Evaluation of performance fatigability through surface EMG in health and muscle disease: state of the art

In literature, it is commonly reported that the progress of performance fatigability may be indirectly assessed through the changes in the features of the surface electromyogram (sEMG) signal. In particular, during isometric constant force contractions, changes in the sEMG signal are caused by several physiological factors, such as a decay in muscle fibers conduction velocity (CV), an increase of the degree of synchronization between the firing times of simultaneously active motor units (MUs), by the central nervous system, and a reduction of the recruitment threshold and a modulation of MUs firing rate. Amplitude and spectral parameters may be used to characterize the global contributions to performance fatigability, such as MU control properties and fiber membrane properties, or central and peripheral factors, respectively. In addition, being CV a physiological parameter, its estimation is of marked interest to the study of fatigue both in physiological and in presence of neuromuscular diseases

Learning and mining from personal digital archives

Given the explosion of new sensing technologies, data storage has become significantly cheaper and consequently, people increasingly rely on wearable devices to create personal digital archives. Lifelogging is the act of recording aspects of life in digital format for a variety of purposes such as aiding human memory, analysing human lifestyle and diet monitoring. In this dissertation we are concerned with Visual Lifelogging, a form of lifelogging based on the passive capture of photographs by a wearable camera. Cameras, such as Microsoft's SenseCam can record up to 4,000 images per day as well as logging data from several incorporated sensors. Considering the volume, complexity and heterogeneous nature of such data collections, it is a signifcant challenge to interpret and extract knowledge for the practical use of lifeloggers and others. In this dissertation, time series analysis methods have been used to identify and extract useful information from temporal lifelogging images data, without benefit of prior knowledge. We focus, in particular, on three fundamental topics: noise reduction, structure and characterization of the raw data; the detection of multi-scale patterns; and the mining of important, previously unknown repeated patterns in the time series of lifelog image data. Firstly, we show that Detrended Fluctuation Analysis (DFA) highlights the feature of very high correlation in lifelogging image collections. Secondly, we show that study of equal-time Cross-Correlation Matrix demonstrates atypical or non-stationary characteristics in these images. Next, noise reduction in the Cross-Correlation Matrix is addressed by Random Matrix Theory (RMT) before Wavelet multiscaling is used to characterize the `most important' or `unusual' events through analysis of the associated dynamics of the eigenspectrum. A motif discovery technique is explored for detection of recurring and recognizable episodes of an individual's image data. Finally, we apply these motif discovery techniques to two known lifelog data collections, All I Have Seen (AIHS) and NTCIR-12 Lifelog, in order to examine multivariate recurrent patterns of multiple-lifelogging users

Dynamical Modeling Techniques for Biological Time Series Data

The present thesis is articulated over two main topics which have in common the modeling of the dynamical properties of complex biological systems from large-scale time-series data. On one hand, this thesis analyzes the inverse problem of reconstructing Gene Regulatory Networks (GRN) from gene expression data. This first topic seeks to reverse-engineer the transcriptional regulatory mechanisms involved in few biological systems of interest, vital to understand the specificities of their different responses. In the light of recent mathematical developments, a novel, flexible and interpretable modeling strategy is proposed to reconstruct the dynamical dependencies between genes from short-time series data. In addition, experimental trade-offs and optimal modeling strategies are investigated for given data availability. Consistent literature on these topics was previously surprisingly lacking. The proposed methodology is applied to the study of circadian rhythms, which consists in complex GRN driving most of daily biological activity across many species. On the other hand, this manuscript covers the characterization of dynamically differentiable brain states in Zebrafish in the context of epilepsy and epileptogenesis. Zebrafish larvae represent a valuable animal model for the study of epilepsy due to both their genetic and dynamical resemblance with humans. The fundamental premise of this research is the early apparition of subtle functional changes preceding the clinical symptoms of seizures. More generally, this idea, based on bifurcation theory, can be described by a progressive loss of resilience of the brain and ultimately, its transition from a healthy state to another characterizing the disease. First, the morphological signatures of seizures generated by distinct pathological mechanisms are investigated. For this purpose, a range of mathematical biomarkers that characterizes relevant dynamical aspects of the neurophysiological signals are considered. Such mathematical markers are later used to address the subtle manifestations of early epileptogenic activity. Finally, the feasibility of a probabilistic prediction model that indicates the susceptibility of seizure emergence over time is investigated. The existence of alternative stable system states and their sudden and dramatic changes have notably been observed in a wide range of complex systems such as in ecosystems, climate or financial markets

OBJECTIVE IMAGING TECHNIQUE FOR PSORIASIS ANALYSIS

Most of skin assessment methods applied in clinical practice use visual and tactile senses of dermatologists to assess features and conditions of skin diseases. However, the assessment can be subjective resulting in intra- and inter-rater variability. This research investigates the objective skin roughness measurement for psoriasis lesion assessment

Models and analysis of vocal emissions for biomedical applications

This book of Proceedings collects the papers presented at the 4th International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications, MAVEBA 2005, held 29-31 October 2005, Firenze, Italy. The workshop is organised every two years, and aims to stimulate contacts between specialists active in research and industrial developments, in the area of voice analysis for biomedical applications. The scope of the Workshop includes all aspects of voice modelling and analysis, ranging from fundamental research to all kinds of biomedical applications and related established and advanced technologies

Pattern Recognition

A wealth of advanced pattern recognition algorithms are emerging from the interdiscipline between technologies of effective visual features and the human-brain cognition process. Effective visual features are made possible through the rapid developments in appropriate sensor equipments, novel filter designs, and viable information processing architectures. While the understanding of human-brain cognition process broadens the way in which the computer can perform pattern recognition tasks. The present book is intended to collect representative researches around the globe focusing on low-level vision, filter design, features and image descriptors, data mining and analysis, and biologically inspired algorithms. The 27 chapters coved in this book disclose recent advances and new ideas in promoting the techniques, technology and applications of pattern recognition