Visual analytics methods for retinal layers in optical coherence tomography data

Optical coherence tomography is an important imaging technology for the early detection of ocular diseases. Yet, identifying substructural defects in the 3D retinal images is challenging. We therefore present novel visual analytics methods for the exploration of small and localized retinal alterations. Our methods reduce the data complexity and ensure the visibility of relevant information. The results of two cross-sectional studies show that our methods improve the detection of retinal defects, contributing to a deeper understanding of the retinal condition at an early stage of disease.Die optische Kohärenztomographie ist ein wichtiges Bildgebungsverfahren zur Früherkennung von Augenerkrankungen. Die Identifizierung von substrukturellen Defekten in den 3D-Netzhautbildern ist jedoch eine Herausforderung. Wir stellen daher neue Visual-Analytics-Methoden zur Exploration von kleinen und lokalen Netzhautveränderungen vor. Unsere Methoden reduzieren die Datenkomplexität und gewährleisten die Sichtbarkeit relevanter Informationen. Die Ergebnisse zweier Querschnittsstudien zeigen, dass unsere Methoden die Erkennung von Netzhautdefekten in frühen Krankheitsstadien verbessern

Biomechanical Locomotion Heterogeneity in Synthetic Crowds

Synthetic crowd simulation combines rule sets at different conceptual layers to represent the dynamic nature of crowds while adhering to basic principles of human steering, such as collision avoidance and goal completion. In this dissertation, I explore synthetic crowd simulation at the steering layer using a critical approach to define the central theme of the work, the impact of model representation and agent diversity in crowds. At the steering layer, simulated agents make regular decisions, or actions, related to steering which are often responsible for the emergent behaviours found in the macro-scale crowd. Because of this bottom-up impact of a steering model's defining rule-set, I postulate that biomechanics and diverse biomechanics may alter the outcomes of dynamic synthetic-crowds-based outcomes. This would mean that an assumption of normativity and/or homogeneity among simulated agents and their mobility would provide an inaccurate representation of a scenario. If these results are then used to make real world decisions, say via policy or design, then those populations not represented in the simulated scenario may experience a lack of representation in the actualization of those decisions. A focused literature review shows that applications of both biomechanics and diverse locomotion representation at this layer of modelling are very narrow and often not present. I respond to the narrowness of this representation by addressing both biomechanics and heterogeneity separately. To address the question of performance and importance of locomotion biomechanics in crowd simulation, I use a large scale comparative approach. The industry standard synthetic crowd models are tested under a battery of benchmarks derived from prior work in comparative analysis of synthetic crowds as well as new scenarios derived from built environments. To address the question of the importance of heterogeneity in locomotion biomechanics, I define tiers of impact in the multi-agent crowds model at the steering layer--from the action space, to the agent space, to the crowds space. To this end, additional models and layers are developed to address the modelling and application of heterogeneous locomotion biomechanics in synthetic crowds. The results of both studies form a research arc which shows that the biomechanics in steering models provides important fidelity in several applications and that heterogeneity in the model of locomotion biomechanics directly impacts both qualitative and quantitative synthetic crowds outcomes. As well, systems, approaches, and pitfalls regarding the analysis of steering model and human mobility diversity are described

Lagrangian Data-Driven Reduced Order Modeling of Finite Time Lyapunov Exponents

There are two main strategies for improving the projection-based reduced order model (ROM) accuracy: (i) improving the ROM, i.e., adding new terms to the standard ROM; and (ii) improving the ROM basis, i.e., constructing ROM bases that yield more accurate ROMs. In this paper, we use the latter. We propose new Lagrangian inner products that we use together with Eulerian and Lagrangian data to construct new Lagrangian ROMs. We show that the new Lagrangian ROMs are orders of magnitude more accurate than the standard Eulerian ROMs, i.e., ROMs that use standard Eulerian inner product and data to construct the ROM basis. Specifically, for the quasi-geostrophic equations, we show that the new Lagrangian ROMs are more accurate than the standard Eulerian ROMs in approximating not only Lagrangian fields (e.g., the finite time Lyapunov exponent (FTLE)), but also Eulerian fields (e.g., the streamfunction). We emphasize that the new Lagrangian ROMs do not employ any closure modeling to model the effect of discarded modes (which is standard procedure for low-dimensional ROMs of complex nonlinear systems). Thus, the dramatic increase in the new Lagrangian ROMs' accuracy is entirely due to the novel Lagrangian inner products used to build the Lagrangian ROM basis

Mobility Prediction-Based Optimisation and Encryption of Passenger Traffic-Flows Using Machine Learning

Information and Communication Technology (ICT) enabled optimisation of train’s passenger traffic flows is a key consideration of transportation under Smart City planning (SCP). Traditional mobility prediction based optimisation and encryption approaches are reactive in nature; however, Artificial Intelligence (AI) driven proactive solutions are required for near real-time optimisation. Leveraging the historical passenger data recorded via Radio Frequency Identification (RFID) sensors installed at the train stations, mobility prediction models can be developed to support and improve the railway operational performance vis-a-vis 5G and beyond. In this paper we have analysed the passenger traffic flows based on an Access, Egress and Interchange (AEI) framework to support train infrastructure against congestion, accidents, overloading carriages and maintenance. This paper predominantly focuses on developing passenger flow predictions using Machine Learning (ML) along with a novel encryption model that is capable of handling the heavy passenger traffic flow in real-time. We have compared and reported the performance of various ML driven flow prediction models using real-world passenger flow data obtained from London Underground and Overground (LUO). Extensive spatio-temporal simulations leveraging realistic mobility prediction models show that an AEI framework can achieve 91.17% prediction accuracy along with secure and light-weight encryption capabilities. Security parameters such as correlation coefficient (7.70), number of pixel change rate (>99%), unified average change intensity (>33), contrast (>10), homogeneity