Functional classification of G-Protein coupled receptors, based on their specific ligand coupling patterns

Functional identification of G-Protein Coupled Receptors (GPCRs) is one of the current focus areas of pharmaceutical research. Although thousands of GPCR sequences are known, many of them re- main as orphan sequences (the activating ligand is unknown). Therefore, classification methods for automated characterization of orphan GPCRs are imperative. In this study, for predicting Level 2 subfamilies of Amine GPCRs, a novel method for obtaining fixed-length feature vectors, based on the existence of activating ligand specific patterns, has been developed and utilized for a Support Vector Machine (SVM)-based classification. Exploiting the fact that there is a non-promiscuous relationship between the specific binding of GPCRs into their ligands and their functional classification, our method classifies Level 2 subfamilies of Amine GPCRs with a high predictive accuracy of 97.02% in a ten-fold cross validation test. The presented machine learning approach, bridges the gulf between the excess amount of GPCR sequence data and their poor functional characterization

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

A sparse multinomial probit model for classification

A recent development in penalized probit modelling using a hierarchical Bayesian approach has led to a sparse binomial (two-class) probit classifier that can be trained via an EM algorithm. A key advantage of the formulation is that no tuning of hyperparameters relating to the penalty is needed thus simplifying the model selection process. The resulting model demonstrates excellent classification performance and a high degree of sparsity when used as a kernel machine. It is, however, restricted to the binary classification problem and can only be used in the multinomial situation via a one-against-all or one-against-many strategy. To overcome this, we apply the idea to the multinomial probit model. This leads to a direct multi-classification approach and is shown to give a sparse solution with accuracy and sparsity comparable with the current state-of-the-art. Comparative numerical benchmark examples are used to demonstrate the method

Flame Detection for Video-based Early Fire Warning Systems and 3D Visualization of Fire Propagation

Early and accurate detection and localization of flame is an essential requirement of modern early fire warning systems. Video-based systems can be used for this purpose; however, flame detection remains a challenging issue due to the fact that many natural objects have similar characteristics with fire. In this paper, we present a new algorithm for video based flame detection, which employs various spatio-temporal features such as colour probability, contour irregularity, spatial energy, flickering and spatio-temporal energy. Various background subtraction algorithms are tested and comparative results in terms of computational efficiency and accuracy are presented. Experimental results with two classification methods show that the proposed methodology provides high fire detection rates with a reasonable false alarm ratio. Finally, a 3D visualization tool for the estimation of the fire propagation is outlined and simulation results are presented and discussed.The original article was published by ACTAPRESS and is available here: http://www.actapress.com/Content_of_Proceeding.aspx?proceedingid=73

PyCARL: A PyNN Interface for Hardware-Software Co-Simulation of Spiking Neural Network

We present PyCARL, a PyNN-based common Python programming interface for hardware-software co-simulation of spiking neural network (SNN). Through PyCARL, we make the following two key contributions. First, we provide an interface of PyNN to CARLsim, a computationally-efficient, GPU-accelerated and biophysically-detailed SNN simulator. PyCARL facilitates joint development of machine learning models and code sharing between CARLsim and PyNN users, promoting an integrated and larger neuromorphic community. Second, we integrate cycle-accurate models of state-of-the-art neuromorphic hardware such as TrueNorth, Loihi, and DynapSE in PyCARL, to accurately model hardware latencies that delay spikes between communicating neurons and degrade performance. PyCARL allows users to analyze and optimize the performance difference between software-only simulation and hardware-software co-simulation of their machine learning models. We show that system designers can also use PyCARL to perform design-space exploration early in the product development stage, facilitating faster time-to-deployment of neuromorphic products. We evaluate the memory usage and simulation time of PyCARL using functionality tests, synthetic SNNs, and realistic applications. Our results demonstrate that for large SNNs, PyCARL does not lead to any significant overhead compared to CARLsim. We also use PyCARL to analyze these SNNs for a state-of-the-art neuromorphic hardware and demonstrate a significant performance deviation from software-only simulations. PyCARL allows to evaluate and minimize such differences early during model development.Comment: 10 pages, 25 figures. Accepted for publication at International Joint Conference on Neural Networks (IJCNN) 202

Secure Virtualization and Multicore Platforms State-of-the-Art report

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Distance-based kernels for real-valued data

We consider distance-based similarity measures for real-valued vectors of interest in kernel-based machine learning algorithms. In particular, a truncated Euclidean similarity measure and a self-normalized similarity measure related to the Canberra distance. It is proved that they are positive semi-definite (p.s.d.), thus facilitating their use in kernel-based methods, like the Support Vector Machine, a very popular machine learning tool. These kernels may be better suited than standard kernels (like the RBF) in certain situations, that are described in the paper. Some rather general results concerning positivity properties are presented in detail as well as some interesting ways of proving the p.s.d. property.Peer ReviewedPostprint (author's final draft