Enhanced algorithms for lesion detection and recognition in ultrasound breast images

Mammography is the gold standard for breast cancer detection. However, it has very high false positive rates and is based on ionizing radiation. This has led to interest in using multi-modal approaches. One modality is diagnostic ultrasound, which is based on non-ionizing radiation and picks up many of the cancers that are generally missed by mammography. However, the presence of speckle noise in ultrasound images has a negative effect on image interpretation. Noise reduction, inconsistencies in capture and segmentation of lesions still remain challenging open research problems in ultrasound images. The target of the proposed research is to enhance the state-of-art computer vision algorithms used in ultrasound imaging and to investigate the role of computer processed images in human diagnostic performance. [Continues.

Detection of Myofascial Trigger Points With Ultrasound Imaging and Machine Learning

Myofascial Pain Syndrome (MPS) is a common chronic muscle pain disorder that affects a large portion of the global population, seen in 85-93% of patients in specialty pain clinics [10]. MPS is characterized by hard, palpable nodules caused by a stiffened taut band of muscle fibers. These nodules are referred to as Myofascial Trigger Points (MTrPs) and can be classified by two states: active MTrPs (A-MTrPs) and latent MtrPs (L-MTrPs). Treatment for MPS involves massage therapy, acupuncture, and injections or painkillers. Given the subjectivity of patient pain quantification, MPS can often lead to mistreatment or drug misuse. A deterministic way to quantify the pain is needed for better diagnosis and treatment. Various medical imaging technologies have been used to try to find quantifiable and measurable biomarkers of MTrPs. Ultrasound imaging, with it’s accessibility and variety of modalities, has shown significant findings in identifying MTrPs. Elastography ultrasound, which is used for measuring stiffness in soft tissues, has shown that MTrPs tend to be stiffer than normal muscle tissue. Doppler ultrasound has shown that bloodflow velocities differ significantly in areas surrounding MTrPs. MTrPs have been identified in standard B-mode grayscale ultrasound, but have varying conclusions with some studies identifying them as dark hypoechoic blobs and other studies showing them as bright hyperechoic blobs. Despite these discoveries, there is a high variance among results with no correlations to severity or pain. As a step towards quantifying the pain associated with MTrPs, this work aims to introduce a machine learning approach using image processing with texture recognition to detect MTrPs in Bmode ultrasound. A texture recognition algorithm called Gray Level Co-Occurrence Matrix (GLCM) is used to extract texture features from the B-mode ultrasound image. Feature maps are generated to emphasize these texture features in an image format in anticipation that a deep convolutional neural network will be able to correlate the features with the presence of a MTrP. The GLCM feature maps are compared to the elastography ultrasound to determine any correlations with muscle stiffness and then evaluated in the presence of MTrPs. The feature map generation is accelerated with a GPU-based implementation for the goal of real-time processing and inference of the machine learning model. Finally, two deep learning models are implemented to detect MTrPs comparing the effect of using GLCM feature maps of B-mode ultrasound to emphasize texture features for machine learning model inputs

Machine learning methods for the characterization and classification of complex data

This thesis work presents novel methods for the analysis and classification of medical images and, more generally, complex data. First, an unsupervised machine learning method is proposed to order anterior chamber OCT (Optical Coherence Tomography) images according to a patient's risk of developing angle-closure glaucoma. In a second study, two outlier finding techniques are proposed to improve the results of above mentioned machine learning algorithm, we also show that they are applicable to a wide variety of data, including fraud detection in credit card transactions. In a third study, the topology of the vascular network of the retina, considering it a complex tree-like network is analyzed and we show that structural differences reveal the presence of glaucoma and diabetic retinopathy. In a fourth study we use a model of a laser with optical injection that presents extreme events in its intensity time-series to evaluate machine learning methods to forecast such extreme events.El presente trabajo de tesis desarrolla nuevos métodos para el análisis y clasificación de imágenes médicas y datos complejos en general. Primero, proponemos un método de aprendizaje automático sin supervisión que ordena imágenes OCT (tomografía de coherencia óptica) de la cámara anterior del ojo en función del grado de riesgo del paciente de padecer glaucoma de ángulo cerrado. Luego, desarrollamos dos métodos de detección automática de anomalías que utilizamos para mejorar los resultados del algoritmo anterior, pero que su aplicabilidad va mucho más allá, siendo útil, incluso, para la detección automática de fraudes en transacciones de tarjetas de crédito. Mostramos también, cómo al analizar la topología de la red vascular de la retina considerándola una red compleja, podemos detectar la presencia de glaucoma y de retinopatía diabética a través de diferencias estructurales. Estudiamos también un modelo de un láser con inyección óptica que presenta eventos extremos en la serie temporal de intensidad para evaluar diferentes métodos de aprendizaje automático para predecir dichos eventos extremos.Aquesta tesi desenvolupa nous mètodes per a l’anàlisi i la classificació d’imatges mèdiques i dades complexes. Hem proposat, primer, un mètode d’aprenentatge automàtic sense supervisió que ordena imatges OCT (tomografia de coherència òptica) de la cambra anterior de l’ull en funció del grau de risc del pacient de patir glaucoma d’angle tancat. Després, hem desenvolupat dos mètodes de detecció automàtica d’anomalies que hem utilitzat per millorar els resultats de l’algoritme anterior, però que la seva aplicabilitat va molt més enllà, sent útil, fins i tot, per a la detecció automàtica de fraus en transaccions de targetes de crèdit. Mostrem també, com en analitzar la topologia de la xarxa vascular de la retina considerant-la una xarxa complexa, podem detectar la presència de glaucoma i de retinopatia diabètica a través de diferències estructurals. Finalment, hem estudiat un làser amb injecció òptica, el qual presenta esdeveniments extrems en la sèrie temporal d’intensitat. Hem avaluat diferents mètodes per tal de predir-los.Postprint (published version

