weights of the network, no a priori knowledge is required, and the representation can be developed in two stages: off-line training and on-line adaptation. Experimental tests were performed using virtualized phantom brain tumors. At the end of the paper, the results of 3D modeling from an ENS database are presented

A Bio-inspired Fusion Method for Data Visualization

This research presents a novel bio-inspired fusion algorithm based on the application of a topology preserving map called Visualization Induced SOM (ViSOM) under the umbrella of an ensemble summarization algorithm, the Weighted Voting Superposition (WeVoS). The presented model aims to obtain more accurate and robust maps, also increasing the models stability by means of the use of an ensemble training schema and a posterior fusion algorithm, been those very suitable for visualization and also classification purposes. This model may be applied alone or under the frame of hybrid intelligent systems, when used for instance in the recovery phase of a case based reasoning system. For the sake of completeness, the comparison of the performance with other topology preserving maps and previous fusion algorithms with several public data set obtained from the UCI repository are also included

A novel ensemble Beta-scale invariant map algorithm

[Abstract]: This research presents a novel topology preserving map (TPM) called Weighted Voting Supervision -Beta-Scale Invariant Map (WeVoS-Beta-SIM), based on the application of the Weighted Voting Supervision (WeVoS) meta-algorithm to a novel family of learning rules called Beta-Scale Invariant Map (Beta-SIM). The aim of the novel TPM presented is to improve the original models (SIM and Beta-SIM) in terms of stability and topology preservation and at the same time to preserve their original features, especially in the case of radial datasets, where they all are designed to perform their best. These scale invariant TPM have been proved with very satisfactory results in previous researches. This is done by generating accurate topology maps in an effectively and efficiently way. WeVoS meta-algorithm is based on the training of an ensemble of networks and the combination of them to obtain a single one that includes the best features of each one of the networks in the ensemble. WeVoS-Beta-SIM is thoroughly analyzed and successfully demonstrated in this study over 14 diverse real benchmark datasets with diverse number of samples and features, using three different well-known quality measures. In order to present a complete study of its capabilities, results are compared with other topology preserving models such as Self Organizing Maps, Scale Invariant Map, Maximum Likelihood Hebbian Learning-SIM, Visualization Induced SOM, Growing Neural Gas and Beta- Scale Invariant Map. The results obtained confirm that the novel algorithm improves the quality of the single Beta-SIM algorithm in terms of topology preservation and stability without losing performance (where this algorithm has proved to overcome other well-known algorithms). This improvement is more remarkable when complexity of the datasets increases, in terms of number of features and samples and especially in the case of radial datasets improving the Topographic Error

C-terminal fusion of eGFP to the bradykinin B-2 receptor strongly affects down-regulation but not receptor internalization or signaling

A functional comparison was made between the wildtype bradykinin B, receptor (B(2)wt) and the chimera B(2)eGFP (enhanced green-fluorescent protein fused to the C-terminus of B(2)Wt), both stably expressed in HEK 293 cells. There was almost no difference in terms of ligand-inducible receptor phosphorylation and internalization, signal transduction (accumulation of inositol phosphates) or expression and affinity. However, stimulation for up to 8 h with 10 mu M bradykinin (BK) resulted in a strong decrease in surface receptors (by 60% within 5 h) in B(2)Wt, but not in B(2)eGFP. When the expression levels of both constructs where comparably reduced using a weaker promoter, long-term stimulation resulted in a reduction in surface receptors for B(2)wt(low) to less than 20% within 1 h, whereas the chimera B(2)eGFP(low) still displayed 50% binding activity after 2 h. A 1-h incubation in the absence of BK resulted in a recovery of 60% of the binding in B(2)wt(low) after 1-h stimulation with BK, but of only 20% after 7-h stimulation. In contrast, B(2)eGFP(low) levels were restored to more than 70%, even after 7-h stimulation. These data indicate that although the fusion of eGFP to B(2)wt does not affect its ligand-induced internalization, it strongly reduces the down-regulation, most likely by promoting receptor recycling over degradation

Proteomic Analysis to Identify Tightly-Bound Cell Wall Protein in Rice Calli.

Rice is a model plant widely used for basic and applied research programs. Plant cell wall proteins play key roles in a broad range of biological processes. However, presently, knowledge on the rice cell wall proteome is rudimentary in nature. In the present study, the tightly-bound cell wall proteome of rice callus cultured cells using sequential extraction protocols was developed using mass spectrometry and bioinformatics methods, leading to the identification of 1568 candidate proteins. Based on bioinformatics analyses, 389 classical rice cell wall proteins, possessing a signal peptide, and 334 putative non-classical cell wall proteins, lacking a signal peptide, were identified. By combining previously established rice cell wall protein databases with current data for the classical rice cell wall proteins, a comprehensive rice cell wall proteome, comprised of 496 proteins, was constructed. A comparative analysis of the rice and Arabidopsis cell wall proteomes revealed a high level of homology, suggesting a predominant conservation between monocot and eudicot cell wall proteins. This study importantly increased information on cell wall proteins, which serves for future functional analyses of these identified rice cell wall proteins