17,348 research outputs found
A practical review on the measurement tools for cellular adhesion force
Cell cell and cell matrix adhesions are fundamental in all multicellular
organisms. They play a key role in cellular growth, differentiation, pattern
formation and migration. Cell-cell adhesion is substantial in the immune
response, pathogen host interactions, and tumor development. The success of
tissue engineering and stem cell implantations strongly depends on the fine
control of live cell adhesion on the surface of natural or biomimetic
scaffolds. Therefore, the quantitative and precise measurement of the adhesion
strength of living cells is critical, not only in basic research but in modern
technologies, too. Several techniques have been developed or are under
development to quantify cell adhesion. All of them have their pros and cons,
which has to be carefully considered before the experiments and interpretation
of the recorded data. Current review provides a guide to choose the appropriate
technique to answer a specific biological question or to complete a biomedical
test by measuring cell adhesion
Polarized cortical tension drives zebrafish epiboly movements
The principles underlying the biomechanics of morphogenesis are
largely unknown. Epiboly is an essential embryonic event in which
three tissues coordinate to direct the expansion of the blastoderm.
How and where forces are generated during epiboly, and how
these are globally coupled remains elusive. Here we developed a
method, hydrodynamic regression (HR), to infer 3D pressure fields,
mechanical power, and cortical surface tension profiles. HR is
based on velocity measurements retrieved from 2D+T microscopy
and their hydrodynamic modeling. We applied HR to identify
biomechanically active structures and changes in cortex local
tension during epiboly in zebrafish. Based on our results, we
propose a novel physical description for epiboly, where tissue
movements are directed by a polarized gradient of cortical tension.
We found that this gradient relies on local contractile forces at the
cortex, differences in elastic properties between cortex components
and the passive transmission of forces within the yolk cell.
All in all, our work identifies a novel way to physically regulate
concerted cellular movements that might be instrumental for the
mechanical control of many morphogenetic processes.Peer ReviewedPostprint (author's final draft
Aerospace medicine and biology: A continuing bibliography with indexes, supplement 128, May 1974
This special bibliography lists 282 reports, articles, and other documents introduced into the NASA scientific and technical information system in April 1974
Aerospace medicine and biology: A continuing bibliography with indexes
This bibliography lists 138 reports, articles, and other documents introduced into the NASA scientific and technical information system in Jun. 1980
Towards a cyber physical system for personalised and automatic OSA treatment
Obstructive sleep apnea (OSA) is a breathing disorder that takes place in the course of the sleep and is produced by a complete or a partial obstruction of the upper airway that manifests itself as frequent breathing stops and starts during the sleep. The real-time evaluation of whether or not a patient is undergoing OSA episode is a very important task in medicine in many scenarios, as for example for making instantaneous pressure adjustments that should take place when Automatic Positive Airway Pressure (APAP) devices are used during the treatment of OSA. In this paper the design of a possible Cyber Physical System (CPS) suited to real-time monitoring of OSA is described, and its software architecture and possible hardware sensing components are detailed. It should be emphasized here that this paper does not deal with a full CPS, rather with a software part of it under a set of assumptions on the environment. The paper also reports some preliminary experiments about the cognitive and learning capabilities of the designed CPS involving its use on a publicly available sleep apnea database
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