Robust density modelling using the student's t-distribution for human action recognition

The extraction of human features from videos is often inaccurate and prone to outliers. Such outliers can severely affect density modelling when the Gaussian distribution is used as the model since it is highly sensitive to outliers. The Gaussian distribution is also often used as base component of graphical models for recognising human actions in the videos (hidden Markov model and others) and the presence of outliers can significantly affect the recognition accuracy. In contrast, the Student's t-distribution is more robust to outliers and can be exploited to improve the recognition rate in the presence of abnormal data. In this paper, we present an HMM which uses mixtures of t-distributions as observation probabilities and show how experiments over two well-known datasets (Weizmann, MuHAVi) reported a remarkable improvement in classification accuracy. © 2011 IEEE

Texture and Colour in Image Analysis

Research in colour and texture has experienced major changes in the last few years. This book presents some recent advances in the field, specifically in the theory and applications of colour texture analysis. This volume also features benchmarks, comparative evaluations and reviews

Feature Enhancement in Medical Ultrasound Videos Using Multifractal and Contrast Adaptive Histogram Equalization Techniques

Speckle noise reduction algorithms are extensively used in the field of ultrasound image analysis with the aim of improving image quality and diagnostic accuracy. However, significant speckle filtering induces blurring, and this would require enhancement of features and fine details. In this paper, we consider the applications of multifractal features and contrast limit adaptive histogram equalization method for improving texture features, contrast, resolvable details, and image structures to which the human visual system is sensitive in ultrasound video frames. The experimental analysis considered various types of ultrasound video scans of the human anatomy e.g. breast cancer, uterine fibroids, transvaginal ovary, ovarian cyst, heart, and chest pleural effusion scan. Subjective assessments by four radiologists and experimental validation using three quality metrics clearly indicate that the proposed algorithm is able to reduce speckle effectively while preserving essential information and enhancing the overall visual quality

Bioinspired metaheuristic algorithms for global optimization

This paper presents concise comparison study of newly developed bioinspired algorithms for global optimization problems. Three different metaheuristic techniques, namely Accelerated Particle Swarm Optimization (APSO), Firefly Algorithm (FA), and Grey Wolf Optimizer (GWO) are investigated and implemented in Matlab environment. These methods are compared on four unimodal and multimodal nonlinear functions in order to find global optimum values. Computational results indicate that GWO outperforms other intelligent techniques, and that all aforementioned algorithms can be successfully used for optimization of continuous functions

Experimental Evaluation of Growing and Pruning Hyper Basis Function Neural Networks Trained with Extended Information Filter

In this paper we test Extended Information Filter (EIF) for sequential training of Hyper Basis Function Neural Networks with growing and pruning ability (HBF-GP). The HBF neuron allows different scaling of input dimensions to provide better generalization property when dealing with complex nonlinear problems in engineering practice. The main intuition behind HBF is in generalization of Gaussian type of neuron that applies Mahalanobis-like distance as a distance metrics between input training sample and prototype vector. We exploit concept of neuron’s significance and allow growing and pruning of HBF neurons during sequential learning process. From engineer’s perspective, EIF is attractive for training of neural networks because it allows a designer to have scarce initial knowledge of the system/problem. Extensive experimental study shows that HBF neural network trained with EIF achieves same prediction error and compactness of network topology when compared to EKF, but without the need to know initial state uncertainty, which is its main advantage over EKF