Reusable Rocket Engine Turbopump Health Management System

A health monitoring expert system software architecture has been developed to support condition-based health monitoring of rocket engines. Its first application is in the diagnosis decisions relating to the health of the high pressure oxidizer turbopump (HPOTP) of Space Shuttle Main Engine (SSME). The post test diagnostic system runs off-line, using as input the data recorded from hundreds of sensors, each running typically at rates of 25, 50, or .1 Hz. The system is invoked after a test has been completed, and produces an analysis and an organized graphical presentation of the data with important effects highlighted. The overall expert system architecture has been developed and documented so that expert modules analyzing other line replaceable units may easily be added. The architecture emphasizes modularity, reusability, and open system interfaces so that it may be used to analyze other engines as well

Atomic: an open-source software platform for multi-level corpus annotation

This paper presents Atomic, an open-source platform-independent desktop application for multi-level corpus annotation. Atomic aims at providing the linguistic community with a user-friendly annotation tool and sustainable platform through its focus on extensibility, a generic data model, and compatibility with existing linguistic formats. It is implemented on top of the Eclipse Rich Client Platform, a pluggable Java-based framework for creating client applications. Atomic - as a set of plug-ins for this framework - integrates with the platform and allows other researchers to develop and integrate further extensions to the software as needed. The generic graph-based meta model Salt serves as Atomic’s domain model and allows for unlimited annotation levels and types. Salt is also used as an intermediate model in the Pepper framework for conversion of linguistic data, which is fully integrated into Atomic, making the latter compatible with a wide range of linguistic formats. Atomic provides tools for both less experienced and expert annotators: graphical, mouse-driven editors and a command-line data manipulation language for rapid annotation

The NEUMA Project: towards Cooperative On-line Music Score Libraries

Περιέχει το πλήρες κείμενοThe NEUMA project (http://neuma.irpmf-cnrs.fr) aims at designing and evaluating an open cooperative system for musician communities, enabling new search and analysis tools for symbolic musical content sharing and dissemination. The project is organized around the French CNRS laboratory of the Bibliothèque Nationale de France which provides sample collections, user requirements and expert validation. The paper presents the project goals, its achitecture and current state of development. We illustrate our approach with an on-line publication of monodic collections centered on XVIIe century French liturgic chants

Power User Interface

Power User Interface 5.0 (PUI) is a system of middleware, written for expert users in the Earth-science community, PUI enables expedited ordering of data granules on the basis of specific granule-identifying information that the users already know or can assemble. PUI also enables expert users to perform quick searches for orderablegranule information for use in preparing orders. PUI 5.0 is available in two versions (note: PUI 6.0 has command-line mode only): a Web-based application program and a UNIX command-line- mode client program. Both versions include modules that perform data-granule-ordering functions in conjunction with external systems. The Web-based version works with Earth Observing System Clearing House (ECHO) metadata catalog and order-entry services and with an open-source order-service broker server component, called the Mercury Shopping Cart, that is provided separately by Oak Ridge National Laboratory through the Department of Energy. The command-line version works with the ECHO metadata and order-entry process service. Both versions of PUI ultimately use ECHO to process an order to be sent to a data provider. Ordered data are provided through means outside the PUI software system

First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion

Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance therapy is the latest breakthrough in the management of newly diagnosed advanced ovarian cancer. The results of the SOLO-1 trial in 2018 led to European Medicines Agency and Food and Drug Administration approval of olaparib as first-line maintenance therapy in patients with BRCA1/2 mutation, establishing a new standard of care. Subsequently, the results of three phase III trials (PRIMA, PAOLA-1, VELIA) evaluating the use of first-line PARP inhibitors beyond patients with BRCA1/2 mutations and as combination strategies were presented in 2019, leading to the recent approval of maintenance niraparib irrespective of biomarker status and olaparib in combination with bevacizumab in homologous recombination deficiencypositive-associated advanced ovarian cancer. An ESMO Open - Cancer Horizons round-table expert panel discussed the four phase III trials of first-line PARP inhibitor therapy and how they are changing the clinical management of advanced ovarian cancer

Differences in views of experts about their role in particulate matter policy advice: Empirical evidence from an international expert consultation

There is ample scientific evidence of adverse health effects of air pollution at exposure levels that are common among the general population. Some points of uncertainty remain, however. Several theories exist regarding the various roles that experts may play when they offer policy advice on uncertain issues such as particulate matter (PM). Roles may vary according to e.g. the views of the expert on the science-policy interface or the extent to which she/he involves stakeholders. Empirical underpinning of these theories, however, does not exist. We therefore conducted a consultation with experts on the following research question: What are PM experts’ views on their roles when providing policy advice? Q methodology was used to empirically test theoretical notions concerning the existence of differences in views on expert roles. Experts were selected based on a structured nominee process. In total, 31 international PM experts participated. Responses were examined via Principal Component Analysis, and for the open-ended questions, we used Atlas.ti software. Four different expert roles were identified among the participating experts. Main differences were found with respect to views on the need for precautionary measures and on the experts positioning within the science-policy interface. There was consensus on certain issues such as the need for transparency, general disagreement with current policies and general agreement on key scientific issues. This empirical study shows that while most PM experts consider their views on the risks of PM to be in line with those of their colleagues, four distinct expert roles were observed. This provides support for thus far largely theoretical debates on the existence of different roles of experts when they provide policy advice

Towards an Expert Network in Open Standards and Open Source Software: Research, Expertise and Synergy for Open and Libres Standards and Software (RESOLL) - Version 2.0

