646 research outputs found

    Control and selection techniques for the automated testing of reactive systems

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    Revisiting Waiting Times in DNA evolution

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    Transcription factors are short stretches of DNA (or kk-mers) mainly located in promoters sequences that enhance or repress gene expression. With respect to an initial distribution of letters on the DNA alphabet, Behrens and Vingron consider a random sequence of length nn that does not contain a given kk-mer or word of size kk. Under an evolution model of the DNA, they compute the probability pn\mathfrak{p}_n that this kk-mer appears after a unit time of 20 years. They prove that the waiting time for the first apparition of the kk-mer is well approximated by Tn=1/pnT_n=1/\mathfrak{p}_n. Their work relies on the simplifying assumption that the kk-mer is not self-overlapping. They observe in particular that the waiting time is mostly driven by the initial distribution of letters. Behrens et al. use an approach by automata that relaxes the assumption related to words overlaps. Their numerical evaluations confirms the validity of Behrens and Vingron approach for non self-overlapping words, but provides up to 44% corrections for highly self-overlapping words such as AAAAA\mathtt{AAAAA}. We devised an approach of the problem by clump analysis and generating functions; this approach leads to prove a quasi-linear behaviour of pn\mathfrak{p}_n for a large range of values of nn, an important result for DNA evolution. We present here this clump analysis, first by language decomposition, and next by an automaton construction; finally, we describe an equivalent approach by construction of Markov automata.Comment: 19 pages, 3 Figures, 2 Table

    Learning Stochastic Tree Edit Distance

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    pages 42-53International audienceTrees provide a suited structural representation to deal with complex tasks such as web information extraction, RNA secondary structure prediction, or conversion of tree structured documents. In this context, many applications require the calculation of similarities between tree pairs. The most studied distance is likely the tree edit distance for which improvements in terms of complexity have been achieved during the last decade. However, this classic edit distance usually uses a priori fixed edit costs which are often difficult to tune, that leaves little room for tackling complex problems. In this paper, we focus on the learning of a stochastic tree edit distance. We use an adaptation of the expectation-maximization algorithm for learning the primitive edit costs. We carried out several series of experiments that confirm the interest to learn a tree edit distance rather than a priori imposing edit costs
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