CIRANO and its partners are proposing the creation of an Expert Network in Open Standards and Open Source Software (Research, Expertise and Synergy for Open and Libres Standards and Software-RESOLL), which would be a partnership between information technology research centres, government and private user organizations, and businesses working in the field. The network will conduct studies and pilot projects that integrate computer solutions based on open standards and open source software, mainly in e-government fields such as health, education, and scientific research, as well as municipal and quasi-public services and business processes for SMEs. The knowledge, expertise and tools thus developed will be disseminated in a number of ways in order to Quebec and Canadian expertise in the field. RESOLL will also have economic and strategic benefits in that it will put the new economic model to the test in terms of open standards and open source software as well as the reuse of software components by organizations. Background The development of on-line government services and e-business is a priority for governments and businesses of all sizes. It requires considerable spending and significant strategic and organizational changes. Of the many information technology solutions available, the use of open standards and open source software is often brought up by those in the know. Although the Internet and many world-renowned software programs were developed largely from open standards and open source software, there is still a need to study, and above all prove the advantages of this approach for public and quasi-public organizations as well as small to medium-sized businesses. It is essential to identify the needs of these organizations, document best practices, experiment with open source software solutions, evaluate the performance of the software and share the knowledge and know-how of Quebec and Canadian research centres and businesses. RESOLL Goals he main goal of the Expert Network on Open Standards and Open Source Software (RESOLL) is to give people an understanding of the benefits of open standards and open source software and suggest an intelligent and advantageous use of them for public and quasi-public organizations and SMEs. More specifically, the goals are as follows: Document and share government and industry policies, strategies, and practices with respect to the use and development of adaptive software and open source software, defining open standards, open source software, adaptive software, and proprietary software; Adapt these practices and share the different methods with partners and the IT management and development communities in government and business; Establish innovative prototypes and pilot projects in order to test and demonstrate the advantages and features of this approach; Develop the expertise of Quebec and Canadian organizations in the field and create synergy between them and their users; P ublish and share the findings of the work, contribute to the enrichment of a collective software asset base available to public and quasi-public organizations and SMEs while explaining the legal issues involved in the various types of licences and electronic services. Process ESOLL is a multilateral partnership founded on the excellence of partners in their respective field. The RESOLL process will be based on the needs of its partners and users. Once these needs have been identified, research will be conducted to identify available solutions, adapt them through an integration process and alpha test them. This would be followed by a pilot project as required by the organizations and businesses. The pilot project will be implemented and evaluated in order to learn from it and ensure that necessary adjustments are made. Solutions thus obtained will be implemented as electronic services either by the client organization’s IT department or by a business partner. It is up to each organization to select their service provider. RESOLL will encourage the transfer of developed tools and services to partners for complete autonomy. Each project will have its own budget, funded by client partners. RESOLL will use part of its operating budget to start projects and develop a start-up asset base for its activities. Expectations and Deliverables The expectations of RESOLL partners and the team can be expressed by the achievement of their goals. RESOLL’s actions will quickly lead to concrete results. The deliverables will be: Policy and position papers to help partners make clear and informed decisions; Needs analyses and suggested solutions; Software solutions based on open standards and open source software integrated into experimental electronic services; Pilot project experiments that combine strategies, plans, software solutions, project support, evaluation and recommendations; Studies and interpretation documents for different types of licences and software; Collaborative Web site for sharing documents and open source software developed in the context of RESOLL projects or available on the Internet, with comments and explanations; Information and knowledge sharing activities for RESOLL and its partners (conferences, workshops, training, etc.). Partners RESOLL is a multilateral partnership. The partners that have been asked to become involved are: CIRANO, CRIM, RISQ, the governments of Quebec and Canada, Industry Canada, university researchers, Canadian and Quebec software and information technology companies, and not-for-profit user organizations from the software and information technology fields. Budget ESOLL’s master infrastructure budget will make it possible to establish a small coordination team involving part-time resources seconded from their parent organizations. We plan to obtain general financing from government and the businesses involved. The individual projects will provide their own financing. Other Benefits RESOLL will contribute to Quebec’s and Canada’s world leadership by sharing the results of its work. It will contribute to the eventual creation of resources that will enable partner companies to commercialize services based on open source software.Open standard, free software, open software, FOSS, e-government, business process, small and medium enterprises,

Controlador difuso basado en la tabla de búsqueda para controlar el proceso de la sala de vapor

Introduction: In this paper, using look-up table control strategy,a fuzzy logic controller is designed for controlling the temperatureof steaming room in terrazzo tile plant corresponding to dedicatedprocess diagrams. Methods: In the proposed method, the temperature and error of temperature are considered as inputs to controlthe duration of valve open time to decrease the activation times ofvalves in order to increase their longevity. The strategy considersan off-line trained look-up table for setting the time of openingvalve in the specific temperature. A fuzzy controller with fifteen extracted rules is designed for controlling the duration of valve opentime. Results: Results show that the number of switching of valvereduces compare to intuitionistic or expert rule extraction. Conclusions: Simulations provide more compatible steaming process routcompare to PID controllers

An automated high-content screening image analysis pipeline for the identification of selective autophagic inducers in human cancer cell lines.

Automated image processing is a critical and often rate-limiting step in high-content screening (HCS) workflows. The authors describe an open-source imaging-statistical framework with emphasis on segmentation to identify novel selective pharmacological inducers of autophagy. They screened a human alveolar cancer cell line and evaluated images by both local adaptive and global segmentation. At an individual cell level, region-growing segmentation was compared with histogram-derived segmentation. The histogram approach allowed segmentation of a sporadic-pattern foreground and hence the attainment of pixel-level precision. Single-cell phenotypic features were measured and reduced after assessing assay quality control. Hit compounds selected by machine learning corresponded well to the subjective threshold-based hits determined by expert analysis. Histogram-derived segmentation displayed robustness against image noise, a factor adversely affecting region growing segmentation